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Article ; Online: United Nations Office on Drugs and Crime: Recommended methods for the Identification and Analysis of Synthetic Cannabinoid Receptor Agonists in Seized Materials.

Tettey, Justice N A / Crean, Conor / Rodrigues, Joao / Angeline Yap, Tiong Whei / Lee Wendy Lim, Jong / Shirley Lee, Hui Zhi / Ching, Mei

Forensic science international. Synergy

2021 Volume 3, Page(s) 100129

Language	English
Publishing date	2021-02-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	424042-x
ISSN	2589-871X ; 1872-6283 ; 0379-0738
ISSN (online)	2589-871X ; 1872-6283
ISSN	0379-0738
DOI	10.1016/j.fsisyn.2020.11.003
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Article ; Online: Sources of Low-Value Care Received by Medicare Beneficiaries and Associated Spending Within US Health Systems.

Chant, Emma D / Crawford, Maia / Yang, Ching-Wen Wendy / Fisher, Elliott S / Morden, Nancy E / Ganguli, Ishani

JAMA network open

2023 Volume 6, Issue 9, Page(s) e2333505

MeSH term(s)	Aged ; United States ; Humans ; Medicare ; Low-Value Care ; Government Programs
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.33505
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Article: Metabolomics Signatures and Subsequent Maternal Health among Mothers with a Congenital Heart Defect-Affected Pregnancy.

Hsu, Ping-Ching / Maity, Suman / Patel, Jenil / Lupo, Philip J / Nembhard, Wendy N

Metabolites

2022 Volume 12, Issue 2

Abstract: Congenital heart defects (CHDs) are the most prevalent and serious of all birth defects in the United States. However, little is known about the impact of CHD-affected pregnancies on subsequent maternal health. Thus, there is a need to characterize the ... ...

Abstract	Congenital heart defects (CHDs) are the most prevalent and serious of all birth defects in the United States. However, little is known about the impact of CHD-affected pregnancies on subsequent maternal health. Thus, there is a need to characterize the metabolic alterations associated with CHD-affected pregnancies. Fifty-six plasma samples were identified from post-partum women who participated in the National Birth Defects Prevention Study between 1997 and 2011 and had (1) unaffected control offspring (n = 18), (2) offspring with tetralogy of Fallot (ToF, n = 22), or (3) hypoplastic left heart syndrome (HLHS, n = 16) in this pilot study. Absolute concentrations of 408 metabolites using the AbsoluteIDQ
Language	English
Publishing date	2022-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo12020100
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Article ; Online: Intragenic FOXC1 deletion in a Vietnamese child with Axenfeld-Rieger syndrome: case report and review of literature.

Hong, Ashley Shuen Ying / Lim, Jiin Ying / Isa, Mas Suhaila / Liew, Wendy Kein-Meng / Tan, Barrie / Ho, Ching Lin / Leo, Seo Wei / Jamuar, Saumya Shekhar

Clinical dysmorphology

2023 Volume 32, Issue 3, Page(s) 124–128

MeSH term(s)	Humans ; Child ; Southeast Asian People ; Anterior Eye Segment ; Eye Abnormalities/diagnosis ; Eye Abnormalities/genetics ; Eye Diseases, Hereditary/diagnosis ; Eye Diseases, Hereditary/genetics ; Forkhead Transcription Factors/genetics
Chemical Substances	FOXC1 protein, human ; Forkhead Transcription Factors
Language	English
Publishing date	2023-05-01
Publishing country	England
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	1121482-x
ISSN	1473-5717 ; 0962-8827
ISSN (online)	1473-5717
ISSN	0962-8827
DOI	10.1097/MCD.0000000000000458
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Article ; Online: Synthesis, characterization and differentiation of the structural isomers of valine and tert-leucine derived synthetic cannabinoids.

Sim, Sui Boon Derek / Lee, Hui Zhi Shirley / Ong, Mei Ching / Zhang, Shuhua / Lim, Kheng Aik / Lim, Jong Lee Wendy / Yap, Tiong Whei Angeline

Drug testing and analysis

2023 Volume 16, Issue 4, Page(s) 420–434

Abstract: The identification of the synthetic cannabinoids receptor agonists (SCRAs) has always posed a great challenge to drug testing laboratories with slight structural modifications aimed at evading drug legislation. In addition, the most prevalent synthetic ... ...

