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Article ; Online: A Prospective Open-Label Dose-Response Study to Correct Vitamin D Deficiency in Cirrhosis.

Bowman, Chip A / Bichoupan, Kian / Posner, Shai / Schonfeld, Emily / Pappas, Alexis / Woodward, Mark / Schiano, Thomas / Branch, Andrea D

Digestive diseases and sciences

2024 Volume 69, Issue 3, Page(s) 1015–1024

Abstract: Background: Patients with advanced liver disease often have vitamin D deficiency, but the daily ... dosages of vitamin D: Objective: We aimed to establish the dose-response relationship between vitamin D ... Design: An open-label study of orally-administered vitamin D: Results: Among the 48 patients, 39 (81 ...

Abstract	Background: Patients with advanced liver disease often have vitamin D deficiency, but the daily dosages of vitamin D Objective: We aimed to establish the dose-response relationship between vitamin D Design: An open-label study of orally-administered vitamin D Results: Among the 48 patients, 39 (81%) had 25(OH)D > 20 ng/mL while on supplements, and none experienced hypercalcemia. The magnitude of the increase in 25(OH)D was approximately twofold greater in patients receiving the higher dose. The mean incremental increase was 5.1 ng/ml ± 3.9 of 25(OH)D per 1000 IU/d of vitamin D Conclusions: A two-tiered dosing regimen of daily oral vitamin D
MeSH term(s)	Adult ; Humans ; Prospective Studies ; Cholecalciferol ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/drug therapy ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/chemically induced ; Dietary Supplements ; Vitamin D
Chemical Substances	Cholecalciferol (1C6V77QF41) ; Vitamin D (1406-16-2)
Language	English
Publishing date	2024-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-023-08224-5
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Article ; Online: Supporting data for impact of filler composition on mechanical and dynamic response of 3-D printed silicone-based nanocomposite elastomers.

Talley, Samantha J / Branch, Brittany / Welch, Cynthia F / Park, Chi Hoon / Dattelbaum, Dana M / Lee, Kwan-Soo

Data in brief

2020 Volume 32, Page(s) 106240

Abstract: ... in direct ink write (DIW) 3-D printing resins. The data reported herein supports interpretation and ... of 3-D Printed Silicone-based Nanocomposite Elastomers" [1]. The datasheet describes ...

Abstract	This research reports on the physical and mechanical effects of various filler materials used in direct ink write (DIW) 3-D printing resins. The data reported herein supports interpretation and discussion provided in the research article "Impact of Filler Composition on Mechanical and Dynamic Response of 3-D Printed Silicone-based Nanocomposite Elastomers" [1]. The datasheet describes the model structures and the interaction energies between the fillers and the other components by using Molecular Dynamics (MD) simulations. This report includes mechanical responses of single-cubic (SC) and face-centered tetragonal (FCT) structures printed using new DIW resin formulations (polydimethylsiloxane-based silicones filled with aluminum oxide, graphite, or titanium dioxide). Using MD simulations and mechanical data, the overall flexibility and interactions between resin components are fully characterized.
Language	English
Publishing date	2020-09-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2020.106240
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Article ; Online: Classical and emerging roles of vitamin D in hepatitis C virus infection.

Gutierrez, Julio A / Parikh, Neil / Branch, Andrea D

Seminars in liver disease

2011 Volume 31, Issue 4, Page(s) 387–398

Abstract: According to the Institute of Medicine, the risk of clinically significant vitamin D deficiency ... increases at 25-hydroxyvitamin D levels below 20 ng/mL. By this standard, most cirrhotic hepatitis C virus ... HCV-) positive patients and many noncirrhotic patients are vitamin D-deficient. The high prevalence ...

