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  1. Article ; Online: Root Repair Has Superior Radiological and Clinical Outcomes Than Partial Meniscectomy and Nonoperative Treatment in the Management of Meniscus Root Tears: A Systematic Review.

    Lee, Dustin R / Lu, Yining / Reinholz, Anna K / Till, Sara E / Lamba, Abhinav / Saris, Daniel B F / Camp, Christopher L / Krych, Aaron J

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

    2024  

    Abstract: ... between studies. Change in joint space width ranged from -2.4 to -0.6 mm (i.e., decreased space) after ... meniscectomy (n = 186) and -0.9 to -0.1 mm after root repair (n = 209); change in medial meniscal extrusion ... ranged from -0.6 to 6.5 mm after root repair (n = 521) and 0.2 to 4.2 mm after meniscectomy (n = 66); and ...

    Abstract Purpose: To compile and analyze structural and clinical outcomes after meniscus root tear treatment as currently described in the literature.
    Methods: A review was conducted to identify studies published since 2011 on efficacy of repair, meniscectomy, and nonoperative management in the treatment of meniscus root tears. Patient cohorts were grouped into treatment categories, with medial and lateral root tears analyzed separately; data were collected on patient demographics, structural outcomes including joint space width, degree of medial meniscal extrusion, progression to total knee arthroplasty, and patient-reported outcome measures. Risk of bias was assessed using the MINORS (methodological index for non-randomized studies) criteria. Heterogeneity was measured using the I-statistic, and outcomes were summarized using forest plots without pooled means.
    Results: The 56 included studies comprised a total of 3,191 patients. Mean age among the included studies ranged from 24.6 to 65.6 years, whereas mean follow-up ranged from 12 to 125.9 months. Heterogeneity analysis identified significant differences between studies. Change in joint space width ranged from -2.4 to -0.6 mm (i.e., decreased space) after meniscectomy (n = 186) and -0.9 to -0.1 mm after root repair (n = 209); change in medial meniscal extrusion ranged from -0.6 to 6.5 mm after root repair (n = 521) and 0.2 to 4.2 mm after meniscectomy (n = 66); and event rate for total knee arthroplasty ranged from 0.00 to 0.22 after root repair (n = 205), 0.35 to 0.60 after meniscectomy (n = 53), and 0.27 to 0.35 after nonoperative treatment (n = 93). Root repair produced the greatest numerical increase in International Knee Documentation Committee and Lysholm scores of the 3 treatment arms. In addition, root repair improvements in Knee Injury and Osteoarthritis Outcome Score Pain (range: 22-32), Sports and Recreational Activities (range: 23-36), Quality of Life (range: 22-42), and Symptoms subscales (range: 10-19), in studies with low risk of bias.
    Conclusions: The literature reporting on the treatment of meniscus root tears is heterogenous and largely limited to Level III and IV studies. Current evidence suggests root repair may be the most effective treatment strategy in lessening joint space narrowing of the knee and producing improvements in patient-reported outcomes.
    Level of evidence: Level IV, systematic review of Level II-IV studies.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632528-2
    ISSN 1526-3231 ; 0749-8063
    ISSN (online) 1526-3231
    ISSN 0749-8063
    DOI 10.1016/j.arthro.2024.02.017
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  2. Article: A historical review of cellular calcium handling, with emphasis on mitochondria.

    Saris, N-E L / Carafoli, E

    Biochemistry. Biokhimiia

    2005  Volume 70, Issue 2, Page(s) 187–194

    Abstract: ... on the mitochondrial transporters, i.e. the calcium uniporter used for Ca(2+) uptake, and the antiporters used ... for the efflux, i.e. the Ca(2+)/Na(+) antiporter in mitochondria and the plasma membrane of excitable cells, and ...

