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Article ; Online: Differential Impact of Relative Dose-Intensity Reductions in Diffuse Large B-Cell Lymphoma Treated with R-CHOP21 or R-CHOP14.

PloS one

2015 Volume 10, Issue 4, Page(s) e0123978

Abstract: DLBCL is an aggressive lymphoma treated with R-CHOP. Recently, attempts have been made to improve ... patients treated with R-CHOP21 or R-CHOP14. From January 2001 to August 2013 we included DLBCL patients ... homogenously treated with R-CHOP21 or R-CHOP14, with or without radiotherapy, at University Hospital Son ...

Abstract	DLBCL is an aggressive lymphoma treated with R-CHOP. Recently, attempts have been made to improve the outcome by increasing both dose-density and intensity but there have been no benefits in terms of survival. When treating malignancies RDI is important to consider but there is little published information on DLBCL. The purpose of this study was to analyze the differential prognostic impact of RDI in two cohorts of DLBCL patients treated with R-CHOP21 or R-CHOP14. From January 2001 to August 2013 we included DLBCL patients homogenously treated with R-CHOP21 or R-CHOP14, with or without radiotherapy, at University Hospital Son Espases, Hospital Son Llatzer of Palma and Hospital del Mar of Barcelona (N = 157). In order to avoid selection bias the patients were retrospectively identified from the Pathology Department and Pharmacy registries. Median follow-up was 68 months. There was no difference in the response or survival between the two cohorts. In the R-CHOP21 group, both a reduction higher than 15% in RDI (RR 7.41) and R-IPI (RR 2.99) were independently associated with OS. However, a reduction higher than 15% in RDI (RR 4.41) was only noted for PFS. In the R-CHOP14 group, NCCN-IPI (RR 7.09) and B-symptoms (RR 5.37) for OS; AA stage III-IV (RR 6.26) and bulky disease (RR 4.05) for PFS. There was a trend towards a higher rate of RDI reduction observed in the R-CHOP14 group but it only made an impact in the R-CHOP21 group. We conclude that R-CHOP21 and R-CHOP14 are equivalent regimens in terms of response and survival, but only if RDI reductions are avoided. For patients receiving R-CHOP21 we recommend using clinical and support measures in order to avoid RDI reductions.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Combined Modality Therapy ; Cyclophosphamide/therapeutic use ; Doxorubicin/therapeutic use ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/mortality ; Lymphoma, Large B-Cell, Diffuse/pathology ; Lymphoma, Large B-Cell, Diffuse/radiotherapy ; Male ; Middle Aged ; Neoplasm Grading ; Prednisone/therapeutic use ; Prognosis ; Treatment Outcome ; Vincristine/therapeutic use ; Young Adult
Chemical Substances	Antibodies, Monoclonal, Murine-Derived ; R-CHOP protocol ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0123978
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Article ; Online: El aborto. Atención humanizada de sus complicaciones como estrategia para la disminución de la mortalidad materna

Miguel Gutiérrez-Ramos

Acta Médica Peruana, Vol 22, Iss

2020 Volume 2

Abstract: La mortalidad materna es un indicador muy importante en salud pública que permite conocer como se encuentra el sistema de salud de un país. A través de este indicador podemos conocer el esfuerzo que los países hacen para proteger la salud de las mujeres, ...

Abstract	La mortalidad materna es un indicador muy importante en salud pública que permite conocer como se encuentra el sistema de salud de un país. A través de este indicador podemos conocer el esfuerzo que los países hacen para proteger la salud de las mujeres, ya que también la muerte materna es considerada como una expresión de la inequidad de género.
Keywords	Aborto ; mortalidad materna ; Medicine ; R
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Colegio Médico del Perú
Document type	Article ; Online
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Article ; Online: Functional characterization of six aspartate (D) recombinant mojastin mutants (r-Moj): A second aspartate amino acid carboxyl to the RGD in r-Moj-D_ peptides is not sufficient to induce apoptosis of SK-Mel-28 cells.

