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  1. Article ; Online: More than meets the eye: 2-[

    Huang, Wenpeng / Son, Mai Hong / Ha, Le Ngoc / Kang, Lei / Cai, Weibo

    European journal of nuclear medicine and molecular imaging

    2024  Volume 51, Issue 6, Page(s) 1725–1728

    MeSH term(s) Humans ; Fluorodeoxyglucose F18 ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/pathology ; Precision Medicine ; Lymphatic Metastasis/diagnostic imaging ; Positron-Emission Tomography ; Image Processing, Computer-Assisted/methods ; Radiopharmaceuticals ; Radiomics
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2024-02-29
    Publishing country Germany
    Document type Editorial
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06664-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
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  2. Article ; Online: Challenges coexist with opportunities: development of a macrocyclic peptide PET radioligand for PD-L1.

    Huang, Wenpeng / Son, Mai Hong / Ha, Le Ngoc / Kang, Lei / Cai, Weibo

    European journal of nuclear medicine and molecular imaging

    2024  Volume 51, Issue 6, Page(s) 1574–1577

    MeSH term(s) Positron-Emission Tomography ; Humans ; B7-H1 Antigen/metabolism ; Ligands ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/pharmacokinetics ; Peptides, Cyclic/chemistry ; Macrocyclic Compounds/chemistry ; Peptides/chemistry
    Chemical Substances B7-H1 Antigen ; Ligands ; Radiopharmaceuticals ; Peptides, Cyclic ; Macrocyclic Compounds ; Peptides
    Language English
    Publishing date 2024-03-16
    Publishing country Germany
    Document type Editorial
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06680-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1227: Show issues Location:
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  3. Article ; Online: Temperature-Tuning Desorption Ionization for Ambient Mass Spectrometry.

    Li, Ningxi / Cai, Zhijun / Zhang, Zhongyao / Zhang, Wenpeng / Ma, Xiaoxiao / Zhou, Xiaoyu / Ouyang, Zheng

    Analytical chemistry

    2023  Volume 95, Issue 29, Page(s) 11099–11105

    Abstract: In the past decade, mass spectrometry (MS) has been widely used for a broad range of on-site applications. This is largely attributed to the rapid advancement of technologies, such as ambient ionization and mass spectrometer miniaturization. Here, we ... ...

    Abstract In the past decade, mass spectrometry (MS) has been widely used for a broad range of on-site applications. This is largely attributed to the rapid advancement of technologies, such as ambient ionization and mass spectrometer miniaturization. Here, we report the development of the temperature-tuning desorption ionization (TTDI) method for versatile on-site applications using a miniature MS system. A unique feature of TTDI is its dynamic temperature range applicable from 30 to 800 °C, which enables optimal desorption ionization applied for chemical and biological compounds through tuning the temperature at the sampling spot. The versatility of TTDI has been demonstrated through on-site MS analysis of a variety of samples, such as explosives on surfaces, drugs of abuse in biofluids, and screening biomarkers in tissues.
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c01942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Risk Perception and Emotion Reaction of Chinese Health Care Workers Varied During COVID-19: A Repeated Cross-Sectional Research.

    Qianlan, Yin / Ying, Liu / Aibin, Chen / Xiangrui, Song / Wenpeng, Cai / Guanghui, Deng / Wei, Dong

    International journal of public health

    2021  Volume 66, Page(s) 613057

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/psychology ; China/epidemiology ; Cross-Sectional Studies ; Emotions ; Health Personnel/psychology ; Humans ; Risk Assessment
    Language English
    Publishing date 2021-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2274130-6
    ISSN 1661-8564 ; 1661-8556
    ISSN (online) 1661-8564
    ISSN 1661-8556
    DOI 10.3389/ijph.2021.613057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 843: Show issues Location:
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  5. Article ; Online: Nuclear medicine radiomics in digestive system tumors: Concept, applications, challenges, and future perspectives.

    Huang, Wenpeng / Tao, Zihao / Younis, Muhsin H / Cai, Weibo / Kang, Lei

    View (Beijing, China)

    2023  Volume 4, Issue 6

    Abstract: Radiomics aims to develop novel biomarkers and provide relevant deeper subvisual information about pathology, immunophenotype, and tumor microenvironment. It uses automated or semiautomated quantitative analysis of high-dimensional images to improve ... ...

