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Article ; Online: A DNA Nanodevice-Based Platform with Diverse Capabilities.

Li, Hua-Dong / Ma, Pei-Qiang / Wang, Jin-Yu / Yin, Bin-Cheng / Ye, Bang-Ce

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 37, Page(s) e2302301

Abstract: Social biotic colonies often perform intricate tasks by interindividual communication and cooperation. Inspired by these biotic behaviors, a DNA nanodevice community is proposed as a universal and scalable platform. The modular nanodevice as the ... ...

Abstract	Social biotic colonies often perform intricate tasks by interindividual communication and cooperation. Inspired by these biotic behaviors, a DNA nanodevice community is proposed as a universal and scalable platform. The modular nanodevice as the infrastructure of platform contains a DNA origami triangular prism framework and a hairpin-swing arm machinery core. By coding and decoding a signal domain on the shuttled output strand in different nanodevices, an orthogonal inter-nanodevice communication network is established to connect multi-nanodevices into a functional platform. The nanodevice platform enables implementation of diverse tasks, including signal cascading and feedback, molecular input recording, distributed logic computing, and modeling of simulation for virus transmission. The nanodevice platform with powerful compatibility and programmability presents an elegant example of the combination of the distributed operation of multiple devices and the complicated interdevice communication network, and may become a new generation of intelligent DNA nanosystems.
MeSH term(s)	DNA/chemistry ; Logic
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-05-04
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202302301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nano-Biohybrid DNA Engager That Reprograms the T-Cell Receptor.

Ma, Pei-Qiang / Liu, Tian-Xian / Li, Hua-Dong / Yin, Bin-Cheng / Ye, Bang-Ce

Journal of the American Chemical Society

2022

Abstract: Although engineered T cells with transgenic chimeric antigen receptors (CARs) have made a breakthrough in cancer therapeutics, this approach still faces many challenges in the specificity, efficacy, and self-safety of genetic engineering. Here, we ... ...

Abstract	Although engineered T cells with transgenic chimeric antigen receptors (CARs) have made a breakthrough in cancer therapeutics, this approach still faces many challenges in the specificity, efficacy, and self-safety of genetic engineering. Here, we developed a nano-biohybrid DNA engager-reprogrammed T-cell receptor (EN-TCR) system to improve the specificity and efficacy, mitigate the excessive activation, and shield against risks from transgenesis, thus achieving a diversiform and precise control of the T-cell response. Utilizing modular assembly, the EN-TCR system can graft different specificities on T cells via antibody assembly. Besides, the designability of DNA hybridization enables precise target recognition by the library of multiantigen cell recognition circuits and allows gradual tuning of the T-cell activation level by the signaling switch and independent control over different types of T cells. Furthermore, we demonstrated the effectiveness of the system in tumor models. Together, this study provides a nongenetic T-cell engineering strategy to overcome major hindrances in T-cell therapy and may be extended to a general and convenient cell engineering strategy.
Language	English
Publishing date	2022-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c05903
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Article ; Online: Universal DNA-Based Sensing Toolbox for Programming Cell Functions.

Ma, Pei-Qiang / Huang, Fu-Wen / Xie, Ya-Qi / Li, Hong-Rui / Li, Hua-Dong / Ye, Bang-Ce / Yin, Bin-Cheng

Journal of the American Chemical Society

2023 Volume 145, Issue 51, Page(s) 28224–28232

Abstract: By recombining natural cell signaling systems and further reprogramming cell functions, use of genetically engineered cells and bacteria as therapies is an innovative emerging concept. However, the inherent properties and structures of the natural signal ...

Abstract	By recombining natural cell signaling systems and further reprogramming cell functions, use of genetically engineered cells and bacteria as therapies is an innovative emerging concept. However, the inherent properties and structures of the natural signal sensing and response pathways constrain further development. We present a universal DNA-based sensing toolbox on the cell surface to endow new signal sensing abilities for cells, control cell states, and reprogram multiple cell functions. The sensing toolbox contains a triangular-prismatic-shaped DNA origami framework and a sensing core anchored inside the internal confined space to enhance the specificity and efficacy of the toolbox. As a proof of principle, the sensing toolbox uses the customizable sensing core with signal sensing switches and converters to recognize unconventional signal inputs, deliver functional components to cells, and then control cell responses, including specific tumor cell death, immune cell disinhibition and adhesion, and bacterial expression. This work expands the diversity of cell sensing signals and reprograms biological functions by constructing nanomechanical-natural hybrid cells, providing new strategies for engineering cells and bacteria in diagnosis and treatment applications.
MeSH term(s)	Signal Transduction ; DNA ; Genetic Engineering ; Bacteria/genetics ; Quorum Sensing
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c11232
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Article: Effects of Cu