Ramos, Carla J / Gutierrez, Daniel A / Aranda, Ana S / Koshlaychuk, Melissa A / Carrillo, David A / Medrano, Rafael / McBride, Terri D / U, Andrew / Medina, Stephanie M / Lombardo, Melissa C / Lucena, Sara E / Sanchez, Elda E / Soto, Julio G

Toxicon : official journal of the International Society on Toxinology

2016 Volume 118, Page(s) 36–42

Abstract: ... mutants were produced by site-directed mutagenesis (r-Moj-DA, r-Moj-DG, r-Moj-DL, r-Moj-DN, and r-Moj-DV ... a second hypothesis: r-Moj-D_ peptides bind to αv integrin. Only r-Moj-DL, r-Moj-DM, and r-Moj-DN induced ... but not in SK-Mel-28 cells with a stable scrambled shRNA. All six r-Moj-D_ peptides inhibited ...

Abstract	Disintegrins are small peptides produced in viper venom that act as integrin antagonists. When bound to integrins, disintegrins induce altered cellular behaviors, such as apoptotic induction. Disintegrins with RGDDL or RGDDM motifs induce apoptosis of normal and cancer cells. We hypothesized that a second aspartate (D) carboxyl to the RGD is sufficient to induce apoptosis. Five recombinant mojastin D mutants were produced by site-directed mutagenesis (r-Moj-DA, r-Moj-DG, r-Moj-DL, r-Moj-DN, and r-Moj-DV). Stable αv integrin knockdown and shRNA scrambled control SK-Mel-28 cell lines were produced to test a second hypothesis: r-Moj-D_ peptides bind to αv integrin. Only r-Moj-DL, r-Moj-DM, and r-Moj-DN induced apoptosis of SK-Mel-28 cells (at 29.4%, 25.6%, and 36.2%, respectively). Apoptotic induction was significantly reduced in SK-Mel-28 cells with a stable αv integrin knockdown (to 2%, 17%, and 2%, respectively), but not in SK-Mel-28 cells with a stable scrambled shRNA. All six r-Moj-D_ peptides inhibited cell proliferation; ranging from 49.56% (r-Moj-DN) to 75.6% (r-Moj-DA). Cell proliferation inhibition by r-Moj-D_ peptides was significantly reduced in SK-Mel-28 cells with a stable αv integrin knockdown. All six r-Moj-D_ peptides inhibited SK-Mel-28 cell migration at high levels (69%-100%). As a consequence, rac-1 mRNA expression levels were significantly reduced as early as 1 h after treatment, suggesting that rac-1 is involved in the cell migration activity of SK-Mel-28.
MeSH term(s)	Amino Acid Motifs ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Aspartic Acid/chemistry ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Disintegrins/genetics ; Disintegrins/metabolism ; Disintegrins/pharmacology ; Drug Design ; Enzyme Repression/drug effects ; Humans ; Integrin alpha Chains/antagonists & inhibitors ; Integrin alpha Chains/genetics ; Integrin alpha Chains/metabolism ; Integrin alphaV/chemistry ; Integrin alphaV/genetics ; Integrin alphaV/metabolism ; Melanoma/drug therapy ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Mutant Proteins/pharmacology ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Peptide Fragments/pharmacology ; RNA Interference ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Recombinant Proteins/pharmacology ; Reptilian Proteins/antagonists & inhibitors ; Reptilian Proteins/genetics ; Reptilian Proteins/metabolism ; Reptilian Proteins/pharmacology ; Viper Venoms/chemistry ; rac1 GTP-Binding Protein/antagonists & inhibitors ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism
Chemical Substances	Antineoplastic Agents ; Disintegrins ; Integrin alpha Chains ; Integrin alphaV ; Mutant Proteins ; Peptide Fragments ; RAC1 protein, human ; Recombinant Proteins ; Reptilian Proteins ; Viper Venoms ; mojastin protein, Crotalus scutulatus ; Aspartic Acid (30KYC7MIAI) ; rac1 GTP-Binding Protein (EC 3.6.5.2)
Language	English
Publishing date	2016-08
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2016.04.038
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Article ; Online: Differential Impact of Relative Dose-Intensity Reductions in Diffuse Large B-Cell Lymphoma Treated with R-CHOP21 or R-CHOP14.

