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Article ; Online: Author Correction: Continuous glucose monitoring and intrapersonal variability in fasting glucose.

Shilo, Smadar / Keshet, Ayya / Rossman, Hagai / Godneva, Anastasia / Talmor-Barkan, Yeela / Aviv, Yaron / Segal, Eran

2024

Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-024-02997-6
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Article ; Online: Nowcasting the spread of SARS-CoV-2.

Rossman, Hagai / Segal, Eran

Nature microbiology

2021 Volume 7, Issue 1, Page(s) 16–17

MeSH term(s)	Basic Reproduction Number ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/transmission ; Forecasting ; Humans ; Prevalence ; SARS-CoV-2/isolation & purification
Language	English
Publishing date	2021-12-31
Publishing country	England
Document type	News
ISSN	2058-5276
ISSN (online)	2058-5276
DOI	10.1038/s41564-021-01035-2
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Article ; Online: Continuous glucose monitoring and intrapersonal variability in fasting glucose.

Shilo, Smadar / Keshet, Ayya / Rossman, Hagai / Godneva, Anastasia / Talmor-Barkan, Yeela / Aviv, Yaron / Segal, Eran

Nature medicine

2024

Abstract: Plasma fasting glucose (FG) levels play a pivotal role in the diagnosis of prediabetes and diabetes worldwide. Here we investigated FG values using continuous glucose monitoring (CGM) devices in nondiabetic adults aged 40-70 years. FG was measured during ...

Abstract	Plasma fasting glucose (FG) levels play a pivotal role in the diagnosis of prediabetes and diabetes worldwide. Here we investigated FG values using continuous glucose monitoring (CGM) devices in nondiabetic adults aged 40-70 years. FG was measured during 59,565 morning windows of 8,315 individuals (7.16 ± 3.17 days per participant). Mean FG was 96.2 ± 12.87 mg dl
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-024-02908-9
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Zs.A 4212: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Signals of hope: gauging the impact of a rapid national vaccination campaign.

Shilo, Smadar / Rossman, Hagai / Segal, Eran

Nature reviews. Immunology

2021 Volume 21, Issue 4, Page(s) 198–199

MeSH term(s)	BNT162 Vaccine ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Hospitalization/trends ; Humans ; Immunization Programs ; Israel/epidemiology ; Mass Vaccination ; SARS-CoV-2 ; Vaccination Coverage
Chemical Substances	COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-021-00531-0
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Zs.A 5565: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: CGMap: Characterizing continuous glucose monitor data in thousands of non-diabetic individuals.

Keshet, Ayya / Shilo, Smadar / Godneva, Anastasia / Talmor-Barkan, Yeela / Aviv, Yaron / Segal, Eran / Rossman, Hagai

Cell metabolism

2023 Volume 35, Issue 5, Page(s) 758–769.e3

Abstract: Despite its rising prevalence, diabetes diagnosis still relies on measures from blood tests. Technological advances in continuous glucose monitoring (CGM) devices introduce a potential tool to expand our understanding of glucose control and variability ... ...

Abstract	Despite its rising prevalence, diabetes diagnosis still relies on measures from blood tests. Technological advances in continuous glucose monitoring (CGM) devices introduce a potential tool to expand our understanding of glucose control and variability in people with and without diabetes. Yet CGM data have not been characterized in large-scale healthy cohorts, creating a lack of reference for CGM data research. Here we present CGMap, a characterization of CGM data collected from over 7,000 non-diabetic individuals, aged 40-70 years, between 2019 and 2022. We provide reference values of key CGM-derived clinical measures that can serve as a tool for future CGM research. We further explored the relationship between CGM-derived measures and diabetes-related clinical parameters, uncovering several significant relationships, including associations of mean blood glucose with measures from fundus imaging and sleep monitoring. These findings offer novel research directions for understanding the influence of glucose levels on various aspects of human health.
MeSH term(s)	Humans ; Blood Glucose ; Blood Glucose Self-Monitoring/methods ; Diabetes Mellitus ; Diabetes Mellitus, Type 1
Chemical Substances	Blood Glucose
Language	English
Publishing date	2023-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2176834-1
ISSN	1932-7420 ; 1550-4131
ISSN (online)	1932-7420
ISSN	1550-4131
DOI	10.1016/j.cmet.2023.04.002
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Article ; Online: Axes of a revolution: challenges and promises of big data in healthcare.

Shilo, Smadar / Rossman, Hagai / Segal, Eran

Nature medicine

2020 Volume 26, Issue 1, Page(s) 29–38

Abstract: Health data are increasingly being generated at a massive scale, at various levels of phenotyping and from different types of resources. Concurrent with recent technological advances in both data-generation infrastructure and data-analysis methodologies, ...

