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  1. Article ; Online: Extracellular vesicles selectively mobilize splenic neutrophils.

    Panda, Rachita / Kubes, Paul

    Cardiovascular research

    2023  Volume 119, Issue 1, Page(s) 1–2

    MeSH term(s) Neutrophils/metabolism ; Vascular Cell Adhesion Molecule-1/metabolism ; Extracellular Vesicles ; Endothelial Cells
    Chemical Substances Vascular Cell Adhesion Molecule-1
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvad015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Insights into genome plasticity and gene regulation in

    Panda, Subhasmita / Swain, Subrat Kumar / Sahu, Basanta Pravas / Sarangi, Rachita

    3 Biotech

    2023  Volume 13, Issue 11, Page(s) 366

    Abstract: Microsatellite markers are being used for molecular identification and characterization as well as estimation of evolution patterns due to their highly polymorphic nature. The repeats hold 40% of the entire genome ... ...

    Abstract Microsatellite markers are being used for molecular identification and characterization as well as estimation of evolution patterns due to their highly polymorphic nature. The repeats hold 40% of the entire genome of
    Language English
    Publishing date 2023-10-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-023-03795-6
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  3. Article: Gene expression and involvement of signaling pathways during host-pathogen interplay in

    Panda, Subhasmita / Swain, Subrat Kumar / Sahu, Basanta Pravas / Sarangi, Rachita

    3 Biotech

    2022  Volume 12, Issue 9, Page(s) 180

    Abstract: Scrub typhus is a neglected tropical disease that affects one-third of the world's population. The disease is caused ... ...

    Abstract Scrub typhus is a neglected tropical disease that affects one-third of the world's population. The disease is caused by
    Language English
    Publishing date 2022-07-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-022-03239-7
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  4. Article ; Online: Activation of Host Cellular Signaling and Mechanism of Enterovirus 71 Viral Proteins Associated with Hand, Foot and Mouth Disease.

    Swain, Subrat Kumar / Panda, Subhasmita / Sahu, Basanta Pravas / Sarangi, Rachita

    Viruses

    2022  Volume 14, Issue 10

    Abstract: Enteroviruses are members of ... ...

    Abstract Enteroviruses are members of the
    MeSH term(s) Child ; Humans ; Enterovirus A, Human/genetics ; Enterovirus/genetics ; Hand, Foot and Mouth Disease ; Viral Proteins/genetics ; Internal Ribosome Entry Sites ; Enterovirus Infections ; Interferons/genetics ; Antiviral Agents/pharmacology ; Cytokines/genetics
    Chemical Substances Viral Proteins ; Internal Ribosome Entry Sites ; Interferons (9008-11-1) ; Antiviral Agents ; Cytokines
    Language English
    Publishing date 2022-10-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14102190
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  5. Article ; Online: Developing Pedestrian Fatality Prediction Models Using Historical Crash Data

    Malaya Mohanty / Bitati Sarkar / Piotr Gorzelańczyk / Rachita Panda / Srinivasa Rao Gandupalli / Ampereza Ankunda

    Communications, Vol 25, Iss 2, Pp D45-D

    Application of Binary Logistic Regression and Boosted Tree Mechanism

    2023  Volume 53

    Abstract: Pedestrian fatality rate plays a key role in examining effectiveness of the road safety. The present study attempts to examine the effect of various categories of accused vehicles and the average 85th percentile speed at accident location on the ... ...

    Abstract Pedestrian fatality rate plays a key role in examining effectiveness of the road safety. The present study attempts to examine the effect of various categories of accused vehicles and the average 85th percentile speed at accident location on the pedestrian crash fatality. The study also attempts to develop pedestrian crash severity models using the binary logistic regression and boosted trees technique. Historical crash data, along with the video recording technique at accident sites, have been utilized for the present study. From regression equations, it is observed that when the heavy vehicle (HV) hits a pedestrian as compared to two-wheeler (2W), the average chance of death increases 2.44 times. According to the Boosted tree model, the contribution of speed is 60 %, whereas the contribution of category of accused vehicle is 40 % for pedestrian fatality prediction. The study should help in planning better strategies like all red time at intersections or pedestrian foot over bridge at critical locations.
    Keywords pedestrian fatalities ; vehicle category ; 85th percentile speed ; binary logistic model ; boosted tree model ; Transportation and communications ; HE1-9990 ; Science ; Q ; Transportation engineering ; TA1001-1280
    Subject code 380
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher University of Žilina
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Molecular characterization and evolutionary analysis of Orientia tsutsugamushi in eastern Indian population.

    Swain, Subrat Kumar / Sahu, Basanta Pravas / Panda, Subhasmita / Sarangi, Rachita

    Archives of microbiology

    2022  Volume 204, Issue 4, Page(s) 221

    Abstract: Scrub typhus is a bacterial zoonotic acute febrile illness (AFI) caused by the obligate intracellular bacterium Orientia tsutsugamushi, which is an antigenically diverse strain frequently observed in the tropical region of Southeast Asian countries. The ... ...