Abstract	The identification of the synthetic cannabinoids receptor agonists (SCRAs) has always posed a great challenge to drug testing laboratories with slight structural modifications aimed at evading drug legislation. In addition, the most prevalent synthetic cannabinoids have valine and tert-leucine amino acid moieties where re-arrangement of the carbon chains can result in structural isomers that are very similar to the parent synthetic cannabinoids. This makes their analysis and identification challenging, and the problem is compounded with the difficulty in purchasing reference standards quickly and a lack of literature for comparison. Therefore, in this investigation, four series of synthetic cannabinoids (AB-PINACA, AB-CHMINACA, MMB-FUBINACA and 5-fluoro-MDMB-PINACA) and their alkyl chain structural isomers at the amino acid moieties were synthesized and characterized using various analytical techniques-gas chromatography-mass spectrometry (GC-MS), gas chromatography-infrared detection (GC-IRD) and nuclear magnetic resonance (NMR) spectroscopy to evaluate the ability of each analytical technique to differentiate the respective isomers for their identification. A total of 12 isomers were synthesized and analysed together with the four parent synthetic cannabinoids. NMR was able to differentiate between all the compounds, whereas GC-IRD was able to discern between most of the synthetic cannabinoids and their isomers. GC-MS had the least discriminating power and was not able to differentiate some of the compounds that has very similar mass spectra. The results from this work will be useful to other drug testing laboratories that are facing the identification of related synthetic cannabinoids.
MeSH term(s)	Gas Chromatography-Mass Spectrometry ; Illicit Drugs/analysis ; Cannabinoids/analysis ; Valine ; Amino Acids ; Leucine/analogs & derivatives
Chemical Substances	Illicit Drugs ; 2-amino-3,3-dimethylbutanoic acid (471-50-1) ; Cannabinoids ; Valine (HG18B9YRS7) ; Amino Acids ; Leucine (GMW67QNF9C)
Language	English
Publishing date	2023-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2462336-2
ISSN	1942-7611 ; 1942-7603
ISSN (online)	1942-7611
ISSN	1942-7603
DOI	10.1002/dta.3561
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Article ; Online: Effects of a universal classroom management teacher training program on elementary children with aggressive behaviors.

Chuang, Chi-Ching / Reinke, Wendy M / Herman, Keith C

School psychology (Washington, D.C.)

2020 Volume 35, Issue 2, Page(s) 128–136

Abstract: The purpose of this study was to examine the treatment effects of the Incredible Years Teacher Classroom Management (IY TCM), a universal classroom management intervention, on the outcomes of children with aggressive behavior in elementary school. ... ...

Abstract	The purpose of this study was to examine the treatment effects of the Incredible Years Teacher Classroom Management (IY TCM), a universal classroom management intervention, on the outcomes of children with aggressive behavior in elementary school. Classroom management has been demonstrated as a factor in either escalating children's aggressive behavior or decreasing those problematic behaviors. Participants included 1,817 students (Grade K to 3) and 105 teachers from nine elementary schools in a large urban Midwestern school district. Teachers were randomly assigned to receive IY TCM or to a wait-list comparison group. The hypotheses were that baseline levels of aggression would moderate the relationship between intervention status and outcomes. Findings indicated the hypothesized moderation effect on several outcome variables; specifically, children with baseline aggression problems who were in IY TCM classrooms had significantly improved math achievement, emotional regulation, prosocial behaviors, and observed aggression in comparison to similar peers in the control classrooms. Implications for practice and future research based on the findings are discussed. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
MeSH term(s)	Adult ; Aggression/psychology ; Child ; Child Behavior/psychology ; Female ; Humans ; Inservice Training/methods ; Male ; Middle Aged ; Midwestern United States ; Program Evaluation/methods ; Teacher Training/methods ; Teaching ; Urban Population
Language	English
Publishing date	2020-01-09
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ISSN	2578-4226
ISSN (online)	2578-4226
DOI	10.1037/spq0000351
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Article ; Online: Who's Accountable? Low-Value Care Received By Medicare Beneficiaries Outside Of Their Attributed Health Systems.

Ganguli, Ishani / Crawford, Maia L / Usadi, Benjamin / Mulligan, Kathleen L / O'Malley, A James / Yang, Ching-Wen Wendy / Fisher, Elliott S / Morden, Nancy E

Health affairs (Project Hope)

2024 Volume 42, Issue 8, Page(s) 1128–1139

Abstract: Policy makers and payers increasingly hold health systems accountable for spending and quality for their attributed beneficiaries. Low-value care-medical services that offer little or no benefit and have the potential for harm in specific clinical ... ...