    Abstract Radiomics aims to develop novel biomarkers and provide relevant deeper subvisual information about pathology, immunophenotype, and tumor microenvironment. It uses automated or semiautomated quantitative analysis of high-dimensional images to improve characterization, diagnosis, and prognosis. Recent years have seen a rapid increase in radiomics applications in nuclear medicine, leading to some promising research results in digestive system oncology, which have been driven by big data analysis and the development of artificial intelligence. Although radiomics advances one step further toward the non-invasive precision medical analysis, it is still a step away from clinical application and faces many challenges. This review article summarizes the available literature on digestive system tumors regarding radiomics in nuclear medicine. First, we describe the workflow and steps involved in radiomics analysis. Subsequently, we discuss the progress in clinical application regarding the utilization of radiomics for distinguishing between various diseases and evaluating their prognosis, and demonstrate how radiomics advances this field. Finally, we offer our viewpoint on how the field can progress by addressing the challenges facing clinical implementation.
    Language English
    Publishing date 2023-07-28
    Publishing country China
    Document type Journal Article
    ISSN 2688-268X
    ISSN (online) 2688-268X
    DOI 10.1002/VIW.20230032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: CD146-targeted nuclear medicine imaging in cancer: state of the art.

    Yang, Qi / Huang, Wenpeng / Hsu, Jessica C / Song, Lele / Sun, Xinyao / Li, Cuicui / Cai, Weibo / Kang, Lei

    View (Beijing, China)

    2023  Volume 4, Issue 5

    Abstract: The transmembrane glycoprotein adhesion molecule CD146 is overexpressed in a wide variety of cancers. Through molecular imaging, a specific biomarker's expression and distribution can be ... ...

    Abstract The transmembrane glycoprotein adhesion molecule CD146 is overexpressed in a wide variety of cancers. Through molecular imaging, a specific biomarker's expression and distribution can be viewed
    Language English
    Publishing date 2023-03-01
    Publishing country China
    Document type Journal Article
    ISSN 2688-268X
    ISSN (online) 2688-268X
    DOI 10.1002/VIW.20220085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Nuclear medicine radiomics in digestive system tumors

    Wenpeng Huang / Zihao Tao / Muhsin H. Younis / Weibo Cai / Lei Kang

    View, Vol 4, Iss 6, Pp n/a-n/a (2023)

    Concept, applications, challenges, and future perspectives

    2023  

    Abstract: Abstract Radiomics aims to develop novel biomarkers and provide relevant deeper subvisual information about pathology, immunophenotype, and tumor microenvironment. It uses automated or semiautomated quantitative analysis of high‐dimensional images to ... ...

    Abstract Abstract Radiomics aims to develop novel biomarkers and provide relevant deeper subvisual information about pathology, immunophenotype, and tumor microenvironment. It uses automated or semiautomated quantitative analysis of high‐dimensional images to improve characterization, diagnosis, and prognosis. Recent years have seen a rapid increase in radiomics applications in nuclear medicine, leading to some promising research results in digestive system oncology, which have been driven by big data analysis and the development of artificial intelligence. Although radiomics advances one step further toward the non‐invasive precision medical analysis, it is still a step away from clinical application and faces many challenges. This review article summarizes the available literature on digestive system tumors regarding radiomics in nuclear medicine. First, we describe the workflow and steps involved in radiomics analysis. Subsequently, we discuss the progress in clinical application regarding the utilization of radiomics for distinguishing between various diseases and evaluating their prognosis, and demonstrate how radiomics advances this field. Finally, we offer our viewpoint on how the field can progress by addressing the challenges facing clinical implementation.
    Keywords artificial intelligence ; digestive system tumors ; machine learning ; medical imaging ; non‐invasive prediction ; nuclear medicine ; Biotechnology ; TP248.13-248.65 ; Medical technology ; R855-855.5
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways.

    Cai, Wenpeng / Ma, Yongfang / Song, Li / Cao, Niandie / Gao, Jiafeng / Zhou, Shuping / Tang, Xiaolong

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 87

    Abstract: Background: Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute to the development of cancers.: Method: This study investigated the effect and mechanism of IGF-1R ...

    Abstract Background: Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute to the development of cancers.
    Method: This study investigated the effect and mechanism of IGF-1R in mediating the desensitization of hepatocellular carcinoma (HCC) to sorafenib.
    Results: IGF-1R, highly expressed in the HCC cell lines SK-Hep1 and HepG2, promotes cell proliferation, migration, and anti-apoptosis through PI3K / Akt and RAS / Raf / ERK signaling pathways, resulting in HCC resistance to sorafenib. Knockdown of IGF-1R by RNA interference decreased proliferation and cell migration and upregulation of sorafenib-induced apoptosis of HCC cells. In vivo studies demonstrated that IGF-1R knockdown inhibited the growth of SK-Hep1 xenografts.
    Conclusion: These data are evidence that IGF-1R participates in regulating the survival and cell growth of HCC through the PI3K / Akt and RAS / Raf / ERK signaling pathways. Intervention in the expression of IGF-1R may increase the inhibitory effect of sorafenib on HCC.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, IGF Type 1/metabolism ; Signal Transduction ; Sorafenib/pharmacology
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Receptor, IGF Type 1 (EC 2.7.10.1) ; Sorafenib (9ZOQ3TZI87) ; IGF1R protein, human
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-10561-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: IL-6 upregulates the expression of IL-6R through the JAK2/STAT3 signalling pathway to promote progression of hepatocellular carcinoma.

