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Article ; Online: Development and validation of a prognostic nomogram model incorporating routine laboratory biomarkers for preoperative patients with endometrial cancer.

Cong, Rong / Li, Mingyang / Xu, Wan / Ma, Xiaoxin / Wang, Shuhe

2023 Volume 23, Issue 1, Page(s) 1167

Abstract: ... receiver operating characteristic (ROC) curves, decision curve analysis (DCA), calibration curves, X-tile analysis and Kaplan‒Meier ... for the nomograms incorporating routine laboratory biomarkers. X-tile analysis and Kaplan‒Meier curves showed ...

Abstract	Background: Some biomarkers collected from routine laboratory tests have shown important value in cancer prognosis. The study aimed to evaluate the prognostic significance of routine laboratory biomarkers in patients with endometrial cancer (EC) and to develop credible prognostic nomogram models for clinical application. Methods: A total of 727 patients were randomly divided into a training set and a validation set. Cox proportional hazards models were used to evaluate each biomarker's prognostic value, and independent prognostic factors were used to generate overall survival (OS) and progression-free survival (PFS) nomgrams. The efficacy of the nomograms were evaluated by Harrell's concordance index (C-index), receiver operating characteristic (ROC) curves, decision curve analysis (DCA), calibration curves, X-tile analysis and Kaplan‒Meier curves. Results: Ten significant biomarkers in multivariate Cox analysis were integrated to develop OS and PFS nomograms. The C-indices of the OS- nomogram in the training and validation sets were 0.885 (95% confidence interval (CI), 0.810-0.960) and 0.850 (95% CI, 0.761-0.939), respectively; those of the PFS- nomogram in the training and validation sets were 0.903 (95% CI, 0.866-0.940) and 0.825 (95% CI, 0.711-0.939), respectively. ROC, DCA and calibration curves showed better clinical application value for the nomograms incorporating routine laboratory biomarkers. X-tile analysis and Kaplan‒Meier curves showed that the nomograms were stable and credible in evaluating patients at different risks. Conclusions: Nomogram models incorporating routine laboratory biomarkers, including NLR, MLR, fibrinogen, albumin and AB blood type, were demonstrated to be simple, reliable and favourable in predicting the outcomes of patients with EC.
MeSH term(s)	Female ; Humans ; Albumins ; Biomarkers ; Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/surgery ; Nomograms ; Prognosis
Chemical Substances	Albumins ; Biomarkers
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-11497-8
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Article ; Online: Optimization of 3D Printing Parameters for Alumina Ceramic Based on the Orthogonal Test.

Wang, Shuo / Xiang, Yongsheng / Feng, Hui / Cui, Yanjun / Liu, Xiaofei / Chang, Xiaoxin / Guo, Jinxiu / Tu, Peng

ACS omega

2024 Volume 9, Issue 14, Page(s) 16734–16742

Abstract: ... samples were characterized using an automatic Brunauer-Emmett-Teller, X-ray diffractometer ...

Abstract	In this paper, an alumina ink with good rheological properties was successfully prepared using pseudoboehmite as the main component, nitric acid as the colloidal solvent, and sesbania powder as the lubricant. The impact of nine different ink formulations, namely, Ink1 to Ink9, on the printability and rheological features of the ink was investigated. Consequently, it was found that Ink3 with 5 wt % nitric acid and 5 wt % sesbania powder exhibited the most favorable formability. This ink was utilized to fabricate alumina samples with direct ink writing (DIW) three-dimensional (3D) printing technology. The printed alumina samples were characterized using an automatic Brunauer-Emmett-Teller, X-ray diffractometer, Fourier transform infrared spectroscopy, and scanning electron microscope. To obtain the optimal printing parameters, a three-factor and three-level orthogonal test was designed to research the influences of different 3D printing parameters (filling ratio, nozzle diameter, and layer thickness) on the specific surface area, pore characteristics (size and volume), and radial crushing strength of the alumina specimens. The primary and secondary orders of the effects on the radial crushing strength and pore structure were determined through analysis of the experimental data. The experimental results showed that the alumina sample with a filling ratio of 80%, nozzle diameter of 0.6 mm, and layer thickness of 0.3 mm was found to have better strength of 48.07 ± 9.53 N/mm and specific surface area of 185.7315 m
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.4c00819
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Article ; Online: Nuclear Receptors and Transcription Factors in Obesity-Related Kidney Disease.

