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  1. Article: CME-Fortbildung. Sinnvolle Antibiotikatherapie in der Hausarztpraxis. Sparsam und gezielt vorgehen! PD Dr. med. Werner C. Albrich, MSCR, St. Gallen / CME-Fortbildungsfragen "Infekte"

    Albrich, Werner C.

    Hausarzt-Praxis

    2018  Volume 13, Issue 4, Page(s) 11/21

    Language German
    Document type Article
    ZDB-ID 2229849-6
    ISSN 1661-6197
    Database Current Contents Medicine

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  2. Article ; Online: Viral-associated Pulmonary Aspergillosis: Have We Finally Overcome the Debate of Colonization versus Infection?

    Albrich, Werner C / Lamoth, Frédéric

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 3, Page(s) 230–231

    MeSH term(s) Humans ; Influenza, Human ; COVID-19 ; Pulmonary Aspergillosis ; Invasive Pulmonary Aspergillosis/diagnosis
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202306-1022ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nicht-antibiotische Prophylaxe von Infekten.

    Seneghini, Marco / Albrich, Werner C

    Praxis

    2022  Volume 111, Issue 8, Page(s) 463–468

    Abstract: Non-antibiotic Prophylaxis of ... ...

    Title translation Non-antibiotic Prophylaxis of Infections.
    Abstract Non-antibiotic Prophylaxis of Infections
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis ; Humans ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/prevention & control ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/prevention & control ; Vaccinium macrocarpon
    Chemical Substances Anti-Bacterial Agents
    Language German
    Publishing date 2022-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 209026-0
    ISSN 1661-8165 ; 1661-8157 ; 0369-8394
    ISSN (online) 1661-8165
    ISSN 1661-8157 ; 0369-8394
    DOI 10.1024/1661-8157/a003822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The potential clinical value of pairing procalcitonin and lung ultrasonography to guide antibiotic therapy in patients with community-acquired pneumonia: a narrative review.

    Bessat, Cécile / Boillat-Blanco, Noémie / Albrich, Werner C

    Expert review of respiratory medicine

    2023  Volume 17, Issue 10, Page(s) 919–927

    Abstract: Introduction: Lower respiratory tract infections (LRTIs) are among the most frequent infections and are prone to inappropriate antibiotic treatments. This results from a limited accuracy of diagnostic tools in identifying bacterial pneumonia. Lung ... ...

    Abstract Introduction: Lower respiratory tract infections (LRTIs) are among the most frequent infections and are prone to inappropriate antibiotic treatments. This results from a limited accuracy of diagnostic tools in identifying bacterial pneumonia. Lung ultrasound (LUS) has excellent sensitivity and specificity in diagnosing pneumonia. Additionally, elevated procalcitonin (PCT) levels correlate with an increased likelihood of bacterial infection. LUS and PCT appear to be complementary in identifying patients with bacterial pneumonia who are likely to benefit from antibiotics.
    Areas covered: This narrative review aims to summarize the current evidence for LUS to diagnose pneumonia, for PCT to guide antibiotic therapy and the clinical value of pairing both tools.
    Expert opinion: LUS has excellent diagnostic accuracy for pneumonia in different settings, regardless of the examiner's experience. PCT guidance safely reduces antibiotic prescription in LRTIs. The combination of both tools has demonstrated an enhanced accuracy in the diagnosis of pneumonia, including CAP in the ED and VAP in the ICU, but randomized controlled studies need to validate the clinical impact of a combined approach.
    MeSH term(s) Humans ; Procalcitonin/therapeutic use ; Pneumonia/diagnostic imaging ; Pneumonia/drug therapy ; Respiratory Tract Infections/drug therapy ; Lung/diagnostic imaging ; Pneumonia, Bacterial/diagnostic imaging ; Pneumonia, Bacterial/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Community-Acquired Infections/diagnostic imaging ; Community-Acquired Infections/drug therapy ; Ultrasonography ; Biomarkers
    Chemical Substances Procalcitonin ; Anti-Bacterial Agents ; Biomarkers
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2023.2254232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: 50/m mit Kopfschmerzen, Husten und Muskelschmerzen : Vorbereitung auf die Facharztprüfung: Fall 88.

    Seneghini, Marco / Albrich, Werner C

    Der Internist

    2021  Volume 62, Issue Suppl 5, Page(s) 571–574

    Title translation 50/m-Headache, cough and myalgia : Preparation for the medical specialist examination: part 88.
    MeSH term(s) Cough/diagnosis ; Headache ; Headache Disorders, Primary ; Humans ; Medicine ; Myalgia/diagnosis
    Language German
    Publishing date 2021-08-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-021-01112-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Levofloxacin prophylaxis in patients with myeloma.

    Albrich, Werner C / Boggian, Katia

    The Lancet. Oncology

    2020  Volume 21, Issue 2, Page(s) e68

    MeSH term(s) Antibiotic Prophylaxis ; Double-Blind Method ; Febrile Neutropenia ; Humans ; Levofloxacin ; Multiple Myeloma
    Chemical Substances Levofloxacin (6GNT3Y5LMF)
    Language English
    Publishing date 2020-01-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(20)30008-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 460: Show issues

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  7. Article: The Effects of Corticosteroids on the Respiratory Microbiome: A Systematic Review.

    Hartmann, Julia E / Albrich, Werner C / Dmitrijeva, Marija / Kahlert, Christian R

    Frontiers in medicine

    2021  Volume 8, Page(s) 588584

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-03-10
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.588584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Measles in Returning Adult Travelers.

