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Article: Probabilistic multi-objective optimization for landslide reinforcement with stabilizing piles in Zigui Basin of Three Gorges Reservoir region, China

Yao, Wenmin / Li, Changdong / Zhan, Hongbin / Zhang, Huawei / Chen, Wenqiang

Stochastic environmental research and risk assessment. 2020 June, v. 34, no. 6

2020

Abstract: Zigui Basin is a major landslide-prone region in the Three Gorges Reservoir region of China, and ...

Abstract	Zigui Basin is a major landslide-prone region in the Three Gorges Reservoir region of China, and the stabilizing pile is an effective and widely employed countermeasure to reinforce landslides in this region. However, stabilizing piles are mostly designed using deterministic and stability-oriented methods, which generally ignore the system performance and cost-effectiveness. Using the Majiagou landslide reinforced with stabilizing piles as a case study, a probabilistic multi-objective optimization framework for the design of stabilizing piles is proposed and illustrated. Specifically, performance objectives related to failure probability, system robustness and life-cycle cost of the landslide-stabilizing pile system with feasible designs are evaluated, then the best compromised design is obtained by means of Pareto optimality. Expert knowledge and professional judgment are required to set necessary restrictions and finally determine the optimal design. The results show that there is a better design of stabilizing piles than the existing one, with which acceptable reinforcement effectiveness, compromised life-cycle cost and robust system performance can be realized. The optimal design will also vary with the concerned performance objectives and knowledge-based judgment. Further relationships and interpretations between design parameters and system responses are discussed through parametric analyses.
Keywords	basins ; case studies ; cost effectiveness ; expert opinion ; landslides ; life cycle costing ; probability ; water reservoirs ; China
Language	English
Dates of publication	2020-06
Size	p. 807-824.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1481263-0
ISSN	1436-3259 ; 1435-151X ; 1436-3240 ; 0931-1955
ISSN (online)	1436-3259 ; 1435-151X
ISSN	1436-3240 ; 0931-1955
DOI	10.1007/s00477-020-01800-5
Database	NAL-Catalogue (AGRICOLA)

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Article: [Landscape pattern change and its simulation forecast in Zigui County of Three Gorges Reservoir Area].

Jiang, Huan-Huan / Li, Ji-Hong / Fan, Wen-Yi / Bao, Chen-Guang

Ying yong sheng tai xue bao = The journal of applied ecology

2009 Volume 20, Issue 2, Page(s) 474–479

Abstract: Based on the TM images of 1987 and 2002, the landscape pattern change of Zigui County from 1987 ... pattern of Zigui County changed dramatically. The area of sparse wood land increased greatly ... obvious human interference. As a whole, the landscape diversity and fragmentation in Zigui County were ...

Abstract	Based on the TM images of 1987 and 2002, the landscape pattern change of Zigui County from 1987 to 2002 was analyzed by using landscape index method; and the simulation forecast of this change in next 50 years was conducted by using Markov model. The results showed that in 1987-2002, the landscape pattern of Zigui County changed dramatically. The area of sparse wood land increased greatly while that of upland and shrub land decreased obviously, and the distribution of the areas of different landscape types tended to balance. The average shape index of landscape had an overall decline, which was represented by the concentrated and connected distribution of different landscape types, simplification of landscape shape, and obvious human interference. As a whole, the landscape diversity and fragmentation in Zigui County were improved to some extent. In next 50 years, the area of sparse wood land in Zigui would have a rapid increase, followed by that of forestland, while the areas of upland and shrub land would be declining, and the other landscape types would have a less fluctuation in their areas. The main driving forces of the landscape pattern change in Zigui were the relocation of the County and the implementation of forestry policies.
MeSH term(s)	China ; Conservation of Natural Resources ; Crops, Agricultural/growth & development ; Ecosystem ; Facility Design and Construction ; Forecasting ; Markov Chains ; Rivers ; Trees/growth & development
Language	Chinese
Publishing date	2009-02
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
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Article: Landslide spatial susceptibility mapping by using GIS and remote sensing techniques: a case study in Zigui County, the Three Georges reservoir, China

Chen, Tao / Niu, Ruiqing / Du, Bo / Wang, Yi

Environmental earth sciences. 2015 May, v. 73, no. 9

2015

Abstract: ... Gorges Project reservoir region on the Yangtze River in Zigui County. The five causative factors used ... in Zigui County that are susceptible to landslides and need immediate protective and mitigation measures ...

