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  1. Article ; Online: Perspectives in the treatment of antibiotic-resistant bacterial infections with active photodynamic partners within the framework of the EURESTOP COST Action (CA21145).

    Mori, Mattia / Dumoulin, Fabienne / Faustino, M Amparo F / Plaetzer, Kristjan

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2024  Volume 23, Issue 4, Page(s) 815–817

    Abstract: The European Network for diagnosis and treatment of antibiotic-resistant bacterial infections-EURESTOP COST Action CA21145 focuses on tackling the burden of antimicrobial resistance (AMR) and has gathered many members working on photodynamic approaches. ... ...

    Abstract The European Network for diagnosis and treatment of antibiotic-resistant bacterial infections-EURESTOP COST Action CA21145 focuses on tackling the burden of antimicrobial resistance (AMR) and has gathered many members working on photodynamic approaches. This European consortium is presented here in the One Health context, to highlight the potential of antimicrobial photodynamic therapy (aPDT) in the fight against AMR.
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteria ; Photochemotherapy ; Anti-Infective Agents/therapeutic use ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Photosensitizing Agents
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1007/s43630-024-00555-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acipimox inhibits human carbonic anhydrases.

    Mori, Mattia / Supuran, Claudiu T

    Journal of enzyme inhibition and medicinal chemistry

    2022  Volume 37, Issue 1, Page(s) 672–679

    Abstract: Acipimox, a nicotinic acid derivative in clinical use for the treatment of hyperlipidaemia, incorporates a free carboxylic acid and an N-oxide moiety, functionalities known to interact with the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) and ... ...

    Abstract Acipimox, a nicotinic acid derivative in clinical use for the treatment of hyperlipidaemia, incorporates a free carboxylic acid and an N-oxide moiety, functionalities known to interact with the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) and inhibit its activity. Herein we report that acipimox acts as a low micromolar CA inhibitor (CAI) against most human (h) isoforms possessing catalytic activity, hCA I - XIV. By using computational techniques (docking and molecular dynamics simulations), we propose that acipimox coordinates through its carboxylate group to the zinc ion from the enzyme active site cavity, whereas the N-oxide group is hydrogen-bonded to the proton shuttle His residue in some isoforms (hCA I) or to active site Thr or Gln residues in other isoforms (hCA II, III, IV, VII, etc). As some CA isoforms are involved in lipogenesis, these data may be useful for the design of more effective CAIs with antiobesity activity.
    MeSH term(s) Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Carbonic Anhydrase Inhibitors/pharmacology ; Carbonic Anhydrases/metabolism ; Dose-Response Relationship, Drug ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Models, Molecular ; Molecular Structure ; Pyrazines/chemical synthesis ; Pyrazines/chemistry ; Pyrazines/pharmacology ; Structure-Activity Relationship
    Chemical Substances Carbonic Anhydrase Inhibitors ; Isoenzymes ; Pyrazines ; Carbonic Anhydrases (EC 4.2.1.1) ; acipimox (K9AY9IR2SD)
    Language English
    Publishing date 2022-03-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2082578-X
    ISSN 1475-6374 ; 1475-6366
    ISSN (online) 1475-6374
    ISSN 1475-6366
    DOI 10.1080/14756366.2022.2037579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3004: Show issues Location:
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  3. Article ; Online: Antimalarial drugs: what's new in the patents?

    Lopes, Elizabeth A / Santos, Maria M M / Mori, Mattia

    Expert opinion on therapeutic patents

    2023  Volume 33, Issue 3, Page(s) 151–168

    Abstract: Introduction: The efficacy of current therapeutic warheads in preventing malaria transmission or treating the disease is often hampered by the emergence of drug-resistance. No effective vaccines are available to date, and novel drugs able to counteract ... ...

