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  1. Article ; Online: Extreme weather events and HIV: development of a conceptual framework through qualitative interviews with people with HIV impacted by the California wildfires and their clinicians.

    Saberi, Parya / Ming, Kristin / Arnold, Emily A / Leddy, Anna M / Weiser, Sheri D

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 950

    Abstract: Background: People with HIV (PWH) are disproportionately vulnerable to the impacts of wildfires, given the need for frequent access to healthcare systems, higher burden of comorbidities, higher food insecurity, mental and behavioral health challenges, ... ...

    Abstract Background: People with HIV (PWH) are disproportionately vulnerable to the impacts of wildfires, given the need for frequent access to healthcare systems, higher burden of comorbidities, higher food insecurity, mental and behavioral health challenges, and challenges of living with HIV in a rural area. In this study, we aim to better understand the pathways through which wildfires impact health outcomes among PWH.
    Methods: From October 2021 through February 2022, we conducted individual semi-structured qualitative interviews with PWH impacted by the Northern California wildfires and clinicians of PWH who were impacted by wildfires. The study aims were to explore the influence of wildfires on the health of PWH and to discuss measures at the individual, clinic, and system levels that helped to mitigate these impacts.
    Results: We interviewed 15 PWH and 7 clinicians. While some PWH felt that surviving the HIV epidemic added to their resilience against wildfires, many felt that the wildfires compounded the HIV-related traumas that they have experienced. Participants outlined five main routes by which wildfires negatively impacted their health: (1) access to healthcare (medications, clinics, clinic staff), (2) mental health (trauma; anxiety, depression, or stress; sleep disturbances; coping strategies), (3) physical health (cardiopulmonary, other co-morbidities), (4) social/economic impacts (housing, finances, community), and (5) nutrition and exercise. The recommendations for future wildfire preparedness were at the (1) individual-level (what to have during evacuation), (2) pharmacy-level (procedural, staffing), and (3) clinic- or county-level (funds and vouchers; case management; mental health services; emergency response planning; other services such as telehealth, home visits, home laboratory testing).
    Conclusions: Based on our data and prior research, we devised a conceptual framework that acknowledges the impact of wildfires at the community-, household-, and individual-level with implications for physical and mental health outcomes among PWH. These findings and framework can help in developing future interventions, programs, and policies to mitigate the cumulative impacts of extreme weather events on the health of PWH, particularly among individuals living in rural areas. Further studies are needed to examine health system strengthening strategies, innovative methods to improve access to healthcare, and community resilience through disaster preparedness.
    Trial registration: N/A.
    MeSH term(s) Humans ; Wildfires ; Extreme Weather ; Disasters ; California/epidemiology ; HIV Infections/epidemiology ; HIV Infections/psychology
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-15957-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Extreme weather events and HIV

    Parya Saberi / Kristin Ming / Emily A. Arnold / Anna M. Leddy / Sheri D. Weiser

    BMC Public Health, Vol 23, Iss 1, Pp 1-

    development of a conceptual framework through qualitative interviews with people with HIV impacted by the California wildfires and their clinicians

    2023  Volume 14

    Abstract: Abstract Background People with HIV (PWH) are disproportionately vulnerable to the impacts of wildfires, given the need for frequent access to healthcare systems, higher burden of comorbidities, higher food insecurity, mental and behavioral health ... ...