Jones, Bryce A / Wang, Xiaoxin X / Myakala, Komuraiah / Levi, Moshe

Seminars in nephrology

2021 Volume 41, Issue 4, Page(s) 318–330

Abstract: ... peroxisome proliferator-activated receptors, the farnesoid X receptor, the Takeda G-protein-coupled receptor 5, and the vitamin D receptor. ...

Abstract	Both obesity and chronic kidney disease are increasingly common causes of morbidity and mortality worldwide. Although obesity often co-exists with diabetes and hypertension, it has become clear over the past several decades that obesity is an independent cause of chronic kidney disease, termed obesity-related glomerulopathy. This review defines the attributes of obesity-related glomerulopathy and describes potential pharmacologic interventions. Interventions discussed include peroxisome proliferator-activated receptors, the farnesoid X receptor, the Takeda G-protein-coupled receptor 5, and the vitamin D receptor.
MeSH term(s)	Humans ; Kidney Diseases/etiology ; Obesity/complications ; Receptors, Cytoplasmic and Nuclear ; Transcription Factors/genetics
Chemical Substances	Receptors, Cytoplasmic and Nuclear ; Transcription Factors
Language	English
Publishing date	2021-10-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	604652-6
ISSN	1558-4488 ; 0270-9295
ISSN (online)	1558-4488
ISSN	0270-9295
DOI	10.1016/j.semnephrol.2021.06.004
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Article ; Online: Bile Acid Receptor Agonist Reverses Transforming Growth Factor-β1-Mediated Fibrogenesis in Human Induced Pluripotent Stem Cells-Derived Kidney Organoids.

Yang, Xiaoping / Delsante, Marco / Daneshpajouhnejad, Parnaz / Fenaroli, Paride / Mandell, Kira Perzel / Wang, Xiaoxin / Takahashi, Shogo / Halushka, Marc K / Kopp, Jeffrey B / Levi, Moshe / Rosenberg, Avi Z

Laboratory investigation; a journal of technical methods and pathology

2024 Volume 104, Issue 5, Page(s) 100336

Abstract: ... transcriptional regulators, Farnesoid X receptor, phosphorylated mothers against decapentaplegic homolog 3 (p ... fibrosis. A dual bile acid receptor agonist (INT-767) increased Farnesoid X receptor and reduced p-SMAD3 ...

Abstract	Chronic kidney disease progresses through the replacement of functional tissue compartments with fibrosis, a maladaptive repair process. Shifting kidney repair toward a physiologically intact architecture, rather than fibrosis, is key to blocking chronic kidney disease progression. Much research into the mechanisms of fibrosis is performed in rodent models with less attention to the human genetic context. Recently, human induced pluripotent stem cell (iPSC)-derived organoids have shown promise in overcoming the limitation. In this study, we developed a fibrosis model that uses human iPSC-based 3-dimensional renal organoids, in which exogenous transforming growth factor-β1 (TGF-β1) induced the production of extracellular matrix. TGF-β1-treated organoids showed tubulocentric collagen 1α1 production by regulating downstream transcriptional regulators, Farnesoid X receptor, phosphorylated mothers against decapentaplegic homolog 3 (p-SMAD3), and transcriptional coactivator with PDZ-binding motif (TAZ). Increased nuclear TAZ expression was confirmed in the tubular epithelium in human kidney biopsies with tubular injury and early fibrosis. A dual bile acid receptor agonist (INT-767) increased Farnesoid X receptor and reduced p-SMAD3 and TAZ, attenuating TGF-β1-induced fibrosis in kidney organoids. Finally, we show that TAZ interacted with TEA-domain transcription factors and p-SMAD3 with TAZ and TEA-domain transcription factor 4 coregulating collagen 1α1 gene transcription. In summary, we establish a novel, readily manipulable fibrogenesis model and posit a role for bile acid receptor agonism early in renal parenchymal fibrosis.
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	80178-1
ISSN	1530-0307 ; 0023-6837
ISSN (online)	1530-0307
ISSN	0023-6837
DOI	10.1016/j.labinv.2024.100336
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Article: Fibrosis quantification using multiphoton excitation imaging of picrosirius red stained cardiac tissue.