Guo, Wei / Wang, Nan / Zhang, Kai-Yue / Song, Pei-Pei / Ma, Zhan-Qiang

Ying yong sheng tai xue bao = The journal of applied ecology

2024 Volume 35, Issue 3, Page(s) 721–730

Abstract: Metal nanoparticles could be accumulated in soils, which threatens the ecological stability of crops. Investigating the effects of cuprous oxide nanoparticles ( ... ...

Title translation	Cu
Abstract	Metal nanoparticles could be accumulated in soils, which threatens the ecological stability of crops. Investigating the effects of cuprous oxide nanoparticles (Cu
MeSH term(s)	Triticum/metabolism ; Triticum/genetics ; Copper/toxicity ; Chlorophyll/metabolism ; Seedlings/metabolism ; Seedlings/drug effects ; Photosystem II Protein Complex/metabolism ; Photosynthesis/drug effects ; Fluorescence ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/toxicity ; Soil Pollutants/metabolism ; Soil Pollutants/toxicity ; Plant Leaves/metabolism ; Plant Leaves/drug effects ; Kinetics
Chemical Substances	Copper (789U1901C5) ; Chlorophyll (1406-65-1) ; cuprous oxide (T8BEA5064F) ; Photosystem II Protein Complex ; Soil Pollutants
Language	English
Publishing date	2024-04-24
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202403.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An miRISC-initiated DNA nanomachine for monitoring MicroRNA activity in living cells.

Wang, Jin-Yu / Li, Hua-Dong / Ma, Pei-Qiang / Zhou, Ying / Yin, Bin-Cheng / Ye, Bang-Ce

Biosensors & bioelectronics

2022 Volume 220, Page(s) 114828

Abstract: MicroRNAs (miRNAs) play an important role in post-transcriptional regulation of gene expression. However, methods to accurately detect miRNA activity in living cells are still limited. Here we developed a DNA nanomachine initiated by a miRNA-induced ... ...

Abstract	MicroRNAs (miRNAs) play an important role in post-transcriptional regulation of gene expression. However, methods to accurately detect miRNA activity in living cells are still limited. Here we developed a DNA nanomachine initiated by a miRNA-induced silencing complex (miRISC) for imaging miRNA activity in living cells. miRISC-mediated RNA cleavage reaction activated the DNA nanomachine by the specific cleavage of an RNA strand on the machine, resulting in autonomous movement of the walking leg around the AuNP surface with the release of a large number of fluorescently labeled DNA strands. The DNA nanomachine was successfully applied to detect miR-21 activity in three cell lines with different miR-21 expression profiles. We also demonstrated that terminal uridylyltransferase Tut4 knockdown by siRNA significantly increased the activity of let-7b miRNA, which further verifies the versatility of our DNA nanomachine. This new nanomachine has distinct advantages compared with reported methods for detecting miRNA activity, including simple operating procedures, short analysis time and sensitive signal output. Collectively, this work not only expands the application of the DNA nanomachine in the detection of miRNA activity, but also provides a promising tool for basic research in cell biology and development of clinical biomedicine.
MeSH term(s)	MicroRNAs/analysis ; Metal Nanoparticles ; Biosensing Techniques/methods ; DNA/genetics ; Cell Line
Chemical Substances	MicroRNAs ; DNA (9007-49-2)
Language	English
Publishing date	2022-10-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2022.114828
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Article ; Online: Catalytic-Hairpin-Assembly-Assisted DNA Tetrahedron Nanoprobe for Intracellular MicroRNA Imaging.

Huang, Qing / Ma, Pei-Qiang / Li, Hua-Dong / Yin, Bin-Cheng / Ye, Bang-Ce

ACS applied bio materials

2020 Volume 3, Issue 5, Page(s) 2861–2866

Abstract: The aberrant expression levels of microRNAs (miRNAs) are tightly linked with the initiation and development of various diseases and genetic disorders. Here, we reported a catalytic-hairpin-assembly-assisted DNA tetrahedron nanoprobe for intracellular ... ...

