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  1. Article ; Online: Non-coding DNA variants for risk in lupus.

    Zhang, Yutong / Hou, Guojun / Shen, Nan

    Best practice & research. Clinical rheumatology

    2024  , Page(s) 101937

    Abstract: Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disease that arises from a dynamic interplay between genetics and environmental triggers. The advent of sophisticated genomics technology has catalyzed a shift in our understanding of ... ...

    Abstract Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disease that arises from a dynamic interplay between genetics and environmental triggers. The advent of sophisticated genomics technology has catalyzed a shift in our understanding of disease etiology, spotlighting the pivotal role of non-coding DNA variants in SLE pathogenesis. In this review, we present a comprehensive examination of the non-coding variants associated with SLE, shedding light on their role in influencing disease risk and progression. We discuss the latest methodological advancements that have been instrumental in the identification and functional characterization of these genomic elements, with a special focus on the transformative power of CRISPR-based gene-editing technologies. Additionally, the review probes into the therapeutic opportunities that arise from modulating non-coding regions associated with SLE. Through an exploration of the complex network of non-coding DNA, this review aspires to decode the genetic puzzle of SLE and set the stage for groundbreaking gene-based therapeutic interventions and the advancement of precision medicine strategies tailored to SLE management.
    Language English
    Publishing date 2024-02-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2024.101937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: A New Method for Extracting Refined Sketches of Ancient Murals.

    Yu, Zhiji / Lyu, Shuqiang / Hou, Miaole / Sun, Yutong / Li, Lihong

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 7

    Abstract: Mural paintings, as the main components of painted cultural relics, have essential research value and historical significance. Due to their age, murals are easily damaged. Obtaining intact sketches is the first step in the conservation and restoration of ...

    Abstract Mural paintings, as the main components of painted cultural relics, have essential research value and historical significance. Due to their age, murals are easily damaged. Obtaining intact sketches is the first step in the conservation and restoration of murals. However, sketch extraction often suffers from problems such as loss of details, too thick lines, or noise interference. To overcome these problems, a mural sketch extraction method based on image enhancement and edge detection is proposed. The experiments utilize Contrast Limited Adaptive Histogram Equalization (CLAHE) and bilateral filtering to enhance the mural images. This can enhance the edge features while suppressing the noise generated by over-enhancement. Finally, we extract the refined sketch of the mural using the Laplacian Edge with fine noise remover (FNR). The experimental results show that this method is superior to other methods in terms of visual effect and related indexes, and it can extract the complex line regions of the mural.
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24072213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Second haploidentical bone marrow transplantation with antithymocyte antibody-containing conditioning regimen for graft failure in eight patients with severe aplastic anemia.

    Zhang, Chengtao / Hou, Yutong / Yang, Yan / Zhang, Jingjing / Zheng, Xiaoli / Yan, Jinsong

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2293

    Abstract: The effects of a second haploidentical bone marrow transplantation with an antithymocyte antibody-containing conditioning regimen after graft failure in patients with severe aplastic anemia remain unclear. Eight severe aplastic anemia patients with graft ...

    Abstract The effects of a second haploidentical bone marrow transplantation with an antithymocyte antibody-containing conditioning regimen after graft failure in patients with severe aplastic anemia remain unclear. Eight severe aplastic anemia patients with graft failure with a median age of 12.5 (range, 3-22) years were retrospectively reviewed. At the second transplantation, they received a median mononuclear cell number of 15.7 (range, 11.2-20.9) × 10
    MeSH term(s) Humans ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Bone Marrow Transplantation ; Anemia, Aplastic/therapy ; Retrospective Studies ; Hematopoietic Stem Cell Transplantation ; Antilymphocyte Serum/therapeutic use ; Graft vs Host Disease/etiology ; Transplantation Conditioning ; Cyclophosphamide
    Chemical Substances Antilymphocyte Serum ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2024-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52917-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Diffusion-weighted Imaging Detection of Acute Ischemia Brain Lesions in Spontaneous Intracerebral Hemorrhage Associated with White Matter Hyperintensities, Enlarged Perivascular Spaces and Diabetes Mellitus.

    Hou, Yutong / Qin, Wei / Yang, Shuna / Li, Yue / Yang, Lei / Hu, Wenli

    Current neurovascular research

    2024  

    Abstract: Objective: Diffusion-weighted imaging [DWI] is commonly detected after spontaneous intracerebral hemorrhage [sICH] and is associated with poor functional outcomes. However, the etiology and significance of DWI lesions remain unclear. Thus, our study ... ...