Jones, Bryce A / Torrado, Belen / Myakala, Komuraiah / Wang, Xiaoxin X / Perry, Priscilla E / Rosenberg, Avi Z / Levi, Moshe / Ranjit, Suman

Research square

2023

Abstract: Traditional methodologies for fibrosis quantification involve histological measurements, staining with Masson's trichrome and picrosirius red (PSR), and label-free imaging using second harmonic generation (SHG). The difficulty of label-free cardiac SHG ... ...

Abstract	Traditional methodologies for fibrosis quantification involve histological measurements, staining with Masson's trichrome and picrosirius red (PSR), and label-free imaging using second harmonic generation (SHG). The difficulty of label-free cardiac SHG imaging is that both collagen (i.e., collagen 1 fibrils) and myosin are harmonophores that generate SHG signals, and specific identification of either collagen or myosin is difficult to achieve. Here we present an alternate method of quantifying cardiac fibrosis by using PSR staining followed by multiphoton excitation fluorescence imaging. Our data from the deoxycorticosterone model of cardiac fibrosis shows that this imaging method and downstream analyses, including background correction, are robust and easy to perform. These advantages are due to the high signal-to-noise ratio provided by PSR in areas of collagen fibers. Furthermore, the hyperspectral and fluorescence lifetime information of PSR-stained area of fibrosis shows better quantification can eventually be obtained using more complex instrumentation.
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3329402/v1
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Article ; Online: Sacubitril/valsartan treatment has differential effects in modulating diabetic kidney disease in

Myakala, Komuraiah / Jones, Bryce A / Wang, Xiaoxin X / Levi, Moshe

American journal of physiology. Renal physiology

2021 Volume 320, Issue 6, Page(s) F1133–F1151

Abstract: Although renin-angiotensin blockade has shown beneficial outcomes in patients with diabetes, renal injury progresses in most of these patients. Therefore, there remains a need for new therapeutic targets in diabetic kidney disease. Enhancement of ... ...

Abstract	Although renin-angiotensin blockade has shown beneficial outcomes in patients with diabetes, renal injury progresses in most of these patients. Therefore, there remains a need for new therapeutic targets in diabetic kidney disease. Enhancement of vasoactive peptides, such as natriuretic peptides, via neprilysin inhibition, has been a new approach. A first-in-class drug, sacubitril/valsartan (Sac/Val), a combination of the angiotensin II receptor blocker Val and neprilysin inhibitor prodrug Sac, has been shown to be more effective than renin-angiotensin blockade alone in the treatment of heart failure with reduced ejection fraction. In this study, we tested the effects of Sac/Val in diabetic kidney disease. We administered Sac/Val or Val to two type 2 diabetes mouse models,
MeSH term(s)	Albuminuria/drug therapy ; Aminobutyrates/pharmacology ; Angiotensin Receptor Antagonists/pharmacology ; Animals ; Biphenyl Compounds/pharmacology ; Blood Pressure/drug effects ; Diabetic Nephropathies/drug therapy ; Drug Combinations ; Inflammation/prevention & control ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Oxidative Stress ; Valsartan/administration & dosage ; Valsartan/pharmacology
Chemical Substances	Aminobutyrates ; Angiotensin Receptor Antagonists ; Biphenyl Compounds ; Drug Combinations ; Valsartan (80M03YXJ7I) ; sacubitril and valsartan sodium hydrate drug combination (WB8FT61183)
Language	English
Publishing date	2021-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00614.2020
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Article: Phosphorus Adsorption on Blast Furnace Slag with Different Magnetism and Its Potential for Phosphorus Recovery

Wu, Xiaoxin / Zhan, Rui / Liu, Lili / Lan, Jinjing / Zhao, Ning / Wang, Zhiping

Water. 2022 Aug. 09, v. 14, no. 16

2022

Abstract: ... of X-ray photoelectron spectroscopy revealed that phosphate mainly existed as HPO₄²⁻ in the surface of BFS ...