    Abstract Calcium ions are of central importance in cellular physiology, as they carry the signal activating cells to perform their programmed function. Ca(2+) is particularly suitable for this role because of its chemical properties and because its free concentration gradient between the extra-cellular and the cytosolic concentrations is very high, about four orders of magnitude. The cytosolic concentration of Ca(2+) is regulated by binding and chelation by various substances and by transport across plasma and intracellular membranes. Various channels, transport ATPases, uniporters, and antiporters in the plasma membrane, endoplasmic and sarcoplasmic reticulum, and mitochondria are responsible for the transport of Ca(2+). The regulation of these transport systems is the subject of an increasing number of studies. In this short review, we focus on the mitochondrial transporters, i.e. the calcium uniporter used for Ca(2+) uptake, and the antiporters used for the efflux, i.e. the Ca(2+)/Na(+) antiporter in mitochondria and the plasma membrane of excitable cells, and the Ca(2+)/nH(+) antiporter in liver and some other mitochondrial types. Mitochondria are of special interest in that Ca(2+) stimulates respiration and oxidative phosphorylation to meet the energy needs of activated cells. The studies on Ca(2+) and mitochondria began in the fifties, but interest in mitochondrial Ca(2+) handling faded in the late seventies since it had become apparent that mitochondria in resting cells contain very low Ca(2+). Interest increased again in the nineties also because it was discovered that mitochondria and Ca(2+) had a central role in apoptosis and necrosis. This is of special interest in calcium overload and oxidative stress conditions, when the opening of the mitochondrial permeability transition pore is stimulated.
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium/physiology ; Calcium Signaling/physiology ; Cell Membrane/metabolism ; Endoplasmic Reticulum/metabolism ; Mitochondria/metabolism
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2005-03-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1109-5
    ISSN 1608-3040 ; 0006-2979 ; 0320-9717
    ISSN (online) 1608-3040
    ISSN 0006-2979 ; 0320-9717
    DOI 10.1007/s10541-005-0100-9
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  3. Article: Ca(2+)-dependent permeabilization of mitochondria and liposomes by palmitic and oleic acids: a comparative study.

    Belosludtsev, Konstantin N / Belosludtseva, Natalia V / Agafonov, Alexey V / Astashev, Maxim E / Kazakov, Alexey S / Saris, Nils-Erik L / Mironova, Galina D

    Biochimica et biophysica acta

    2014  Volume 1838, Issue 10, Page(s) 2600–2606

    Abstract: In the present work, we examine and compare the effects of saturated (palmitic) and unsaturated (oleic) fatty acids in relation to their ability to cause the Ca(2+)-dependent membrane permeabilization. The results obtained can be summarized as follows. ( ... ...

    Abstract In the present work, we examine and compare the effects of saturated (palmitic) and unsaturated (oleic) fatty acids in relation to their ability to cause the Ca(2+)-dependent membrane permeabilization. The results obtained can be summarized as follows. (1) Oleic acid (OA) permeabilizes liposomal membranes at much higher concentrations of Ca(2+) than palmitic acid (PA): 1mM versus 100μM respectively. (2) The OA/Ca(2+)-induced permeabilization of liposomes is not accompanied by changes in the phase state of lipid bilayer, in contrast to what is observed with PA and Ca(2+). (3) The addition of Ca(2+) to the PA-containing vesicles does not change their size; in the case of OA, it leads to the appearance of larger and smaller vesicles, with larger vesicles dominating. This can be interpreted as a result of fusion and fission of liposomes. (4) Like PA, OA is able to induce a Ca(2+)-dependent high-amplitude swelling of mitochondria, yet it requires higher concentrations of Ca(2+) (30 and 100μM for PA and OA respectively). (5) In contrast to PA, OA is unable to cause the Ca(2+)-dependent high-amplitude swelling of mitoplasts, suggesting that the cause of OA/Ca(2+)-induced permeability transition in mitochondria may be the fusion of the inner and outer mitochondrial membranes. (6) The presence of OA enhances PA/Ca(2+)-induced permeabilization of liposomes and mitochondria. The paper discusses possible mechanisms of PA/Ca(2+)- and OA/Ca(2+)-induced membrane permeabilization, the probability of these mechanisms to be realized in the cell, and their possible physiological role.
    MeSH term(s) Animals ; Calcium/chemistry ; Calcium/metabolism ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Liposomes/chemistry ; Liposomes/metabolism ; Mitochondria, Liver/chemistry ; Mitochondria, Liver/metabolism ; Mitochondrial Membrane Transport Proteins/chemistry ; Mitochondrial Membrane Transport Proteins/metabolism ; Mitochondrial Membranes/chemistry ; Mitochondrial Membranes/metabolism ; Oleic Acid/chemistry ; Oleic Acid/metabolism ; Oleic Acid/pharmacology ; Palmitic Acid/chemistry ; Palmitic Acid/metabolism ; Palmitic Acid/pharmacology ; Permeability ; Rats ; Rats, Wistar
    Chemical Substances Enzyme Inhibitors ; Liposomes ; Mitochondrial Membrane Transport Proteins ; mitochondrial permeability transition pore ; Oleic Acid (2UMI9U37CP) ; Palmitic Acid (2V16EO95H1) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2014-10
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamem.2014.06.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lymphopenia is associated with broad host response aberrations in community-acquired pneumonia.