PLoS ONE, Vol 10, Iss 4, p e

2015 Volume 0123978

Abstract	DLBCL is an aggressive lymphoma treated with R-CHOP. Recently, attempts have been made to improve the outcome by increasing both dose-density and intensity but there have been no benefits in terms of survival. When treating malignancies RDI is important to consider but there is little published information on DLBCL. The purpose of this study was to analyze the differential prognostic impact of RDI in two cohorts of DLBCL patients treated with R-CHOP21 or R-CHOP14. From January 2001 to August 2013 we included DLBCL patients homogenously treated with R-CHOP21 or R-CHOP14, with or without radiotherapy, at University Hospital Son Espases, Hospital Son Llatzer of Palma and Hospital del Mar of Barcelona (N = 157). In order to avoid selection bias the patients were retrospectively identified from the Pathology Department and Pharmacy registries. Median follow-up was 68 months. There was no difference in the response or survival between the two cohorts. In the R-CHOP21 group, both a reduction higher than 15% in RDI (RR 7.41) and R-IPI (RR 2.99) were independently associated with OS. However, a reduction higher than 15% in RDI (RR 4.41) was only noted for PFS. In the R-CHOP14 group, NCCN-IPI (RR 7.09) and B-symptoms (RR 5.37) for OS; AA stage III-IV (RR 6.26) and bulky disease (RR 4.05) for PFS. There was a trend towards a higher rate of RDI reduction observed in the R-CHOP14 group but it only made an impact in the R-CHOP21 group. We conclude that R-CHOP21 and R-CHOP14 are equivalent regimens in terms of response and survival, but only if RDI reductions are avoided. For patients receiving R-CHOP21 we recommend using clinical and support measures in order to avoid RDI reductions.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Human antigen R contributes to hepatic stellate cell activation and liver fibrosis.

Woodhoo, Ashwin / Iruarrizaga-Lejarreta, Marta / Beraza, Naiara / García-Rodríguez, Juan L / Embade, Nieves / Fernández-Ramos, David / Martínez-López, Nuria / Gutiérrez-De Juan, Virginia / Arteta, Beatriz / Caballeria, Juan / Lu, Shelly C / Mato, José M / Varela-Rey, Marta / Martínez-Chantar, María L

Hepatology (Baltimore, Md.)

2012 Volume 56, Issue 5, Page(s) 1870–1882

Abstract: ... turnover and translation rates. We examined the role of the RBP, human antigen R (HuR), during cholestatic ...