    Abstract Abstract Background People with HIV (PWH) are disproportionately vulnerable to the impacts of wildfires, given the need for frequent access to healthcare systems, higher burden of comorbidities, higher food insecurity, mental and behavioral health challenges, and challenges of living with HIV in a rural area. In this study, we aim to better understand the pathways through which wildfires impact health outcomes among PWH. Methods From October 2021 through February 2022, we conducted individual semi-structured qualitative interviews with PWH impacted by the Northern California wildfires and clinicians of PWH who were impacted by wildfires. The study aims were to explore the influence of wildfires on the health of PWH and to discuss measures at the individual, clinic, and system levels that helped to mitigate these impacts. Results We interviewed 15 PWH and 7 clinicians. While some PWH felt that surviving the HIV epidemic added to their resilience against wildfires, many felt that the wildfires compounded the HIV-related traumas that they have experienced. Participants outlined five main routes by which wildfires negatively impacted their health: (1) access to healthcare (medications, clinics, clinic staff), (2) mental health (trauma; anxiety, depression, or stress; sleep disturbances; coping strategies), (3) physical health (cardiopulmonary, other co-morbidities), (4) social/economic impacts (housing, finances, community), and (5) nutrition and exercise. The recommendations for future wildfire preparedness were at the (1) individual-level (what to have during evacuation), (2) pharmacy-level (procedural, staffing), and (3) clinic- or county-level (funds and vouchers; case management; mental health services; emergency response planning; other services such as telehealth, home visits, home laboratory testing). Conclusions Based on our data and prior research, we devised a conceptual framework that acknowledges the impact of wildfires at the community-, household-, and individual-level with implications for physical ...
    Keywords HIV ; Extreme weather events ; Climate change ; Wildfire ; Mental health ; Qualitative research ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A conceptual model for understanding the rapid COVID-19-related increase in food insecurity and its impact on health and healthcare.

    Leddy, Anna M / Weiser, Sheri D / Palar, Kartika / Seligman, Hilary

    The American journal of clinical nutrition

    2020  Volume 112, Issue 5, Page(s) 1162–1169

    Abstract: Food insecurity, a well-established determinant of chronic disease morbidity and mortality, is rapidly increasing due to the coronavirus disease 2019 (COVID-19) pandemic. We present a conceptual model to understand the multiple mechanisms through which ... ...

    Abstract Food insecurity, a well-established determinant of chronic disease morbidity and mortality, is rapidly increasing due to the coronavirus disease 2019 (COVID-19) pandemic. We present a conceptual model to understand the multiple mechanisms through which the economic and public health crises sparked by COVID-19 might increase food insecurity and contribute to poor health outcomes in the short- and long-term. We hypothesize that, in the short-term, increased food insecurity, household economic disruption, household stress, and interruptions in healthcare will contribute to acute chronic disease complications. However, the impact of the pandemic on food security will linger after social-distancing policies are lifted and the health system stabilizes, resulting in increased risk for chronic disease development, morbidity, and mortality among food-insecure households in the long-term. Research is needed to examine the impact of the pandemic-related increase in food insecurity on short- and long-term chronic health outcomes, and to delineate the underlying causal mechanisms. Such research is critical to inform the development of effective programs and policies to address food insecurity and its downstream health impacts during COVID-19 and future pandemics.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Chronic Disease/economics ; Chronic Disease/epidemiology ; Coronavirus Infections/economics ; Coronavirus Infections/epidemiology ; Delivery of Health Care ; Family Characteristics ; Food Supply ; Humans ; Income ; Pandemics/economics ; Pneumonia, Viral/economics ; Pneumonia, Viral/epidemiology ; Population Health ; Poverty ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.1093/ajcn/nqaa226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Social Determinants of Adherence to Treatment for Tuberculosis Infection and Disease Among Children, Adolescents, and Young Adults: A Narrative Review.

    Leddy, Anna M / Jaganath, Devan / Triasih, Rina / Wobudeya, Eric / Bellotti de Oliveira, Marcia C / Sheremeta, Yana / Becerra, Mercedes C / Chiang, Silvia S

    Journal of the Pediatric Infectious Diseases Society

    2022  Volume 11, Issue Supplement_3, Page(s) S79–S84

    Abstract: Global efforts to eliminate tuberculosis (TB) must address the unique barriers that children (ages 0 through 9 years) and adolescents/young adults (AYA; ages 10 through 24 years) face in adhering to treatment for TB infection and disease. We conducted a ... ...