    Abstract Introduction: The efficacy of current therapeutic warheads in preventing malaria transmission or treating the disease is often hampered by the emergence of drug-resistance. No effective vaccines are available to date, and novel drugs able to counteract drug-resistant forms of malaria and/or to target multiple stages of the parasite's lifecycle are urgently needed.
    Areas covered: This review covers patents that protect antimalarial small molecules bearing the artemisinin or other chemical scaffolds, as well as vaccines, that have been published in the period 2015-2022. Literature was searched in public databases of articles and patents. Patents protecting small molecules that prevent malaria transmission are not discussed herein.
    Expert opinion: Significant progress has been made in the design of antimalarial agents. Most of these candidates have been tested in standardized strains, with the use of
    MeSH term(s) Humans ; Animals ; Mice ; Antimalarials/pharmacology ; Antimalarials/chemistry ; Antimalarials/therapeutic use ; Patents as Topic ; Malaria/drug therapy ; Malaria/prevention & control ; Plasmodium ; Drug Resistance ; Plasmodium falciparum
    Chemical Substances Antimalarials
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1186201-4
    ISSN 1744-7674 ; 0962-2594 ; 1354-3776
    ISSN (online) 1744-7674
    ISSN 0962-2594 ; 1354-3776
    DOI 10.1080/13543776.2023.2203814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3962: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: In Memory of Maurizio Botta: His Vision of Medicinal Chemistry.

    Botta, Lorenzo / Mori, Mattia

    ACS medicinal chemistry letters

    2020  Volume 11, Issue 5, Page(s) 611

    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Editorial
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.0c00210
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  5. Article ; Online: Recent developments of agents targeting

    Melfi, Francesco / Carradori, Simone / Mencarelli, Noemi / Campestre, Cristina / Granese, Arianna / Mori, Mattia

    Expert opinion on therapeutic patents

    2024  , Page(s) 1–18

    Abstract: Introduction: Vibrio cholerae: Areas covered: After a description of the most recent literature on the pathophysiology of this infection, we searched for patents and literature articles following the PRISMA guidelines, filtering the results disclosed ...

    Abstract Introduction: Vibrio cholerae
    Areas covered: After a description of the most recent literature on the pathophysiology of this infection, we searched for patents and literature articles following the PRISMA guidelines, filtering the results disclosed from 2020 to present. Moreover, some innovative molecular targets (e.g., carbonic anhydrases) and pathways to counteract this rising problem were also discussed in terms of design, structure-activity relationships and structural analyses.
    Expert opinion: This review aims to cover and analyze the most recent advances on the new druggable targets and bioactive compounds against this fastidious pathogen, overcoming the use of old antibiotics which currently suffer from high resistance rate.
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1186201-4
    ISSN 1744-7674 ; 0962-2594 ; 1354-3776
    ISSN (online) 1744-7674
    ISSN 0962-2594 ; 1354-3776
    DOI 10.1080/13543776.2024.2327305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3962: Show issues Location:
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  6. Article: Acute FPIES and DIES: is a G lacking?

    Novembre, Elio / Giovannini, Mattia / Catamerò, Francesco / Liccioli, Giulia / Sarti, Lucrezia / Barni, Simona / Mori, Francesca

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1185196

    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1185196
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  7. Article ; Online: Natural Products as an Important Source in Drug Discovery.

    Rijo, Patrícia / Mori, Mattia

    Current pharmaceutical design

    2020  Volume 26, Issue 24, Page(s) 2805–2806

    MeSH term(s) Biological Products ; Drug Discovery ; Humans
    Chemical Substances Biological Products
    Language English
    Publishing date 2020-07-10
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/138161282624200625104355
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    Zs.A 4714: Show issues Location:
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  8. Article ; Online: Dupilumab treatment of eosinophilic gastrointestinal disease in an adolescent.

    Mori, Francesca / Renzo, Sara / Barni, Simona / Scarallo, Luca / Giovannini, Mattia / Villanacci, Vincenzo / Lionetti, Paolo

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 6, Page(s) e13973

    MeSH term(s) Humans ; Adolescent ; Antibodies, Monoclonal, Humanized/therapeutic use ; Eosinophilia/drug therapy ; Enteritis/drug therapy
    Chemical Substances dupilumab (420K487FSG) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Letter
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13973
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    Zs.A 3096: Show issues Location:
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  9. Article ; Online: From the Global Initiative for Asthma report and asthma guidelines to real-life asthma control: is there room for improvement?

