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  1. Article ; Online: Clinical outcome of rapid diagnosis and antibiotic stewardship in patients with bloodstream infection in Lampang Hospital.

    Sakulkonkij, Parichart / Bruminhent, Jackrapong

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2022  Volume 2, Issue 1, Page(s) e174

    Abstract: Bloodstream infection is a significant cause of morbidity and mortality. Early diagnosis and appropriate antibiotic treatment contribute to a favorable prognosis. We demonstrate a reduction of time to proper antibiotics and reduced mortality utilizing ... ...

    Abstract Bloodstream infection is a significant cause of morbidity and mortality. Early diagnosis and appropriate antibiotic treatment contribute to a favorable prognosis. We demonstrate a reduction of time to proper antibiotics and reduced mortality utilizing prompt diagnosis and antibiotic stewardship by infectious diseases physicians at a general hospital in Thailand.
    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2022.311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical outcome of rapid diagnosis and antibiotic stewardship in patients with bloodstream infection in Lampang Hospital

    Parichart Sakulkonkij / Jackrapong Bruminhent

    Antimicrobial Stewardship & Healthcare Epidemiology, Vol

    2022  Volume 2

    Abstract: Bloodstream infection is a significant cause of morbidity and mortality. Early diagnosis and appropriate antibiotic treatment contribute to a favorable prognosis. We demonstrate a reduction of time to proper antibiotics and reduced mortality utilizing ... ...

    Abstract Bloodstream infection is a significant cause of morbidity and mortality. Early diagnosis and appropriate antibiotic treatment contribute to a favorable prognosis. We demonstrate a reduction of time to proper antibiotics and reduced mortality utilizing prompt diagnosis and antibiotic stewardship by infectious diseases physicians at a general hospital in Thailand.
    Keywords Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A family cluster of diagnosed coronavirus disease 2019 (COVID-19) kidney transplant recipient in Thailand.

    Sakulkonkij, Parichart / Bruminhent, Jackrapong / Pankongngam, Charan / Chalermphunchai, Nipon

    Immunity, inflammation and disease

    2020  Volume 8, Issue 4, Page(s) 534–543

    Abstract: Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes an ongoing outbreak of respiratory illness called coronavirus disease 2019 (COVID-19). The clinical course could be ranging from mild to severe illness especially the ... ...

    Abstract Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes an ongoing outbreak of respiratory illness called coronavirus disease 2019 (COVID-19). The clinical course could be ranging from mild to severe illness especially the individuals with an immunocompromised condition such as solid organ transplant recipients.
    Method: We described a family cluster of COVID-19 patients who were admitted during 3rd April 2020 to 30th April 2020. COVID-19 was confirmed by a presence of SARS-CoV-2 ribonucleic acid in the respiratory specimens detected by a qualitative, real-time reverse transcription-polymerase chain reaction. The study focused on the clinical course and management of our cases.
    Results: A family cluster of four laboratory-confirmed COVID-19 patients, one of those carried an underlying kidney transplant (KT) receiving immunosuppressants. Clinical presentation and severity of our case series are variable depending on each individual immune status. By far, a KT recipient seems to develop more severity despite antiviral therapy, cessation of immunosuppressant, and aggressive intensive care support.
    Conclusion: Our case series plausibly affirmed a person-to-person transmission and potentially severe disease in the transplant population. Clinicians who are encountering with transplant recipients should be aware of possible transmission among family members.
    MeSH term(s) Adult ; Betacoronavirus/immunology ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Family ; Female ; Graft Rejection/etiology ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Humans ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; Lung/diagnostic imaging ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/immunology ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Radiography ; SARS-CoV-2 ; Thailand
    Chemical Substances Immunosuppressive Agents
    Keywords covid19
    Language English
    Publishing date 2020-08-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 2050-4527
    ISSN (online) 2050-4527
    DOI 10.1002/iid3.337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A family cluster of diagnosed coronavirus disease 2019 (COVID‐19) kidney transplant recipient in Thailand

    Parichart Sakulkonkij / Jackrapong Bruminhent / Charan Pankongngam / Nipon Chalermphunchai

    Immunity, Inflammation and Disease, Vol 8, Iss 4, Pp 534-

    2020  Volume 543

    Abstract: Abstract Introduction Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes an ongoing outbreak of respiratory illness called coronavirus disease 2019 (COVID‐19). The clinical course could be ranging from mild to severe illness especially ... ...

    Abstract Abstract Introduction Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes an ongoing outbreak of respiratory illness called coronavirus disease 2019 (COVID‐19). The clinical course could be ranging from mild to severe illness especially the individuals with an immunocompromised condition such as solid organ transplant recipients. Method We described a family cluster of COVID‐19 patients who were admitted during 3rd April 2020 to 30th April 2020. COVID‐19 was confirmed by a presence of SARS‐CoV‐2 ribonucleic acid in the respiratory specimens detected by a qualitative, real‐time reverse transcription‐polymerase chain reaction. The study focused on the clinical course and management of our cases. Results A family cluster of four laboratory‐confirmed COVID‐19 patients, one of those carried an underlying kidney transplant (KT) receiving immunosuppressants. Clinical presentation and severity of our case series are variable depending on each individual immune status. By far, a KT recipient seems to develop more severity despite antiviral therapy, cessation of immunosuppressant, and aggressive intensive care support. Conclusion Our case series plausibly affirmed a person‐to‐person transmission and potentially severe disease in the transplant population. Clinicians who are encountering with transplant recipients should be aware of possible transmission among family members.
    Keywords COVID‐19 ; family cluster ; pneumonia ; post kidney transplant ; transmission ; Immunologic diseases. Allergy ; RC581-607 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A family cluster of diagnosed coronavirus disease 2019 (COVID‐19) kidney transplant recipient in Thailand