    Abstract Objective: Diffusion-weighted imaging [DWI] is commonly detected after spontaneous intracerebral hemorrhage [sICH] and is associated with poor functional outcomes. However, the etiology and significance of DWI lesions remain unclear. Thus, our study aimed to explore the prevalence and risk factors of acute ischemic lesions in sICH and discussed the possible mechanisms.
    Methods: We conducted a retrospective review of a consecutive cohort of 408 patients from June 2013 to October 2019 with sICH, who had brain computed tomography [CT] and magnetic resonance imaging [MRI] within 14 days of symptoms onset. Acute ischemic lesions were assessed on MRI using DWI] lesions. We compared the clinical and imaging characteristics of patients with and without DWI lesions. The data were analyzed by univariate and multivariate logistic regression.
    Results: Among the enrolled 408 patients, the mean age was 56.8±14.5 years, 68 [16.7%] of them had been diagnosed with diabetes mellitus [DM]. DWI lesions were observed in 89 [21.8%] patients, and most of them had a history of lacunar infarctions, which were located in cortical or subcortical. In multivariate logistic regression analysis, DM [odds ratio [OR] 3.962, p <0.001], severe deep white matter hypertensities [DWMH] [OR 2.463, p =0.001] and severe centrum semiovale enlarged perivascular spaces [CSO-EPVS] [OR 2.679, p =0.001] were independently associated with the presence of DWI lesions.
    Conclusion: In our cohort, we found DM, severe DWMH and severe CSO-EPVS were the independent risk factors in sICH patients with DWI lesions.
    Language English
    Publishing date 2024-01-26
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2296350-9
    ISSN 1875-5739 ; 1567-2026
    ISSN (online) 1875-5739
    ISSN 1567-2026
    DOI 10.2174/0115672026283323240108052711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6646: Show issues Location:
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  5. Article ; Online: Metabarcode insights into the airborne fungal diversity in the indoor and outdoor environments in archives from Yunnan, Southwestern China.

    Zhang, Qian / Wang, Yuan / Hou, Yutong / Zhao, Qingxue / Yang, Liu / Zhang, Ying / Zhou, Lu

    Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

    2024  

    Abstract: Monitoring dynamics of airborne fungal species and controlling of harmful ones are of vital importance to conservation of cultural relics. However, the evaluation of air quality and the community structure characteristics of microorganisms, especially ... ...

    Abstract Monitoring dynamics of airborne fungal species and controlling of harmful ones are of vital importance to conservation of cultural relics. However, the evaluation of air quality and the community structure characteristics of microorganisms, especially fungi, in the atmosphere of archives is in a stage of continuous exploration though more than 4,000 archives were constructed in China. Seventy-two air samples were collected in this study under different spatial and weather conditions from the archives of Kunming Medical University, located in the Kunming metropolitan area, Yunnan province, southwestern China. A total of 22 airborne fungal classes, 160 genera and 699 ASVs were identified, the species diversity is on the rise with the strengthening of air circulation with the outside space, and thus the intensive energy metabolism and activity were found in the spaces with window and sunny weather, except for the higher lipid synthesis of indoor samples than that of outdoor ones. Furthermore, there were significant differences in fungal community composition and abundance between sunny and rainy weathers. A considerable number of species have been identified as indicator in various environmental and weather conditions of the archives, and temperature and humidity were thought to have significant correlations with the abundance of these species. Meanwhile, Cladosporium and Alternaria were the dominant genera here, which may pose a threat to the health of archive professionals. Therefore, monitoring and controlling the growth of these fungal species is crucial for both conservation of paper records and health of archive professionals.
    Language English
    Publishing date 2024-04-08
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2017175-4
    ISSN 1678-4405 ; 1517-8382
    ISSN (online) 1678-4405
    ISSN 1517-8382
    DOI 10.1007/s42770-024-01323-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Sogatella furcifera

    Liu, Yudi / Yi, Jinyu / Jia, Haokang / Miao, Yutong / Hou, Maolin

    International journal of molecular sciences

    2022  Volume 23, Issue 15

    Abstract: The white-backed planthopper (WBPH), ...

    Abstract The white-backed planthopper (WBPH),
    MeSH term(s) Animals ; Hemiptera/genetics ; Mucins ; Oryza/genetics ; Saliva ; Salivary Glands
    Chemical Substances Mucins
    Language English
    Publishing date 2022-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23158239
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  7. Article ; Online: Diversity of astroviruses in wild animals in Yunnan province, China.

    Huang, Xingyu / Hou, Junjie / Le, Xiang / Hou, Yutong / Yang, Lingsi / Li, Qian / Wang, Binghui / Xia, Xueshan

    Virology journal

    2024  Volume 21, Issue 1, Page(s) 51

    Abstract: Background: Astroviruses (AstVs) are single-stranded RNA viruses that have been detected in a wide range of mammals and birds. They are associated with numerous interspecies transmissions and viral recombination events, posing a threat to human and ... ...