Abstract	According to the Institute of Medicine, the risk of clinically significant vitamin D deficiency increases at 25-hydroxyvitamin D levels below 20 ng/mL. By this standard, most cirrhotic hepatitis C virus- (HCV-) positive patients and many noncirrhotic patients are vitamin D-deficient. The high prevalence of vitamin D deficiency among HCV patients is a cause for concern for several specific reasons. Classic studies established the importance of vitamin D and calcium in maintaining bone. Vitamin D's beneficial effects on bone are likely to be vital for HCV-infected patients because these individuals have a high prevalence of low bone mineral density. Many pharmaceutical agents reduce bone density and exposure to these drugs may increase bone disease in HCV-positive patients. Bone loss occurs following liver transplantation and bone density is often low in patients with HIV/HCV co-infection who are on combination antiretroviral therapy. Some evidence suggests that ribavirin reduces bone density, underscoring the special need to monitor vitamin D in patients receiving HCV treatment and to prescribe supplements, as appropriate. In addition to its role in calcium metabolism, vitamin D is also an immune modulator that reduces inflammation while enhancing protective immune responses. Higher vitamin D levels are associated with less liver fibrosis and less inflammation in HCV patients. Recent studies show that low vitamin D levels are associated with treatment failure among HCV-infected patients receiving pegylated-interferon and ribavirin. If confirmed, these findings will provide an additional reason to ensure adequate levels of vitamin D. Information about how to monitor vitamin D status and how to use vitamin D supplements most effectively in HCV-infected patients is provided.
MeSH term(s)	Antiviral Agents/adverse effects ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/metabolism ; Hepacivirus/immunology ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/immunology ; Hepatitis C, Chronic/metabolism ; Humans ; Interferons/adverse effects ; Liver Neoplasms/complications ; Liver Neoplasms/metabolism ; Osteoporosis/complications ; Osteoporosis/metabolism ; Ribavirin/adverse effects ; Vitamin D/pharmacology ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/immunology ; Vitamin D Deficiency/metabolism ; Vitamins/pharmacology ; Vitamins/therapeutic use
Chemical Substances	Antiviral Agents ; Vitamins ; Vitamin D (1406-16-2) ; Ribavirin (49717AWG6K) ; Interferons (9008-11-1)
Language	English
Publishing date	2011-12-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	603177-8
ISSN	1098-8971 ; 0272-8087
ISSN (online)	1098-8971
ISSN	0272-8087
DOI	10.1055/s-0031-1297927
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Article ; Online: Vitamin D for your patients with chronic hepatitis C?

Rahman, Adeeb H / Branch, Andrea D

Journal of hepatology

2013 Volume 58, Issue 1, Page(s) 184–189

Abstract: Vitamin D is increasingly becoming recognized as an important physiological regulator ... evidence highlights the prevalence and risks of vitamin D deficiency in patients suffering from chronic ... hepatitis C infection, and vitamin D supplementation has been proposed as an adjunct to current standards ...

Abstract	Vitamin D is increasingly becoming recognized as an important physiological regulator with pleiotropic functions outside of its classical role in skeletal homeostasis. A growing body of clinical evidence highlights the prevalence and risks of vitamin D deficiency in patients suffering from chronic hepatitis C infection, and vitamin D supplementation has been proposed as an adjunct to current standards of care. This review considers the experimental evidence for the anti-inflammatory, antifibrotic and antiviral effects of vitamin D, and discusses the therapeutic potential of vitamin D supplementation to protect against liver disease progression and improve responses to treatment.
MeSH term(s)	Bone Density Conservation Agents/therapeutic use ; Bone Diseases/drug therapy ; Hepatitis C, Chronic/drug therapy ; Humans ; Vitamin D/therapeutic use ; Vitamin D Deficiency/drug therapy
Chemical Substances	Bone Density Conservation Agents ; Vitamin D (1406-16-2)
Language	English
Publishing date	2013-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2012.07.026
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Article: TUBERCULIN P.P.D. (PURIFIED PROTEIN DERIVATIVE).