Abstract	Health data are increasingly being generated at a massive scale, at various levels of phenotyping and from different types of resources. Concurrent with recent technological advances in both data-generation infrastructure and data-analysis methodologies, there have been many claims that these events will revolutionize healthcare, but such claims are still a matter of debate. Addressing the potential and challenges of big data in healthcare requires an understanding of the characteristics of the data. Here we characterize various properties of medical data, which we refer to as 'axes' of data, describe the considerations and tradeoffs taken when such data are generated, and the types of analyses that may achieve the tasks at hand. We then broadly describe the potential and challenges of using big data in healthcare resources, aiming to contribute to the ongoing discussion of the potential of big data resources to advance the understanding of health and disease.
MeSH term(s)	Big Data ; Cohort Studies ; Delivery of Health Care ; Disease Progression ; Humans ; Medicine ; Reference Standards
Language	English
Publishing date	2020-01-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-019-0727-5
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Zs.A 4212: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The role of models in the covid-19 pandemic.

Steinberg, David M / Balicer, Ran D / Benjamini, Yoav / De-Leon, Hilla / Gazit, Doron / Rossman, Hagai / Sprecher, Eli

Israel journal of health policy research

2022 Volume 11, Issue 1, Page(s) 36

Abstract: Mathematical and statistical models have played an important role in the analysis of data from COVID-19. They are important for tracking the progress of the pandemic, for understanding its spread in the population, and perhaps most significantly for ... ...

Abstract	Mathematical and statistical models have played an important role in the analysis of data from COVID-19. They are important for tracking the progress of the pandemic, for understanding its spread in the population, and perhaps most significantly for forecasting the future course of the pandemic and evaluating potential policy options. This article describes the types of models that were used by research teams in Israel, presents their assumptions and basic elements, and illustrates how they were used, and how they influenced decisions. The article grew out of a "modelists' dialog" organized by the Israel National Institute for Health Policy Research with participation from some of the leaders in the local modeling effort.
MeSH term(s)	Humans ; COVID-19 ; Pandemics/prevention & control ; SARS-CoV-2 ; Israel/epidemiology ; Models, Statistical
Language	English
Publishing date	2022-10-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2657655-7
ISSN	2045-4015 ; 2045-4015
ISSN (online)	2045-4015
ISSN	2045-4015
DOI	10.1186/s13584-022-00546-5
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Article ; Online: COVID-19 dynamics after a national immunization program in Israel.

Rossman, Hagai / Shilo, Smadar / Meir, Tomer / Gorfine, Malka / Shalit, Uri / Segal, Eran

Nature medicine

2021 Volume 27, Issue 6, Page(s) 1055–1061

Abstract: Studies on the real-life effect of the BNT162b2 vaccine for Coronavirus Disease 2019 (COVID-19) prevention are urgently needed. In this study, we conducted a retrospective analysis of data from the Israeli Ministry of Health collected between 28 August ... ...

Abstract	Studies on the real-life effect of the BNT162b2 vaccine for Coronavirus Disease 2019 (COVID-19) prevention are urgently needed. In this study, we conducted a retrospective analysis of data from the Israeli Ministry of Health collected between 28 August 2020 and 24 February 2021. We studied the temporal dynamics of the number of new COVID-19 cases and hospitalizations after the vaccination campaign, which was initiated on 20 December 2020. To distinguish the possible effects of the vaccination on cases and hospitalizations from other factors, including a third lockdown implemented on 8 January 2021, we performed several comparisons: (1) individuals aged 60 years and older prioritized to receive the vaccine first versus younger age groups; (2) the January lockdown versus the September lockdown; and (3) early-vaccinated versus late-vaccinated cities. A larger and earlier decrease in COVID-19 cases and hospitalization was observed in individuals older than 60 years, followed by younger age groups, by the order of vaccination prioritization. This pattern was not observed in the previous lockdown and was more pronounced in early-vaccinated cities. Our analysis demonstrates the real-life effect of a national vaccination campaign on the pandemic dynamics.
MeSH term(s)	Adult ; Aged ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/therapeutic use ; Communicable Disease Control ; Hospitalization ; Humans ; Israel/epidemiology ; Male ; Middle Aged ; Pandemics ; Retrospective Studies ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity ; Vaccination
Chemical Substances	COVID-19 Vaccines ; BNT162 vaccine (N38TVC63NU)
Language	English
Publishing date	2021-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-021-01337-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Head-to-head efficacy and safety of rivaroxaban, apixaban, and dabigatran in an observational nationwide targeted trial.

Talmor-Barkan, Yeela / Yacovzada, Nancy-Sarah / Rossman, Hagai / Witberg, Guy / Kalka, Iris / Kornowski, Ran / Segal, Eran

European heart journal. Cardiovascular pharmacotherapy

2022 Volume 9, Issue 1, Page(s) 26–37

Abstract: Aims: The advantages of direct oral anticoagulants (DOACs) over warfarin are well established in atrial fibrillation (AF) patients, however, studies that can guide the selection between different DOACs are limited. The aim was to compare the clinical ... ...