Abstract	Landslides are one of the most destructive phenomena in nature and damage both property and lives every year. In this paper, a logistic regression model with datasets developed via a geographic information system and remotely sensed data was used to create a landslide spatial susceptibility map for the Three Gorges Project reservoir region on the Yangtze River in Zigui County. The five causative factors used in the logistic regression model were evaluated in different ways: topographic slope and topographic aspect were derived from a topographical map at 1:50,000 scale; bed rock-slope relationship and lithology were obtained from a geological map at 1:50,000 scale; and fractional vegetation cover (FVC), which represents the reduced frequency of landslides due to the vegetation canopy and ground cover and is also one of the most difficult parameters to estimate over broad geographic areas, was generated using a back propagation neural network (BPNN) method based on CBERS (China–Brazil Earth Resources Satellite) data, the results of which were compared with values measured in the field. The obtained Pearson correlation coefficient (r) was 0.899. Then, the FVC factor and the other four factors were used as the input to a logistic regression model. By integrating the five factor maps in the geographical information system (GIS) via pixel-based computing, the landslide spatial susceptibility map was obtained. The study area was reclassified into four categories of landslide susceptibility: severe, moderate, low, and very low. Approximately 15.0 % of the study area was identified as severe susceptibility, and very low, low, and moderate susceptibility zones covered 21.8, 41.7, and 21.5 % of the area, respectively. These results have an accuracy of 78.90 %. Thus, by using a logistic regression model in a GIS environment, a spatial susceptibility map of landslides can be obtained, and the regions in Zigui County that are susceptible to landslides and need immediate protective and mitigation measures can be identified.
Keywords	canopy ; case studies ; correlation ; data collection ; geographic information systems ; landslides ; neural networks ; regression analysis ; remote sensing ; topographic aspect ; topographic slope ; vegetation cover ; China ; Yangtze River
Language	English
Dates of publication	2015-05
Size	p. 5571-5583.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	2493699-6
ISSN	1866-6299 ; 1866-6280
ISSN (online)	1866-6299
ISSN	1866-6280
DOI	10.1007/s12665-014-3811-7
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Article ; Online: Preparation of Sulfonated Poly(arylene ether)/SiO

Ye, Zhoulin / Chen, Nanjie / Zheng, Zigui / Xiong, Lei / Chen, Dongyang

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 7

Abstract: Proton exchange membranes (PEMs) are an important type of vanadium redox flow battery (VRFB) separator that play the key role of separating positive and negative electrolytes while transporting protons. In order to lower the vanadium ion permeability and ...

Abstract	Proton exchange membranes (PEMs) are an important type of vanadium redox flow battery (VRFB) separator that play the key role of separating positive and negative electrolytes while transporting protons. In order to lower the vanadium ion permeability and improve the proton selectivity of PEMs for enhancing the Coulombic efficiency of VRFBs, herein, various amounts of nano-sized SiO
Language	English
Publishing date	2023-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28073130
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Article ; Online: Systematic review on oral microbial dysbiosis and its clinical associations with head and neck squamous cell carcinoma.

Ting, Haaron S L / Chen, Zigui / Chan, Jason Y K

Head & neck

2023 Volume 45, Issue 8, Page(s) 2120–2135

Abstract: Objectives: The relationship between head and neck squamous cell carcinoma (HNSCC) and the oral microbiome has been drawn in various studies. Microbial diversities, microbiome profiles, metagenomic analysis, and host-pathogen interactions were collected ...

Abstract	Objectives: The relationship between head and neck squamous cell carcinoma (HNSCC) and the oral microbiome has been drawn in various studies. Microbial diversities, microbiome profiles, metagenomic analysis, and host-pathogen interactions were collected from these studies to highlight similarities and account for inconsistencies. We also evaluate the possible clinical applications of the microbiome regarding screening and diagnosis of HNSCC. Methods: Systematic analysis of studies regarding HNSCC and the microbiome was done according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guidelines. Articles were retrieved from four databases (PubMed, ScienceDirect, CUHK Full-Text Journals, and Cochrane database) and were screened using predefined criteria. Results: Twenty studies were chosen after screening for full-text review. α-diversity comparison was inconsistent whereas β-diversity between HNSCC and normal samples showed distinct clustering. Microbial dysbiosis characterized by change in the relative abundances of several bacterial species were also seen in HNSCC patients. At a phylum level, inconsistencies were seen between studies using HNSCC tumor tissue samples and saliva samples. At a genus level, Fusobacterium, Peptostreptococcus, Alloprevotella, Capnocytophaga, Catonella, and Prevotella were differentially enriched in HNSCC while Streptococcus, Actinomyces Veillonella, and Rothia were differentially depleted. Co-occurrence network analysis revealed a positive correlation of HNSCC with periodontal pathogens and a negative correlation with commensal bacteria. Metagenomic analysis of microbiota revealed a differential enrichment of pro-inflammatory genomic pathways which was consistent across various studies. Microbial dysbiosis was applied in clinical use as a tool for HNSCC screening. Random-forest analysis was adopted to differentiate between tumor and normal tissue, at 95.7% and 70.0% accuracies respectively in two studies. Microbial dysbiosis index was also used to predict prognosis. Conclusions: Oral microbial dysbiosis could be a promising tool for HNSCC screening and diagnosis. However, more research should be conducted pertaining to clinical applications to improve diagnostic accuracy and explore other clinical uses.
MeSH term(s)	Humans ; Bacteria ; Dysbiosis/diagnosis ; Dysbiosis/microbiology ; Head and Neck Neoplasms/diagnosis ; Microbiota/genetics ; Squamous Cell Carcinoma of Head and Neck
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27422
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Zs.A 1493: Show issues