Abstract	Policy makers and payers increasingly hold health systems accountable for spending and quality for their attributed beneficiaries. Low-value care-medical services that offer little or no benefit and have the potential for harm in specific clinical scenarios-received outside of these systems could threaten success on both fronts. Using national Medicare data for fee-for-service beneficiaries ages sixty-five and older and attributed to 595 US health systems, we describe where and from whom they received forty low-value services during 2017-18 and identify factors associated with out-of-system receipt. Forty-three percent of low-value services received by attributed beneficiaries originated from out-of-system clinicians: 38 percent from specialists, 4 percent from primary care physicians, and 1 percent from advanced practice clinicians. Recipients of low-value care were more likely to obtain that care out of system if age 75 or older (versus ages 65-74), male (versus female), non-Hispanic White (versus other races or ethnicities), rural dwelling (versus metropolitan dwelling), more medically complex, or experiencing lower continuity of care. However, out-of-system service receipt was not associated with recipients' health systems' accountable care organization status. Health systems might improve quality and reduce spending for their attributed beneficiaries by addressing out-of-system receipt of low-value care-for example, by improving continuity.
MeSH term(s)	Aged ; Humans ; Male ; Female ; United States ; Medicare ; Low-Value Care ; Health Expenditures ; Fee-for-Service Plans ; Government Programs ; Accountable Care Organizations
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	632712-6
ISSN	1544-5208 ; 0278-2715
ISSN (online)	1544-5208
ISSN	0278-2715
DOI	10.1377/hlthaff.2022.01319
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Article ; Online: Burnout among public sector pharmacy staff two years into the COVID-19 pandemic.

Kho, Boon Phiaw / Chua, Wan Ching Wendy / Liu, Wei Tiing Emily / Lim, Siau Choon / Leong, Hui Hui Lynn / Chai, Yeehui Aleen

The International journal of pharmacy practice

2023 Volume 31, Issue 5, Page(s) 496–503

Abstract: Objectives: This study aimed to determine the prevalence and factors contributing to burnout among public sector pharmacy staff in Sarawak, Malaysia, two years into the COVID-19 pandemic. Impact of burnout on their lives and their coping strategies were ...

Abstract	Objectives: This study aimed to determine the prevalence and factors contributing to burnout among public sector pharmacy staff in Sarawak, Malaysia, two years into the COVID-19 pandemic. Impact of burnout on their lives and their coping strategies were also examined. Methods: A cross-sectional online survey was carried out among all pharmacy staff in public healthcare facilities throughout Sarawak. Burnout was measured using the Copenhagen Burnout Inventory. Multiple logistic regression analysed demographic and work characteristics associated with burnout. Open-ended replies on burnout causes, impact, coping strategies and employer's role were coded and thematically analysed. Key findings: A total of 329 responses were received. The prevalence of personal, work and patient-related burnout was 54.7, 47.1 and 35.3%, respectively. Respondents facing problems with child support were 8.26 and 3.62 times more likely to suffer from personal and work-related burnout. Working in areas with potential exposure to COVID-19 patients increased the odds of patient and work-related burnout by 2.80 and 1.86 times, respectively. Burnout symptoms affected their quality of life; nevertheless, self-reported coping strategies were mostly positive. Respondents emphasised the need for organisational interventions, including increased resource allocation, better workload distribution and promotion of work-life balance, to mitigate burnout. Conclusions: A significant percentage of public sector pharmacy staff continue to experience burnout two years into the pandemic. Regular well-being assessments and supportive policies are recommended to help them cope with increased stress. Additional training for supervisors may be necessary to effectively manage staff and workload during a pandemic.
MeSH term(s)	Child ; Humans ; COVID-19/epidemiology ; Pandemics ; Cross-Sectional Studies ; Public Sector ; Quality of Life ; Burnout, Professional/epidemiology ; Burnout, Professional/diagnosis ; Pharmacy ; Surveys and Questionnaires
Language	English
Publishing date	2023-10-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1087040-4
ISSN	2042-7174 ; 0961-7671
ISSN (online)	2042-7174
ISSN	0961-7671
DOI	10.1093/ijpp/riad043
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Article ; Online: Isoform-selective TGF-β3 inhibition for systemic sclerosis.

