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  1. Article ; Online: Multifocal pigmented lesions in the maxilla.

    Heifetz-Li, Jiean Joseph / Smith, Molly Housley / Roche, Ansley

    Oral surgery, oral medicine, oral pathology and oral radiology

    2023  Volume 137, Issue 3, Page(s) 205–208

    MeSH term(s) Humans ; Maxilla/diagnostic imaging ; Maxilla/surgery
    Language English
    Publishing date 2023-11-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2023.11.008
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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.121: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications.

    Roche, Joseph A / Roche, Renuka

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2020  Volume 34, Issue 6, Page(s) 7265–7269

    Abstract: As of April 20, 2020, over time, the COVID-19 pandemic has resulted in 157 970 deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of ~6.8%. With the pandemic rapidly spreading, and health delivery systems being overwhelmed, it is imperative ...

    Abstract As of April 20, 2020, over time, the COVID-19 pandemic has resulted in 157 970 deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of ~6.8%. With the pandemic rapidly spreading, and health delivery systems being overwhelmed, it is imperative that safe and effective pharmacotherapeutic strategies are rapidly explored to improve survival. In this paper, we use established and emerging evidence to propose a testable hypothesis that, a vicious positive feedback loop of des-Arg(9)-bradykinin- and bradykinin-mediated inflammation → injury → inflammation, likely precipitates life threatening respiratory complications in COVID-19. Through our hypothesis, we make the prediction that the FDA-approved molecule, icatibant, might be able to interrupt this feedback loop and, thereby, improve the clinical outcomes. This hypothesis could lead to basic, translational, and clinical studies aimed at reducing COVID-19 morbidity and mortality.
    MeSH term(s) Betacoronavirus ; Bradykinin/analogs & derivatives ; Bradykinin/pharmacology ; Bradykinin/physiology ; Bradykinin/therapeutic use ; Bradykinin B2 Receptor Antagonists/pharmacology ; Bradykinin B2 Receptor Antagonists/therapeutic use ; Compassionate Use Trials ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/physiopathology ; Dyspnea/etiology ; Dyspnea/physiopathology ; Feedback, Physiological/drug effects ; Humans ; Inflammation ; Models, Biological ; Off-Label Use ; Pandemics ; Peptidyl-Dipeptidase A/physiology ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/physiopathology ; Receptors, Bradykinin/drug effects ; Receptors, Bradykinin/physiology ; Receptors, Virus/physiology
    Chemical Substances Bradykinin B2 Receptor Antagonists ; Receptors, Bradykinin ; Receptors, Virus ; bradykinin, des-Arg(9)- (15958-92-6) ; icatibant (7PG89G35Q7) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; angiotensin converting enzyme 2 (EC 3.4.17.-) ; Bradykinin (S8TIM42R2W)
    Keywords covid19
    Language English
    Publishing date 2020-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202000967
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    Zs.A 2266: Show issues Location:
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    Zs.MO 296: Show issues

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  3. Article: Protection against Severe Illness versus Immunity-Redefining Vaccine Effectiveness in the Aftermath of COVID-19.

    Roche, Renuka / Odeh, Nouha H / Andar, Abhay U / Tulapurkar, Mohan E / Roche, Joseph A

    Microorganisms

    2023  Volume 11, Issue 8

    Abstract: Anti-SARS-CoV-2 vaccines have played a pivotal role in reducing the risk of developing severe illness from COVID-19, thus helping end the COVID-19 global public health emergency after more than three years. Intriguingly, as SARS-CoV-2 variants emerged, ... ...

    Abstract Anti-SARS-CoV-2 vaccines have played a pivotal role in reducing the risk of developing severe illness from COVID-19, thus helping end the COVID-19 global public health emergency after more than three years. Intriguingly, as SARS-CoV-2 variants emerged, individuals who were fully vaccinated did get infected in high numbers, and viral loads in vaccinated individuals were as high as those in the unvaccinated. However, even with high viral loads, vaccinated individuals were significantly less likely to develop severe illness; this begs the question as to whether the main effect of anti-SARS-CoV-2 vaccines is to confer protection against severe illness or immunity against infection. The answer to this question is consequential, not only to the understanding of how anti-SARS-CoV-2 vaccines work, but also to public health efforts against existing and novel pathogens. In this review, we argue that immune system sensitization-desensitization rather than sterilizing immunity may explain vaccine-mediated protection against severe COVID-19 illness even when the SARS-CoV-2 viral load is high. Through the lessons learned from COVID-19, we make the case that in the disease's aftermath, public health agencies must revisit healthcare policies, including redefining the term "vaccine effectiveness."
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11081963
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  4. Article ; Online: A hypothesized role for dysregulated bradykinin signaling in COVID‐19 respiratory complications

    Roche, Joseph A. / Roche, Renuka

    The FASEB Journal

    2020  Volume 34, Issue 6, Page(s) 7265–7269

    Keywords Biotechnology ; Genetics ; Biochemistry ; Molecular Biology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202000967
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
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    Zs.MO 296: Show issues

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  5. Article: Assessment of the Pharmacokinetics and Pharmacodynamics of Injectable Lidocaine and a Lidocaine-Impregnated Latex Band for Castration and Tail Docking in Lambs.

