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  1. Article ; Online: No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses.

    Gilbert, Clément / Tengs, Torstein

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 16145

    Abstract: The genetic element s2m has been acquired through horizontal transfer by many distantly related viruses, including the SARS-related coronaviruses. Here we show that s2m is evolutionarily conserved in these viruses. Though several lineages of severe acute ...

    Abstract The genetic element s2m has been acquired through horizontal transfer by many distantly related viruses, including the SARS-related coronaviruses. Here we show that s2m is evolutionarily conserved in these viruses. Though several lineages of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) devoid of the element can be found, these variants seem to have been short lived, indicating that they were less evolutionary fit than their s2m-containing counterparts. On a species-level, however, there do not appear to be any losses and this pattern strongly suggests that the s2m element is essential to virus replication in SARS-CoV-2 and related viruses. Further experiments are needed to elucidate the function of s2m.
    MeSH term(s) Animals ; Base Sequence ; COVID-19/virology ; Coronaviridae/classification ; Coronaviridae/genetics ; Evolution, Molecular ; Gene Transfer, Horizontal ; Humans ; Interspersed Repetitive Sequences/genetics ; Phylogeny ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; Sequence Homology, Nucleic Acid ; Species Specificity ; Virus Replication/genetics
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-08-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-95496-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses

    Clément Gilbert / Torstein Tengs

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 5

    Abstract: Abstract The genetic element s2m has been acquired through horizontal transfer by many distantly related viruses, including the SARS-related coronaviruses. Here we show that s2m is evolutionarily conserved in these viruses. Though several lineages of ... ...

    Abstract Abstract The genetic element s2m has been acquired through horizontal transfer by many distantly related viruses, including the SARS-related coronaviruses. Here we show that s2m is evolutionarily conserved in these viruses. Though several lineages of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) devoid of the element can be found, these variants seem to have been short lived, indicating that they were less evolutionary fit than their s2m-containing counterparts. On a species-level, however, there do not appear to be any losses and this pattern strongly suggests that the s2m element is essential to virus replication in SARS-CoV-2 and related viruses. Further experiments are needed to elucidate the function of s2m.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Intergenerational effects of early life-stage temperature modulation on gene expression and DNA methylation in Atlantic cod (

    Puvanendran, Velmurugu / Burgerhout, Erik / Andersen, Øivind / Kent, Matthew / Hansen, Øyvind / Tengs, Torstein

    Epigenetics

    2023  Volume 18, Issue 1, Page(s) 2237759

    Abstract: After suffering several collapses, the cod farming industry is now in the process of trying to re-establish itself. We have used material from Norway's National Cod Breeding Program to study how different early life-stage temperature regimes affect DNA ... ...

    Abstract After suffering several collapses, the cod farming industry is now in the process of trying to re-establish itself. We have used material from Norway's National Cod Breeding Program to study how different early life-stage temperature regimes affect DNA methylation and gene expression. Long-term effects were detected by sampling fish several weeks after the end of differential treatments, and offspring from the different exposure groups was also sampled. Many overlapping genes were found between the different exposure groups and generations, coupled with genes associated with differential CpG methylation levels. Genes involved in muscle fibre development, general metabolic processes and formation of deformities were significantly affected, and genes relevant for intergenerational transfer of epigenetic marks were also detected. We believe the use of environmental cues can be a useful strategy for improving the production of Atlantic cod.
    MeSH term(s) Animals ; Gadus morhua/genetics ; Gadus morhua/metabolism ; Temperature ; DNA Methylation ; Gene Expression
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1559-2308
    ISSN (online) 1559-2308
    DOI 10.1080/15592294.2023.2237759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A genetic element in the SARS-CoV-2 genome is shared with multiple insect species.

    Tengs, Torstein / Delwiche, Charles F / Monceyron Jonassen, Christine

    The Journal of general virology

    2021  Volume 102, Issue 3

    Abstract: SARS-CoV-2 is a member of the subgenus Sarbecovirus and thus contains the genetic element s2m. We have extensively mined nucleotide data in GenBank in order to obtain a comprehensive list of s2m sequences both in the four virus families where s2m has ... ...

