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  1. Book ; Thesis: Role of NFAT (nuclear factor of activated T-cells) in vascular smooth muscle

    Nilsson-Berglund, Lisa

    (Doctoral dissertation series ; 2009,16)

    2009  

    Title variant Role of NFAT in vascular smooth muscle ; Role of nuclear factor of activated T-cells in vascular smooth muscle
    Author's details Lisa Nilsson-Berglund
    Series title Doctoral dissertation series ; 2009,16
    Collection
    Language English
    Size getr. Zählung : Ill., graph. Darst.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lund, Univ., Diss., 2009
    Note Zsfassung in schwed. Sprache ; Enth. 4 Sonderabdr.
    HBZ-ID HT016822133
    ISBN 978-91-86253-03-5 ; 91-86253-03-4
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Loneliness in Relation to Social Factors and Self-Reported Health Among Older Adults: A Cross-Sectional Study.

    Axén, Anna / Taube, Elin / Sanmartin Berglund, Johan / Skär, Lisa

    Journal of primary care & community health

    2023  Volume 14, Page(s) 21501319231198644

    Abstract: Background: Loneliness is described as a public health problem and can be both a consequence of aging and a cause of ill health. Lonely older adults tend to have difficulties making new social connections, essential in reducing loneliness. Loneliness ... ...

    Abstract Background: Loneliness is described as a public health problem and can be both a consequence of aging and a cause of ill health. Lonely older adults tend to have difficulties making new social connections, essential in reducing loneliness. Loneliness often varies over time, but established loneliness tends to persist. Maintaining good health is fundamental throughout the life course. Social connections change with aging, which can contribute to loneliness.
    Aim: This study aimed to investigate loneliness in relation to social factors and self-reported health among older adults.
    Method: A cross-sectional research design was used based on data from the Swedish National Study on Aging and Care, Blekinge (SNAC-B), from February 2019 to April 2021. Statistical analysis consisted of descriptive and inferential analysis.
    Results: Of n = 394 participants, 31.7% (n = 125) stated loneliness. Close emotional connections were necessary for less loneliness. Loneliness was more common among those who did not live with their spouse or partner and met more rarely. Furthermore, seeing grandchildren and neighbors less often increased loneliness, and a more extensive social network decreased loneliness.
    Conclusion: This study underlined the importance of social connections and having someone to share a close, emotional connection with to reduce loneliness.
    MeSH term(s) Humans ; Aged ; Loneliness/psychology ; Cross-Sectional Studies ; Self Report ; Social Factors ; Social Support
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2550221-9
    ISSN 2150-1327 ; 2150-1319
    ISSN (online) 2150-1327
    ISSN 2150-1319
    DOI 10.1177/21501319231198644
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  3. Article ; Online: Burden of care related to monitoring patient vital signs during intensive care; a descriptive retrospective database study.

    Romare, Charlotte / Anderberg, Peter / Sanmartin Berglund, Johan / Skär, Lisa

    Intensive & critical care nursing

    2022  Volume 71, Page(s) 103213

    Abstract: Objective: The aim of this study was to describe burden of care related to monitoring patient vital signs of intensive care unit patients in a Swedish hospital.: Setting: Data collected by "The Swedish Intensive Care Registry" from one general ... ...

