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  1. Article ; Online: Acinetobacter baumannii

    Feng, Zhengshan / Wang, Lidong / Guan, Qingtian / Chu, Xiao / Luo, Zhao-Qing

    mBio

    2023  , Page(s) e0227623

    Abstract: Plasmid conjugation plays an important role in the dissemination of antibiotic-resistance genes. The emergence of multidrug-resistant isolates ... ...

    Abstract Plasmid conjugation plays an important role in the dissemination of antibiotic-resistance genes. The emergence of multidrug-resistant isolates of
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02276-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A bidirectional Mendelian randomization study investigating the relationship between genetically predicted systemic inflammatory regulators and chronic obstructive pulmonary disease.

    Zhang, Mengyuan / Wang, Shengnan / Guan, Qingtian / Wang, Jianglong / Yan, Bailing / Zhang, Li / Li, Dan

    Heliyon

    2024  Volume 10, Issue 1, Page(s) e24109

    Abstract: Research has shown a connection between inflammation and chronic obstructive pulmonary disease (COPD), however the relationship between inflammation mediators and COPD causation remains unknown. To investigate the causal relationship of mediators of ... ...

    Abstract Research has shown a connection between inflammation and chronic obstructive pulmonary disease (COPD), however the relationship between inflammation mediators and COPD causation remains unknown. To investigate the causal relationship of mediators of inflammation and COPD, we conducted a two-sample Mendelian randomization (MR) study. In our study, we incorporated 41 regulators of inflammation from 8293 Finnish individuals from genome-wide association studies (GWASs) of COPD corresponding to GWAS summary data for 2115 cases and 454,233 healthy individuals in Europe. Our research validated that higher levels of interleukin 8 (IL-8) are related with a decrease occurrence of COPD (OR = 0.795, 95 % CI = 0.642-0.984, p = 0.035) but that elevated levels of interleukin 18(IL-18) and interleukin 2 (IL-2) may be connected to an amplified risk of COPD (OR = 1.247, 95 % CI = 1.011-1.538; p = 0.039; OR = 1.257, 95 % CI = 1.037-1.523, p = 0.020, respectively). According to our research, cytokines play a crucial role in the development of COPD, and further investigation is necessary to explore the potential of utilizing these cytokines as targets for treatment and prevention of COPD.
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A bidirectional Mendelian randomization study investigating the relationship between genetically predicted systemic inflammatory regulators and chronic obstructive pulmonary disease

    Mengyuan Zhang / Shengnan Wang / Qingtian Guan / Jianglong Wang / Bailing Yan / Li Zhang / Dan Li

    Heliyon, Vol 10, Iss 1, Pp e24109- (2024)

    2024  

    Abstract: Research has shown a connection between inflammation and chronic obstructive pulmonary disease (COPD), however the relationship between inflammation mediators and COPD causation remains unknown. To investigate the causal relationship of mediators of ... ...

    Abstract Research has shown a connection between inflammation and chronic obstructive pulmonary disease (COPD), however the relationship between inflammation mediators and COPD causation remains unknown. To investigate the causal relationship of mediators of inflammation and COPD, we conducted a two-sample Mendelian randomization (MR) study. In our study, we incorporated 41 regulators of inflammation from 8293 Finnish individuals from genome-wide association studies (GWASs) of COPD corresponding to GWAS summary data for 2115 cases and 454,233 healthy individuals in Europe. Our research validated that higher levels of interleukin 8 (IL-8) are related with a decrease occurrence of COPD (OR = 0.795, 95 % CI = 0.642–0.984, p = 0.035) but that elevated levels of interleukin 18(IL-18) and interleukin 2 (IL-2) may be connected to an amplified risk of COPD (OR = 1.247, 95 % CI = 1.011–1.538; p = 0.039; OR = 1.257, 95 % CI = 1.037–1.523, p = 0.020, respectively). According to our research, cytokines play a crucial role in the development of COPD, and further investigation is necessary to explore the potential of utilizing these cytokines as targets for treatment and prevention of COPD.
    Keywords IL-18 ; IL-2 ; IL-8 ; Cytokines ; Chronic obstructive pulmonary disease ; Mendelian randomization ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Metal-dependent programmed cell death-related lncRNA prognostic signatures and natural drug sensitivity prediction for gastric cancer.

    Song, Xuesong / Hou, Lin / Zhao, Yuanyuan / Guan, Qingtian / Li, Zhiwen

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 1039499

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.1039499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction.