    Song, Li / Xu, Ruyue / Cai, Wenpeng / Liang, Jiaojiao / Cao, Niandie / Gao, Jiafeng / Tang, Xiaolong

    Scandinavian journal of immunology

    2023  Volume 98, Issue 1, Page(s) e13271

    Abstract: The progression of hepatocellular carcinoma (HCC) involves multifactor, multistep interactions. High expression of interleukin-6 receptor (IL-6R) plays an important role in the occurrence and development of tumours, but the regulatory mechanism of IL-6R ... ...

    Abstract The progression of hepatocellular carcinoma (HCC) involves multifactor, multistep interactions. High expression of interleukin-6 receptor (IL-6R) plays an important role in the occurrence and development of tumours, but the regulatory mechanism of IL-6R expression and its function in HCC have not been fully defined. Western blot was used to evaluate the phosphorylation of key kinases in the JAK2/STAT3 pathway and the protein expression levels of related proliferation molecules, migration molecules and apoptotic molecules. The antiapoptosis, migration and proliferation of cells of each group were analysed with JC-1 to judge the cell apoptosis rate, the EdU method to determine the proliferation vitality of the cells, clone formation experiments and Transwell experiments. High expression of IL-6R in cell lines, lower protein levels of the apoptotic molecules c-Caspase7 and c-Caspase3 and higher protein levels of the proliferative molecules p-P70S6K and migration molecules MMP9 and MMP2 were consistent with stronger antiapoptosis, proliferation and migration. Interestingly, IL-6 upregulated the expression of IL-6R by activating the JAK2/STAT3 signalling pathway. Also, the expression of IL-6R protein was downregulated after lentivirus knockdown of STAT3. In nude mice bearing subcutaneous tumours, upregulation of IL-6R expression after activation of the JAK2/STAT3 signalling pathway by IL-6 significantly increased tumour growth. Moreover, the expression of IL-6R protein was downregulated, and the terminal tumour volume was significantly downregulated in the lentiviral STAT3 knockdown group. IL-6 regulated the transcription of IL-6R through the activation of the JAK2/STAT3 signalling pathway.
    MeSH term(s) Animals ; Mice ; Carcinoma, Hepatocellular/genetics ; Interleukin-6 ; Mice, Nude ; Liver Neoplasms/genetics ; Receptors, Interleukin-6/genetics
    Chemical Substances Interleukin-6 ; Receptors, Interleukin-6
    Language English
    Publishing date 2023-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 120476-2
    ISSN 1365-3083 ; 0300-9475
    ISSN (online) 1365-3083
    ISSN 0300-9475
    DOI 10.1111/sji.13271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 806: Show issues Location:
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  10. Article ; Online: Temperature-Tuning Desorption Ionization for Ambient Mass Spectrometry

    Li, Ningxi / Cai, Zhijun / Zhang, Zhongyao / Zhang, Wenpeng / Ma, Xiaoxiao / Zhou, Xiaoyu / Ouyang, Zheng

    Analytical Chemistry. 2023 July 11, v. 95, no. 29 p.11099-11105

    2023  

    Abstract: In the past decade, mass spectrometry (MS) has been widely used for a broad range of on-site applications. This is largely attributed to the rapid advancement of technologies, such as ambient ionization and mass spectrometer miniaturization. Here, we ... ...

    Abstract In the past decade, mass spectrometry (MS) has been widely used for a broad range of on-site applications. This is largely attributed to the rapid advancement of technologies, such as ambient ionization and mass spectrometer miniaturization. Here, we report the development of the temperature-tuning desorption ionization (TTDI) method for versatile on-site applications using a miniature MS system. A unique feature of TTDI is its dynamic temperature range applicable from 30 to 800 °C, which enables optimal desorption ionization applied for chemical and biological compounds through tuning the temperature at the sampling spot. The versatility of TTDI has been demonstrated through on-site MS analysis of a variety of samples, such as explosives on surfaces, drugs of abuse in biofluids, and screening biomarkers in tissues.
    Keywords analytical chemistry ; biomarkers ; desorption ; explosives ; ionization ; mass spectrometry ; spectrometers ; temperature
    Language English
    Dates of publication 2023-0711
    Size p. 11099-11105.
    Publishing place American Chemical Society
    Document type Article ; Online
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c01942
    Database NAL-Catalogue (AGRICOLA)

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