Abstract	Aims: The advantages of direct oral anticoagulants (DOACs) over warfarin are well established in atrial fibrillation (AF) patients, however, studies that can guide the selection between different DOACs are limited. The aim was to compare the clinical outcomes of treatment with apixaban, rivaroxaban, and dabigatran in patients with AF. Methods and results: We conducted a retrospective, nationwide, propensity score-matched-based observational study from Clalit Health Services. Data from 141 992 individuals with AF was used to emulate a target trial for head-to-head comparison of DOACs therapy. Three-matched cohorts of patients assigned to DOACs, from January-2014 through January-2020, were created. One-to-one propensity score matching was performed. Efficacy/safety outcomes were compared using KaplanMeier survival estimates and Cox proportional hazards models. The trial included 56 553 patients (apixaban, n = 35 101; rivaroxaban, n = 15 682; dabigatran, n = 5 770). Mortality and ischaemic stroke rates in patients treated with rivaroxaban were lower compared with apixaban (HR,0.88; 95% CI,0.78-0.99; P,0.037 and HR 0.92; 95% CI,0.86-0.99; P,0.024, respectively). No significant differences in the rates of myocardial infarction, systemic embolism, and overall bleeding were noticed between the different DOACs groups. Patients treated with rivaroxaban demonstrated lower rate of intracranial haemorrhage compared with apixaban (HR,0.86; 95% CI,0.74-1.0; P,0.044). The rate of gastrointestinal bleeding in patients treated with rivaroxaban was higher compared with apixaban (HR, 1.22; 95% CI,1.01-1.44; P, 0.016). Conclusion: We demonstrated significant differences in outcomes between the three studied DOACs. The results emphasize the need for randomized controlled trials that will compare rivaroxaban, apixaban, and dabigatran in order to better guide the selection among them.
MeSH term(s)	Humans ; Dabigatran/adverse effects ; Rivaroxaban/adverse effects ; Brain Ischemia ; Retrospective Studies ; Anticoagulants ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/prevention & control ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/chemically induced ; Gastrointestinal Hemorrhage/chemically induced
Chemical Substances	Dabigatran (I0VM4M70GC) ; Rivaroxaban (9NDF7JZ4M3) ; apixaban (3Z9Y7UWC1J) ; Anticoagulants
Language	English
Publishing date	2022-11-03
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2808613-2
ISSN	2055-6845 ; 2055-6837
ISSN (online)	2055-6845
ISSN	2055-6837
DOI	10.1093/ehjcvp/pvac063
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genome-wide association studies and polygenic risk score phenome-wide association studies across complex phenotypes in the human phenotype project.

Levine, Zachary / Kalka, Iris / Kolobkov, Dmitry / Rossman, Hagai / Godneva, Anastasia / Shilo, Smadar / Keshet, Ayya / Weissglas-Volkov, Daphna / Shor, Tal / Diament, Alon / Talmor-Barkan, Yeela / Aviv, Yaron / Sharon, Tom / Weinberger, Adina / Segal, Eran

Med (New York, N.Y.)

2023 Volume 5, Issue 1, Page(s) 90–101.e4

Abstract: Background: Genome-wide association studies (GWASs) associate phenotypes and genetic variants across a study cohort. GWASs require large-scale cohorts with both phenotype and genetic sequencing data, limiting studied phenotypes. The Human Phenotype ... ...

Abstract	Background: Genome-wide association studies (GWASs) associate phenotypes and genetic variants across a study cohort. GWASs require large-scale cohorts with both phenotype and genetic sequencing data, limiting studied phenotypes. The Human Phenotype Project is a longitudinal study that has measured a wide range of clinical and biomolecular features from a self-assignment cohort over 5 years. The phenotypes collected are quantitative traits, providing higher-resolution insights into the genetics of complex phenotypes. Methods: We present the results of GWASs and polygenic risk score phenome-wide association studies with 729 clinical phenotypes and 4,043 molecular features from the Human Phenotype Project. This includes clinical traits that have not been previously associated with genetics, including measures from continuous sleep monitoring, continuous glucose monitoring, liver ultrasound, hormonal status, and fundus imaging. Findings: In GWAS of 8,706 individuals, we found significant associations between 169 clinical traits and 1,184 single-nucleotide polymorphisms. We found genes associated with both glycemic control and mental disorders, and we quantify the strength of genetic signals in serum metabolites. In polygenic risk score phenome-wide association studies for clinical traits, we found 16,047 significant associations. Conclusions: The entire set of findings, which we disseminate publicly, provides newfound resolution into the genetic architecture of complex human phenotypes. Funding: E.S. is supported by the Minerva foundation with funding from the Federal German Ministry for Education and Research and by the European Research Council and the Israel Science Foundation.
MeSH term(s)	Humans ; Genome-Wide Association Study ; Genetic Risk Score ; Longitudinal Studies ; Blood Glucose Self-Monitoring ; Blood Glucose/genetics ; Phenotype
Chemical Substances	Blood Glucose
Language	English
Publishing date	2023-12-28
Publishing country	United States
Document type	Journal Article
ISSN	2666-6340
ISSN (online)	2666-6340
DOI	10.1016/j.medj.2023.12.001
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