Abstract	Unlabelled: RNA-binding proteins (RBPs) play a major role in the control of messenger RNA (mRNA) turnover and translation rates. We examined the role of the RBP, human antigen R (HuR), during cholestatic liver injury and hepatic stellate cell (HSC) activation. HuR silencing attenuated fibrosis development in vivo after BDL, reducing liver damage, oxidative stress, inflammation, and collagen and alpha smooth muscle actin (α-SMA) expression. HuR expression increased in activated HSCs from bile duct ligation mice and during HSC activation in vitro, and HuR silencing markedly reduced HSC activation. HuR regulated platelet-derived growth factor (PDGF)-induced proliferation and migration and controlled the expression of several mRNAs involved in these processes (e.g., Actin, matrix metalloproteinase 9, and cyclin D1 and B1). These functions of HuR were linked to its abundance and cytoplasmic localization, controlled by PDGF, by extracellular signal-regulated kinases (ERK) and phosphatidylinositol 3-kinase activation as well as ERK/LKB1 (liver kinase B1) activation, respectively. More important, we identified the tumor suppressor, LKB1, as a novel downstream target of PDGF-induced ERK activation in HSCs. HuR also controlled transforming growth factor beta (TGF-β)-induced profibrogenic actions by regulating the expression of TGF-β, α-SMA, and p21. This was likely the result of an increased cytoplasmic localization of HuR, controlled by TGF-β-induced p38 mitogen-activated protein kinase activation. Finally, we found that HuR and LKB1 (Ser428) levels were highly expressed in activated HSCs in human cirrhotic samples. Conclusion: Our results show that HuR is important for the pathogenesis of liver fibrosis development in the cholestatic injury model, for HSC activation, and for the response of activated HSC to PDGF and TGF-β.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Actins/metabolism ; Animals ; Antigens, Surface/genetics ; Antigens, Surface/metabolism ; Butadienes/pharmacology ; Carbon Tetrachloride ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Common Bile Duct ; ELAV Proteins ; ELAV-Like Protein 1 ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Regulation ; Gene Silencing ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/physiology ; Humans ; Ligation ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Mice ; Nitriles/pharmacology ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphorylation/drug effects ; Platelet-Derived Growth Factor/pharmacology ; Protein-Serine-Threonine Kinases/drug effects ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; RNA, Messenger/drug effects ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Rats ; Transforming Growth Factor beta/metabolism ; Transforming Growth Factor beta/pharmacology
Chemical Substances	ACTA2 protein, human ; Actins ; Antigens, Surface ; Butadienes ; ELAV Proteins ; ELAV-Like Protein 1 ; ELAVL1 protein, human ; Nitriles ; Platelet-Derived Growth Factor ; RNA, Messenger ; RNA-Binding Proteins ; Transforming Growth Factor beta ; U 0126 ; Carbon Tetrachloride (CL2T97X0V0) ; STK11 protein, human (EC 2.7.1.-) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2012-10-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.25828
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Article ; Online: Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.

Embade, Nieves / Fernández-Ramos, David / Varela-Rey, Marta / Beraza, Naiara / Sini, Marcella / Gutiérrez de Juan, Virginia / Woodhoo, Ashwin / Martínez-López, Nuria / Rodríguez-Iruretagoyena, Begoña / Bustamante, Francisco Javier / de la Hoz, Ana Belén / Carracedo, Arkaitz / Xirodimas, Dimitris P / Rodríguez, Manuel S / Lu, Shelly C / Mato, José M / Martínez-Chantar, María L

Hepatology (Baltimore, Md.)

2012 Volume 55, Issue 4, Page(s) 1237–1248

Abstract: Unlabelled: Hu antigen R (HuR) is a central RNA-binding protein regulating cell dedifferentiation ...

Abstract	Unlabelled: Hu antigen R (HuR) is a central RNA-binding protein regulating cell dedifferentiation, proliferation, and survival, which are well-established hallmarks of cancer. HuR is frequently overexpressed in tumors correlating with tumor malignancy, which is in line with a role for HuR in tumorigenesis. However, the precise mechanism leading to changes in HuR expression remains unclear. In the liver, HuR plays a crucial role in hepatocyte proliferation, differentiation, and transformation. Here, we unraveled a novel mean of regulation of HuR expression in hepatocellular carcinoma (HCC) and colon cancer. HuR levels correlate with the abundance of the oncogene, murine double minute 2 (Mdm2), in human HCC and colon cancer metastases. HuR is stabilized by Mdm2-mediated NEDDylation in at least three lysine residues, ensuring its nuclear localization and protection from degradation. Conclusion: This novel Mdm2/NEDD8/HuR regulatory framework is essential for the malignant transformation of tumor cells, which, in turn, unveils a novel signaling paradigm that is pharmacologically amenable for cancer therapy.
MeSH term(s)	Animals ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Case-Control Studies ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cell Transformation, Neoplastic/pathology ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Cytoplasm/metabolism ; Disease Models, Animal ; ELAV Proteins/metabolism ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Inbred C57BL ; NEDD8 Protein ; Proto-Oncogene Proteins c-mdm2/metabolism ; Signal Transduction/physiology ; Ubiquitins/metabolism
Chemical Substances	ELAV Proteins ; NEDD8 Protein ; NEDD8 protein, human ; Nedd8 protein, mouse ; Ubiquitins ; MDM2 protein, human (EC 2.3.2.27) ; Mdm2 protein, mouse (EC 2.3.2.27) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27)
Language	English
Publishing date	2012-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.24795
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Article: Perfil epidemiológico de los ingresos al Módulo de Cirugía de Cadera y Pelvis del Hospital General Xoco de la Secretaría de Salud.