    Abstract Objective: The aim of this study was to describe burden of care related to monitoring patient vital signs of intensive care unit patients in a Swedish hospital.
    Setting: Data collected by "The Swedish Intensive Care Registry" from one general category II intensive care unit in a Swedish hospital was included in this study. Data from year 2014 to 2020 was analysed comprising a total of 3617 intensive care episodes and 29,165 work shifts.
    Research methodology: This is a retrospective database study. Descriptive statistics gave an overview of the dataset. To test for differences between variables related to burden of care for "Documentation of monitoring" Mann Whitney U test and Kruskal Wallis test was performed using STATA.
    Results: "Documentation of monitoring" was reported to generate a prominent burden of care during intensive care. Nearly all patients had continuous monitoring. Comparison for burden of care related to "Documentation of monitoring" for sexes generated no statistically significant difference. Comparison for burden of care related to "Documentation of monitoring" among age groups, diagnose groups and time of day generated statistically significant differences.
    Conclusion: Monitoring patient vital signs was clearly present during intensive care, hence impacting intensive care nurses' clinical practice. Further research is endorsed to improve and facilitate monitoring to keep improving patient safety.
    MeSH term(s) Critical Care ; Humans ; Intensive Care Units ; Monitoring, Physiologic ; Retrospective Studies ; Vital Signs
    Language English
    Publishing date 2022-02-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1105892-4
    ISSN 1532-4036 ; 0964-3397
    ISSN (online) 1532-4036
    ISSN 0964-3397
    DOI 10.1016/j.iccn.2022.103213
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  4. Article: Cross-Sectional Study of Sexual Activity and Satisfaction Among Older Adult's ≥60 Years of Age.

    Stentagg, Magnus / Skär, Lisa / Berglund, Johan Sanmartin / Lindberg, Terese

    Sexual medicine

    2021  Volume 9, Issue 2, Page(s) 100316

    Abstract: ... into account during caring encounters with older persons. M Stentagg, L Skär, JS Berglund, et al ...

    Abstract Introduction: Despite the rapidly increasing population of older adults, little is currently known about sexual activity and sexual satisfaction among the oldest people.
    Aim: The present study aimed to investigate sexual activity and sexual satisfaction among people of ≥60 years of age. We also examined whether sexual activity and sexual satisfaction were influenced by age, gender, cohabiting, socioeconomic factors, education, functional ability, and self-reported health.
    Methods: We performed a descriptive analysis of self-stated sexual activity and sexual satisfaction among 1680 participants who were 60 years and older from the Swedish National Study on Aging and Care. Chi-square tests and logistic regression were used to analyze relationships between factors.
    Main outcome measure: Sexual activity and sexual satisfaction.
    Results: Among participants aged ≥90 years, about 10% were sexually active. Within the total study population, 46% (654/1680) were sexually active. Overall, sexually activity was more commonly reported by men (55%) than women (40%). However, men in all age cohorts reported sexual dissatisfaction more commonly than women. In the total sample, 24% (246/1680) reported dissatisfaction with their sex life. Sexual activity and sexual satisfaction were positively associated with self-reported health and cohabitation.
    Conclusion: The present results suggest that sexual activity is present throughout life. For persons older than 90 years, about 10% of participants were sexually active, regardless of gender. Every third man reported dissatisfaction with his sex life. Women were more satisfied with their sex lives than men, and this difference varies more widely among age cohorts. These findings confirm that it is important that health professional take sexuality into account during caring encounters with older persons. M Stentagg, L Skär, JS Berglund, et al. Cross-Sectional Study of Sexual Activity and Satisfaction Among Older Adult's ≥60 Years of Age. Sex Med 2021;9:100316.
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2734882-9
    ISSN 2050-1161
    ISSN 2050-1161
    DOI 10.1016/j.esxm.2020.100316
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  5. Article ; Online: The effects of the COVID-19 pandemic on hallucinations and delusions in youth at clinical high-risk for psychosis and outpatients with schizophrenia.

    Berglund, Alysia M / Raugh, Ian M / Macdonald, Kelsey I / James, Sydney H / Bartolomeo, Lisa A / Knippenberg, Anna R / Strauss, Gregory P

    European archives of psychiatry and clinical neuroscience

    2023  Volume 273, Issue 6, Page(s) 1329–1338

    Abstract: Although the COVID-19 pandemic has had detrimental effects on mental health in the general population, the impact on those with schizophrenia-spectrum disorders has received relatively little attention. Assessing pandemic-related changes in positive ... ...