    Abstract Scrub typhus is a bacterial zoonotic acute febrile illness (AFI) caused by the obligate intracellular bacterium Orientia tsutsugamushi, which is an antigenically diverse strain frequently observed in the tropical region of Southeast Asian countries. The recent investigation was conducted to delineate the genotype identification of Orientia tsutsugamushi predominating in the eastern zone of India such as Odisha to decipher its strain type, and evaluate its diversity as well as evolutionary pattern based on the nucleotide analysis of the immune dominant 56 KDa gene. During this study, we have investigated 100 clinical samples (2014-2018), out of which 28 were positive for scrub typhus followed by its molecular characterization and phylogenetic analysis utilizing 56 KDa partial genes. Population genetic parameters showed the presence of 287 polymorphic sites within the analyzed 56 KDa gene. The gene diversity (Hd) and sequence diversity (π) was estimated 0.638 and 0.280, respectively. Selection pressure analysis (θ = dN/dS) having the value 0.222 suggests that the gene lied under purifying selection. The present study suggested a high rate of genetic diversity within the isolates. This research study sheds light on the hereditary and evolutionary relationships of Orientia strains found in the eastern Indian population. Understanding regional genetic variation is critical for vaccine development and sero-diagnostics methods. A significant level of genetic variability was observed during this study. This information has a way to understand more about antigen diversity that leads to develop an effective vaccine candidate for this pathogen.
    MeSH term(s) Genetic Variation ; Humans ; Orientia tsutsugamushi/genetics ; Phylogeny ; Scrub Typhus/epidemiology ; Scrub Typhus/microbiology ; Sequence Analysis, DNA
    Language English
    Publishing date 2022-03-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124824-8
    ISSN 1432-072X ; 0302-8933
    ISSN (online) 1432-072X
    ISSN 0302-8933
    DOI 10.1007/s00203-022-02823-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 805: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Diversity and seasonal dynamics of dipteran flies infesting cattle and its habitation in Bhubaneswar, India

    Shety, Rachita / Dehuri, Manaswini / Panda, Mitraranjan / Mohanty, Bijayendranath

    International journal of tropical insect science. 2022 Feb., v. 42, no. 1

    2022  

    Abstract: Dipteran flies are important ectoparasites of cattle that causes economic losses by virtue of their ability to cause annoyance, blood loss, and act as a vector of widespread diseases. The abundance of dipteran flies affecting the dairy population is ... ...

    Abstract Dipteran flies are important ectoparasites of cattle that causes economic losses by virtue of their ability to cause annoyance, blood loss, and act as a vector of widespread diseases. The abundance of dipteran flies affecting the dairy population is poorly documented in India and the present study was planned to investigate the diversity and seasonal abundance of dipteran flies in and around Bhubaneswar. Dipteran flies were collected from cattle sheds and habitations for one year (August 2017 to July 2018) covering four seasons. Higher recovery of flies was documented for Musca fly (21.51%) followed by mosquitoes. Amongst different mosquitoes, Culex spp. was the most common (18.11%) followed by Aedes spp. (11.58%), and Anopheles spp. (8.82%). Stomoxys fly, Tabanus fly, Chrysops fly, Sarcophaga fly, Hippobosca fly, and Coproica fly showed a relative abundance of 10.29%, 9.93%, 6.8%, 6.07%, 4.5%, and 2.39% respectively. There was significant variation (p < 0.01) in the seasonal abundance of flies. The highest relative abundance of flies was recorded in June whereas the least relative abundance was from November to January. The correlation analysis of the monthly fly population with climatic factors showed a highly significant correlation (p < 0.01) of the fly population with average temperature (r = 0.840), average relative humidity (r = 0.808), and rainfall (r = 0.796). The present communication reports abundance of different biting and non biting flies around cattle habitations and the insect activity were dependant on climatic parameters.
    Keywords Aedes ; Anopheles ; Chrysops ; Coproica ; Culex ; Hippobosca ; Musca ; Sarcophaga ; Stomoxys ; Tabanus ; blood ; cattle ; ectoparasites ; rain ; relative humidity ; temperature ; India
    Language English
    Dates of publication 2022-02
    Size p. 983-988.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 2166668-4
    ISSN 1742-7592 ; 1742-7584
    ISSN (online) 1742-7592
    ISSN 1742-7584
    DOI 10.1007/s42690-021-00612-6
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    In stock of ZB MED Bonn / Germany

    Z 4487: Show issues

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  8. Article: Immuno-inflammatory predictors of disease severity in COVID-19: A systematic review and meta-analysis.

    Panda, Suchismita / Nanda, Rachita / Tripathy, Prasanta Kumar / Mangaraj, Manaswini

    Journal of family medicine and primary care

    2021  Volume 10, Issue 3, Page(s) 1102–1116

    Abstract: Deregulated immune response and raised inflammation are the cardinal laboratory features in COVID-19 infection reflecting severity of condition. Detection of the markers will help in early diagnosis with timely therapeutic implementation and effective ... ...