    Sakulkonkij, Parichart / Bruminhent, Jackrapong / Pankongngam, Charan / Chalermphunchai, Nipon

    Immunity, Inflammation and Disease ; ISSN 2050-4527 2050-4527

    2020  

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/iid3.337
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: A family cluster of diagnosed coronavirus disease 2019 (COVID-19) kidney transplant recipient in Thailand

    Sakulkonkij, Parichart / Bruminhent, Jackrapong / Pankongngam, Charan / Chalermphunchai, Nipon

    Immun Inflamm Dis

    Abstract: INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes an ongoing outbreak of respiratory illness called coronavirus disease 2019 (COVID-19). The clinical course could be ranging from mild to severe illness especially the ... ...

    Abstract INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes an ongoing outbreak of respiratory illness called coronavirus disease 2019 (COVID-19). The clinical course could be ranging from mild to severe illness especially the individuals with an immunocompromised condition such as solid organ transplant recipients. METHOD: We described a family cluster of COVID-19 patients who were admitted during 3rd April 2020 to 30th April 2020. COVID-19 was confirmed by a presence of SARS-CoV-2 ribonucleic acid in the respiratory specimens detected by a qualitative, real-time reverse transcription-polymerase chain reaction. The study focused on the clinical course and management of our cases. RESULTS: A family cluster of four laboratory-confirmed COVID-19 patients, one of those carried an underlying kidney transplant (KT) receiving immunosuppressants. Clinical presentation and severity of our case series are variable depending on each individual immune status. By far, a KT recipient seems to develop more severity despite antiviral therapy, cessation of immunosuppressant, and aggressive intensive care support. CONCLUSION: Our case series plausibly affirmed a person-to-person transmission and potentially severe disease in the transplant population. Clinicians who are encountering with transplant recipients should be aware of possible transmission among family members.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #696607
    Database COVID19

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  7. Article ; Online: Molnupiravir versus favipiravir in at-risk outpatients with COVID-19: A randomized controlled trial in Thailand.

    Salvadori, Nicolas / Jourdain, Gonzague / Krittayaphong, Rungroj / Siripongboonsitti, Taweegrit / Kongsaengdao, Subsai / Atipornwanich, Kriangsak / Sakulkonkij, Parichart / Angkasekwinai, Nasikarn / Sirijatuphat, Rujipas / Chusri, Sarunyou / Mekavuthikul, Tanavit / Apisarnthanarak, Anucha / Srichatrapimuk, Sirawat / Sungkanuparph, Somnuek / Kirdlarp, Suppachok / Phongnarudech, Thanyakamol / Sangsawang, Suraphan / Napinkul, Panuwat / Achalapong, Jullapong /
    Khusuwan, Suwimon / Pratipanawat, Piyanut / Nookeu, Pornboonya / Danpipat, Namphol / Leethong, Pornvimol / Hanvoravongchai, Piya / Sukrakanchana, Pra-Ornsuda / Auewarakul, Prasert

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  Volume 143, Page(s) 107021

    Abstract: Objectives: Evaluate and compare the efficacy and safety of molnupiravir and favipiravir in outpatients with mild to moderate COVID-19 and at risk of severe COVID-19.: Methods: In an open-label, parallel-group, multicenter trial in Thailand, ... ...

    Abstract Objectives: Evaluate and compare the efficacy and safety of molnupiravir and favipiravir in outpatients with mild to moderate COVID-19 and at risk of severe COVID-19.
    Methods: In an open-label, parallel-group, multicenter trial in Thailand, participants with moderate COVID-19 and at least one factor associated with severe COVID-19 were randomly assigned 1:1 to receive oral molnupiravir or oral favipiravir (standard of care). Phone calls for remote symptom assessment were made on Days 6, 15, and 29. Participants with worsening symptoms were instructed to return to the hospital. The primary endpoint was pulmonary involvement by Day 29, as evidenced by ≥2 of the following: dyspnea, oxygen saturation <92% or imaging.
    Results: Nine hundred seventy-seven participants (487 molnupiravir, 490 favipiravir) were enrolled from 8 July 2022 to 19 January 2023. 98% had received ≥1 dose of COVID-19 vaccine and 83% ≥3 doses. By Day 29, pulmonary involvement occurred in 0% (0/483) in molnupiravir arm versus 1% (5/482) in favipiravir arm (-1.0%; Newcombe 95.2% CI: -2.4% to -0.0%; P = 0.021); all-cause death in 0% (0/483) and <1% (1/482); COVID-19 related hospitalization in <1% (1/483) and 1% (3/482); treatment-related adverse event in 1% (5/483) and 1% (4/486); and serious adverse event in 1% (4/483) and 1% (4/486).
    Conclusions: Favipiravir and molnupiravir had a similar efficacy and safety profile. Whether either of the two reduced the risk of complications during the omicron era in this population with a low risk of pulmonary involvement and a high vaccine coverage remains unclear. There were no differences in any of the safety endpoints.
    Thai clinical trials registry id: TCTR20230111009.
    Language English
    Publishing date 2024-03-30
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.107021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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