Sun, Tianhe / Vander Heiden, Jason A / Gao, Xia / Yin, Jianping / Uttarwar, Salil / Liang, Wei-Ching / Jia, Guiquan / Yadav, Rajbharan / Huang, Zhiyu / Mitra, Mayurranjan / Halpern, Wendy / Bender, Hannah S / Brightbill, Hans D / Wu, Yan / Lupardus, Patrick / Ramalingam, Thirumalai / Arron, Joseph R

Med (New York, N.Y.)

2024 Volume 5, Issue 2, Page(s) 132–147.e7

Abstract: Background: Transforming growth factor β (TGF-β) is implicated as a key mediator of pathological fibrosis, but its pleiotropic activity in a range of homeostatic functions presents challenges to its safe and effective therapeutic targeting. There are ... ...

Abstract	Background: Transforming growth factor β (TGF-β) is implicated as a key mediator of pathological fibrosis, but its pleiotropic activity in a range of homeostatic functions presents challenges to its safe and effective therapeutic targeting. There are three isoforms of TGF-β, TGF-β1, TGF-β2, and TGF-β3, which bind to a common receptor complex composed of TGF-βR1 and TGF-βR2 to induce similar intracellular signals in vitro. We have recently shown that the cellular expression patterns and activation thresholds of TGF-β2 and TGF-β3 are distinct from those of TGF-β1 and that selective short-term TGF-β2 and TGF-β3 inhibition can attenuate fibrosis in vivo without promoting excessive inflammation. Isoform-selective inhibition of TGF-β may therefore provide a therapeutic opportunity for patients with chronic fibrotic disorders. Methods: Transcriptomic profiling of skin biopsies from patients with systemic sclerosis (SSc) from multiple clinical trials was performed to evaluate the role of TGF-β3 in this disease. Antibody humanization, biochemical characterization, crystallization, and pre-clinical experiments were performed to further characterize an anti-TGF-β3 antibody. Findings: In the skin of patients with SSc, TGF-β3 expression is uniquely correlated with biomarkers of TGF-β signaling and disease severity. Crystallographic studies establish a structural basis for selective TGF-β3 inhibition with a potent and selective monoclonal antibody that attenuates fibrosis effectively in vivo at clinically translatable exposures. Toxicology studies suggest that, as opposed to pan-TGF-β inhibitors, this anti-TGF-β3 antibody has a favorable safety profile for chronic administration. Conclusion: We establish a rationale for targeting TGF-β3 in SSc with a favorable therapeutic index. Funding: This study was funded by Genentech, Inc.
MeSH term(s)	Humans ; Transforming Growth Factor beta3/metabolism ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factor beta2/metabolism ; Fibrosis ; Scleroderma, Systemic/drug therapy ; Protein Isoforms/metabolism
Chemical Substances	Transforming Growth Factor beta3 ; Transforming Growth Factor beta1 ; Transforming Growth Factor beta2 ; Protein Isoforms
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ISSN	2666-6340
ISSN (online)	2666-6340
DOI	10.1016/j.medj.2023.12.011
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Article ; Online: The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine.

Hernandez, Juan E / Llorente, Cristina / Ma, Shengyun / Miyamoto, Kiana T / Sinha, Saptarshi / Steele, Scarlet / Xiao, Zihui / Lai, Ching-Jung / Zuniga, Elina I / Ghosh, Pradipta / Schnabl, Bernd / Huang, Wendy Jia Men

Life science alliance

2023 Volume 6, Issue 11

Abstract: PRMT5 is a type II arginine methyltransferase abundantly expressed in the colonic epithelium. It is up-regulated in inflammatory bowel disease and colorectal cancer. However, its role in mucosal defense against enteric infection has not been studied. ... ...

Abstract	PRMT5 is a type II arginine methyltransferase abundantly expressed in the colonic epithelium. It is up-regulated in inflammatory bowel disease and colorectal cancer. However, its role in mucosal defense against enteric infection has not been studied. Here, we report that
MeSH term(s)	Animals ; Mice ; Intestines ; Intracellular Signaling Peptides and Proteins ; Protein-Arginine N-Methyltransferases/genetics ; Colon ; Enterobacteriaceae Infections/genetics
Chemical Substances	PRMT2 protein, human (EC 2.1.1.319) ; Intracellular Signaling Peptides and Proteins ; Protein-Arginine N-Methyltransferases (EC 2.1.1.319)
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2575-1077
ISSN (online)	2575-1077
DOI	10.26508/lsa.202302026
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