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Article ; Online: Uveal metastasis arising from thyroid neoplasms: A case study synthesis.

Abdollahi, Mirsaeed / Nateghian, Hooman / Sobhi, Navid / Abdshah, Alireza / Jafarizadeh, Ali

2024 , Page(s) 11206721241236528

Abstract: Purpose: We systematically reviewed the case report literature to identify cases of uveal metastases originating from thyroid cancer (TC), evaluate factors and indications in uveal metastases from TC, and provide clinical insights through recent case ... ...

Abstract	Purpose: We systematically reviewed the case report literature to identify cases of uveal metastases originating from thyroid cancer (TC), evaluate factors and indications in uveal metastases from TC, and provide clinical insights through recent case studies. Methods: Web of Science, Medline, and Scopus databases were searched for case reports or series reporting uveal metastasis from a thyroid neoplasm. Articles published in any language from inception through November 2022 were searched and screened independently by two reviewers. The quality of the included studies was assessed using the JBI Critical Appraisal Checklist for Case Reports. Results: A total of 1049 records were screened, resulting in the identification of 46 cases from 43 studies. The mean (SD) age at uveal metastases diagnosis was 58.44 (±17.99) years with the median (interquartile range) of 56.5 (29.75) (range, 20-83 years), with 34.8% of cases (16/46) cases reported in elderly patients (>64 years). The sample consisted of 56.5% (26/46) male patients. Uveal metastases were observed in the right eye in 16 cases, the left eye in 19 cases, and both eyes in 11 cases. Choroidal involvement was present in 84.8% of cases (39/46) cases. Papillary carcinoma was the most common thyroid cancer type (34.8%, 16/46), followed by follicular carcinoma (32.6%, 15/46), and medullary carcinoma (21.7%, 10/46). Conclusion: Uveal metastases have been observed to appear in metastatic TC, and physicians should approach ocular symptoms cautiously in cases that accompany a neck mass or a history of previous TC.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721241236528
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Article ; Online: Evaluation of C4d expression and staining patterns by immunohistochemistry in renal biopsy samples with focal segmental glomerulosclerosis and minimal change disease.

Abedi, Maryam / Nili, Fatemeh / Dehkhoda, Farshid / Abdollahi, Alireza / Salarvand, Samaneh

Annals of diagnostic pathology

2024 Volume 70, Page(s) 152281

Abstract: Introduction: C4d is an activation product of lectin pathway of complement. Glomerular deposition of C4d is associated with poor prognosis in different types of immune-related glomerulonephritis. The present study was conducted to investigate expression ...

Abstract	Introduction: C4d is an activation product of lectin pathway of complement. Glomerular deposition of C4d is associated with poor prognosis in different types of immune-related glomerulonephritis. The present study was conducted to investigate expression level of C4d and its staining pattern in renal biopsy of patients with focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) by immunohistochemistry method. Materials and methods: In this retrospective cross-sectional study, renal biopsy specimens from 46 samples of MCD, 47 samples of FSGS, and 15 samples without glomerular disease as the controls, were subjected to immunohistochemistry staining with C4d. Demographic characteristics and information obtained from light and electron microscopy (EM) of patients were also extracted from their files. Results: C4d positive staining was observed in 97.9 % of FSGS and 43.5 % of MCD samples, which showed a statistically significant difference (P < 0.001). The sensitivity and specificity of C4d expression for diagnosing FSGS were 97.9 % and 56.5 %, respectively. There was no significant correlation between C4d expression and any of the light and electron microscopy findings, including presence of foam cells, mesangial matrix expansion, interstitial fibrosis and tubular atrophy, and basement membrane changes in MCD patients. Also, no significant correlation was observed between C4d expression and clinical symptoms of proteinuria or prolonged high level of creatinine in patients with MCD. Discussion and conclusion: The expression of C4d marker had a good sensitivity and negative predictive value in the diagnosis of FSGS.
MeSH term(s)	Humans ; Glomerulosclerosis, Focal Segmental/metabolism ; Glomerulosclerosis, Focal Segmental/pathology ; Glomerulosclerosis, Focal Segmental/diagnosis ; Nephrosis, Lipoid/metabolism ; Nephrosis, Lipoid/pathology ; Nephrosis, Lipoid/diagnosis ; Male ; Female ; Retrospective Studies ; Adult ; Cross-Sectional Studies ; Immunohistochemistry/methods ; Middle Aged ; Biopsy/methods ; Complement C4b/metabolism ; Kidney/pathology ; Kidney/metabolism ; Young Adult ; Adolescent ; Peptide Fragments/metabolism ; Peptide Fragments/analysis ; Sensitivity and Specificity ; Kidney Glomerulus/pathology ; Kidney Glomerulus/metabolism
Chemical Substances	Complement C4b (80295-50-7) ; complement C4d (80295-52-9) ; Peptide Fragments
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440011-x
ISSN	1532-8198 ; 1092-9134
ISSN (online)	1532-8198
ISSN	1092-9134
DOI	10.1016/j.anndiagpath.2024.152281
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Article: Evaluation of Etiology, Clinical Manifestations, Diagnosis, Follow-up, Histopathology and Prognosis Factors in Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-analysis.