Abstract	Phosphorus (P) is one of the essential nutrients for all life but also is involved in the major factor of water eutrophication. This study aimed to investigate a low-cost approach for highly efficient P removal and recovery from wastewater with blast furnace slag (BFS) as the adsorbent. The adsorption characteristics were consistent with the Langmuir adsorption isotherm (q₀ 0.1370~0.3848 mg/g) and quasi-secondary kinetic model (R² = 0.9986~0.9997), suggesting monomolecular-layer chemical adsorption might be the dominant pathway. According to the determination of scanning electron microscope and energy dispersive spectroscopy, P was distributed uniformly with other elements in the surface of BFS and even formed needle-like crystals. This indicated that P might be also further deposited in the surface of BFS after the initially chemical adsorption via coordination with the active sites, which led to the slow accumulation of P along with the adsorption experiments. The binding energy and atomic composition analysis of X-ray photoelectron spectroscopy revealed that phosphate mainly existed as HPO₄²⁻ in the surface of BFS, especially for those non-magnetic particles with relative low Fe content (<30%), indicating the preference of P to the hydroxyl basic sites. Compared with those magnetic particles, the adsorption capacity of the non-magnetic particles was larger and could be restored more easily with the elution of sulfate acid, resulting in about two times the P recovery capability. Based on the P adsorption mechanism in the surface of BFS, the operation conditions of the BFS adsorption column for P recovery were optimized in an alkaline condition with a low phosphate concentration and long residual time. Therefore, non-magnetic BFS with small size could be used to recover P resources from rural wastewater with low P concentration and facilitated the on-site reuse of P resources in rural districts.
Keywords	X-ray photoelectron spectroscopy ; adsorbents ; adsorption ; energy ; energy-dispersive X-ray analysis ; eutrophication ; furnaces ; kinetics ; magnetism ; phosphates ; phosphorus ; slags ; sorption isotherms ; sulfates ; wastewater ; water
Language	English
Dates of publication	2022-0809
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2521238-2
ISSN	2073-4441
ISSN	2073-4441
DOI	10.3390/w14162452
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Synergistic Photon Management and Strain-Induced Band Gap Engineering of Two-Dimensional MoS2 Using Semimetal Composite Nanostructures

Gao, Xiaoxue / Fu, Sidan / Fang, Tao / Yu, Xiaobai / Wang, Haozhe / Ji, Qingqing / Kong, Jing / Wang, Xiaoxin / Liu, Jifeng

2023

Abstract: ... periodic Sn nanodots, (2) conductive SnOx (x<1) core-shell nanoneedle structures. Without sophisticated ... 900 nm under SnOx (x<1) nanoneedles, both spanning from visible to near infrared regime. Enhanced ... nanoneedle-structured SnOx (x<1), which reduces the band gap by ~0.35 eV to further enhance light absorption ...

Abstract	2D MoS2 attracts increasing attention for its application in flexible electronics and photonic devices. For 2D material optoelectronic devices, light absorption of the molecularly thin 2D absorber would be one of the key limiting factors in device efficiency, and conventional photon management techniques are not necessarily compatible with them. In this paper, we show two semimetal composite nanostructures for synergistic photon management and strain-induced band gap engineering of 2D MoS2: (1) pseudo-periodic Sn nanodots, (2) conductive SnOx (x<1) core-shell nanoneedle structures. Without sophisticated nanolithography, both nanostructures are self-assembled from physical vapor deposition. 2D MoS2 achieves up to >15x enhancement in absorption at {\lambda}=650-950 nm under Sn nanodots, and 20-30x at {\lambda}=700-900 nm under SnOx (x<1) nanoneedles, both spanning from visible to near infrared regime. Enhanced absorption in MoS2 results from strong near field enhancement and reduced MoS2 band gap due to the tensile strain induced by the Sn nanostructures, as confirmed by Raman and photoluminescence spectroscopy. Especially, we demonstrate that up to 3.5% biaxial tensile strain is introduced to 2D MoS2 using conductive nanoneedle-structured SnOx (x<1), which reduces the band gap by ~0.35 eV to further enhance light absorption at longer wavelengths. To the best of our knowledge, this is the first demonstration of a synergistic triple-functional photon management, stressor, and conductive electrode layer on 2D MoS2. Such synergistic photon management and band gap engineering approach for extended spectral response can be further applied to other 2D materials for future 2D photonic devices.
Keywords	Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Materials Science ; Physics - Optics
Subject code	535
Publishing date	2023-01-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Farnesoid X receptor prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease.