    Ross, Joseph A / Roche, Steven M / Beaugrand, Kendall / Schatz, Crystal / Hammad, Ann / Ralston, Brenda J / Hanson, Andrea M / Allan, Nicholas / Olson, Merle

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 2

    Abstract: The objectives of this study were to assess the pharmacokinetics and pharmacodynamics of the current standard-of-care for pain mitigation in lambs during castration and tail docking (injectable lidocaine) and assess the ability of Lidocaine-Loaded Bands ( ...

    Abstract The objectives of this study were to assess the pharmacokinetics and pharmacodynamics of the current standard-of-care for pain mitigation in lambs during castration and tail docking (injectable lidocaine) and assess the ability of Lidocaine-Loaded Bands (LLBs) to deliver therapeutic concentrations into the contacted tissues over time. The study was comprised of four different trials: (1) investigation of in vitro release of lidocaine from LLBs; (2) pharmacokinetics and pharmacodynamics of injectable lidocaine in scrotal and tail tissue; (3) pharmacokinetics and pharmacodynamics of in vivo delivery of lidocaine with LLBs placed on the tail and scrotum of lambs; and (4) a "proof-of-concept" study comparing the sensation of control- versus LLB-banded tail tissue over time. The use of injectable lidocaine provides effective short-term anesthesia for 120 to 180 min following the injection; however, additional strategies are needed to manage long-term pain. The use of an LLB could provide an alternative where tissue lidocaine concentrations meet or exceed the EC
    Language English
    Publishing date 2024-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14020255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Assessment of the Effective Tissue Concentrations of Injectable Lidocaine and a Lidocaine-Impregnated Latex Band for Castration in Calves.

    Ross, Joseph A / Roche, Steven M / Beaugrand, Kendall / Schatz, Crystal / Hammad, Ann / Ralston, Brenda J / Hanson, Andrea M / Allan, Nicholas / Olson, Merle

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 6

    Abstract: This study aimed to assess the effective tissue concentrations of the current standard of care for pain mitigation in calves during castration (injectable lidocaine) and to assess the ability of a lidocaine-loaded elastration band (LLB) to deliver ... ...

    Abstract This study aimed to assess the effective tissue concentrations of the current standard of care for pain mitigation in calves during castration (injectable lidocaine) and to assess the ability of a lidocaine-loaded elastration band (LLB) to deliver effective concentrations into the scrotal tissue over time. This study comprised two different trials: (1) effective concentrations of injectable lidocaine in the scrotal tissue; and (2) the in vivo delivery of effective concentrations of lidocaine from LLBs placed on the calf scrotums. Sensation in the scrotal tissue was assessed by electrocutaneous stimulation. Injectable lidocaine allowed for short-term anesthesia for up to 60 min, highlighting the importance of finding additional strategies to mitigate long-term pain. An elastomeric ligation band impregnated with lidocaine could provide a suitable alternative, as it yielded tissue levels of lidocaine that approached EC
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14060977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications

    Roche, Joseph A / Roche, Renuka

    FASEB J

    Abstract: As of April 20, 2020, over time, the COVID-19 pandemic has resulted in 157 970 deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of ~6.8%. With the pandemic rapidly spreading, and health delivery systems being overwhelmed, it is imperative ...

    Abstract As of April 20, 2020, over time, the COVID-19 pandemic has resulted in 157 970 deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of ~6.8%. With the pandemic rapidly spreading, and health delivery systems being overwhelmed, it is imperative that safe and effective pharmacotherapeutic strategies are rapidly explored to improve survival. In this paper, we use established and emerging evidence to propose a testable hypothesis that, a vicious positive feedback loop of des-Arg(9)-bradykinin- and bradykinin-mediated inflammation → injury → inflammation, likely precipitates life threatening respiratory complications in COVID-19. Through our hypothesis, we make the prediction that the FDA-approved molecule, icatibant, might be able to interrupt this feedback loop and, thereby, improve the clinical outcomes. This hypothesis could lead to basic, translational, and clinical studies aimed at reducing COVID-19 morbidity and mortality.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #155381
    Database COVID19

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  8. Article ; Online: Conference Report: 6th Annual International Symposium on Regenerative Rehabilitation.

    Loghmani, M Terry / Roche, Joseph A

    Regenerative medicine

    2018  Volume 13, Issue 4, Page(s) 371–374

    Abstract: The 6th International Symposium on Regenerative Rehabilitation, hosted by the Alliance for Regenerative Rehabilitation Research and Training ( ... ...