Didehban, Shiva / Abdollahi, Alireza / Meysamie, Alipasha

Iranian journal of pathology

2023 Volume 18, Issue 4, Page(s) 380–391

Abstract: Background & objective: The most frequent type of cancer found in the endocrine system is thyroid carcinoma. Among well-differentiated thyroid malignancies, the most commonly occurring type is identified as papillary thyroid carcinoma (PTC), which makes ...

Abstract	Background & objective: The most frequent type of cancer found in the endocrine system is thyroid carcinoma. Among well-differentiated thyroid malignancies, the most commonly occurring type is identified as papillary thyroid carcinoma (PTC), which makes up 70-90% of the cases. A subtype of PTC is papillary thyroid microcarcinoma (PTMC), which includes tumors smaller than 10 mm in diameter. Due to the advancements in diagnostic techniques, the incidence of this type of cancer is on the rise. In this study, we aimed to analyze the factors worsening the PTMC prognosis. Methods: In the first step, we searched various databases for the factors affecting this tumor. The relevant articles were collected and different outcomes of this tumor and its associated factors which were studied in more than one article, were classified. Finally, we conducted a meta-analysis of these outcomes and their related factors. Results: In the meta-analysis, a significantly association was found between the following factors: recurrence with gender ( Conclusion: In conclusion, it is essential to note that greater awareness and understanding of this tumor characteristics and special and separate attention to PTMC can significantly improve the society overall health
Language	English
Publishing date	2023-10-15
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2478278-6
ISSN	1735-5303 ; 2345-3656
ISSN	1735-5303 ; 2345-3656
DOI	10.30699/IJP.2023.2005196.3134
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Article: An uncommon problem: Overcoming the challenges of rectal foreign bodies-A case series and literature review.

Maddah, Ghodratollah / Abdollahi, Abbas / Tavassoli, Alireza / Mashhadi, Mohammad Taghi Rajabi / Mehri, Ali / Etezadpour, Mohammad

Clinical case reports

2023 Volume 11, Issue 12, Page(s) e8313

Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.8313
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Article: Evaluation of HER2 Positivity Based on Clinicopathological Findings in HER2 Borderline Tumors in Iranian Patients with Breast Cancer.

Omranipour, Ramesh / Nazarian, Newsha / Alipour, Sadaf / Abdollahi, Alireza / Eslami, Bita

Iranian journal of pathology

2023 Volume 18, Issue 4, Page(s) 403–409

Abstract: Background & objective: Human epidermal growth receptor-2 (HER2) gene amplification is an important predictive and prognostic factor in breast cancer treatment. However, the expression of HER2 determined by immunohistochemistry (IHC) is considered as ... ...

Abstract	Background & objective: Human epidermal growth receptor-2 (HER2) gene amplification is an important predictive and prognostic factor in breast cancer treatment. However, the expression of HER2 determined by immunohistochemistry (IHC) is considered as borderline in some cases, and confirmation of the HER2 status by either fluorescent in situ hybridization (FISH) or chromogenic in situ hybridization (CISH) is necessary for correct treatment decision-making. Considering the high cost of FISH and CISH, we aimed to investigate whether clinicopathological findings of the tumor could predict the HER2 status. Methods: A retrospective study was performed using the data from 584 patients with breast cancer with HER2-borderline disease, confirmed by IHC. Final HER2 status, pathologic tumor size and type, nodal involvement, Ki67 index, presence of estrogen and progesterone receptors (ER, PR), lymphovascular invasion (LVI), and stage were retrieved from the clinical records. Results: One hundred twenty-one (20.7%) patients were HER2-positive according to the FISH or CISH results. Logistic regression analysis showed that the pathologic size was positively associated with HER2 positivity with an odds ratio (OR) of 1.02 (95% CI: 1.01-1.04). In addition, the adjusted OR illustrated a statistically significant association between HER2 positivity and PR negativity (OR= 2.22, 95% CI: 1.29-3.83). Conclusion: In HER2 borderline breast cancer, HER2 positivity significantly increases with tumor size and PR negativity. Further studies are recommended that may find an applicable model to predict the actual status of HER2 in borderline cases.
Language	English
Publishing date	2023-10-15
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2478278-6
ISSN	1735-5303 ; 2345-3656
ISSN	1735-5303 ; 2345-3656
DOI	10.30699/IJP.2023.561915.2970
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Article ; Online: Geographic variation in urinary tract and genital cancers in Iran: a hypothesis involving exposure to solar radiation.