    Doeleman, Susanne E / Reijnders, Tom D Y / Joosten, Sebastiaan C M / Schuurman, Alex R / van Engelen, Tjitske S R / Verhoeff, Jan / Léopold, Valentine / Brands, Xanthe / Haak, Bastiaan W / Prins, Jan M / Kanglie, Maadrika M N P / van den Berk, Inge A H / Faber, Daniël R / Douma, Renée A / Stoker, Jaap / Saris, Anno / Garcia Vallejo, Juan J / Wiersinga, W Joost / van der Poll, Tom

    The Journal of infection

    2024  Volume 88, Issue 4, Page(s) 106131

    Abstract: ... underexplored. We evaluated outcomes and immune features of patients with lymphopenic CAP (L-CAP), a previously ... phenotypes in 29 patients using spectral flow cytometry.: Results: L-CAP occurred in 45 patients (30.2 ... subdistribution hazard ratio 0.63; 95% confidence interval 0.45-0.88). L-CAP patients demonstrated a proportional ...

    Abstract Objectives: Lymphopenia at hospital admission occurs in over one-third of patients with community-acquired pneumonia (CAP), yet its clinical relevance and pathophysiological implications remain underexplored. We evaluated outcomes and immune features of patients with lymphopenic CAP (L-CAP), a previously described immunophenotype characterized by admission lymphocyte count <0.724 × 10
    Methods: Observational study in 149 patients admitted to a general ward for CAP. We measured 34 plasma biomarkers reflective of inflammation, endothelial cell responses, coagulation, and immune checkpoints. We characterized lymphocyte phenotypes in 29 patients using spectral flow cytometry.
    Results: L-CAP occurred in 45 patients (30.2%) and was associated with prolonged time-to-clinical-stability (median 5 versus 3 days), also when we accounted for competing events for reaching clinical stability and adjusted for baseline covariates (subdistribution hazard ratio 0.63; 95% confidence interval 0.45-0.88). L-CAP patients demonstrated a proportional depletion of CD4 T follicular helper cells, CD4 T effector memory cells, naïve CD8 T cells and IgG+ B cells. Plasma biomarker analyses indicated increased activation of the cytokine network and the vascular endothelium in L-CAP.
    Conclusions: L-CAP patients have a protracted clinical recovery course and a more broadly dysregulated host response. These findings highlight the prognostic and pathophysiological relevance of admission lymphopenia in patients with CAP.
    MeSH term(s) Humans ; Pneumonia ; Lymphopenia ; Community-Acquired Infections ; Inflammation ; Hospitalization
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2024.106131
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  5. Article ; Online: The inhibitors of antioxidant cell enzymes induce permeability transition in yeast mitochondria.

    Deryabina, Yulia / Isakova, Elena / Antipov, Alexey / Saris, Nils-Erik L

    Journal of bioenergetics and biomembranes

    2013  Volume 45, Issue 5, Page(s) 491–504

    Abstract: ... on mitochondrial membrane permeability transition in yeast cells. E. magnusii yeast was used in the study as it is the only ... fully characterized. At least five isoforms of SODs and only one isoform of CATs were found in the E ...