Jones, Bryce A / Myakala, Komuraiah / Guha, Mahilan / Davidson, Shania / Adapa, Sharmila / Lopez Santiago, Isabel / Schaffer, Isabel / Yue, Yang / Allegood, Jeremy C / Cowart, L Ashley / Wang, Xiaoxin X / Rosenberg, Avi Z / Levi, Moshe

American journal of physiology. Renal physiology

2023 Volume 325, Issue 6, Page(s) F792–F810

Abstract: Farnesoid X receptor (FXR) activation reduces renal inflammation, but the underlying mechanisms ...

Abstract	Farnesoid X receptor (FXR) activation reduces renal inflammation, but the underlying mechanisms remain elusive. Neutrophil extracellular traps (NETs) are webs of DNA formed when neutrophils undergo specialized programmed cell death (NETosis). The signaling lipid sphingosine-1-phosphate (S1P) stimulates NETosis via its receptor on neutrophils. Here, we identify FXR as a negative regulator of NETosis via repressing S1P signaling. We determined the effects of the FXR agonist obeticholic acid (OCA) in mouse models of adenosine phosphoribosyltransferase (APRT) deficiency and Alport syndrome, both genetic disorders that cause chronic kidney disease. Renal FXR activity is greatly reduced in both models, and FXR agonism reduces disease severity. Renal NETosis and sphingosine kinase 1 (
MeSH term(s)	Animals ; Female ; Humans ; Male ; Mice ; Biomarkers ; Extracellular Traps/metabolism ; Inflammation ; Nephritis ; Renal Insufficiency, Chronic/drug therapy ; Sphingosine/metabolism
Chemical Substances	Biomarkers ; Sphingosine (NGZ37HRE42) ; sphingosine 1-phosphate (26993-30-6) ; farnesoid X-activated receptor (0C5V0MRU6P)
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00292.2023
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Article: Three RNA-binding protein signature as a novel biomarker to predict endometrial cancer prognosis.

Wang, Bo / Ma, Xiaoxin

American journal of translational research

2023 Volume 15, Issue 1, Page(s) 476–492

Abstract: The aim of this study was to build a prognostic model for endometrial cancer (EC) patients based on RNA-binding proteins (RBPs). RNA sequencing and clinical data for uterine corpus EC (UCEC) were obtained from The Cancer Genome Atlas (TCGA). Univariate ... ...

Abstract	The aim of this study was to build a prognostic model for endometrial cancer (EC) patients based on RNA-binding proteins (RBPs). RNA sequencing and clinical data for uterine corpus EC (UCEC) were obtained from The Cancer Genome Atlas (TCGA). Univariate and multivariate Cox regression analysis were used to obtain the following risk formula: score = sum (corresponding coefficient × expression of each gene). A nomogram was developed to accurately predict patient survival based on risk score, age, stage, and grade. Immunohistochemistry (IHC) was used to verify the expression of RBPs in EC. The mRNA expression of RBPs was measured by qRT-PCR. The effects of RBPs on the malignant biologic behavior of EC were detected using CCK-8, colony formation, and transwell invasion assays. A novel prognostic signature was constructed, comprising three RBPs (CD3EAP, SBDS, and TDRKH). The risk score was: Risk score = (0.860 × CD3EAP expression) + (0.622 × 6SBDS expression) + (0.427 × 4TDRKH expression). The area under the receiver operating characteristic curves (AUCs) of risk score for 1-, 3-, and 5-year overall survival (OS) was 0.75, 0.68, and 0.65, respectively. The AUCs of the nomogram for 1-, 3-, and 5-year OS were 0.811, 0.793, and 0.814, respectively. In our independent cohort, the IHC results revealed that CD3EAP (P < 0.001) and TDRKH (P < 0.001) were upregulated and SBDS (P < 0.001) was downregulated in EC. Immunostaining showed the expression levels of CD3EAP, SBDS and TDRKH for each patient and these were multiplied by their respective coefficients of 0.860, 0.622 and 0.427 to obtain the risk scores. The AUCs of risk score for 1-, 3-, and 5-year OS were 0.888, 0.793, and 0.780 respectively. The AUCs of the nomogram for 1-, 3-, and 5-year OS were 0.790, 0.826, and 0.906, respectively. Cell functional experiments also confirmed the influence of the key RBPs on the malignant biologic behavior of EC. In summary, a characteristic model based on our three RBPs accurately predicted the prognosis of EC. Our in-depth analysis of these RBPs may inform the development of novel strategies for the diagnosis and treatment of EC.
Language	English
Publishing date	2023-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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