Khanjani, Narges / Moradabadi, Alireza / Najafi, Esmail / Hayati, Bagher / Abdollahi, Reza

BMC research notes

2023 Volume 16, Issue 1, Page(s) 65

Abstract: Objective: Sunlight and vitamin D intake are considered as essential elements for human health. Insufficient intake of this vitamin is one of the causes of various cancers and some other diseases. The aim of this study was to investigate the relation ... ...

Abstract	Objective: Sunlight and vitamin D intake are considered as essential elements for human health. Insufficient intake of this vitamin is one of the causes of various cancers and some other diseases. The aim of this study was to investigate the relation between bladder, prostate, cervical and ovarian cancers with solar ultraviolet exposure in Iran. In this ecological study, data from 30 provinces were studied and analyzed by correlation and linear regression tests in SPSS software version 22. Physical activity, gender, human development index, lung cancer and altitude were adjusted at population level. Results: The incidence of bladder cancer in both sexes was inversely related to ultraviolet radiation, but it was significant only in men. Unlike bladder cancer, the incidence of cervical cancer showed a positive relation with ultraviolet radiation. No relation was found between the incidence of prostate and ovarian cancers with ultraviolet radiation. Among the adjusting variables, the incidence of lung cancer (surrogate for smoking) in women had the highest coefficient in the linear regression model.
MeSH term(s)	Male ; Humans ; Female ; Ultraviolet Rays/adverse effects ; Iran/epidemiology ; Lung Neoplasms/epidemiology ; Lung Neoplasms/etiology ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/etiology ; Urinary Tract ; Ovarian Neoplasms ; Genitalia ; Vitamin D
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-023-06334-x
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Article: The value of machine learning for prognosis prediction of diphenhydramine exposure: National analysis of 50,000 patients in the United States.

Mehrpour, Omid / Saeedi, Farhad / Abdollahi, Jafar / Amirabadizadeh, Alireza / Goss, Foster

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

2023 Volume 28, Page(s) 49

Abstract: Background: Diphenhydramine (DPH) is an antihistamine medication that in overdose can result in anticholinergic symptoms and serious complications, including arrhythmia and coma. We aimed to compare the value of various machine learning (ML) models, ... ...

Abstract	Background: Diphenhydramine (DPH) is an antihistamine medication that in overdose can result in anticholinergic symptoms and serious complications, including arrhythmia and coma. We aimed to compare the value of various machine learning (ML) models, including light gradient boosting machine (LGBM), logistic regression (LR), and random forest (RF), in the outcome prediction of DPH poisoning. Materials and methods: We used the National Poison Data System database and included all of the human exposures of DPH from January 01, 2017 to December 31, 2017, and excluded those cases with missing information, duplicated cases, and those who reported co-ingestion. Data were split into training and test datasets, and three ML models were compared. We developed confusion matrices for each, and standard performance metrics were calculated. Results: Our study population included 53,761 patients with DPH exposure. The most common reasons for exposure, outcome, chronicity of exposure, and formulation were captured. Our results showed that the average precision-recall area under the curve (AUC) of 0.84. LGBM and RF had the highest performance (average AUC of 0.91), followed by LR (average AUC of 0.90). The specificity of the models was 87.0% in the testing groups. The precision of models was 75.0%. Recall (sensitivity) of models ranged between 73% and 75% with an F1 score of 75.0%. The overall accuracy of LGBM, LR, and RF models in the test dataset was 74.8%, 74.0%, and 75.1%, respectively. In total, just 1.1% of patients (mostly those with major outcomes) received physostigmine. Conclusion: Our study demonstrates the application of ML in the prediction of DPH poisoning.
Language	English
Publishing date	2023-06-12
Publishing country	India
Document type	Journal Article
ZDB-ID	2513029-8
ISSN	1735-7136 ; 1735-1995
ISSN (online)	1735-7136
ISSN	1735-1995
DOI	10.4103/jrms.jrms_602_22
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Article: Importance of the COVID-19 Vaccine Booster Dose in Protection and Immunity.

Abdollahi, Alireza / Afsharyzad, Yeganeh / Vaezi, Atefeh / Meysamie, Alipasha

Vaccines

2022 Volume 10, Issue 10

Abstract: Background: There is debate on the necessity of booster doses of COVID-19 vaccination, especially in countries with limited resources.: Methods: This cross-sectional study was conducted in a referral laboratory in Tehran, Iran. The level of COVID-19 ... ...