    Abstract SARS-CoV-2 is a member of the subgenus Sarbecovirus and thus contains the genetic element s2m. We have extensively mined nucleotide data in GenBank in order to obtain a comprehensive list of s2m sequences both in the four virus families where s2m has previously been described and in other groups of organisms. Surprisingly, there seems to be a xenologue of s2m in a large number of insect species. The function of s2m is unknown, but our data show a very high degree of sequence conservation both in insects and in viruses and that the version of s2m found in SARS-CoV-2 has unique features, not seen in any other virus or insect strains.
    MeSH term(s) Animals ; Data Mining ; Gene Transfer, Horizontal ; Genome, Viral ; Insecta/genetics ; Phylogeny ; RNA, Viral/genetics ; SARS-CoV-2/genetics
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/jgv.0.001551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Major transcriptomic differences are induced by warmer temperature conditions experienced during asexual and sexual reproduction in

    Zhang, Yupeng / Viejo, Marcos / Yakovlev, Igor / Tengs, Torstein / Krokene, Paal / Hytönen, Timo / Grini, Paul E / Fossdal, Carl Gunnar

    Frontiers in plant science

    2023  Volume 14, Page(s) 1213311

    Abstract: A major challenge for plants in a rapidly changing climate is to adapt to rising temperatures. Some plants adapt to temperature conditions by generating an epigenetic memory that can be transmitted both meiotically and mitotically. Such epigenetic ... ...

    Abstract A major challenge for plants in a rapidly changing climate is to adapt to rising temperatures. Some plants adapt to temperature conditions by generating an epigenetic memory that can be transmitted both meiotically and mitotically. Such epigenetic memories may increase phenotypic variation to global warming and provide time for adaptation to occur through classical genetic selection. The goal of this study was to understand how warmer temperature conditions experienced during sexual and asexual reproduction affect the transcriptomes of different strawberry (
    Language English
    Publishing date 2023-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1213311
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  6. Article: Epitype-inducing temperatures drive DNA methylation changes during somatic embryogenesis in the long-lived gymnosperm Norway spruce.

    Viejo, Marcos / Tengs, Torstein / Yakovlev, Igor / Cross, Hugh / Krokene, Paal / Olsen, Jorunn E / Fossdal, Carl Gunnar

    Frontiers in plant science

    2023  Volume 14, Page(s) 1196806

    Abstract: An epigenetic memory of the temperature sum experienced during embryogenesis is part of the climatic adaptation strategy of the long-lived gymnosperm Norway spruce. This memory has a lasting effect on the timing of bud phenology and frost tolerance in ... ...

    Abstract An epigenetic memory of the temperature sum experienced during embryogenesis is part of the climatic adaptation strategy of the long-lived gymnosperm Norway spruce. This memory has a lasting effect on the timing of bud phenology and frost tolerance in the resulting epitype trees. The epigenetic memory is well characterized phenotypically and at the transcriptome level, but to what extent DNA methylation changes are involved have not previously been determined. To address this, we analyzed somatic epitype embryos of Norway spruce clones produced at contrasting epitype-inducing conditions (18 and 28°C). We screened for differential DNA methylation in 2744 genes related mainly to the epigenetic machinery, circadian clock, and phenology. Of these genes, 68% displayed differential DNA methylation patterns between contrasting epitype embryos in at least one methylation context (CpG, CHG, CHH). Several genes related to the epigenetic machinery (e.g., DNA methyltransferases,
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1196806
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  7. Article ; Online: Dose rate dependent reduction in chromatin accessibility at transcriptional start sites long time after exposure to gamma radiation.

    Dahl, Hildegunn / Ballangby, Jarle / Tengs, Torstein / Wojewodzic, Marcin W / Eide, Dag M / Brede, Dag Anders / Graupner, Anne / Duale, Nur / Olsen, Ann-Karin

    Epigenetics

    2023  Volume 18, Issue 1, Page(s) 2193936

    Abstract: Ionizing radiation (IR) impact cellular and molecular processes that require chromatin remodelling relevant for cellular integrity. However, the cellular implications of ionizing radiation (IR) delivered per time unit (dose rate) are still debated. This ... ...