    Abstract Deregulated immune response and raised inflammation are the cardinal laboratory features in COVID-19 infection reflecting severity of condition. Detection of the markers will help in early diagnosis with timely therapeutic implementation and effective outcome. Observational studies have suggested alteration in these parameters with severity of the condition. This systematic review and meta-analysis was conducted to assess the relevance of the fact. Observational studies from databases were scrutinised and 3669 articles were identified. Further screening, based on the inclusion criteria a total of 19 articles with 3115 participants, were reviewed for meta-analysis using random effects model. Any data in median and interquartile range were converted to mean ± SD. There was a significant rise in total leukocyte count, C-reactive protein, ferritin, IL-6, IL-10, procalcitonin in severe cases but absolute lymphocyte count, CD4+ and CD8+ registered a fall in severe cases in comparison to non-severe group. Immune and inflammatory markers are significantly altered and related to severity of manifestation in COVID-19 infection.
    Language English
    Publishing date 2021-04-08
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_2196_20
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  9. Article: Gene expression and involvement of signaling pathways during host–pathogen interplay in Orientia tsutsugamushi infection

    Panda, Subhasmita / Swain, Subrat Kumar / Sahu, Basanta Pravas / Sarangi, Rachita

    3 Biotech. 2022 Sept., v. 12, no. 9

    2022  

    Abstract: Scrub typhus is a neglected tropical disease that affects one-third of the world’s population. The disease is caused by Orientia tsutsugamushi (OT), an obligate intracellular Gram-negative bacterium. OT efficiently escapes from the endosomal pathway ... ...

    Abstract Scrub typhus is a neglected tropical disease that affects one-third of the world’s population. The disease is caused by Orientia tsutsugamushi (OT), an obligate intracellular Gram-negative bacterium. OT efficiently escapes from the endosomal pathway after entering the host cell and replicates inside cytosol. OT infection promotes cellular autophagy, the autonomous defense mechanism unlike other bacteria. This study has discussed the bacterial invasion process through the extracellular matrix and the immune response activated by the bacterium within the hosts. Furthermore, we have emphasized the importance of extracellular matrix and their cross-talk with the immune cells, such as, macrophages, neutrophils, and dendritic cells followed by their inflammatory response. We have also put an insight into the host factors associated with signaling pathways during scrub typhus disease with a special focus on the OT-induced stress response, autophagy, apoptosis, and innate immunity. Multiple cytokines and chemokines play a significant role in activating different immune-related signaling pathways. Due to the presence of high antigenic diversity among strains, the signaling pathways during the host–pathogen interplay of OT with its host is very complicated. Thus, it hinders to mitigate the severity of the pandemic occurred by the respective pathogen. Our investigation will provide a useful guide to better understand the virulence and physiology of this intracellular pathogen which will lead towards a better therapeutic diagnosis and vaccine development.
    Keywords Gram-negative bacteria ; Orientia tsutsugamushi ; antigenic variation ; apoptosis ; autophagy ; chemokines ; cytosol ; extracellular matrix ; gene expression ; immune response ; inflammation ; innate immunity ; macrophages ; neutrophils ; pandemic ; pathogens ; scrub typhus ; stress response ; therapeutics ; tropical diseases ; vaccine development ; virulence
    Language English
    Dates of publication 2022-09
    Size p. 180.
    Publishing place Springer International Publishing
    Document type Article
    Note Review
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-022-03239-7
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  10. Article: Factors propelling fatalities during road crashes: A detailed investigation and modelling of historical crash data with field studies.

    Mohanty, Malaya / Panda, Rachita / Gandupalli, Srinivasa Rao / Arya, Ritik Raj / Lenka, Sarthak Kumar

    Heliyon

    2022  Volume 8, Issue 11, Page(s) e11531

    Abstract: One of the major concerns in developing countries like India is to maintain traffic safety under mixed and heterogenous scenario. Although zero accidents is the need of the hour, the first step to attain it is ensuring zero deaths and no serious long- ... ...

    Abstract One of the major concerns in developing countries like India is to maintain traffic safety under mixed and heterogenous scenario. Although zero accidents is the need of the hour, the first step to attain it is ensuring zero deaths and no serious long-term disabling injuries in road crashes. To reduce the road crash fatalities, explicit and detailed studies have been conducted by utilising historical road crash data of two emerging smart cities of India - Bhubaneswar and Visakhapatnam. Traffic flow data and characteristics of road infrastructure has also been collected by performing field studies at accident prone locations. Various factors including vehicular characteristics, road user characteristics, and road infrastructure have been analyzed using various non-parametric tests to identify the contributing factors resulting in fatalities. It is observed that out of 14 variables used for study, 8 factors were significantly related to fatal crashes. These included categories of victim and accused, 85th percentile speed, presence of road markings, availability of sight distance, etc. The significant factors were subjected to binary logistic regression to determine the odd's ratio of significant factors. The logistic regression predicted 79% of deaths correctly. Crash fatality prediction models are developed using both Classification and Regression Tree (CART) classification tree with 83% accuracy. Although CART classification led to higher accuracy, binary logistic regression is more robust as it considered more significant factors as compared to CART. Subsequently, a severity index has been proposed based on proportions of actual fatal crashes and usage of K-means clustering technique. The proposed indices shall be really helpful in traffic safety management, specifically in reduction of fatalities during road crashes.
    Language English
    Publishing date 2022-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e11531
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