    Abstract Global efforts to eliminate tuberculosis (TB) must address the unique barriers that children (ages 0 through 9 years) and adolescents/young adults (AYA; ages 10 through 24 years) face in adhering to treatment for TB infection and disease. We conducted a narrative review to summarize current knowledge on the social determinants of treatment adherence among these age groups to guide efforts and policy to address their unique needs. Our findings revealed that research on TB treatment adherence among children and AYA is still in its nascent stage. The current literature revealed structural/community-, health system-, household-, and individual-level factors that influence treatment adherence and varied with developmental stage. There is a need to develop multilevel interventions to address the unique challenges that children and AYA face in adhering to TB treatment.
    MeSH term(s) Child ; Adolescent ; Young Adult ; Humans ; Infant, Newborn ; Social Determinants of Health ; Tuberculosis/drug therapy ; Latent Tuberculosis ; Family Characteristics
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piac058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correlation between gender-based violence and poor treatment outcomes among transgender women living with HIV in Brazil.

    de Sousa Mascena Veras, Maria Amelia / Menezes, Neia Prata / Mocello, Adrienne Rain / Leddy, Anna M / Saggese, Gustavo Santa Roza / Bassichetto, Katia Cristina / Gilmore, Hailey J / de Carvalho, Paula Galdino Cardin / Maschião, Luca Fasciolo / Neilands, Torsten B / Sevelius, Jae / Lippman, Sheri A

    BMC public health

    2024  Volume 24, Issue 1, Page(s) 791

    Abstract: Background: Transgender women are disproportionately affected by both HIV and gender-based violence (GBV), defined as physical, sexual, or emotional violence perpetrated against an individual based on their gender identity/expression. While a growing ... ...

    Abstract Background: Transgender women are disproportionately affected by both HIV and gender-based violence (GBV), defined as physical, sexual, or emotional violence perpetrated against an individual based on their gender identity/expression. While a growing body of evidence demonstrates that GBV leads to poor HIV care and treatment outcomes among cisgender women, less research has examined this association among transgender women. We assessed the impact of lifetime experiences of GBV on subsequent retention in HIV care and laboratory confirmed viral suppression among a sample of transgender women living with HIV (TWH) in Brazil.
    Methods: A pilot trial of a peer navigation intervention to improve HIV care and treatment among TWH was conducted in São Paulo, Brazil between 2018 and 2019. TWH were recruited and randomized into the intervention or control arm and participated in a baseline and 9-month follow-up survey and ongoing extraction of clinical visit, prescribing, and laboratory data. Generalized linear model regressions with a Poisson distribution estimated the relative risk (RR) for the association of lifetime physical and sexual violence reported at baseline with treatment outcomes (retention in HIV care and viral suppression) at follow-up, adjusting for baseline sociodemographic characteristics.
    Results: A total of 113 TWH participated in the study. At baseline, median age was 30 years, and the prevalence of lifetime physical and sexual violence was 62% and 45%, respectively. At follow-up, 58% (n = 66/113) were retained in care and 35% (n = 40/113) had evidence of viral suppression. In adjusted models, lifetime physical violence was non-significantly associated with a 10% reduction in retention in care (aRR: 0.90, 95% CI: 0.67, 1.22) and a 31% reduction in viral suppression (aRR: 0.69; 95% CI: 0.43, 1.11). Lifetime sexual violence was non-significantly associated with a 28% reduction in retention in HIV care (aRR: 0.72, 95% CI: 0.52, 1.00) and significantly associated with a 56% reduction in viral suppression (aRR: 0.44; 95% CI: 0.24, 0.79).
    Conclusion: Our findings are among the first to demonstrate that lifetime experiences with physical and sexual violence are associated with poor HIV outcomes over time among transgender women. Interventions seeking to improve HIV treatment outcomes should assess and address experiences of GBV among this population.
    Trial registration: ClinicalTrials.gov Identifier: NCT03525340.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Brazil/epidemiology ; Gender Identity ; Gender-Based Violence/psychology ; HIV Infections/therapy ; HIV Infections/drug therapy ; Transgender Persons/psychology ; Treatment Outcome
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-024-18224-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Gender-based violence and engagement in biomedical HIV prevention, care and treatment: a scoping review.

    Leddy, Anna M / Weiss, Ellen / Yam, Eileen / Pulerwitz, Julie

    BMC public health

    2019  Volume 19, Issue 1, Page(s) 897

    Abstract: Background: While gender-based violence (GBV) has been shown to increase women's risk of HIV acquisition, the role of GBV in the HIV testing to care continuum is less clear. Clarifying how GBV may act as a barrier to accessing HIV services, treatment ... ...