Abstract	The aberrant expression levels of microRNAs (miRNAs) are tightly linked with the initiation and development of various diseases and genetic disorders. Here, we reported a catalytic-hairpin-assembly-assisted DNA tetrahedron nanoprobe for intracellular miRNA detection. The target miRNA initiated the catalytic-hairpin-assembly reaction between the tetrahedron nanoprobes to generate large tetrahedron clusters with an enhanced fluorescence resonance energy transfer between the Cy3 and Cy5 dyes. The proposed nanoprobes were capable of visualizing the expression levels and spatial distributions of miRNA in living cells, providing a feasible approach in designing versatile nanostructures for reliable bioanalysis and clinical diagnosis.
Language	English
Publishing date	2020-02-05
Publishing country	United States
Document type	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.9b01210
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Article: Multimachine Communication Network That Mimics the Adaptive Immune Response

Ma, Pei-Qiang / Huang, Qing / Li, Hua-Dong / Yin, Bin-Cheng / Ye, Bang-Ce

Journal of the American Chemical Society. 2020 Feb. 07, v. 142, no. 8

2020

Abstract: Biological organisms capable of controlling and performing a wide variety of functions have inspired attempts to mimic biological systems with designable intelligence. Here we develop a multimachine communication network (MMCN) to mimic the operation and ...

Abstract	Biological organisms capable of controlling and performing a wide variety of functions have inspired attempts to mimic biological systems with designable intelligence. Here we develop a multimachine communication network (MMCN) to mimic the operation and function of adaptive immune response (AIR) via connecting three kinds of DNA machines built from module-functionalized gold nanoparticles. These machines simulate three critical immune cells, dendritic cells, T and B lymphocytes, and their differentiation and coordinated interaction upon exposure and response to an invading pathogen. MMCN is composed of standard modules with track, movement, and fuel components that allow for the (1) integration and adaptability of a single machine, (2) convenient spatiotemporal control of the sequential activation of a single machine, and (3) rapid reaction rate and high efficiency owing to an enhanced local concentration of interacting species. We show that the proposed network can sense and clear the corresponding pathogen via consecutive activation and connection of the machines, simultaneously forming a memory to respond more rapidly and effectively upon the second invasion of the pathogen. This system may be extended to construct powerful networks to execute more sophisticated tasks and accomplish diverse functions.
Keywords	B-lymphocytes ; DNA ; adaptive immunity ; dendritic cells ; equipment ; fuels ; nanogold ; pathogens
Language	English
Dates of publication	2020-0207
Size	p. 3851-3861.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.9b11545
Database	NAL-Catalogue (AGRICOLA)

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Article: Application of antibiotic impregnated beads on the patients with tibial chronic osteomyelitis.

Sun, Pei-Qiang / Ma, Yong / Zhang, Yong-Chun / Cheng, Ming-Guo

Pakistan journal of pharmaceutical sciences

2019 Volume 31, Issue 6(Special), Page(s) 2783–2786

Abstract: To investigate the clinical efficacy of antibiotic impregnated beads on the tibial chronic osteomyelitis, so as to search for a more applicable method for the treatment. Through comparative analysis, we divided 72 patients with chronic tibial ... ...

Abstract	To investigate the clinical efficacy of antibiotic impregnated beads on the tibial chronic osteomyelitis, so as to search for a more applicable method for the treatment. Through comparative analysis, we divided 72 patients with chronic tibial osteomyelitis who received treatment in hospital between January 2016 and December 2016 randomly into two groups: Control group (n=36) and the experiment group (n=36). Patients in the control group underwent closed lavage plus drainage for treatment, while those in the experiment group received the antibiotic impregnated beads. After treatment, we compared the times of treatment, average length of stay in hospital and the efficacy between two groups, and data were analyzed using SPSS 15.0 software. In the control group, average length of stay in hospital was ((3.3±0.9) months, average time of surgery was (2.9±1.8) times, cure rate was 25.0% and elimination rate of bacteria was 88.0%; in the experiment group, average length of stay in hospital was ((2.2±1.3) months, average time of surgery was (2.4±1.0) times, cure rate was 47.2%, and elimination rate of bacteria was 93.8%. Differences in the average length of stay in hospital, the cure rate and elimination rate of bacteria between two groups showed statistical significance (p<0.05). For tibial chronic osteomyelitis, antibiotic impregnated bead implantation can reduce the chance of secondary infection after operation and shorten the hospitalization time, showing a more promising effect than the closed lavage and drainage, and this method is worthy of being promoted in clinical practice.
MeSH term(s)	Adolescent ; Adult ; Anti-Bacterial Agents/therapeutic use ; Child ; Chronic Disease/drug therapy ; Drainage ; Drug Carriers/therapeutic use ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Microspheres ; Middle Aged ; Operative Time ; Osteomyelitis/drug therapy ; Osteomyelitis/microbiology ; Osteomyelitis/surgery ; Therapeutic Irrigation ; Tibia/drug effects ; Treatment Outcome ; Young Adult
Chemical Substances	Anti-Bacterial Agents ; Drug Carriers
Language	English
Publishing date	2019-01-10
Publishing country	Pakistan
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Article ; Online: Multimachine Communication Network That Mimics the Adaptive Immune Response.