    Abstract In this study we investigated the effects of exogenous and endogenous oxidative stress on mitochondrial membrane permeability transition in yeast cells. E. magnusii yeast was used in the study as it is the only yeast strain possessing a natural high-capacity Са²⁺ transport system. The key reactive oxygen species (ROS) detoxifying enzymes in the yeast cells--catalases (CATs) and superoxide dismutases (SODs)--were fully characterized. At least five isoforms of SODs and only one isoform of CATs were found in the E. magnusii mitochondria. The assessment of the main properties of mitochondrial non-specific permeability under physiological conditions such as dynamics of the membrane potential (∆Ψ) and swelling in mitochondria showed that under physiological conditions classical inhibitors of CATs (ATZ--3-amino-1, 2, 4-triazole) and of SODs (DDC--diethyldithiocarbamate) caused irreversible decline in ∆Ψ in the yeast mitochondria. This decline was accelerated in the presence of 500 μM Са²⁺. The combined action of the inhibitors (ATZ + DDC) promoted moderate swelling in the isotonic medium, which was confirmed by transmission electron microscopy. Mitochondrial swelling in the cells exposed to antioxidant system inhibitors was accompanied by typical signs of early apoptosis, namely by chromatin margination and condensation, vacuolization of the cytosol, and damage of the plasma membrane. Here we showed, at both cellular and mitochondrial levels, that the deregulation of oxidant-scavenging enzymes directly leads to the opening of the mPTP, followed by induction of apoptotic markers in the whole yeast cells. Our studies are the first to clarify the highly contradictory data in the literature on mPTP in yeast mitochondria.
    MeSH term(s) Antioxidants/metabolism ; Calcium/metabolism ; Cell Membrane Permeability/drug effects ; Endomyces/enzymology ; Enzyme Inhibitors/pharmacology ; Membrane Potential, Mitochondrial/drug effects ; Microscopy, Electron, Transmission ; Mitochondria/drug effects ; Mitochondria/enzymology ; Mitochondria/metabolism ; Mitochondrial Membranes/drug effects ; Mitochondrial Membranes/metabolism ; Oxidative Stress/physiology ; Permeability ; Reactive Oxygen Species/metabolism
    Chemical Substances Antioxidants ; Enzyme Inhibitors ; Reactive Oxygen Species ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2013-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 198499-8
    ISSN 1573-6881 ; 0145-479X ; 0449-5705
    ISSN (online) 1573-6881
    ISSN 0145-479X ; 0449-5705
    DOI 10.1007/s10863-013-9511-2
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  6. Article: [Purification of the mitochondrial calcium uniporter from the beef heart and characterization of its properties].

    Gritsenko, E N / Kutyshenko, V P / Saris, N E-L / Wahlsten, M / Jokela, J / Mironova, G D

    Biofizika

    2010  Volume 55, Issue 5, Page(s) 803–808

    Abstract: A low-molecular-weight component (LMC) inducing selective transport of calcium across the bilayer lipid membrane has been isolated from mitochondria of the bovine heart by the method developed in our laboratory, which excludes the use of detergents and ... ...

    Abstract A low-molecular-weight component (LMC) inducing selective transport of calcium across the bilayer lipid membrane has been isolated from mitochondria of the bovine heart by the method developed in our laboratory, which excludes the use of detergents and proteolytic enzymes. It was shown that, in the presence of 10 mM CaCl2, LMC forms conduction channels in the membrane multiples of 5 pS. The specific inhibitor of mitochondrial calcium uniporter, ruthenium red, closes Ca2(+)-induced channels formed in the membrane by LMC. In the absence of calcium or in the presence of potassium ions only, the component is incapable of forming channels of conduction. It was shown using nuclear magnetic resonance that LMC is a complex consisting of lipids, amino acids, and sugars with a molecular weight of 1-2 kDa.
    MeSH term(s) Animals ; Calcium/chemistry ; Calcium Channel Blockers/chemistry ; Calcium Channels/chemistry ; Calcium Channels/isolation & purification ; Cations, Divalent ; Cattle ; Ion Transport ; Lipid Bilayers/chemistry ; Magnetic Resonance Spectroscopy ; Mitochondrial Proteins/chemistry ; Mitochondrial Proteins/isolation & purification ; Ruthenium Red/chemistry
    Chemical Substances Calcium Channel Blockers ; Calcium Channels ; Cations, Divalent ; Lipid Bilayers ; Mitochondrial Proteins ; mitochondrial calcium uniporter ; Ruthenium Red (11103-72-3) ; Calcium (SY7Q814VUP)
    Language Russian
    Publishing date 2010-09
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 280283-1
    ISSN 0006-3029
    ISSN 0006-3029
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  7. Article ; Online: Inhibition of free radical scavenging enzymes affects mitochondrial membrane permeability transition during growth and aging of yeast cells.

    Deryabina, Yulia / Isakova, Elena / Sekova, Varvara / Antipov, Alexey / Saris, Nils-Erik L

    Journal of bioenergetics and biomembranes

    2014  Volume 46, Issue 6, Page(s) 479–492

    Abstract: ... functioning while the E. magnusii yeasts grow and age. Moreover, this system provides unimpaired ...