    Abstract Although the COVID-19 pandemic has had detrimental effects on mental health in the general population, the impact on those with schizophrenia-spectrum disorders has received relatively little attention. Assessing pandemic-related changes in positive symptoms is particularly critical to inform treatment protocols and determine whether fluctuations in hallucinations and delusions are related to telehealth utilization and treatment adherence. In the current longitudinal study, we evaluated changes in the frequency of hallucinations and delusions and distress resulting from them across three-time points. Participants included: (1) outpatients with chronic schizophrenia (SZ: n = 32) and healthy controls (CN: n = 31); (2) individuals at clinically high risk for psychosis (CHR: n = 25) and CN (n = 30). A series of questionnaires were administered to assess hallucination and delusion severity, medication adherence, telehealth utilization, and protective factors during the pandemic. While there were no significant increases in the frequency of hallucinations and delusions in SZ and CHR, distress increased from pre-pandemic to early pandemic in both groups and then decreased at the third time point. Additionally, changes in positive symptom severity in SZ were related to psychiatric medication adherence. Findings suggest that positive symptoms are a critical treatment target during the pandemic and that ongoing medication services will be beneficial.
    MeSH term(s) Humans ; Adolescent ; Schizophrenia/complications ; Schizophrenia/epidemiology ; Schizophrenia/diagnosis ; Delusions/epidemiology ; Delusions/etiology ; Delusions/diagnosis ; Pandemics ; Longitudinal Studies ; Outpatients ; COVID-19/epidemiology ; Psychotic Disorders/drug therapy ; Psychotic Disorders/epidemiology ; Psychotic Disorders/psychology ; Hallucinations/epidemiology ; Hallucinations/etiology ; Hallucinations/diagnosis
    Language English
    Publishing date 2023-01-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-023-01551-8
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    Ui I Zs.45: Show issues Location:
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  6. Article ; Online: Nonclinical safety evaluation of two vaccine candidates for herpes simplex virus type 2 to support combined administration in humans.

    Piras, Fabienne / Plitnick, Lisa M / Berglund, Peter / Bernard, Marie-Clotilde / Desert, Paul

    Journal of applied toxicology : JAT

    2022  Volume 43, Issue 4, Page(s) 534–556

    Abstract: Herpes simplex virus type 2 (HSV-2) is the most common cause of genital disease worldwide. The development of an effective HSV-2 vaccine would significantly impact global health based on the psychological distress caused by genital herpes for some ... ...

    Abstract Herpes simplex virus type 2 (HSV-2) is the most common cause of genital disease worldwide. The development of an effective HSV-2 vaccine would significantly impact global health based on the psychological distress caused by genital herpes for some individuals, the risk transmitting the infection from mother to infant, and the elevated risk of acquiring HIV-1. Five nonclinical safety studies were conducted with the replication defective HSV529 vaccine, alone or adjuvanted with GLA-SE, and the G103 subunit vaccine containing GLA-SE. A biodistribution study was conducted in guinea pigs to evaluate distribution, persistence, and shedding of HSV529. A preliminary immunogenicity study was conducted in rabbits to demonstrate HSV529-specific humoral response and its enhancement by GLA-SE. Three repeated-dose toxicity studies, one in guinea pigs and two in rabbits, were conducted to assess systemic toxicity and local tolerance of HSV529, alone or adjuvanted with GLA-SE, or G103 containing GLA-SE. Data from these studies show that both vaccines are safe and well tolerated and support the ongoing HSV-2 clinical trial in which the two vaccine candidates will be given either sequentially or concomitantly to explore their potential synergistic and incremental effects.
    MeSH term(s) Humans ; Animals ; Guinea Pigs ; Rabbits ; Herpesvirus 2, Human ; Tissue Distribution ; Antibodies, Viral ; Viral Envelope Proteins ; Adjuvants, Immunologic ; Vaccines, Subunit
    Chemical Substances Antibodies, Viral ; Viral Envelope Proteins ; Adjuvants, Immunologic ; Vaccines, Subunit
    Language English
    Publishing date 2022-11-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604625-3
    ISSN 1099-1263 ; 0260-437X
    ISSN (online) 1099-1263
    ISSN 0260-437X
    DOI 10.1002/jat.4404
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  7. Article ; Online: Nuclear Hsp104 safeguards the dormant translation machinery during quiescence.