    Sadykov, Mukhtar / Mourier, Tobias / Guan, Qingtian / Pain, Arnab

    Journal of molecular cell biology

    2021  Volume 13, Issue 3, Page(s) 225–227

    MeSH term(s) COVID-19 ; CpG Islands/genetics ; Cytosine ; Deamination ; Humans ; SARS-CoV-2
    Chemical Substances Cytosine (8J337D1HZY)
    Language English
    Publishing date 2021-02-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2500949-7
    ISSN 1759-4685 ; 1759-4685
    ISSN (online) 1759-4685
    ISSN 1759-4685
    DOI 10.1093/jmcb/mjab011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction.

    Sadykov, Mukhtar / Mourier, Tobias / Guan, Qingtian / Pain, Arnab

    bioRxiv : the preprint server for biology

    2021  

    Abstract: RNA viruses use CpG reduction to evade the host cell defense, but the driving mechanisms are still largely unknown. In an attempt to address this we used a rapidly growing genomic dataset of SARS-CoV-2 with relevant metadata information. Remarkably, by ... ...

    Abstract RNA viruses use CpG reduction to evade the host cell defense, but the driving mechanisms are still largely unknown. In an attempt to address this we used a rapidly growing genomic dataset of SARS-CoV-2 with relevant metadata information. Remarkably, by simply ordering SARS-CoV-2 genomes by their date of collection, we find a progressive increase of C-to-U substitutions resulting in 5'-UCG-3' motif reduction that in turn have reduced the CpG frequency over just a few months of observation. This is consistent with APOBEC-mediated RNA editing resulting in CpG reduction, thus allowing the virus to escape ZAP-mediated RNA degradation. Our results thus link the dynamics of target sequences in the viral genome for two known host molecular defense mechanisms, mediated by the APOBEC and ZAP proteins.
    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2020.06.19.161687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Acinetobacter baumannii Kills Fungi via a Type VI DNase Effector.

    Luo, Jingjing / Chu, Xiao / Jie, Jing / Sun, Yu / Guan, Qingtian / Li, Dan / Luo, Zhao-Qing / Song, Lei

    mBio

    2023  Volume 14, Issue 1, Page(s) e0342022

    Abstract: Many Gram-negative bacteria deploy a type VI secretion system (T6SS) to inject toxins into target cells to promote their survival and replication in complex environments. Here, we report that Acinetobacter baumannii uses its T6SS to kill fungi and that ... ...

    Abstract Many Gram-negative bacteria deploy a type VI secretion system (T6SS) to inject toxins into target cells to promote their survival and replication in complex environments. Here, we report that Acinetobacter baumannii uses its T6SS to kill fungi and that the effector TafE (
    MeSH term(s) Acinetobacter baumannii/genetics ; Type VI Secretion Systems/genetics ; Type VI Secretion Systems/metabolism ; Deoxyribonucleases/metabolism ; Anti-Bacterial Agents/metabolism ; Fungi/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
    Chemical Substances Type VI Secretion Systems ; Deoxyribonucleases (EC 3.1.-) ; Anti-Bacterial Agents ; Bacterial Proteins
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03420-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis.

    Guan, Qingtian / Alhuthali, Bushra / Mfarrej, Sara / Halim, Magid Abdel / Almaghrabi, Reem S / Pain, Arnab

    Journal of travel medicine

    2021  Volume 29, Issue 4

    MeSH term(s) Central Nervous System Protozoal Infections/diagnosis ; Central Nervous System Protozoal Infections/genetics ; Communicable Diseases, Imported/diagnosis ; Communicable Diseases, Imported/genetics ; Fatal Outcome ; Humans ; Metagenomics ; Rare Diseases/diagnosis ; Rare Diseases/genetics
    Language English
    Publishing date 2021-11-01
    Publishing country England
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taab172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4120: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Corrigendum to "Antroquinonol Exerts Immunosuppressive Effect on CD8

    Guan, Cuiping / Li, Qingtian / Song, Xiuzu / Xu, Wen / Li, Liuyu / Xu, Aie

    Oxidative medicine and cellular longevity

    2020  Volume 2020, Page(s) 1402346

    Abstract: This corrects the article DOI: 10.1155/2017/9303054.]. ...

    Abstract [This corrects the article DOI: 10.1155/2017/9303054.].
    Language English
    Publishing date 2020-10-19
    Publishing country United States
    Document type Published Erratum
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2020/1402346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Corrigendum to Crohn's Disease Patient Infected With Multiple Co-occurring Nontuberculous Mycobacteria.

    Hala, Sharif / Antony, Chakkiath Paul / Guan, Qingtian / Alshehri, Mohammed / Alsaedi, Asim / Alsharief, Alaa / Al-Amri, Abdulfattah / Pain, Arnab

    Inflammatory bowel diseases

    2020  Volume 27, Issue 7, Page(s) 1174

    Language English
    Publishing date 2020-12-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izaa271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4530: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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