    Abstract In this study, we investigated the change in the antioxidant enzymes activity, cell respiration, reactive oxygen species (ROS), and impairment of membrane mitochondria permeability in the Endomyces magnusii yeasts during culture growth and aging. We showed that the transition into stationary phase is the key tool to understanding interaction of these processes. This growth stage is distinguished by two-fold increase in ROS production and respiration rate as compared to those in the logarithmic phase. It results in induction of alternative oxidase (AO) in the stationary phase, decline of the main antioxidant enzymes activities, ROS-production, and mitochondria membrane permeability. Significant increase in the share of mitochondrial isoform of superoxide dismutase (SOD2) occurred in the stationary phase from 51.8% (24 h of cultivation) to 68.6% (48 h of cultivation). Upon blocking the essential ROS-scavenging enzymes, SODs and catalases (CATs) some heterogeneity of cell population was observed: 80-90% of cells displayed evident signs of early apoptosis (such as disorientation of mitochondria cristae, mitochondrial fragmentation and deformation of nuclear chromatine). However, 10-20% of the population were definitely healthy. It allowed to draw the conclusion that a complete system of cell antioxidant protection underlies normal mitochondria functioning while the E. magnusii yeasts grow and age. Moreover, this system provides unimpaired cell physiology under oxidative stress during culture aging in the stationary phase. Failures in mitochondria functions due to inhibition of ROS-scavenging enzymes of CATs and SODs could lead to damage of the cells and some signs of early apoptosis.
    MeSH term(s) Antioxidants/metabolism ; Apoptosis ; Cell Membrane Permeability ; Free Radical Scavengers/chemistry ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Reactive Oxygen Species ; Yeasts/growth & development
    Chemical Substances Antioxidants ; Free Radical Scavengers ; Reactive Oxygen Species
    Language English
    Publishing date 2014-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 198499-8
    ISSN 1573-6881 ; 0145-479X ; 0449-5705
    ISSN (online) 1573-6881
    ISSN 0145-479X ; 0449-5705
    DOI 10.1007/s10863-014-9582-8
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  8. Article ; Online: Ultrasound can differentiate inclusion body myositis from disease mimics.

    Leeuwenberg, Kristofoor E / van Alfen, Nens / Christopher-Stine, Lisa / Paik, Julie J / Tiniakou, Eleni / Mecoli, Christopher / Doorduin, Jonne / Saris, Christiaan G J / Albayda, Jemima

    Muscle & nerve

    2020  Volume 61, Issue 6, Page(s) 783–788

    Abstract: Introduction: The diagnosis of inclusion body myositis (IBM) can be challenging, and its presentation can be confused with other forms of myositis or neuromuscular disorders. In this study we evaluate the ability of quantitative muscle ultrasound to ... ...

    Abstract Introduction: The diagnosis of inclusion body myositis (IBM) can be challenging, and its presentation can be confused with other forms of myositis or neuromuscular disorders. In this study we evaluate the ability of quantitative muscle ultrasound to differentiate between IBM and mimicking diseases.
    Methods: Patients 50 years of age and older were included from two specialty centers. Muscle echogenicity and muscle thickness of four characteristically involved muscles in IBM were measured and compared with polymyositis (PM)/dermatomyositis (DM), other neuromuscular disorders, and healthy controls.
    Results: Echogenicity was higher and muscle thickness generally lower in all four muscles in IBM compared with PM/DM and normal controls. When comparing IBM with the comparator groups, the flexor digitorum profundus was the most discriminative muscle.
    Discussion: Ultrasound appears to be a good test to differentiate established IBM from PM/DM and neuromuscular controls, with value as a diagnostic tool for IBM.
    MeSH term(s) Aged ; Aged, 80 and over ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Myositis, Inclusion Body/diagnostic imaging ; Myositis, Inclusion Body/physiopathology ; Neuromuscular Diseases/diagnostic imaging ; Neuromuscular Diseases/physiopathology ; Retrospective Studies ; Ultrasonography, Interventional/methods ; Ultrasonography, Interventional/standards
    Language English
    Publishing date 2020-04-11
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.26875
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  9. Article ; Online: Health related quality of life in children with sickle cell disease: A systematic review and meta-analysis.

    Stokoe, Mehak / Zwicker, Hailey M / Forbes, Caitlin / Abu-Saris, Nur E L Huda / Fay-McClymont, Taryn B / Désiré, Naddley / Guilcher, Gregory M T / Singh, Gurpreet / Leaker, Michael / Yeates, Keith Owen / Russell, K Brooke / Cho, Sara / Carrels, Tessa / Rahamatullah, Iqra / Henry, Brianna / Dunnewold, Nicole / Schulte, Fiona S M

    Blood reviews

    2022  Volume 56, Page(s) 100982

    Abstract: This review had three aims: 1) describe the measures used to assess health-related quality of life (HRQL) in pediatric patients diagnosed with sickle cell disease (SCD); 2) document the biopsychosocial factors related to HRQL in pediatric patients ... ...