    Abstract Background: While gender-based violence (GBV) has been shown to increase women's risk of HIV acquisition, the role of GBV in the HIV testing to care continuum is less clear. Clarifying how GBV may act as a barrier to accessing HIV services, treatment and care - such as anti-retroviral treatment (ART) or pre-exposure prophylaxis (PrEP) - will not only provide insights into how to best meet individual women's HIV care needs, but also inform public health oriented HIV epidemic control strategies.
    Methods: Through a comprehensive scoping review, we synthesized and analyzed existing evidence regarding the influence of GBV on engagement in PrEP and the HIV care continuum among women living with HIV, including members of key populations (female sex workers, transgender women and women who use drugs). We explored PubMed, Scopus and Web of Science for peer-reviewed studies published in 2003-2017. Of the 279 sources identified, a subset of 51 sources met the criteria and were included in the scoping review.
    Results: Studies were identified from 17 countries. The majority of studies utilized quantitative cross-sectional designs (n = 33), with the rest using longitudinal (n = 4), qualitative (n = 10) or mixed methods (n = 4) designs. Taken together, findings suggest that GBV impedes women's uptake of HIV testing, care, and treatment, yet this can vary across different geographic and epidemic settings. Substantial gaps in the literature do still exist, including studies on the impact of GBV on engagement in PrEP, and research among key populations.
    Conclusions: This scoping review contributes to our knowledge regarding the role GBV plays in women's engagement in PrEP and the HIV care continuum. Findings reveal the need for more longitudinal research to provide insights into the causal pathways linking GBV and HIV care and treatment outcomes. Research is also needed to illuminate the impact of GBV on PrEP use and adherence as well as the impact of GBV on engagement along the HIV care continuum among key populations. It is critical that programs and research keep pace with these findings in order to reduce the global burden of GBV and HIV among women.
    MeSH term(s) Anti-Retroviral Agents/therapeutic use ; Cross-Sectional Studies ; Female ; Gender Identity ; Gender-Based Violence/psychology ; HIV ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; HIV Infections/psychology ; Humans ; Male ; Patient Acceptance of Health Care/psychology ; Pre-Exposure Prophylaxis/statistics & numerical data ; Sex Workers/psychology ; Substance-Related Disorders/psychology ; Substance-Related Disorders/virology ; Transgender Persons/psychology
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2019-07-08
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1471-2458
    ISSN (online) 1471-2458
    DOI 10.1186/s12889-019-7192-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bidirectional Violence Is Associated with Poor Engagement in HIV Care and Treatment in Malawian Couples.

    Conroy, Amy A / Leddy, Anna M / Darbes, Lynae A / Neilands, Torsten B / Mkandawire, James / Stephenson, Rob

    Journal of interpersonal violence

    2020  Volume 37, Issue 7-8, Page(s) NP4258–NP4277

    Abstract: Growing evidence suggests that intimate partner violence (IPV) is a barrier to engagement in HIV care. Bidirectional IPV-being both a perpetrator and victim-may be the most common pattern of IPV, yet no research has examined its effect on engagement in ... ...

    Abstract Growing evidence suggests that intimate partner violence (IPV) is a barrier to engagement in HIV care. Bidirectional IPV-being both a perpetrator and victim-may be the most common pattern of IPV, yet no research has examined its effect on engagement in care, which could identify couples in most need of interventions. Married couples (
    MeSH term(s) HIV Infections/drug therapy ; Humans ; Intimate Partner Violence/psychology ; Prevalence ; Risk Factors ; Sexual Partners/psychology ; Violence
    Language English
    Publishing date 2020-09-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2028900-5
    ISSN 1552-6518 ; 0886-2605
    ISSN (online) 1552-6518
    ISSN 0886-2605
    DOI 10.1177/0886260520959632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Exploring the role of social capital in managing food insecurity among older women in the United States.

    Leddy, Anna M / Whittle, Henry J / Shieh, Jacqueline / Ramirez, Catalina / Ofotokun, Ighovwerha / Weiser, Sheri D

    Social science & medicine (1982)

    2020  Volume 265, Page(s) 113492

    Abstract: Food insecurity, which affects 37 million individuals in the United States (U.S.) and disproportionately burdens women, minorities and older adults, is a well-established determinant of poor health. Previous studies suggest social capital, defined as the ...