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Article ; Online: Preparation of Sulfonated Poly(arylene ether)/SiO 2 Composite Membranes with Enhanced Proton Selectivity for Vanadium Redox Flow Batteries

Zhoulin Ye / Nanjie Chen / Zigui Zheng / Lei Xiong / Dongyang Chen

Molecules, Vol 28, Iss 3130, p

2023 Volume 3130

Abstract	Proton exchange membranes (PEMs) are an important type of vanadium redox flow battery (VRFB) separator that play the key role of separating positive and negative electrolytes while transporting protons. In order to lower the vanadium ion permeability and improve the proton selectivity of PEMs for enhancing the Coulombic efficiency of VRFBs, herein, various amounts of nano-sized SiO 2 particles were introduced into a previously optimized sulfonated poly(arylene ether) (SPAE) PEMs through the acid-catalyzed sol-gel reaction of tetraethyl orthosilicate (TEOS). The successful incorporation of SiO 2 was confirmed by FT-IR spectra. The scanning electron microscopy (SEM) images revealed that the SiO 2 particles were well distributed in the SPAE membrane. The ion exchange capacity, water uptake, and swelling ratio of the PEMs were decreased with the increasing amount of SiO 2 , while the mechanical properties and thermal stability were improved significantly. The proton conductivity was reduced gradually from 93.4 to 76.9 mS cm −1 at room temperature as the loading amount of SiO 2 was increased from 0 to 16 wt.%; however, the VO 2+ permeability was decreased dramatically after the incorporation of SiO 2 and reached a minimum value of 2.57 × 10 −12 m 2 s −1 at 12 wt.% of SiO 2. As a result, the H + /VO 2+ selectivity achieved a maximum value of 51.82 S min cm −3 for the composite PEM containing 12 wt.% of SiO 2 . This study demonstrates that the properties of PEMs can be largely tuned by the introduction of SiO 2 with low cost for VRFB applications.
Keywords	proton exchange membrane ; sulfonated poly(arylene ether) ; composite ; proton conductivity ; vanadium permeability ; Organic chemistry ; QD241-441
Subject code	333
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: [Retracted] MicroRNA‑203 inhibits the proliferation and invasion of U251 glioblastoma cells by directly targeting PLD2.

Chen, Zigui / Li, Dazhi / Cheng, Quan / Ma, Zhiming / Jiang, Bing / Peng, Renjun / Chen, Rui / Cao, Yiqiang / Wan, Xin

Molecular medicine reports

2024 Volume 29, Issue 2

Abstract: Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the PLD2 western blotting data shown in Fig. 3A and the Transwell invasion assay data shown in Fig. 6 were strikingly similar to data appearing in ... ...

Abstract	Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the PLD2 western blotting data shown in Fig. 3A and the Transwell invasion assay data shown in Fig. 6 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to Molecular Medicine Reports, or were under consideration for publication at around the same time. In view of the fact that certain of these data had already apparently been published previously, the Editor of
Language	English
Publishing date	2024-01-08
Publishing country	Greece
Document type	Retraction of Publication
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2023.13154
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Article ; Online: Effect of silver diamine fluoride upon the microbial community of carious lesions: A scoping review.

Zhang, Josie Shizhen / Chen, Zigui / Chu, Chun-Hung / Yu, Ollie Yiru

Journal of dentistry

2023 Volume 134, Page(s) 104554

Abstract: Objectives: To explore the effects of silver diamine fluoride (SDF) on the microbial community of carious lesions.: Data: Original studies evaluating the effect of SDF treatment on the microbial community of human carious lesions were included.: ... ...