    Abstract Background: Astroviruses (AstVs) are single-stranded RNA viruses that have been detected in a wide range of mammals and birds. They are associated with numerous interspecies transmissions and viral recombination events, posing a threat to human and animal health.
    Methods: We collected 1,333 samples from wild animals, including bats, rodents, wild boars, and birds, from various states and cities in the Yunnan Province, China, between 2020 and 2023 to investigate the presence of AstVs. AstVs were detected using a polymerase chain reaction targeting the RdRp gene. Finally, the Molecular Evolutionary Genetics Analysis software was used to construct the phylogenetic tree.
    Results: The overall positivity rate for AstVs was 7.12% in four species, indicating their widespread occurrence in the region. High genetic diversity among AstVs was observed in different animal species, suggesting the potential for interspecies transmission, particularly among rodents and birds. Additionally, we identified a novel AstV strain and, for the first time, provided information on the presence of bastroviruses in Yunnan, China.
    Conclusions: The widespread distribution and high genetic diversity of AstVs, along with the observed potential for interspecies transmission, highlight the importance of further investigation and surveillance in the region. The findings emphasize the need for increased attention to AstVs and their potential impact on human and animal health in Yunnan and other regions.
    MeSH term(s) Animals ; Humans ; Animals, Wild ; Astroviridae Infections/epidemiology ; Astroviridae Infections/veterinary ; Phylogeny ; China/epidemiology ; RNA Viruses ; Mammals ; Chiroptera ; Rodentia
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2160640-7
    ISSN 1743-422X ; 1743-422X
    ISSN (online) 1743-422X
    ISSN 1743-422X
    DOI 10.1186/s12985-024-02314-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Comparative analysis of the intestinal microbiome in

    Shah, Taif / Hou, Yutong / Jiang, Jinyong / Shah, Zahir / Wang, Yuhan / Li, Qian / Xu, Xiang / Wang, Yixuan / Wang, Binghui / Xia, Xueshan

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1283453

    Abstract: ... Rat ... ...

    Abstract Rat species
    Language English
    Publishing date 2023-11-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1283453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: New insights on the preparation of amine covalent organic polymer and its adsorption properties.

    Hou, Yutong / Jia, Aiyuan / Qin, Xueming / Yang, Xinru / Xie, Jiayin / Li, Xiaoyu / Zhao, Yongsheng

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 340, Issue Pt 1, Page(s) 122659

    Abstract: Dye pollution is becoming increasingly severe. This study used the Schiff base reaction to synthesize a polyaromatic ring covalent organic polymer material with amide bonds and high electronegativity named SLEL-9 to adsorb Methylene Blue (MB) and ... ...

    Abstract Dye pollution is becoming increasingly severe. This study used the Schiff base reaction to synthesize a polyaromatic ring covalent organic polymer material with amide bonds and high electronegativity named SLEL-9 to adsorb Methylene Blue (MB) and Rhodamine B (RhB). SLEL-9 was characterized by Fourier transform infra-red spectra, X-ray photoelectron spectra, Brunauer-Emmett-Teller (BET), zeta potential analysis, and other techniques. It was found that SLEL-9 material contains C-C, CN, C-N, and CO. SLEL-9 had a zeta potential of about -45 mV under neutral conditions, which proved that the material had been synthesized successfully. The BET and Langmuir surface areas of SLEL-9 were 35.187 m
    MeSH term(s) Adsorption ; Methylene Blue/chemistry ; Polymers ; Amines ; Water Pollutants, Chemical/chemistry ; Coloring Agents/chemistry ; Water/chemistry ; Kinetics
    Chemical Substances Methylene Blue (T42P99266K) ; Polymers ; Amines ; Water Pollutants, Chemical ; Coloring Agents ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.122659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: RNA virus diversity in rodents.

    Fan, Yayu / Hou, Yutong / Li, Qian / Dian, Ziqin / Wang, Binghui / Xia, Xueshan

    Archives of microbiology

    2023  Volume 206, Issue 1, Page(s) 9

    Abstract: Many zoonotic disease emergencies are associated with RNA viruses in rodents that substantially impact public health. With the widespread application of meta-genomics and meta-transcriptomics for virus discovery over the last decade, viral sequences ... ...

    Abstract Many zoonotic disease emergencies are associated with RNA viruses in rodents that substantially impact public health. With the widespread application of meta-genomics and meta-transcriptomics for virus discovery over the last decade, viral sequences deposited in public databases have expanded rapidly, and the number of novel viruses discovered in rodents has increased. As important reservoirs of zoonotic viruses, rodents have attracted increasing attention for the risk of potential spillover of rodent-borne viruses. However, knowledge of rodent viral diversity and the major factors contributing to the risk of zoonotic epidemic outbreaks remains limited. Therefore, this study analyzes the diversity and composition of rodent RNA viruses using virus records from the Database of Rodent-associated Viruses (DRodVir/ZOVER), which covers the published literatures and records in GenBank database, reviews the main rodent RNA virus-induced human infectious diseases, and discusses potential challenges in this field.
    MeSH term(s) Animals ; Humans ; Rodentia ; Zoonoses/epidemiology ; Viruses/genetics ; RNA Viruses/genetics ; Disease Outbreaks
    Language English
    Publishing date 2023-12-01
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124824-8
    ISSN 1432-072X ; 0302-8933
    ISSN (online) 1432-072X
    ISSN 0302-8933
    DOI 10.1007/s00203-023-03732-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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