    Novembre, Elio / Giovannini, Mattia / Barni, Simona / Mori, Francesca

    Italian journal of pediatrics

    2022  Volume 48, Issue 1, Page(s) 110

    Abstract: Available guidelines for asthma management represent an important and suitable tool to make the entire medical process evidence-based, effective, and safe for patients. Their purpose is to help doctors and patients formulate the best decisions in regard ... ...

    Abstract Available guidelines for asthma management represent an important and suitable tool to make the entire medical process evidence-based, effective, and safe for patients. Their purpose is to help doctors and patients formulate the best decisions in regard to asthma management by choosing the most appropriate strategies in each specific clinical situation.The Global Initiative for Asthma (GINA) document, together with other national and international recommendations, is one of the main documents used for asthma prevention and management in Italy, but several studies reported that these recommendations are often not applied in real-life clinical practice, which consequently results in inadequate asthma control.In this context, a substantial simplification of the GINA document and asthma guidelines may represent a feasible strategy to be pursued to ameliorate the knowledge among GPs, primary care pediatricians, and specialists taking care of children and adults with asthma.On the other hand, another critical factor that may explain unsatisfactory control of asthma is the limited importance that all recommendations place on asthma heterogeneity. In the era of personalized medicine and target therapies, phenotype-driven asthma management may become a desirable approach for optimizing the management of asthmatic patients. In addition, digital health strategies have been investigated in the literature to improve asthma monitoring and may represent a promising tool in the future from this point of view.Relevant stakeholders should continue to investigate how to optimize real-life asthma control to propose novel solutions to translate into clinical practice.
    MeSH term(s) Asthma/drug therapy ; Asthma/prevention & control ; Humans ; Italy ; Precision Medicine
    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Letter
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-022-01304-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1961: Show issues Location:
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  10. Article: How to manage drug-virus interplay underlying skin eruptions in children.

    Mori, Francesca / Liccioli, Giulia / Tomei, Leonardo / Barni, Simona / Giovannini, Mattia / Sarti, Lucrezia / Pessina, Benedetta / Torres, María José

    The World Allergy Organization journal

    2024  Volume 17, Issue 3, Page(s) 100877

    Abstract: The majority of viral rashes occurring during an antibiotic therapy are considered as a drug hypersensitivity reaction (DHR). Differentiating a viral rash versus a DHR is difficult or even impossible. In delayed DHRs the interplay between viruses and ... ...

    Abstract The majority of viral rashes occurring during an antibiotic therapy are considered as a drug hypersensitivity reaction (DHR). Differentiating a viral rash versus a DHR is difficult or even impossible. In delayed DHRs the interplay between viruses and drugs is summarized according to the recent literature. The question is if the same reaction will again occur in case of drug re-exposure in absence of the concomitant viral infection because of persistent immune reactivity. Epstein Barr Virus (EBV) and Human Herpes virus 6 (HHV-6) models are analyzed in case of maculopapular exanthemas (MPEs) and drug reaction with eosinophilia and systemic symptoms (DRESS) over a course of drug therapy. MPEs are the most common skin manifestation during a viral infection and a concomitant drug therapy. In type IVb reactions to drugs a hapten/pro-hapten mechanism and a pharmacological interaction (p-i mechanism) are described as the 2 major ways to make T cells response functional. Rarely the altered repertoire model is involved. The Human Leukocyte Antigen (HLA) predisposition is an additional essential factor that can facilitate DHR. In MPEs rarely a DHR is confirmed by allergy testing. Severity and duration of MPEs, the presence of eosinophilia and systemic symptoms make more reliable the persistent nature of the reaction. Research on this topic is needed in order to provide the clinicians with instruments to decide when to suspect future reactions upon drug re-exposure even in the absence of a viral infection, because those patients should be investigated by a complete drug allergy work up.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1016/j.waojou.2024.100877
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