Abstract	Objectives: To explore the effects of silver diamine fluoride (SDF) on the microbial community of carious lesions. Data: Original studies evaluating the effect of SDF treatment on the microbial community of human carious lesions were included. Sources: A systematic search of English-language publications was performed in PubMed, EMBASE, Scopus, and Web of Science. Gray literature was searched in ClinicalTrials.gov and Google Scholar. Study selection/results: This review included seven publications reporting the effects of SDF on microbial community of dental plaque or carious dentin, including the microbial biodiversity, relative abundance of microbial taxa, and predicted functional pathways of the microbial community. The studies on microbial community of dental plaque reported that SDF did not have a significant effect on both the within-community species diversity (alpha-diversity) and inter-community microbial compositional dissimilarity (beta-diversity) of the plaque microbial communities. However, SDF changed the relative abundance of 29 bacterial species of plaque community, inhibited carbohydrate transportation and interfered with the metabolic functions of the plaque microbial community. A study on the microbial community in dentin carious lesions reported that SDF affected its beta-diversity and changed the relative abundance of 14 bacterial species. Conclusion: SDF showed no significant effects on the biodiversity of the plaque microbial community but changed the beta-diversity of the carious dentin microbial community. SDF could change the relative abundance of certain bacterial species in the dental plaque and the carious dentin. SDF could also affect the predicted functional pathways of the microbial community. Clinical significance: This review provided comprehensive evidence on the potential effect of SDF treatment on the microbial community of carious lesions.
MeSH term(s)	Humans ; Dental Plaque/drug therapy ; Fluorides, Topical/pharmacology ; Fluorides, Topical/therapeutic use ; Dental Caries/therapy ; Silver Compounds/pharmacology ; Silver Compounds/therapeutic use ; Quaternary Ammonium Compounds/pharmacology ; Quaternary Ammonium Compounds/therapeutic use ; Bacteria
Chemical Substances	silver diamine fluoride (DDU19UEV1Y) ; Fluorides, Topical ; Silver Compounds ; Quaternary Ammonium Compounds
Language	English
Publishing date	2023-05-21
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	186068-9
ISSN	1879-176X ; 0300-5712
ISSN (online)	1879-176X
ISSN	0300-5712
DOI	10.1016/j.jdent.2023.104554
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Zs.A 860: Show issues

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Article ; Online: Exploring the impact of ITGB2 on glioma progression and treatment: Insights from non-apoptotic cell death and immunotherapy.

Zhuang, Junhong / Miao, Changfeng / Liu, Chao / Zeng, Biying / Hu, Linwang / Peng, Jun / Xia, Ying / Chen, Zigui

Environmental toxicology

2024

Abstract: In the realm of glioma treatment, our groundbreaking research has uncovered the pivotal role of Integrin Beta 2 (ITGB2) in non-apoptotic cell death and its profound implications for immunotherapy efficacy. Gliomas, known for their aggressive and ... ...

Abstract	In the realm of glioma treatment, our groundbreaking research has uncovered the pivotal role of Integrin Beta 2 (ITGB2) in non-apoptotic cell death and its profound implications for immunotherapy efficacy. Gliomas, known for their aggressive and infiltrative nature, demand innovative therapeutic strategies for improved patient outcomes. Our study bridges a critical gap by examining the interplay between non-apoptotic cell death and immunotherapy response in gliomas. Through comprehensive analysis of ten diverse glioma datasets, we developed a unique death enrichment score and identified ITGB2 as a significant risk marker. This study demonstrates that ITGB2 can predict immune activity, mutation characteristics, and drug response in glioma patients. We reveal that ITGB2 not only mediates glioma proliferation and migration but also crucially influences immunotherapy responses by modulating the interaction between gliomas and macrophages by single-cell sequencing analysis (iTalk and ICELLNET). Employing a variety of molecular and cellular methodologies, including in vitro models, our findings highlight ITGB2 as a potent marker in glioma biology, particularly impacting macrophage migration and polarization. We present compelling evidence of ITGB2's dual role in regulating tumor cell behavior and shaping the immune landscape, thereby influencing therapeutic outcomes. The study underlines the potential of ITGB2-targeted strategies in enhancing the efficacy of immunotherapy and opens new avenues for personalized treatment approaches in glioma management. In conclusion, this research marks a significant stride in understanding glioma pathology and therapy, positioning ITGB2 as a key biomarker and a promising target in the quest for effective glioma treatments.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.24231
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Zs.A 2676: Show issues

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Article: Interaction between Human Papillomavirus-Encoded E6 Protein and AurB Induces Cell Immortalization and Proliferation-A Potential Target of Intervention.

Boon, Siaw Shi / Lee, Yin Ching / Yip, Ka Lai / Luk, Ho Yin / Xiao, Chuanyun / Yim, Man Kin / Chen, Zigui / Chan, Paul Kay Sheung

Cancers

2023 Volume 15, Issue 9

Abstract: The human papillomavirus E6 and E7 oncoproteins interact with a different subset of host proteins, leading to dysregulation of the apoptotic, cell cycle, and signaling pathways. In this study, we identified, for the first time, that Aurora kinase B (AurB) ...

Abstract	The human papillomavirus E6 and E7 oncoproteins interact with a different subset of host proteins, leading to dysregulation of the apoptotic, cell cycle, and signaling pathways. In this study, we identified, for the first time, that Aurora kinase B (AurB) is a
Language	English
Publishing date	2023-04-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15092465
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