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  1. Book ; Online ; E-Book: Long term safety of assisted reproduction

    D'Angelo, Arianna / Rodriguez-Wallberg, Kenny A. / Nogueira, Daniela

    2022  

    Author's details edited by Arianna D'Angelo, Kenny A. Rodriguez-Wallberg, Daniela Nogueira
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (x, 211 Seiten), Diagramme
    Edition First edition
    Publisher CRC Press, Taylor & Francis Group
    Publishing place Boca Raton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021305186
    ISBN 978-1-00-054353-7 ; 978-1-003-05252-4 ; 9780367511234 ; 9780367511203 ; 1-00-054353-6 ; 1-003-05252-5 ; 0367511231 ; 0367511207
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The challenges of cancer during pregnancy.

    Rodriguez-Wallberg, Kenny A / Pettersson, Karin

    Acta obstetricia et gynecologica Scandinavica

    2024  Volume 103, Issue 4, Page(s) 628–629

    MeSH term(s) Pregnancy ; Female ; Humans ; Pregnancy Complications, Neoplastic/diagnosis ; Pregnancy Complications, Neoplastic/therapy
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 80019-3
    ISSN 1600-0412 ; 0001-6349
    ISSN (online) 1600-0412
    ISSN 0001-6349
    DOI 10.1111/aogs.14835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fertilitetsbevarande åtgärder.

    Rodriguez-Wallberg, Kenny

    Lakartidningen

    2023  Volume 120

    Abstract: Methods for cryopreservation of sperms, eggs, embryos and gonadal tissue have been developed and are available at many centers that have programs for fertility preservation. In Sweden, such programs are established at university hospitals and fertility ... ...

    Title translation Methods for fertility preservation.
    Abstract Methods for cryopreservation of sperms, eggs, embryos and gonadal tissue have been developed and are available at many centers that have programs for fertility preservation. In Sweden, such programs are established at university hospitals and fertility preservation is offered within the publicly financed healthcare to patients when medically indicated. The largest patient groups undergoing procedures for fertility preservation include those with a cancer diagnosis, but also individuals with benign diseases, gender dysphoria and genetic conditions facing infertility risk may be offered fertility preservation. It is of outmost importance to evaluate the long-term safety of fertility preservation, particularly in individuals with cancer. Sweden belongs to a minority of countries that account with population-based registration, which has allowed the use of the Swedish healthcare registers for research on this subject. These studies have shown safety of the procedures in the group of women with breast cancer.
    MeSH term(s) Humans ; Female ; Fertility Preservation/methods ; Cryopreservation/methods ; Breast Neoplasms ; Sweden ; Hospitals, University
    Language Swedish
    Publishing date 2023-01-04
    Publishing country Sweden
    Document type English Abstract ; Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
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  4. Article ; Online: Higher obstetric and perinatal risks for twins and the need for single embryo transfers in assisted reproduction.

    Rodriguez-Wallberg, Kenny A / Veleva, Zdravka

    Acta obstetricia et gynecologica Scandinavica

    2023  Volume 102, Issue 8, Page(s) 968–969

    MeSH term(s) Pregnancy ; Female ; Humans ; Single Embryo Transfer ; Twins ; Pregnancy Outcome ; Reproductive Techniques, Assisted
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80019-3
    ISSN 1600-0412 ; 0001-6349
    ISSN (online) 1600-0412
    ISSN 0001-6349
    DOI 10.1111/aogs.14639
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  5. Article ; Online: Fertility and reproductive concerns related to the new generation of cancer drugs and the clinical implication for young individuals undergoing treatments for solid tumors.

    Helgadottir, Hildur / Matikas, Alexios / Fernebro, Josefin / Frödin, Jan-Erik / Ekman, Simon / Rodriguez-Wallberg, Kenny A

    European journal of cancer (Oxford, England : 1990)

    2024  Volume 202, Page(s) 114010

    Abstract: The treatment landscape of solid tumors has changed markedly in the last years. Molecularly targeted treatments and immunotherapies have been implemented and have, in many cancers, lowered the risk of relapse and prolonged survival. Patients with tumors ... ...