    Abstract Food insecurity, which affects 37 million individuals in the United States (U.S.) and disproportionately burdens women, minorities and older adults, is a well-established determinant of poor health. Previous studies suggest social capital, defined as the material and social benefits arising from relationships among individuals within and between groups, may be protective against food insecurity. Drawing on this evidence, calls have been made for interventions and policies to promote social capital to address food insecurity. However, limited research has explored in-depth how social capital shapes the lived experience of food insecurity in the U.S. We explored how older women from three settings in the U.S. used forms of social capital to navigate their food environments. Between November 2017-July 2018, we conducted 38 semi-structured interviews with food-insecure women aged 50 years or older enrolled in the Northern California, Georgia, and North Carolina sites of the Women's Interagency HIV study, an ongoing cohort study of women living with and at risk of HIV. Interviews were analyzed using an inductive-deductive approach. Women from the three sites explained how they drew upon different forms of capital to access food. Women in Georgia and North Carolina depended on support from members within their social group (bonding social capital) to address food insecurity but described limited opportunities to build relationships with members from other social groups (bridging social capital) or representatives of institutions (linking social capital). In contrast, women from Northern California frequently used bridging and linking social capital to access food but described limited bonding social capital. Findings show how the role of social capital in protecting against food insecurity is diverse, complex, and structurally determined. Intervention implications are discussed.
    MeSH term(s) Aged ; Cohort Studies ; Female ; Food Insecurity ; Food Supply ; Georgia ; HIV Infections ; Humans ; Middle Aged ; North Carolina ; Social Capital ; Socioeconomic Factors ; United States
    Language English
    Publishing date 2020-11-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2020.113492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Addressing Intersectional Stigma in Programs Focused on Ending the HIV Epidemic.

    Kerr, Jelani / Lelutiu-Weinberger, Corina / Nelson, LaRon E / Turan, Janet M / Frye, Victoria / Matthews, David W / Leddy, Anna M / Jackson, Skyler D / Boyd, Donte / Hightow-Weidman, Lisa

    American journal of public health

    2022  Volume 112, Issue S4, Page(s) S362–S366

    MeSH term(s) Epidemics/prevention & control ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Humans ; Social Stigma
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2021.306657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Point-of-Care Test for Assessing Tenofovir Adherence: Feasibility and Recommendations from Women in an Oral PrEP Program in Kenya and Their Healthcare Providers.

    Thuo, Nicholas / Polay, Madison / Leddy, Anna M / Ngure, Kenneth / Chatterhee, Purba / Gandhi, Monica / Amico, K Rivet

    AIDS and behavior

    2021  Volume 25, Issue 11, Page(s) 3617–3629

    Abstract: Oral pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention modality when taken as recommended. Women in sub-Saharan Africa may have adherence challenges that remain undisclosed to providers. Real-time measures that identify non-adherence ... ...

    Abstract Oral pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention modality when taken as recommended. Women in sub-Saharan Africa may have adherence challenges that remain undisclosed to providers. Real-time measures that identify non-adherence can allow for immediate exploration of adherence challenges, counseling and interventions. We conducted a formative qualitative study in Kenya to explore oral PrEP experiences and reactions to a point-of-care urine test (UT) identifying recent (past 4 days) non-adherence to tenofovir-based PrEP among female PrEP users (25 in-depth interviews; 4 focus groups) and health care provider (10 key informant interviews). Findings indicate that use of the UT would be highly feasible in the context of regular PrEP care, largely acceptable to clients and providers, and could improve adherence. Clients emphasized the need for transparent client-centered strategies in delivering results. This formative study informs the development of tools to implement this point-of-care UT in future interventional studies and clinical settings.
    MeSH term(s) Anti-HIV Agents/therapeutic use ; Feasibility Studies ; Female ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Health Personnel ; Humans ; Kenya ; Medication Adherence ; Point-of-Care Testing ; Pre-Exposure Prophylaxis ; Tenofovir
    Chemical Substances Anti-HIV Agents ; Tenofovir (99YXE507IL)
    Language English
    Publishing date 2021-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-021-03255-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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