    Kohler, Verena / Kohler, Andreas / Berglund, Lisa Larsson / Hao, Xinxin / Gersing, Sarah / Imhof, Axel / Nyström, Thomas / Höög, Johanna L / Ott, Martin / Andréasson, Claes / Büttner, Sabrina

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 315

    Abstract: The resilience of cellular proteostasis declines with age, which drives protein aggregation and compromises viability. The nucleus has emerged as a key quality control compartment that handles misfolded proteins produced by the cytosolic protein ... ...

    Abstract The resilience of cellular proteostasis declines with age, which drives protein aggregation and compromises viability. The nucleus has emerged as a key quality control compartment that handles misfolded proteins produced by the cytosolic protein biosynthesis system. Here, we find that age-associated metabolic cues target the yeast protein disaggregase Hsp104 to the nucleus to maintain a functional nuclear proteome during quiescence. The switch to respiratory metabolism and the accompanying decrease in translation rates direct cytosolic Hsp104 to the nucleus to interact with latent translation initiation factor eIF2 and to suppress protein aggregation. Hindering Hsp104 from entering the nucleus in quiescent cells results in delayed re-entry into the cell cycle due to compromised resumption of protein synthesis. In sum, we report that cytosolic-nuclear partitioning of the Hsp104 disaggregase is a critical mechanism to protect the latent protein synthesis machinery during quiescence in yeast, ensuring the rapid restart of translation once nutrients are replenished.
    MeSH term(s) Cell Cycle ; Cell Division ; Cytosol ; Protein Aggregates ; Saccharomyces cerevisiae/metabolism ; Heat-Shock Proteins/metabolism ; Protein Biosynthesis ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Protein Aggregates ; HsP104 protein, S cerevisiae (143012-44-6) ; Heat-Shock Proteins ; Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44538-8
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  8. Article ; Online: Older People's Use and Nonuse of the Internet in Sweden.

    Anderberg, Peter / Skär, Lisa / Abrahamsson, Linda / Berglund, Johan Sanmartin

    International journal of environmental research and public health

    2020  Volume 17, Issue 23

    Abstract: The use of the internet has considerably increased over recent years, and the importance of internet use has also grown as services have gone online. Sweden is largely an information society like other countries with high reported use amongst European ... ...

    Abstract The use of the internet has considerably increased over recent years, and the importance of internet use has also grown as services have gone online. Sweden is largely an information society like other countries with high reported use amongst European countries. In line with digitalization development, society is also changing, and many activities and services today take place on the internet. This development could potentially lead to those older persons who do not use the internet or do not follow the development of services on the internet finding it difficult to take part in information and activities that no longer occur in the physical world. This has led to a digital divide between groups, where the older generations (60+), in particular, have been affected. In a large study of Sweden's adult population in 2019, 95 percent of the overall population was said to be internet users, and the corresponding number for users over 66 years of age was 84%. This study shows that the numbers reported about older peoples' internet use, most likely, are vastly overestimated and that real use is significantly lower, especially among the oldest age groups. We report that 62.4% of the study subjects are internet users and that this number most likely also is an overestimation. When looking at nonresponders to the questionnaire, we find that they display characteristics generally attributed to non-use, such as lower education, lower household economy, and lower cognitive functioning.
    MeSH term(s) Aged ; Aged, 80 and over ; Educational Status ; Europe ; Female ; Humans ; Internet ; Male ; Surveys and Questionnaires ; Sweden
    Language English
    Publishing date 2020-12-04
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17239050
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  9. Article ; Online: Using a Mobile Application for Health Communication to Facilitate a Sense of Coherence: Experiences of Older Persons with Cognitive Impairment.