    Abstract The treatment landscape of solid tumors has changed markedly in the last years. Molecularly targeted treatments and immunotherapies have been implemented and have, in many cancers, lowered the risk of relapse and prolonged survival. Patients with tumors harboring specific targetable molecular alterations or mutations are often of a younger age, and hence future fertility and family building can be important concerns in this group. However, there are great uncertainties regarding the effect of the new drugs on reproductive functions, including fertility, pregnancy and lactation and how young patients with cancers, both women and men should be advised. The goal with this review is to gather the current knowledge regarding oncofertility and the different novel therapies, including immune checkpoint inhibitors, antibody-drug conjugates, small molecules and monoclonal antibody targeted therapies. The specific circumstances and reproductive concerns in different patient groups where novel treatments have been broadly introduced are also discussed, including those with melanoma, lung, breast, colorectal and gynecological cancers. It is clear, that more awareness is needed regarding potential drug toxicity on reproductive tissues, and it is of essence that individuals are informed based on current expertise and on available fertility preservation methods.
    MeSH term(s) Male ; Pregnancy ; Humans ; Female ; Neoplasm Recurrence, Local/drug therapy ; Fertility ; Antineoplastic Agents/adverse effects ; Fertility Preservation ; Melanoma/drug therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2024.114010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Late Effects of Cancer Treatment on Female Fertility and the Current Status of Fertility Preservation-A Narrative Review.

    Rodriguez-Wallberg, Kenny A / Jiang, Yanyu / Lekberg, Tobias / Nilsson, Hanna P

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: Fertility counseling should be offered to all individuals of young reproductive age early in the patient's trajectory following a cancer diagnosis. Systemic cancer treatment and radiotherapy often have an inherent gonadotoxic effect with the potential to ...

    Abstract Fertility counseling should be offered to all individuals of young reproductive age early in the patient's trajectory following a cancer diagnosis. Systemic cancer treatment and radiotherapy often have an inherent gonadotoxic effect with the potential to induce permanent infertility and premature ovarian failure. For the best chances to preserve a patient's fertility potential and to improve future quality of life, fertility preservation methods should be applied before cancer treatment initiation, thus multidisciplinary team-work and timely referral to reproductive medicine centers specialized in fertility preservation is recommended. We aim to review the current clinical possibilities for fertility preservation and summarize how infertility, as a late effect of gonadotoxic treatment, affects the growing population of young female cancer survivors.
    Language English
    Publishing date 2023-05-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13051195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: First 15 Years of Assisted Reproductive Technology Using Washed Sperm in HIV-Positive Individuals Under Antiretroviral Therapy: Sweden's Nationwide Outcomes.

    Sergouniotis, Fotios / Olofsson, Jan I / Westling, Katarina / Rodriguez-Wallberg, Kenny A

    AIDS patient care and STDs

    2023  Volume 37, Issue 12, Page(s) 566–573

    Abstract: Antiretroviral therapy has made HIV a chronic infectious disease. In Sweden, assisted reproductive technologies using sperm washing were implemented in 2004 for treatment of all HIV-positive males in serodiscordant couples at Karolinska Hospital in ... ...

    Abstract Antiretroviral therapy has made HIV a chronic infectious disease. In Sweden, assisted reproductive technologies using sperm washing were implemented in 2004 for treatment of all HIV-positive males in serodiscordant couples at Karolinska Hospital in Stockholm. This study aimed to assess efficacy and safety of this approach and to investigate the effect of antiretroviral regimens on sperm quality of men treated for HIV. The study included all HIV-positive men (
    MeSH term(s) Pregnancy ; Female ; Humans ; Male ; HIV Infections/drug therapy ; Sweden/epidemiology ; Semen ; Sperm Motility ; Reproductive Techniques, Assisted ; Spermatozoa ; DNA-Directed RNA Polymerases ; Retrospective Studies
    Chemical Substances DNA-Directed RNA Polymerases (EC 2.7.7.6)
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1326868-5
    ISSN 1557-7449 ; 0893-5068 ; 1087-2914
    ISSN (online) 1557-7449
    ISSN 0893-5068 ; 1087-2914
    DOI 10.1089/apc.2023.0163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2328: Show issues Location:
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  8. Article: Update on the Epigenomic Implication of Embryo Cryopreservation Methods Applied in Assisted Reproductive Technologies With Potential Long-Term Health Effects.

    Reyes Palomares, Arturo / Rodriguez-Wallberg, Kenny A

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 881550

    Abstract: Cryopreservation of embryos has become an efficient method in Assisted Reproductive Technologies (ART) and these methods are currently performed at nearly all fertility centers around the globe. Cryopreservation of supernumerary embryos has contributed ... ...