Ma, Pei-Qiang / Huang, Qing / Li, Hua-Dong / Yin, Bin-Cheng / Ye, Bang-Ce

Journal of the American Chemical Society

2020 Volume 142, Issue 8, Page(s) 3851–3861

Abstract	Biological organisms capable of controlling and performing a wide variety of functions have inspired attempts to mimic biological systems with designable intelligence. Here we develop a multimachine communication network (MMCN) to mimic the operation and function of adaptive immune response (AIR) via connecting three kinds of DNA machines built from module-functionalized gold nanoparticles. These machines simulate three critical immune cells, dendritic cells, T and B lymphocytes, and their differentiation and coordinated interaction upon exposure and response to an invading pathogen. MMCN is composed of standard modules with track, movement, and fuel components that allow for the (1) integration and adaptability of a single machine, (2) convenient spatiotemporal control of the sequential activation of a single machine, and (3) rapid reaction rate and high efficiency owing to an enhanced local concentration of interacting species. We show that the proposed network can sense and clear the corresponding pathogen via consecutive activation and connection of the machines, simultaneously forming a memory to respond more rapidly and effectively upon the second invasion of the pathogen. This system may be extended to construct powerful networks to execute more sophisticated tasks and accomplish diverse functions.
MeSH term(s)	Adaptive Immunity ; DNA/chemistry ; Gold/chemistry ; Humans ; Metal Nanoparticles/chemistry
Chemical Substances	Gold (7440-57-5) ; DNA (9007-49-2)
Language	English
Publishing date	2020-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.9b11545
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Article ; Online: Correlation between contrast-enhanced cone-beam breast computed tomography features and prognostic staging in breast cancer.

Ma, Wei-Mei / Li, Jiao / Chen, Shuang-Gang / Cai, Pei-Qiang / Chen, Shen / Chen, Jie-Ting / Zhou, Chun-Yan / He, Ni / Wu, Yaopan

The British journal of radiology

2022 Volume 95, Issue 1132, Page(s) 20210466

Abstract: Objective: To evaluate whether contrast-enhanced cone-beam breast CT (CE-CBBCT) features can risk-stratify prognostic stage in breast cancer.: Methods: Overall, 168 biopsy-proven breast cancer patients were analysed: 115 patients in the training set ... ...

Abstract	Objective: To evaluate whether contrast-enhanced cone-beam breast CT (CE-CBBCT) features can risk-stratify prognostic stage in breast cancer. Methods: Overall, 168 biopsy-proven breast cancer patients were analysed: 115 patients in the training set underwent scanning using v. 1.5 CE-CBBCT between August 2019 and December 2019, whereas 53 patients in the test set underwent scanning using v. 1.0 CE-CBBCT between May 2012 and August 2014. All patients were restaged according to the American Joint Committee on Cancer eighth edition prognostic staging system. Following the combination of CE-CBBCT imaging parameters and clinicopathological factors, predictors that were correlated with stratification of prognostic stage via logistic regression were analysed. Predictive performance was assessed according to the area under the receiver operating characteristic curve (AUC). Goodness-of-fit of the models was assessed using the Hosmer-Lemeshow test. Results: As regards differentiation between prognostic stage (PS) I and II/III, increased tumour-to-breast volume ratio (TBR), rim enhancement pattern, and the presence of penetrating vessels were significant predictors for PS II/III disease ( Conclusion: CE-CBBCT imaging biomarkers may provide a large amount of anatomical and radiobiological information for the pre-operative distinction of prognostic stage. Advances in knowledge: CE-CBBCT features have distinctive promise for stratification of prognostic stage in breast cancer.
MeSH term(s)	Breast/diagnostic imaging ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Cone-Beam Computed Tomography/methods ; Female ; Humans ; Mammography/methods ; Neoplasm Staging ; Prognosis ; Reproducibility of Results ; Retrospective Studies
Language	English
Publishing date	2022-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20210466
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