    Kositz, Christian / Albrich, Werner C

    The American journal of tropical medicine and hygiene

    2018  Volume 99, Issue 1, Page(s) 5–6

    MeSH term(s) Adult ; Conjunctivitis, Viral/diagnosis ; Conjunctivitis, Viral/immunology ; Conjunctivitis, Viral/physiopathology ; Conjunctivitis, Viral/transmission ; Contact Tracing ; Exanthema ; Humans ; Male ; Measles/diagnosis ; Measles/immunology ; Measles/physiopathology ; Measles/transmission ; Morbillivirus/pathogenicity ; Morbillivirus/physiology ; Switzerland ; Travel ; Vaccination/statistics & numerical data
    Language English
    Publishing date 2018-07-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.18-0053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: How representative is a point-of-care randomized trial? Clinical outcomes of patients excluded from a point-of-care randomized controlled trial evaluating antibiotic duration for Gram-negative bacteraemia: a multicentre prospective observational cohort study.

    Rossel, Anne / Zandberg, Kimberly P M / Albrich, Werner C / Huttner, Angela

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 28, Issue 2, Page(s) 297.e1–297.e6

    Abstract: ... excluded from the PIRATE trial. As in PIRATE, whose patients were randomized to 7-day, 14-day, or C ...

    Abstract Objectives: Patients included in randomized controlled trials (RCT) are poorly representative of the general population. We compared outcomes of patients excluded from the PIRATE trial, a point-of-care RCT evaluating antibiotic durations for Gram-negative bacteraemia, with those of enrolled patients.
    Methods: A prospective observational cohort study, 'EPCO' (Excluded Patients' Clinical Outcomes) included patients excluded from the PIRATE trial. As in PIRATE, whose patients were randomized to 7-day, 14-day, or C-reactive-protein (CRP)-guided antibiotic durations, EPCO's primary outcome was occurrence of clinical success at 30 days. We also compared baseline characteristics, outcome rates and treatment-effect estimates.
    Results: In all, 405 patients were included in EPCO and compared with the 503 PIRATE patients. Reasons for exclusion were mainly medical (317/405; 78%), the most frequent being complicated infection. Excluded patients had more co-morbidities (Charlson median 3 versus 1, p < 0.001). Bacteraemia was more often health-care-associated (26% versus 9%, p < 0.001). The 30-day success rate was significantly lower among EPCO patients (299/396; 76% versus 469/493; 95%, p < 0.001), but the success rate was not significantly different for those excluded for non-medical reasons (68/75; 91%, p 0.09). There was no significant difference in failure rates of EPCO patients according to their treatment duration (difference 7 days versus 14 days: p 0.75; 7 days versus CRP-correspondent: p 1.00; 14 days versus CRP-correspondent: p 1.00).
    Conclusion: Although point-of-care-randomized trials are more inclusive and representative than traditional RCTs, they are still likely to select patients with lower failure risk. Shorter antibiotic durations were not associated with failure in either included or excluded patients, supporting the generalizability of the PIRATE trial's findings.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Cohort Studies ; Duration of Therapy ; Humans ; Point-of-Care Systems
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-06-08
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Randomized Controlled Trial
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.05.050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pediatric hospital admissions, case severity, and length of hospital stay during the first 18 months of the COVID-19 pandemic in a tertiary children's hospital in Switzerland.

    Bögli, Jasmin / Güsewell, Sabine / Strässle, Rita / Kahlert, Christian R / Albrich, Werner C

    Infection

    2022  Volume 51, Issue 2, Page(s) 439–446

    Abstract: Background: SARS-CoV-2 directly contributes to the burden of respiratory disease in children, but indirect effects of protective measures also need to be considered to assess the overall impact of the pandemic on children's health.: Methods: We ... ...

    Abstract Background: SARS-CoV-2 directly contributes to the burden of respiratory disease in children, but indirect effects of protective measures also need to be considered to assess the overall impact of the pandemic on children's health.
    Methods: We retrospectively compared pre-pandemic and pandemic data of main admission diagnoses, sorted by ICD-10 diagnosis groups, in a tertiary children's hospital in Switzerland from 2017 until August 2021. Hospital admission rates, severity, and length of stay (LOS) of the individual ICD-10 groups during the pandemic were compared with three previous years accounting for seasonal differences.
    Results: Among 20,168 hospital admissions (n = 13'950 in pre-pandemic years; n = 3'120 in 2020 and n = 3'098 in 2021), there were significant decreases in numbers of admissions for respiratory diseases during the early pandemic with a rebound in summer 2021. During the pandemic, admissions for non-respiratory infections, neoplasms, and skin diseases decreased but increased for trauma. Particularly, a drop in admissions for different respiratory infections [e.g. respiratory syncytial virus (RSV) and bronchiolitis] was pronounced after introduction of strict measures, but admissions increased again after restrictions were loosened. While disease severity was lower for respiratory and neurologic diseases and bronchiolitis throughout the pandemic, gastrointestinal disease admissions had longer LOS and in the first pandemic year greater severity. For RSV and pneumonia, disease severity and LOS were higher in the first pandemic year and lower in the second pandemic year.
    Conclusion: The pandemic and associated protective measures had a significant effect on respiratory and non-respiratory admissions, particularly with decreases in hospital admissions for respiratory infections followed by a rebound after loosening of measures.
    MeSH term(s) Humans ; Child ; Length of Stay ; Pandemics ; Respiratory Syncytial Virus Infections ; Retrospective Studies ; Switzerland/epidemiology ; Hospitals, Pediatric ; COVID-19/epidemiology ; SARS-CoV-2 ; Hospitalization ; Respiratory Syncytial Virus, Human ; Bronchiolitis/epidemiology ; Respiratory Tract Infections
    Language English
    Publishing date 2022-09-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-022-01911-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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