    Abstract Cryopreservation of embryos has become an efficient method in Assisted Reproductive Technologies (ART) and these methods are currently performed at nearly all fertility centers around the globe. Cryopreservation of supernumerary embryos has contributed to an increase in cumulative pregnancy rates and as a consequence, an increasing number of children are being born through these techniques worldwide. However, long-term follow-up studies of children born through ART are scarce, and concerns about the long-term health effects on individuals conceived through ART have been raised. The relevant genomic transformations that occur at the time cryopreservation is usually applied to embryos may have potential epigenetic risks. With advances in multi-omic single cell technologies, new ways to assess the (epi)genomic status during early embryo development have now become feasible. These novel strategies could provide a revolutionary opportunity to understand the actual impact of ART, but also may help future developments aiming at increase both their efficiency and safety. Here we outline insights in current knowledge and research on the impact of cryopreservation on embryos, the possible consequences at epigenetic level and how emerging new high-throughput technologies can be used for their assessment.
    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.881550
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  9. Article ; Online: Live birth and pregnancy rates after in vitro fertilization/intracytoplasmic sperm injection in women with previous unilateral oophorectomy: a systematic review and meta-analysis.

    Rodriguez-Wallberg, Kenny A / Nilsson, Hanna P / Lind, Tekla

    Fertility and sterility

    2022  Volume 117, Issue 5, Page(s) 992–1002

    Abstract: Objective: To quantify the effect of unilateral oophorectomy (UO) on the rates of live birth and pregnancy in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI).: Design: Systematic review and meta-analysis.: ... ...

    Abstract Objective: To quantify the effect of unilateral oophorectomy (UO) on the rates of live birth and pregnancy in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI).
    Design: Systematic review and meta-analysis.
    Setting: Search of databases of published articles.
    Patient(s): The final analytical cohort encompassed 1,057 IVF/ICSI cycles in women with previous UO and 45,813 IVF/ICSI cycles in control women. Eighteen studies were identified by database searches of MEDLINE, Embase, Web of Science, and cited references. The review encompassed studies published up to June 1, 2021.
    Intervention(s): UO prior to IVF/ICSI.
    Main outcome measure(s): The primary outcomes were the rates of live birth and pregnancy following IVF/ICSI. The secondary outcomes included the amount of gonadotropins administered for ovarian stimulation and the number of retrieved oocytes.
    Result(s): The studies were rated from medium to high quality (from 5 to 8) according to the Newcastle-Ottawa Quality Assessment Scale. All studies were observational, with inherent bias, and heterogeneity was high. The primary outcome of live birth had a significantly lower odds ratio (OR) in women with previous UO compared with controls (OR = 0.72, 95% confidence interval [CI] 0.57 to 0.91, z = -2.72). The OR for pregnancy rate per initiated treatment cycle was also significantly lower in women with previous UO compared with controls (OR = 0.70, 95% CI 0.57 to 0.86, z = -3.35). Additionally, the dose of administered gonadotropins was significantly higher and the number of retrieved oocytes was significantly lower in women with UO.
    Conclusion(s): The meta-analysis showed a significant detrimental effect of UO on the rates of live birth and pregnancy. The analysis further supports previous data showing a decreased sensitivity to gonadotropins and a lower number of recovered oocytes in women with previous UO.
    Study registration number: PROSPERO 2020, CRD42020160313.
    MeSH term(s) Female ; Fertilization in Vitro/adverse effects ; Gonadotropins/adverse effects ; Humans ; Live Birth ; Ovariectomy ; Ovulation Induction/adverse effects ; Pregnancy ; Pregnancy Rate ; Sperm Injections, Intracytoplasmic/adverse effects
    Chemical Substances Gonadotropins
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2022.01.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Feasibility of Secondary Follicle Isolation, Culture and Achievement of In-Vitro Oocyte Maturation from Superovulated Ovaries: An Experimental Proof-of-Concept Study Using Mice.

    Hao, Xia / Anastácio, Amandine / Rodriguez-Wallberg, Kenny A

    Journal of clinical medicine

    2021  Volume 10, Issue 13

    Abstract: Fertility preservation through ovarian stimulation, aiming at cryopreserving mature oocytes or embryos, is sometimes unsuccessful. This clinical situation deserves novel approaches to overcome infertility following cancer treatment in patients facing ... ...

    Abstract Fertility preservation through ovarian stimulation, aiming at cryopreserving mature oocytes or embryos, is sometimes unsuccessful. This clinical situation deserves novel approaches to overcome infertility following cancer treatment in patients facing highly gonadotoxic treatment. In this controlled experimental study, we investigated the feasibility of in-vitro culturing secondary follicles isolated from superovulated ovaries of mice recently treated with gonadotropins. The follicle yields of superovulated ovaries were 45.9% less than in unstimulated controls. Follicles from superovulated ovaries showed faster growth pace during the initial 7 days of culture and secreted more 17β-estradiol by the end of culture
    Language English
    Publishing date 2021-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10132757
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