Bahena-Peniche, L A / Gutiérrez-Ramos, R / Contreras-Blancas, H

Acta ortopedica mexicana

2018 Volume 31, Issue 6, Page(s) 273–278

Abstract: Background: The present study was carried out in order to know, evaluate and classify hip fractures treated by the orthopedic service of a general hospital.: Material and methods: Retrospective, cross-sectional and descriptive study based on the ... ...

Title translation	Epidemiological profile of admissions to the hip and pelvic surgery module in a general hospital.
Abstract	Background: The present study was carried out in order to know, evaluate and classify hip fractures treated by the orthopedic service of a general hospital. Material and methods: Retrospective, cross-sectional and descriptive study based on the files of the hip and pelvic surgery module of a general hospital in the period from July 2009 to December 2016. Results: We included a total of 1,545 patients aged between 14 and 107 years; the affected side, the reason for admission, their previous underlying pathologies, the type of fracture, the type of treatment given and the end result were analyzed for each patient. Statistical analysis was performed with the program SPSS version 18. Due to the relevance of the topic, the causes of the registered deaths were examined (n = 58); in relation to the data gathered, 2 and binary logistic regression were obtained. Conclusions: Hip fractures are still an undervalued subject with great economic and social impact; knowing the most frequent fracture type as well as the population most affected will help to establish effective preventive measures to decrease the morbidity and mortality of this disease in a general hospital.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Hip Fractures/surgery ; Hospitalization ; Hospitals, General ; Humans ; Middle Aged ; Patient Admission/statistics & numerical data ; Retrospective Studies ; Young Adult
Language	Spanish
Publishing date	2018-04-06
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	2205424-8
ISSN	2306-4102
ISSN	2306-4102
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Article: Prevalencia de datos radiográficos de pinzamiento femoroacetabular en adultos mexicanos.

Gutiérrez-Ramos, R / Ávalos-Calderón, S A / Bahena-Peniche, L A

Acta ortopedica mexicana

2017 Volume 31, Issue 3, Page(s) 134–140

Abstract: Background: Femoroacetabular impingement (FAI) is a suggested diagnosis for pain in the hip in the absence of other apparent causes. It is thought to be a cause of progressive arthrosis of the hip. Our objective was to determine the prevalence of ... ...

Title translation	Prevalence of X-ray signs of femoroacetabular impingement in Mexican population.
Abstract	Background: Femoroacetabular impingement (FAI) is a suggested diagnosis for pain in the hip in the absence of other apparent causes. It is thought to be a cause of progressive arthrosis of the hip. Our objective was to determine the prevalence of radiographic data of FAI in the adult population without hip pathology over a period of six months. Material and methods: Analytical, observational, multicentric, ambispective and transverse study based on digital X-rays analysis. Measurements of the lateral center-edge angle of Wiberg, acetabular inclination, Tönnis angle and the neck shaft angle of the proximal femur were made; a pistol grip deformity of the femoral head, the triangular index and the shape of the coxofemoral joint were also evaluated. Results: From a total of 212 hips evaluated, 104 were in males and 108 in females, with an average age of 42.81 years; 21 had a pistol grip deformity and a positive triangular index for cam type. The pincer type was found in 12 hips. Discussion: In this multicentric study, the FAI cam type predominated in men on the right side; the pincer type predominated in women on the left side; this is similar to what has been reported in other populations. This study is limited by the wide variation in the femoral rotation; as an advantage, it was randomly carried out and provides some data on the prevalence of deformities of the hip, not previously registered.
MeSH term(s)	Acetabulum ; Adult ; Female ; Femoracetabular Impingement/diagnostic imaging ; Femoracetabular Impingement/epidemiology ; Hip Joint ; Humans ; Male ; Prevalence ; X-Rays
Language	Spanish
Publishing date	2017-12-07
Publishing country	Mexico
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2205424-8
ISSN	2306-4102
ISSN	2306-4102
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Article ; Online: Induced clustering of Escherichia coli by acoustic fields

Salomé Gutiérrez-Ramos / Mauricio Hoyos / J. C. Ruiz-Suárez

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 8

Abstract: Abstract Brownian or self-propelled particles in aqueous suspensions can be trapped by acoustic fields generated by piezoelectric transducers usually at frequencies in the megahertz. The obtained confinement allows the study of rich collective behaviours ...