Branch, A

Canadian Medical Association journal

2010 Volume 32, Issue 5, Page(s) 550–551

Language	English
Publishing date	2010-03-22
Publishing country	Canada
Document type	Journal Article
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
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Article ; Online: Reduction of disulfide bonds within anti-D results in enhanced Fcgamma receptor blockade.

Kruspe, Andrew S / Katsman, Yulia / Sakac, Darinka / Chagneau, Cécile / Glistvain, Anna / Langler, Richard F / Branch, Donald R

Transfusion

2009 Volume 49, Issue 5, Page(s) 928–936

Abstract: ... of altering immunoglobulin anti-D structure resulting in an increased efficacy of the chemically modified anti ... D to inhibit Fcgamma receptor (FcgammaR)-mediated phagocytosis. If successful, this would provide ... in immunoglobulin therapies for immune cytopenias.: Study design and methods: Anti-D that was shown to block 50 percent ...

Abstract	Background: We have investigated whether chemicals known to disrupt disulfide bonds are capable of altering immunoglobulin anti-D structure resulting in an increased efficacy of the chemically modified anti-D to inhibit Fcgamma receptor (FcgammaR)-mediated phagocytosis. If successful, this would provide a rationale to explore this mechanism of enhancing FcgammaR blockade for future use in immunoglobulin therapies for immune cytopenias. Study design and methods: Anti-D that was shown to block 50 percent of the FcgammaR-mediated phagocytosis of opsonized red blood cells (RBCs) using a monocyte monolayer assay (MMA) was combined with two different thiol-containing compounds, dithiothreitol (DTT) or p-toluenesulfonylmethyl mercaptan, with or without treatment with iodoacetamide, and allowed to react. Excess chemical was removed by extensive dialysis. FcgammaR blockade was assessed by MMA with dialyzed, untreated, or chemically treated anti-D using both D+ and D- opsonized target RBCs. Toxicity was determined by fluorescence-activated cell sorting. Aggregates and oligomerization of chemically treated anti-D were examined using gel filtration-high pressure liquid chromatography. Results: Using disulfide-reducing compounds to chemically modify anti-D significantly increases the efficacy of the anti-D to induce an FcgammaR blockade and decrease phagocytosis in vitro of opsonized D+ or D- RBCs. This effect was shown not due to unbound residual chemical, toxicity, or formation of immunoglobulin G oligomers. S-alkylation was required when using low concentrations of reducing compound. Conclusion: Our results demonstrate that irreversible reduction of interchain disulfide bonds within the immunoglobulin anti-D results in a significantly increased efficacy to inhibit FcgammaR-mediated phagocytosis regardless of opsonized target cell. With the use of this strategy, more effective and less expensive immunoglobulin treatment for immune cytopenias such as immune thrombocytopenic purpura or autoimmune hemolytic anemia may be developed.
MeSH term(s)	Autoimmune Diseases/therapy ; Cells, Cultured ; Disulfides/metabolism ; Drug Design ; Hematologic Diseases ; Humans ; Immunoglobulins/therapeutic use ; Isoantibodies/chemistry ; Isoantibodies/pharmacology ; Isoantibodies/therapeutic use ; Oxidation-Reduction ; Phagocytosis/drug effects ; Receptors, IgG/antagonists & inhibitors ; Rho(D) Immune Globulin
Chemical Substances	Disulfides ; Immunoglobulins ; Isoantibodies ; RHO(D) antibody ; Receptors, IgG ; Rho(D) Immune Globulin
Language	English
Publishing date	2009-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/j.1537-2995.2008.02052.x
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Article ; Online: Supporting data for impact of filler composition on mechanical and dynamic response of 3-D printed silicone-based nanocomposite elastomers

Samantha J. Talley / Brittany Branch / Cynthia F. Welch / Chi Hoon Park / Dana M. Dattelbaum / Kwan-Soo Lee

Data in Brief, Vol 32, Iss , Pp 106240- (2020)

2020

Abstract: ... in direct ink write (DIW) 3-D printing resins. The data reported herein supports interpretation and ... of 3-D Printed Silicone-based Nanocomposite Elastomers” [1]. The datasheet describes ...

Abstract	This research reports on the physical and mechanical effects of various filler materials used in direct ink write (DIW) 3-D printing resins. The data reported herein supports interpretation and discussion provided in the research article “Impact of Filler Composition on Mechanical and Dynamic Response of 3-D Printed Silicone-based Nanocomposite Elastomers” [1]. The datasheet describes the model structures and the interaction energies between the fillers and the other components by using Molecular Dynamics (MD) simulations. This report includes mechanical responses of single-cubic (SC) and face-centered tetragonal (FCT) structures printed using new DIW resin formulations (polydimethylsiloxane-based silicones filled with aluminum oxide, graphite, or titanium dioxide). Using MD simulations and mechanical data, the overall flexibility and interactions between resin components are fully characterized.
Keywords	3-D printing ; Nanocomposite elastomer ; Molecular dynamics simulation ; Dynamic response ; Silicone ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: Supporting data for impact of filler composition on mechanical and dynamic response of 3-D printed silicone-based nanocomposite elastomers

Talley, Samantha J. / Branch, Brittany / Welch, Cynthia F. / Park, Chi Hoon / Dattelbaum, Dana M. / Lee, Kwan-Soo

Data in Brief. 2020 Oct., v. 32

2020

Abstract	This research reports on the physical and mechanical effects of various filler materials used in direct ink write (DIW) 3-D printing resins. The data reported herein supports interpretation and discussion provided in the research article “Impact of Filler Composition on Mechanical and Dynamic Response of 3-D Printed Silicone-based Nanocomposite Elastomers” [1]. The datasheet describes the model structures and the interaction energies between the fillers and the other components by using Molecular Dynamics (MD) simulations. This report includes mechanical responses of single-cubic (SC) and face-centered tetragonal (FCT) structures printed using new DIW resin formulations (polydimethylsiloxane-based silicones filled with aluminum oxide, graphite, or titanium dioxide). Using MD simulations and mechanical data, the overall flexibility and interactions between resin components are fully characterized.
Keywords	aluminum oxide ; graphene ; molecular dynamics ; nanocomposites ; titanium dioxide
Language	English
Dates of publication	2020-10
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2020.106240
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Vitamin D status of human immunodeficiency virus-positive patients with advanced liver disease enrolled in the solid organ transplantation in HIV: multi-site study.

Branch, Andrea D / Barin, Burc / Rahman, Adeeb / Stock, Peter / Schiano, Thomas D

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

2013 Volume 20, Issue 2, Page(s) 156–164

Abstract: An optimal vitamin D status may benefit liver transplantation (LT) patients. Higher levels of 25 ... hydroxyvitamin D [25(OH)D] mitigate steroid-induced bone loss after LT, correlate with better hepatitis C virus ... treatment responses, and increase graft survival. This study investigated 25(OH)D levels and assessed ...

Abstract	An optimal vitamin D status may benefit liver transplantation (LT) patients. Higher levels of 25-hydroxyvitamin D [25(OH)D] mitigate steroid-induced bone loss after LT, correlate with better hepatitis C virus treatment responses, and increase graft survival. This study investigated 25(OH)D levels and assessed strategies for vitamin D deficiency prevention in human immunodeficiency virus (HIV)-positive patients with advanced liver disease who were enrolled in the Solid Organ Transplantation in HIV: Multi-Site Study. 25(OH)D was measured in banked specimens from 154 LT candidates/recipients with the DiaSorin assay; deficiency was defined as a 25(OH)D level < 20 ng/mL. Information about vitamin D supplement use after LT was obtained from medication logs and via surveys. Logistic regression, Cox regression, and linear repeated measures analyses were performed with SAS software. We found that none of the 17 academic medical centers in the United States routinely recommended vitamin D supplements before LT, and only a minority (4/17) recommended vitamin D supplements to all patients after LT. Seventy-one percent of the 139 patients with pre-LT values had vitamin D deficiency, which was significantly associated with cirrhosis (P = 0.01) but no other variable. The vitamin D status improved modestly after LT; however, the status was deficient for 40% of the patients 1 year after LT. In a multivariate linear repeated measures model, a higher pre-LT 25(OH)D level (P < 0.001), specimen collection in the summer (P < 0.001), a routine vitamin D supplementation strategy after LT (P < 0.001), and the time elapsing since LT (P = 0.01) were significantly associated with increases in the post-LT 25(OH)D level; black race was associated with a decreased level (P = 0.02). In conclusion, the majority of patients awaiting LT were vitamin D deficient, and approximately half were vitamin D deficient after LT. More extensive use of vitamin D supplements, more sun exposure, or both are needed to prevent this deficiency in HIV-positive LT candidates and recipients.
MeSH term(s)	Adult ; African Americans ; Dietary Supplements ; Ethnic Groups ; Female ; HIV Infections/complications ; Hepatitis C/complications ; Humans ; Liver Cirrhosis/complications ; Liver Failure/blood ; Liver Failure/complications ; Liver Transplantation ; Male ; Middle Aged ; Multivariate Analysis ; Proportional Hazards Models ; Prospective Studies ; Recurrence ; Regression Analysis ; Retrospective Studies ; Seasons ; Vitamin D/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/prevention & control
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2013-12-12
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, N.I.H., Extramural
ZDB-ID	2006866-9
ISSN	1527-6473 ; 1527-6465
ISSN (online)	1527-6473
ISSN	1527-6465
DOI	10.1002/lt.23784
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Article: Classical and Emerging Roles of Vitamin D in Hepatitis C Virus Infection

Gutierrez, Julio A. / Parikh, Neil / Branch, Andrea D.

Seminars in Liver Disease

2011 Volume 31, Issue 04, Page(s) 387–398

Abstract	According to the Institute of Medicine, the risk of clinically significant vitamin D deficiency increases at 25-hydroxyvitamin D levels below 20 ng/mL. By this standard, most cirrhotic hepatitis C virus- (HCV-) positive patients and many noncirrhotic patients are vitamin D-deficient. The high prevalence of vitamin D deficiency among HCV patients is a cause for concern for several specific reasons. Classic studies established the importance of vitamin D and calcium in maintaining bone. Vitamin D's beneficial effects on bone are likely to be vital for HCV-infected patients because these individuals have a high prevalence of low bone mineral density. Many pharmaceutical agents reduce bone density and exposure to these drugs may increase bone disease in HCV-positive patients. Bone loss occurs following liver transplantation and bone density is often low in patients with HIV/HCV co-infection who are on combination antiretroviral therapy. Some evidence suggests that ribavirin reduces bone density, underscoring the special need to monitor vitamin D in patients receiving HCV treatment and to prescribe supplements, as appropriate. In addition to its role in calcium metabolism, vitamin D is also an immune modulator that reduces inflammation while enhancing protective immune responses. Higher vitamin D levels are associated with less liver fibrosis and less inflammation in HCV patients. Recent studies show that low vitamin D levels are associated with treatment failure among HCV-infected patients receiving pegylated-interferon and ribavirin. If confirmed, these findings will provide an additional reason to ensure adequate levels of vitamin D. Information about how to monitor vitamin D status and how to use vitamin D supplements most effectively in HCV-infected patients is provided.
Keywords	Hepatitis C virus ; vitamin D ; hepatocellular carcinoma ; bone mineral density ; fracture ; fibrosis ; sustained virologic response ; interferon ; ribavirin
Language	English
Publishing date	2011-11-01
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	603177-8
ISSN	1098-8971 ; 0272-8087
ISSN (online)	1098-8971
ISSN	0272-8087
DOI	10.1055/s-0031-1297927
Database	Thieme publisher's database

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