Abstract	Background: There is debate on the necessity of booster doses of COVID-19 vaccination, especially in countries with limited resources. Methods: This cross-sectional study was conducted in a referral laboratory in Tehran, Iran. The level of COVID-19 antibodies was measured and compared between individuals regarding the number of COVID-19 vaccine shots. Results: In this study, 176 individuals with a mean age of 36.3 (±11.7) years participated. A total of 112 individuals received two doses of the COVID-19 vaccine, and 64 individuals received three doses. Level of all antibodies was higher in those who received three doses than in those who received two doses of the COVID-19 vaccine. Considering the SARS-CoV-2 Spike IgG, the difference was not statistically significant but for the SARS-CoV-2 RBD IgG and SARS-CoV-2 NAB the difference was statistically significant. Regarding to the background variables, receiving influenza vaccine in the past year, history of autoimmune diseases and past medical history of chicken pox showed a significant association with the number of vaccine doses received. Their effects on the outcome variables assessed with multivariate logistic regression analysis. Conclusion: The results of our study show that a booster dose of the COVID-19 vaccine enhances the antibody response.
Language	English
Publishing date	2022-10-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10101708
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Article ; Online: Optimization of geographical space of ecosystem service areas and land-use planning, Iran.

Abdollahi, Sedighe / Ildoromi, Alireza / Salmanmahini, Abdolrassoul / Fakheran, Sima

Environmental monitoring and assessment

2022 Volume 194, Issue 8, Page(s) 527

Abstract: This study provides a framework for optimizing ecosystem service zones based on landscape patterns. Ecosystem service zoning is a tool for making more informed land-use decisions and integrating ecosystem services into land development strategies. ... ...

Abstract	This study provides a framework for optimizing ecosystem service zones based on landscape patterns. Ecosystem service zoning is a tool for making more informed land-use decisions and integrating ecosystem services into land development strategies. Accordingly, a meta-heuristic algorithm (simulated annealing-genetic hybrid) was applied to optimize zones of three ecosystem services, including aesthetic value, recreation value, and noise pollution reduction service. The goal was to select ecosystem service zones in terms of area, percentage of landscape, shape, and number of patches in two land-use types, including the built-up and green cover. The results indicated that optimum zones based on green infrastructure comprised more extent and average suitability than human infrastructure. The western and southern parts of the target area showed the highest values of ecosystem services for the two land-use classes. The convergence curve of the objective functions indicated the good performance of the employed algorithm in optimizing ecosystem service zones. Overall, the results indicated that optimizing ecosystem service zones based on landscape patterns improved the land-use management framework in the study area. Moreover, the used algorithm allowed for integrating different parameters into ecosystem services zone configurations.
MeSH term(s)	China ; City Planning ; Conservation of Natural Resources/methods ; Ecosystem ; Environmental Monitoring/methods ; Humans ; Iran
Language	English
Publishing date	2022-06-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-022-10204-7
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Article ; Online: Optimization of geographical space of ecosystem service areas and land-use planning, Iran

Abdollahi, Sedighe / Ildoromi, Alireza / Salmanmahini, Abdolrassoul / Fakheran, Sima

Environ Monit Assess. 2022 Aug., v. 194, no. 8 p.527-527

2022

Abstract	This study provides a framework for optimizing ecosystem service zones based on landscape patterns. Ecosystem service zoning is a tool for making more informed land-use decisions and integrating ecosystem services into land development strategies. Accordingly, a meta-heuristic algorithm (simulated annealing-genetic hybrid) was applied to optimize zones of three ecosystem services, including aesthetic value, recreation value, and noise pollution reduction service. The goal was to select ecosystem service zones in terms of area, percentage of landscape, shape, and number of patches in two land-use types, including the built-up and green cover. The results indicated that optimum zones based on green infrastructure comprised more extent and average suitability than human infrastructure. The western and southern parts of the target area showed the highest values of ecosystem services for the two land-use classes. The convergence curve of the objective functions indicated the good performance of the employed algorithm in optimizing ecosystem service zones. Overall, the results indicated that optimizing ecosystem service zones based on landscape patterns improved the land-use management framework in the study area. Moreover, the used algorithm allowed for integrating different parameters into ecosystem services zone configurations.
Keywords	aesthetic value ; algorithms ; ecosystem services ; ecosystems ; green infrastructure ; humans ; hybrids ; land use ; landscapes ; noise pollution ; recreation ; Iran
Language	English
Dates of publication	2022-08
Size	p. 527.
Publishing place	Springer International Publishing
Document type	Article ; Online
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-022-10204-7
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