Abstract	Abstract Brownian or self-propelled particles in aqueous suspensions can be trapped by acoustic fields generated by piezoelectric transducers usually at frequencies in the megahertz. The obtained confinement allows the study of rich collective behaviours like clustering or spreading dynamics in microgravity-like conditions. The acoustic field induces the levitation of self-propelled particles and provides secondary lateral forces to capture them at nodal planes. Here, we give a step forward in the field of confined active matter, reporting levitation experiments of bacterial suspensions of Escherichia coli. Clustering of living bacteria is monitored as a function of time, where different behaviours are clearly distinguished. Upon the removal of the acoustic signal, bacteria rapidly spread, impelled by their own swimming. Nevertheless, long periods of confinement result in irreversible bacteria entanglements that could act as seeds for levitating bacterial aggregates.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2018-03-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
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Article ; Online: Levetiracetam prescription profile in children younger than 4 years treated at a tertiary care hospital in Chile.

Kyonen, Mónica / Acuña, Lily / Ramos, Bárbara / Gutiérrez, Jocelyn / Barría, R Mauricio

Archivos argentinos de pediatria

2024 , Page(s) e202310233

Abstract: Introduction. Levetiracetam (LEV) is an antiepileptic drug approved by the Chilean Institute of Public Health as concomitant therapy for epileptic seizures in children older than 4 years of age. However, it is widely prescribed from the neonatal period, ... ...

Title translation	Perfil de prescripción de levetiracetam en niños menores de cuatro años atendidos en un hospital de alta complejidad de Chile.
Abstract	Introduction. Levetiracetam (LEV) is an antiepileptic drug approved by the Chilean Institute of Public Health as concomitant therapy for epileptic seizures in children older than 4 years of age. However, it is widely prescribed from the neonatal period, which makes it necessary to evaluate its off-label use. Objective. To determine the prescription-indication profile of LEV in the treatment of epileptic seizures in children younger than 4 years in a tertiary care hospital in southern Chile. Population and method. Observational, descriptive, and retrospective study. The medical records of patients who started treatment with LEV between 2014 and 2019 were reviewed, and data on sociodemographic, pharmacological, and clinical variables were collected. The analysis was based on the description of the profile of patients, prescriptions, follow-up, and safety. Results. A total of 68 patients were included: 40 (58.8%) were males, 49 (72.1%) were born at a gestational age ≥ 37 weeks. The main etiology of epilepsy was structural (35.3%); LEV was mostly used in children diagnosed with central nervous system malformation (17.6%), and monotherapy was the prevailing dosage (55.9%). LEV was used for focal seizures in 50% of cases. Five children (7.3%) had psychiatric disorders, classified as probable adverse drug reactions. Conclusion. LEV was used in children with various diagnoses, with a low rate of adverse events. The profile of drug use varied in the different age groups. Future studies are needed to identify effectiveness, especially in newborn infants and patients with refractory epilepsy.
Language	Spanish
Publishing date	2024-03-14
Publishing country	Argentina
Document type	Journal Article
ZDB-ID	424449-7
ISSN	1668-3501 ; 0325-0075 ; 0004-0487
ISSN (online)	1668-3501
ISSN	0325-0075 ; 0004-0487
DOI	10.5546/aap.2023-10233.eng
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Inter-library loan at ZB MED

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In stock of ZB MED Cologne/Königswinter

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Inter-library loan at ZB MED

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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

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In stock of ZB MED Cologne/Königswinter

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More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito