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Article ; Online: Update on incidence of inpatient tubal ligation and long-acting reversible contraception in the United States.

Fang, Nancy Z / Westhoff, Carolyn L

American journal of obstetrics and gynecology

2022 Volume 227, Issue 3, Page(s) 477.e1–477.e7

Abstract: Background: Inpatient insertion of long-acting reversible contraception and immediate postpartum tubal ligation allow women to initiate highly effective contraception before hospital discharge.: Objective: We measured rates of intrauterine device and ...

Abstract	Background: Inpatient insertion of long-acting reversible contraception and immediate postpartum tubal ligation allow women to initiate highly effective contraception before hospital discharge. Objective: We measured rates of intrauterine device and contraceptive implant initiation and tubal ligations performed during delivery hospitalizations from 2016 to 2018 from a representative sample of US hospital discharges. Study design: We used the 2016 to 2018 National Inpatient Sample database, a 20% sample of all community hospital discharges in the United States, to identify delivery hospitalizations with concomitant intrauterine device insertion, contraceptive implant insertion, or tubal ligation. We performed weighted multivariable logistic regression to examine associations between possible predictors (age, delivery mode, payer, geographic region, and year) and odds of long-acting reversible contraception and tubal ligation, and to compare characteristics of users. Results: This sample included 2,216,638 discharges, representing 20% of 11,083,180 delivery hospitalizations across the United States. Intrauterine device insertion increased from 2.2 per 1000 deliveries (2016) to approximately 5.0 per 1000 deliveries (2018; P<.0001); implant insertion increased from 0.3 per 1000 deliveries (2016) to 2.5 per 1000 deliveries (2018; P<.0001); tubal ligation procedures decreased (64.2 to 62.1 per 1000 deliveries; P<.0001). Women who underwent a cesarean delivery had higher odds of having a tubal ligation than those who had a vaginal delivery (adjusted odds ratio, 8.83; 95% confidence interval, 8.73-8.97). Women aged <25 years had 7 times higher odds of receiving long-acting reversible contraception than of receiving tubal ligation (adjusted odds ratio, 7.38; 95% confidence interval, 6.90-7.90). Women with public insurance had almost 5 times the odds of receiving long-acting reversible contraception compared with those with commercial insurance (adjusted odds ratio, 4.83; 95% confidence interval, 4.59-5.06). Conclusion: Rates of long-acting reversible contraception insertion continue to increase while the rates of inpatient postpartum tubal ligations slowly decline. Variations in patient characteristics are associated with receiving long-acting reversible contraception or tubal ligation.
MeSH term(s)	Adult ; Contraception/methods ; Contraceptive Agents, Female ; Female ; Humans ; Incidence ; Inpatients ; Intrauterine Devices ; Long-Acting Reversible Contraception ; Pregnancy ; Sterilization, Tubal ; United States/epidemiology
Chemical Substances	Contraceptive Agents, Female
Language	English
Publishing date	2022-05-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2022.05.021
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Article ; Online: A hospital-based COVID-19 abortion case in the early phase of the pandemic.

Fang, Nancy Z / Castaño, Paula M / Davis, Anne

Contraception

2020 Volume 102, Issue 2, Page(s) 137–138

Abstract: In this case report we discuss changes in hospital-based abortion care due to the COVID-19 pandemic. We highlight our experience with exposure to an asymptomatic COVID-19 positive patient. We hope early lessons from the United States epicenter will guide ...

Abstract	In this case report we discuss changes in hospital-based abortion care due to the COVID-19 pandemic. We highlight our experience with exposure to an asymptomatic COVID-19 positive patient. We hope early lessons from the United States epicenter will guide clinicians providing abortion care during this and future pandemics.
MeSH term(s)	Abortion, Induced ; Adult ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/therapy ; Asymptomatic Infections ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Deep Sedation ; Disease Progression ; Female ; Hospitalization ; Humans ; Length of Stay ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Pregnancy ; Pregnancy Complications, Hematologic/therapy ; Pregnancy Complications, Infectious ; SARS-CoV-2 ; Time-to-Treatment
Keywords	covid19
Language	English
Publishing date	2020-05-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	80106-9
ISSN	1879-0518 ; 0010-7824
ISSN (online)	1879-0518
ISSN	0010-7824
DOI	10.1016/j.contraception.2020.05.005
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Article ; Online: A hospital-based COVID-19 abortion case in the early phase of the pandemic

Fang, Nancy Z. / Castaño, Paula M. / Davis, Anne

Contraception

2020 Volume 102, Issue 2, Page(s) 137–138

Keywords	Obstetrics and Gynaecology ; Reproductive Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	80106-9
ISSN	0010-7824
ISSN	0010-7824
DOI	10.1016/j.contraception.2020.05.005
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Article ; Online: Satisfaction with medication abortion and marijuana use: A prospective cohort study.

Fang, Nancy Z / Guiahi, Maryam / Lazorwitz, Aaron

Contraception

2020 Volume 102, Issue 1, Page(s) 30–33

Abstract: Objectives: This exploratory study compared self-reported satisfaction rates and pain scores between patients who used marijuana during their medication abortion versus non-users.: Study design: We recruited medication abortion patients at a ... ...

Abstract	Objectives: This exploratory study compared self-reported satisfaction rates and pain scores between patients who used marijuana during their medication abortion versus non-users. Study design: We recruited medication abortion patients at a University-affiliated abortion clinic in Denver, Colorado. Participants completed a pre-abortion questionnaire, pain diary, and follow-up survey that assessed satisfaction with pain control, symptoms, and abortion experience. Using medians test, we compared the sums of median satisfaction scores between patients who used marijuana versus non-users. Based on diary entries, we also compared reported pain over 24 h after misoprostol (area under the curve [AUC]) between cohorts. Results: We enrolled 51 participants; 16 marijuana users and 35 non-marijuana users. Marijuana users and non-users had similar sums of median satisfaction scores (22 vs. 20 out of 30, p = 0.90) and median question-specific satisfaction scores (range 7-8 vs. 6.5-8, p = 0.6-1.0). Sixteen marijuana users (100%) and 20 (57%) non-users completed their pain diary; median AUCs for pain were similar (65.0 vs. 59.5, p = 0.73). Thirteen (81%) patients subjectively correlated marijuana use with pain reduction, seven (44%) with anxiety reduction, and six (38%) with nausea/vomiting improvement. Conclusions: We found no significant difference in measures of medication abortion satisfaction and pain when comparing marijuana users to non-users. However, marijuana users often attributed symptom improvement during their medication abortion to marijuana use. Implications: Until randomized studies are available, clinicians can counsel patients that marijuana use may not necessarily affect satisfaction or pain with medication abortion. It remains unknown whether marijuana has potential benefits in a marijuana-naïve population undergoing medication abortion. Future studies should explore the role that marijuana and its derivatives may play for pain and side effect management during medication abortion among marijuana-naïve patients.
MeSH term(s)	Abortion, Induced ; Female ; Humans ; Marijuana Use ; Misoprostol ; Personal Satisfaction ; Pregnancy ; Prospective Studies
Chemical Substances	Misoprostol (0E43V0BB57)
Language	English
Publishing date	2020-04-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80106-9
ISSN	1879-0518 ; 0010-7824
ISSN (online)	1879-0518
ISSN	0010-7824
DOI	10.1016/j.contraception.2020.03.008
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Article ; Online: Female permanent contraception trends and updates.

Fang, Nancy Z / Advaney, Simone P / Castaño, Paula M / Davis, Anne / Westhoff, Carolyn L

American journal of obstetrics and gynecology

2021 Volume 226, Issue 6, Page(s) 773–780

Abstract: Permanent contraception remains one of the most popular methods of contraception worldwide. This article has reviewed recent literature related to demographic characteristics of users, prevalence of use and trends over time, surgical techniques, and ... ...

Abstract	Permanent contraception remains one of the most popular methods of contraception worldwide. This article has reviewed recent literature related to demographic characteristics of users, prevalence of use and trends over time, surgical techniques, and barriers to obtain the procedure. We have emphasized the patient's perspective as a key element of choosing permanent contraception. This review has incorporated sections on salpingectomy, hysteroscopy, unmet need, impact of policies at religiously affiliated institutions, and reproductive coercion.
MeSH term(s)	Contraception/methods ; Female ; Humans ; Hysteroscopy/methods ; Pregnancy ; Reproduction ; Salpingectomy/methods ; Sterilization, Tubal/methods
Language	English
Publishing date	2021-12-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2021.12.261
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Article: A hospital-based COVID-19 abortion case in the early phase of the pandemic

Fang, Nancy Z / Castaño, Paula M / Davis, Anne

Contraception

Abstract	In this case report we discuss changes in hospital-based abortion care due to the COVID-19 pandemic. We highlight our experience with exposure to an asymptomatic COVID-19 positive patient. We hope early lessons from the United States epicenter will guide clinicians providing abortion care during this and future pandemics.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32416144
Database	COVID19

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Article ; Online: Factors associated with initiating long-acting reversible contraception immediately after first-trimester abortion.

Fang, Nancy Z / Sheeder, Jeanelle / Teal, Stephanie B

Contraception

2018 Volume 98, Issue 4, Page(s) 292–295

Abstract: Objective: The objective was to identify predictors of postabortion long-acting reversible contraception (LARC) initiation to increase providers' understanding of motivators of contraceptive choices.: Study design: We prospectively enrolled a cohort ... ...

Abstract	Objective: The objective was to identify predictors of postabortion long-acting reversible contraception (LARC) initiation to increase providers' understanding of motivators of contraceptive choices. Study design: We prospectively enrolled a cohort of women having abortions at <13 weeks' gestational age who were eligible to receive no-cost contraceptive methods immediately postprocedure (N=1662) to evaluate the demographic and reproductive factors associated with choosing and receiving a long-acting contraceptive versus a short-acting method. We used stepwise logistic regression to identify independent predictors of LARC initiation. Results: During the study period, 1072 (64.5%) chose an immediate postabortion LARC method and 590 (35.5%) chose another method. Compared to the group of women who chose a non-LARC method, women who chose a LARC method were more likely to have a surgical abortion and were younger, more likely to be Hispanic, more likely to live greater than 70 miles from the clinic, more likely to have a nonurban address and less likely to have had a prior abortion. Conclusions: We found that the differences in the demographic and reproductive factors of women choosing and receiving postabortion LARC were those which have been shown to be associated with difficulty in accessing contraception. Providers should offer a full range of contraceptive options to women immediately postabortion. Implications: Postabortion LARC is more likely to be utilized by women from groups who have been shown to have difficulty accessing traditional family planning clinical care: those who are young, do not live in a city and are from groups with recognized health disparities. Offering postabortion LARC increases the options for these women.
MeSH term(s)	Abortion, Induced ; Adolescent ; Adult ; Female ; Humans ; Long-Acting Reversible Contraception/statistics & numerical data ; Middle Aged ; Pregnancy ; Pregnancy Trimester, First ; Prospective Studies ; Young Adult
Language	English
Publishing date	2018-06-11
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	80106-9
ISSN	1879-0518 ; 0010-7824
ISSN (online)	1879-0518
ISSN	0010-7824
DOI	10.1016/j.contraception.2018.06.001
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Article ; Online: The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis

Rawad Hodeify / Maya Dib / Ethel Alcantara-Adap / Raphael Courjaret / Nancy Nader / Cleo Z. Reyes / Ayat S. Hammad / Satanay Hubrack / Fang Yu / Khaled Machaca

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 12

Abstract: Abstract Regulation of Ca2+ signaling is critical for the progression of cell division, especially during meiosis to prepare the egg for fertilization. The primary Ca2+ influx pathway in oocytes is Store-Operated Ca2+ Entry (SOCE). SOCE is tightly ... ...

Abstract	Abstract Regulation of Ca2+ signaling is critical for the progression of cell division, especially during meiosis to prepare the egg for fertilization. The primary Ca2+ influx pathway in oocytes is Store-Operated Ca2+ Entry (SOCE). SOCE is tightly regulated during meiosis, including internalization of the SOCE channel, Orai1. Orai1 is a four-pass membrane protein with cytosolic N- and C-termini. Orai1 internalization requires a caveolin binding motif (CBM) in the N-terminus as well as the C-terminal cytosolic domain. However, the molecular determinant for Orai1 endocytosis in the C-terminus are not known. Here we show that the Orai1 C-terminus modulates Orai1 endocytosis during meiosis through a structural motif that is based on the strength of the C-terminal intersubunit coiled coil (CC) domains. Deletion mutants show that a minimal C-terminal sequence after transmembrane domain 4 (residues 260–275) supports Orai1 internalization. We refer to this region as the C-terminus Internalization Handle (CIH). Access to CIH however is dependent on the strength of the intersubunit CC. Mutants that increase the stability of the coiled coil prevent internalization independent of specific mutation. We further used human and Xenopus Orai isoforms with different propensity to form C-terminal CC and show a strong correlation between the strength of the CC and Orai internalization. Furthermore, Orai1 internalization does not depend on clathrin, flotillin or PIP2. Collectively these results argue that Orai1 internalization requires both the N-terminal CBM and C-terminal CIH where access to CIH is controlled by the strength of intersubunit C-terminal CC.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis.

Hodeify, Rawad / Dib, Maya / Alcantara-Adap, Ethel / Courjaret, Raphael / Nader, Nancy / Reyes, Cleo Z / Hammad, Ayat S / Hubrack, Satanay / Yu, Fang / Machaca, Khaled

Scientific reports

2021 Volume 11, Issue 1, Page(s) 2290

Abstract: Regulation of ... ...

Abstract	Regulation of Ca
MeSH term(s)	Animals ; Calcium/metabolism ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Calcium Signaling/genetics ; Calcium Signaling/physiology ; Caveolin 1/genetics ; Caveolin 1/metabolism ; Clathrin/genetics ; Clathrin/metabolism ; Endocytosis/genetics ; Endocytosis/physiology ; Female ; Meiosis/genetics ; Meiosis/physiology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Microscopy, Confocal ; Mutation/genetics ; ORAI1 Protein/genetics ; ORAI1 Protein/metabolism ; Xenopus laevis ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
Chemical Substances	Calcium Channels ; Caveolin 1 ; Clathrin ; Membrane Proteins ; ORAI1 Protein ; flotillins ; rab5 GTP-Binding Proteins (EC 3.6.5.2) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-01-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-82048-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunogenicity of standard, high-dose, MF59-adjuvanted, and recombinant-HA seasonal influenza vaccination in older adults.

Li, Athena P Y / Cohen, Carolyn A / Leung, Nancy H L / Fang, Vicky J / Gangappa, Shivaprakash / Sambhara, Suryaprakash / Levine, Min Z / Iuliano, A Danielle / Perera, Ranawaka A P M / Ip, Dennis K M / Peiris, J S Malik / Thompson, Mark G / Cowling, Benjamin J / Valkenburg, Sophie A

NPJ vaccines

2021 Volume 6, Issue 1, Page(s) 25

Abstract: The vaccine efficacy of standard-dose seasonal inactivated influenza vaccines (S-IIV) can be improved by the use of vaccines with higher antigen content or adjuvants. We conducted a randomized controlled trial in older adults to compare cellular and ... ...

Abstract	The vaccine efficacy of standard-dose seasonal inactivated influenza vaccines (S-IIV) can be improved by the use of vaccines with higher antigen content or adjuvants. We conducted a randomized controlled trial in older adults to compare cellular and antibody responses of S-IIV versus enhanced vaccines (eIIV): MF59-adjuvanted (A-eIIV), high-dose (H-eIIV), and recombinant-hemagglutinin (HA) (R-eIIV). All vaccines induced comparable H3-HA-specific IgG and elevated antibody-dependent cellular cytotoxicity (ADCC) activity at day 30 post vaccination. H3-HA-specific ADCC responses were greatest following H-eIIV. Only A-eIIV increased H3-HA-IgG avidity, HA-stalk IgG and ADCC activity. eIIVs also increased polyfunctional CD4+ and CD8+ T cell responses, while cellular immune responses were skewed toward single-cytokine-producing T cells among S-IIV subjects. Our study provides further immunological evidence for the preferential use of eIIVs in older adults as each vaccine platform had an advantage over the standard-dose vaccine in terms of NK cell activation, HA-stalk antibodies, and T cell responses.
Language	English
Publishing date	2021-02-16
Publishing country	England
Document type	Journal Article
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-021-00289-5
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