    Abstract The 6th International Symposium on Regenerative Rehabilitation, hosted by the Alliance for Regenerative Rehabilitation Research and Training (AR
    MeSH term(s) Animals ; Congresses as Topic ; Humans ; Occupational Therapy/methods ; Occupational Therapy/trends ; Physical Therapy Modalities/trends ; Regenerative Medicine/methods ; Regenerative Medicine/trends
    Language English
    Publishing date 2018-04-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2018-0026
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    Zs.A 6627: Show issues Location:
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    Zs.MO 629: Show issues

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  9. Article ; Online: Impact of Dystocia on Milk Production, Somatic Cell Count, Reproduction and Culling in Holstein Dairy Cows

    Roche, Steven M. / Ross, Joseph A. / Schatz, Crystal / Beaugrand, Kendall / Zuidhof, Sjoert / Ralston, Brenda / Allan, Nick / Olson, Merle

    Animals. 2023 Jan. 19, v. 13, no. 3

    2023  

    Abstract: This study investigated the effects of dystocia on milk production, somatic cell count, reproductivity, disease, and milk production. A total of 2159 cows across 21 dairy farms in Alberta, Canada were enrolled in this study. Multivariable models were ... ...

    Abstract This study investigated the effects of dystocia on milk production, somatic cell count, reproductivity, disease, and milk production. A total of 2159 cows across 21 dairy farms in Alberta, Canada were enrolled in this study. Multivariable models were created to explore associations between outcome variables and calving ease score. In total, 89.5% of calvings were unassisted, 6.1% were an easy pull, and 4.3% were a moderate–hard pull. Cows that had a moderate–hard pull produced 4.01 kg less milk, 0.12 kg less volume of milk fat, and 0.12 kg less milk protein per day than those that had an unassisted calving. No difference was found between calving ease groups with respect to SCC. Cows with a moderate or hard pull produced 510 kg less milk per lactation than unassisted cows. Cows with a moderate to high level of assistance at birth had a higher hazard of being culled over the duration of their lactation. Cows with an easy pull had increased odds of developing a retained placenta. It is evident that assistance at calving, particularly a moderate–hard pull, is associated with significant impacts on future milk production and risk of being culled; therefore, efforts should be made to minimize dystocia and prevent these impacts.
    Keywords Holstein ; dystocia ; lactation ; milk ; milk fat ; milk production ; milk proteins ; reproduction ; retained placenta ; risk ; somatic cell count ; Alberta
    Language English
    Dates of publication 2023-0119
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13030346
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Damaged muscle fibers might masquerade as hybrid fibers - a cautionary note on immunophenotyping mouse muscle with mouse monoclonal antibodies.

    Begam, Morium / Roche, Joseph A

    European journal of histochemistry : EJH

    2018  Volume 62, Issue 3

    Abstract: We report that, labeling mouse muscle tissue, with mouse monoclonal antibodies specific to slow or fast myosin heavy chain (sMyHC and fMyHC, respectively), can lead to artefactual labeling of damaged muscle fibers, as hybrid fibers (sMyHC+ and fMyHC+). ... ...

    Abstract We report that, labeling mouse muscle tissue, with mouse monoclonal antibodies specific to slow or fast myosin heavy chain (sMyHC and fMyHC, respectively), can lead to artefactual labeling of damaged muscle fibers, as hybrid fibers (sMyHC+ and fMyHC+).  We demonstrate that such erroneous immunophenotyping of muscle may be avoided, by performing colabeling or serial-section-labeling, to identify damaged fibers. The quadriceps femoris muscle group (QF) in 7-month-old, male, C57BL/6J mice had: 1.21 ± 0.21%, 98.34 ± 1.06%, 0.07 ± 0.01%, and 0.53 ± 0.85% fibers, that were, sMyHC+, fMyHC+, hybrid, and damaged, respectively.  All fibers in the tibialis anterior muscle (TA) of 3-month-old, male, C57BL/6J mice were fMyHC+; and at 3 days after injurious eccentric contractions, there was no fiber-type shift, but ~ 18% fibers were damaged.
    MeSH term(s) Affinity Labels ; Animals ; Antibodies, Monoclonal/chemistry ; Immunophenotyping ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal ; Myosin Heavy Chains/chemistry
    Chemical Substances Affinity Labels ; Antibodies, Monoclonal ; Myosin Heavy Chains (EC 3.6.4.1)
    Language English
    Publishing date 2018-07-24
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1109511-8
    ISSN 2038-8306 ; 0391-7258 ; 1121-4201 ; 1121-760X
    ISSN (online) 2038-8306
    ISSN 0391-7258 ; 1121-4201 ; 1121-760X
    DOI 10.4081/ejh.2018.2896
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    Zs.A 739: Show issues Location:
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