    Piculell, Erik / Skär, Lisa / Sanmartin Berglund, Johan / Anderberg, Peter / Bohman, Doris

    International journal of environmental research and public health

    2021  Volume 18, Issue 21

    Abstract: The increasing use of technology by older persons and their preferences for living at home and being independent have created an avenue for self-care and care delivery using mobile technologies and health communication. This study aimed to explain how ... ...

    Abstract The increasing use of technology by older persons and their preferences for living at home and being independent have created an avenue for self-care and care delivery using mobile technologies and health communication. This study aimed to explain how older persons with cognitive impairment experienced technology-based health communication through the use of a mobile application to facilitate a sense of coherence. Individual, semi-structured interviews with 16 participants in the SMART4MD project were conducted. The interviews were transcribed then coded deductively and thematically, creating themes that corresponded to the central components of the sense of coherence model: comprehensibility, manageability, and meaningfulness. The findings produced an overall theme: a challenging technology that can provide support, based on the three identified themes: making sense of mobile technologies, mastering mobile technologies, and the potential added value to use mobile technologies. The participants' experiences were influenced by their previous use and expectations for the application. Personal support, cognitive and physical ability, and different sources for information impacted use. The participants experienced that using the application created an ambiguity to be challenging and have possible benefits. The study suggests that the sense of coherence model may be used as a method to understand the use of technology by older populations.
    MeSH term(s) Aged ; Aged, 80 and over ; Cognitive Dysfunction ; Health Communication ; Humans ; Mobile Applications ; Self Care ; Sense of Coherence
    Language English
    Publishing date 2021-10-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph182111332
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  10. Article ; Online: Nurse anesthetists' experiences using smart glasses to monitor patients' vital signs during anesthesia care: A qualitative study.

    Romare, Charlotte / Enlöf, Per / Anderberg, Peter / Jildenstål, Pether / Sanmartin Berglund, Johan / Skär, Lisa

    PloS one

    2021  Volume 16, Issue 4, Page(s) e0250122

    Abstract: Purpose: To describe nurse anesthetists' experiences using smart glasses to monitor patients' vital signs during anesthesia care.: Methods: Data was collected through individual semi-structured interviews with seven nurse anesthetists who had used ... ...

    Abstract Purpose: To describe nurse anesthetists' experiences using smart glasses to monitor patients' vital signs during anesthesia care.
    Methods: Data was collected through individual semi-structured interviews with seven nurse anesthetists who had used smart glasses, with a customized application for monitoring vital signs, during clinical anesthesia care. Data was analyzed using thematic content analysis.
    Results: An overarching theme became evident during analysis; Facing and embracing responsibility. Being a nurse anesthetist entails a great responsibility, and the participants demonstrated that they shouldered this responsibility with pride. The theme was divided in two sub-themes. The first of these, A new way of working, comprised the categories Adoption and Utility. This involved incorporating smart glasses into existing routines in order to provide safe anesthesia care. The second sub-theme, Encountering side effects, consisted of the categories Obstacles and Personal affect. This sub-theme concerned the possibility to use smart glasses as intended, as well as the affect on nurse anesthetists as users.
    Conclusion: Smart glasses improved access to vital signs and enabled continuous monitoring regardless of location. Continued development and improvement, both in terms of the application software and the hardware, are necessary for smart glasses to meet nurse anesthetists' needs in clinical practice.
    MeSH term(s) Adult ; Anesthesia/methods ; Anesthesiology/methods ; Female ; Humans ; Male ; Middle Aged ; Nurse Anesthetists ; Qualitative Research ; Smart Glasses ; Vital Signs/physiology
    Language English
    Publishing date 2021-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0250122
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