    Abstract Ionizing radiation (IR) impact cellular and molecular processes that require chromatin remodelling relevant for cellular integrity. However, the cellular implications of ionizing radiation (IR) delivered per time unit (dose rate) are still debated. This study investigates whether the dose rate is relevant for inflicting changes to the epigenome, represented by chromatin accessibility, or whether it is the total dose that is decisive. CBA/CaOlaHsd mice were whole-body exposed to either chronic low dose rate (2.5 mGy/h for 54 d) or the higher dose rates (10 mGy/h for 14 d and 100 mGy/h for 30 h) of gamma radiation (
    MeSH term(s) Animals ; Mice ; Chromatin/genetics ; Gamma Rays/adverse effects ; Mice, Inbred CBA ; DNA Methylation ; Radiation, Ionizing
    Chemical Substances Chromatin
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1559-2308
    ISSN (online) 1559-2308
    DOI 10.1080/15592294.2023.2193936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Warmer temperature during asexual reproduction induce methylome, transcriptomic, and lasting phenotypic changes in

    Zhang 张宇鹏, YuPeng / Fan, Guangxun / Toivainen, Tuomas / Tengs, Torstein / Yakovlev, Igor / Krokene, Paal / Hytönen, Timo / Fossdal, Carl Gunnar / Grini, Paul E

    Horticulture research

    2023  Volume 10, Issue 9, Page(s) uhad156

    Abstract: Plants must adapt with increasing speed to global warming to maintain their fitness. One rapid adaptation mechanism is epigenetic memory, which may provide organisms sufficient time to adapt to climate change. We studied how the ... ...

    Abstract Plants must adapt with increasing speed to global warming to maintain their fitness. One rapid adaptation mechanism is epigenetic memory, which may provide organisms sufficient time to adapt to climate change. We studied how the perennial
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Journal Article
    ISSN 2662-6810
    ISSN 2662-6810
    DOI 10.1093/hr/uhad156
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  9. Article ; Online: Emerging pathogens in the fish farming industry and sequencing-based pathogen discovery.

    Tengs, Torstein / Rimstad, Espen

    Developmental and comparative immunology

    2017  Volume 75, Page(s) 109–119

    Abstract: The use of large scale DNA/RNA sequencing has become an integral part of biomedical research. Reduced sequencing costs and the availability of efficient computational resources has led to a revolution in how problems concerning genomics and ... ...

    Abstract The use of large scale DNA/RNA sequencing has become an integral part of biomedical research. Reduced sequencing costs and the availability of efficient computational resources has led to a revolution in how problems concerning genomics and transcriptomics are addressed. Sequencing-based pathogen discovery represents one example of how genetic data can now be used in ways that were previously considered infeasible. Emerging pathogens affect both human and animal health due to a multitude of factors, including globalization, a shifting environment and an increasing human population. Fish farming represents a relevant, interesting and challenging system to study emerging pathogens. This review summarizes recent progress in pathogen discovery using sequence data, with particular emphasis on viruses in Atlantic salmon (Salmo salar).
    Language English
    Publishing date 2017-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2017.01.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Distribution and Evolutionary History of the Mobile Genetic Element s2m in Coronaviruses.

    Tengs, Torstein / Jonassen, Christine M

    Diseases (Basel, Switzerland)

    2016  Volume 4, Issue 3

    Abstract: The mobile genetic element s2m has been described in several families of single-stranded RNA viruses. The function remains elusive, but an increasing number of s2m-containing sequences are being deposited in publicly available databases. Currently, more ... ...

    Abstract The mobile genetic element s2m has been described in several families of single-stranded RNA viruses. The function remains elusive, but an increasing number of s2m-containing sequences are being deposited in publicly available databases. Currently, more than 700 coronavirus sequences containing s2m can be found in GenBank, including the severe acute respiratory syndrome (SARS) coronavirus genome. This is an updated review of the pattern of s2m in coronaviruses, the possible functional implications and the evolutionary history.
    Keywords covid19
    Language English
    Publishing date 2016-07-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases4030027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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