    Abstract This review had three aims: 1) describe the measures used to assess health-related quality of life (HRQL) in pediatric patients diagnosed with sickle cell disease (SCD); 2) document the biopsychosocial factors related to HRQL in pediatric patients diagnosed with SCD; and 3) complete a meta-analysis comparing HRQL in pediatric patients diagnosed with SCD to healthy controls. Included studies were published in English, quantitatively assessed HRQL as a primary aim, in both SCD and controls, and included participants between 0 and 21 years of age. The final review included 66 articles, with a total of 8642 participants with SCD, 4 months-21 years of age, and 62,458 controls, 5-27 years of age. HRQL was predominately measured using the Pediatric Quality of Life Inventory Generic Core and Sickle Cell Disease Module. Meta-analyses revealed children with SCD had significantly worse HRQL compared to healthy controls (standardized mean difference = -0.93, 95% CI = -1.25, -0.61, p < 0.00001). Worse HRQL was associated with more severe SCD, female sex, and pain. The findings indicate that children with SCD are at risk for worse HRQL compared to their healthy peers and their HRQL may be impacted by several biopsychosocial factors. Future research is needed to examine how sociocultural factors uniquely impact this population and their overall quality of life.
    MeSH term(s) Child ; Humans ; Female ; Quality of Life/psychology ; Anemia, Sickle Cell/complications ; Health Status
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2022.100982
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  10. Article ; Online: Ultrafast vascular strain compounding using plane wave transmission.

    Hansen, H H G / Saris, A E C M / Vaka, N R / Nillesen, M M / de Korte, C L

    Journal of biomechanics

    2014  Volume 47, Issue 4, Page(s) 815–823

    Abstract: ... ratio (SNR(e) and CNR(e)) increased with 2.1 dB and 3.7 dB radially, and 5.6 dB and 16.2dB ...

    Abstract Deformations of the atherosclerotic vascular wall induced by the pulsating blood can be estimated using ultrasound strain imaging. Because these deformations indirectly provide information on mechanical plaque composition, strain imaging is a promising technique for differentiating between stable and vulnerable atherosclerotic plaques. This paper first explains 1-D radial strain estimation as applied intravascularly in coronary arteries. Next, recent methods for noninvasive vascular strain estimation in a transverse imaging plane are discussed. Finally, a compounding technique that our group recently developed is explained. This technique combines motion estimates of subsequently acquired focused ultrasound images obtained at various insonification angles. However, because the artery moves and deforms during the multi-angle acquisition, errors are introduced when compounding. Recent advances in computational power have enabled plane wave ultrasound acquisition, which allows 100 times faster image acquisition and thus might resolve the motion artifacts. In this paper the performance of strain imaging using plane wave compounding is investigated using simulations of an artery with a vulnerable plaque and experimental data of a two-layered vessel phantom. The results show that plane wave compounding outperforms 0° focused strain imaging. For the simulations, the root mean squared error reduced by 66% and 50% for radial and circumferential strain, respectively. For the experiments, the elastographic signal-to-noise and contrast-to-noise ratio (SNR(e) and CNR(e)) increased with 2.1 dB and 3.7 dB radially, and 5.6 dB and 16.2dB circumferentially. Because of the high frame rate, the plane wave compounding technique can even be further optimized and extended to 3D in future.
    MeSH term(s) Artifacts ; Carotid Arteries/diagnostic imaging ; Carotid Arteries/physiology ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/physiopathology ; Computer Simulation ; Elasticity Imaging Techniques/methods ; Humans ; Models, Cardiovascular ; Phantoms, Imaging ; Plaque, Atherosclerotic/diagnostic imaging ; Plaque, Atherosclerotic/physiopathology ; Pulsatile Flow/physiology ; Signal-To-Noise Ratio ; Stress, Mechanical
    Language English
    Publishing date 2014-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218076-5
    ISSN 1873-2380 ; 0021-9290
    ISSN (online) 1873-2380
    ISSN 0021-9290
    DOI 10.1016/j.jbiomech.2014.01.015
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