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  1. Article ; Online: S

    Ramachandran, Muthu

    Blockchain in healthcare today

    2023  Volume 6

    Abstract: Blockchain applications in healthcare have grown rapidly. They include record-keeping, clinical trials, medical supply chains, patient monitoring, etc., where blockchain characteristics are needed to improve safety, privacy, and security. Blockchain ... ...

    Abstract Blockchain applications in healthcare have grown rapidly. They include record-keeping, clinical trials, medical supply chains, patient monitoring, etc., where blockchain characteristics are needed to improve safety, privacy, and security. Blockchain technology is one of the most significant disruptive technologies today. However, Porru et al.
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ISSN 2573-8240
    ISSN (online) 2573-8240
    DOI 10.30953/bhty.v6.286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Development of double-layer metamaterial with high effective medium ratio values for S- and C-band applications.

    Sifat, Rasheduzzaman / Faruque, Mohammad Rashed Iqbal / Ramachandran, Tayaallen / Abdullah, Mardina / Islam, Mohammad Tariqul / Al-Mugren, K S

    Heliyon

    2023  Volume 10, Issue 1, Page(s) e23851

    Abstract: ... material that is highly suitable for microwave S and C band covering applications. The popular low-loss ...

    Abstract This study introduces a compact double negative metamaterial (DNM) composed of three split rings connected slab resonator (TSRCSR) based double-layer design with a high 13.9 EMR (effective medium ratio) value. A double-layer patch is introduced to achieve the novel double negative properties, including negative behaviours of effective medium parameters, including refractive index, permittivity, and permeability with a high effective medium ratio for the miniaturised size of the introduced unconventional material that is highly suitable for microwave S and C band covering applications. The popular low-loss Rogers RT5880 (thickness 1.575 mm) substrate and copper resonator materials are utilized to develop the metamaterial unit cell that offers triple resonance between frequencies from 1 to 8 GHz. Therefore, the proposed metamaterial exhibits resonance peaks at 2.75, 5.2, and 6.3 GHz, suitable for radar, communication satellite, and long-distance telecommunication applications, respectively. The commercially available simulator known as Computer Simulation Technology (CST) is adopted to develop and simulate the 8 × 8 mm
    Language English
    Publishing date 2023-12-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e23851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Observation of D_{s}^{±}/D^{0} Enhancement in Au+Au Collisions at sqrt[s_{NN}]=200  GeV.

    Adam, J / Adamczyk, L / Adams, J R / Adkins, J K / Agakishiev, G / Aggarwal, M M / Ahammed, Z / Alekseev, I / Anderson, D M / Aparin, A / Aschenauer, E C / Ashraf, M U / Atetalla, F G / Attri, A / Averichev, G S / Bairathi, V / Barish, K / Behera, A / Bellwied, R /
    Bhasin, A / Bielcik, J / Bielcikova, J / Bland, L C / Bordyuzhin, I G / Brandenburg, J D / Brandin, A V / Butterworth, J / Caines, H / Calderón de la Barca Sánchez, M / Cebra, D / Chakaberia, I / Chaloupka, P / Chan, B K / Chang, F-H / Chang, Z / Chankova-Bunzarova, N / Chatterjee, A / Chen, D / Chen, J / Chen, J H / Chen, X / Chen, Z / Cheng, J / Cherney, M / Chevalier, M / Choudhury, S / Christie, W / Chu, X / Crawford, H J / Csanád, M / Daugherity, M / Dedovich, T G / Deppner, I M / Derevschikov, A A / Didenko, L / Dong, X / Drachenberg, J L / Dunlop, J C / Edmonds, T / Elsey, N / Engelage, J / Eppley, G / Esumi, S / Evdokimov, O / Ewigleben, A / Eyser, O / Fatemi, R / Fazio, S / Federic, P / Fedorisin, J / Feng, C J / Feng, Y / Filip, P / Finch, E / Fisyak, Y / Francisco, A / Fu, C / Fulek, L / Gagliardi, C A / Galatyuk, T / Geurts, F / Ghimire, N / Gibson, A / Gopal, K / Gou, X / Grosnick, D / Guryn, W / Hamad, A I / Hamed, A / Harabasz, S / Harris, J W / He, S / He, W / He, X / He, Y / Heppelmann, S / Herrmann, N / Hoffman, E / Holub, L / Hong, Y / Horvat, S / Hu, Y / Huang, H Z / Huang, S L / Huang, T / Huang, X / Humanic, T J / Huo, P / Igo, G / Isenhower, D / Jacobs, W W / Jena, C / Jentsch, A / Ji, Y / Jia, J / Jiang, K / Jowzaee, S / Ju, X / Judd, E G / Kabana, S / Kabir, M L / Kagamaster, S / Kalinkin, D / Kang, K / Kapukchyan, D / Kauder, K / Ke, H W / Keane, D / Kechechyan, A / Kelsey, M / Khyzhniak, Y V / Kikoła, D P / Kim, C / Kimelman, B / Kincses, D / Kinghorn, T A / Kisel, I / Kiselev, A / Kocan, M / Kochenda, L / Kosarzewski, L K / Kramarik, L / Kravtsov, P / Krueger, K / Kulathunga Mudiyanselage, N / Kumar, L / Kumar, S / Kunnawalkam Elayavalli, R / Kwasizur, J H / Lacey, R / Lan, S / Landgraf, J M / Lauret, J / Lebedev, A / Lednicky, R / Lee, J H / Leung, Y H / Li, C / Li, W / Li, X / Li, Y / Liang, Y / Licenik, R / Lin, T / Lin, Y / Lisa, M A / Liu, F / Liu, H / Liu, P / Liu, T / Liu, X / Liu, Y / Liu, Z / Ljubicic, T / Llope, W J / Longacre, R S / Lukow, N S / Luo, S / Luo, X / Ma, G L / Ma, L / Ma, R / Ma, Y G / Magdy, N / Majka, R / Mallick, D / Margetis, S / Markert, C / Matis, H S / Mazer, J A / Minaev, N G / Mioduszewski, S / Mohanty, B / Mooney, I / Moravcova, Z / Morozov, D A / Nagy, M / Nam, J D / Nasim, Md / Nayak, K / Neff, D / Nelson, J M / Nemes, D B / Nie, M / Nigmatkulov, G / Niida, T / Nogach, L V / Nonaka, T / Nunes, A S / Odyniec, G / Ogawa, A / Oh, S / Okorokov, V A / Page, B S / Pak, R / Pandav, A / Panebratsev, Y / Pawlik, B / Pawlowska, D / Pei, H / Perkins, C / Pinsky, L / Pintér, R L / Pluta, J / Pokhrel, B R / Porter, J / Posik, M / Pruthi, N K / Przybycien, M / Putschke, J / Qiu, H / Quintero, A / Radhakrishnan, S K / Ramachandran, S / Ray, R L / Reed, R / Ritter, H G / Rogachevskiy, O V / Romero, J L / Ruan, L / Rusnak, J / Sahoo, N R / Sako, H / Salur, S / Sandweiss, J / Sato, S / Schmidke, W B / Schmitz, N / Schweid, B R / Seck, F / Seger, J / Sergeeva, M / Seto, R / Seyboth, P / Shah, N / Shahaliev, E / Shanmuganathan, P V / Shao, M / Sheikh, A I / Shen, W Q / Shi, S S / Shi, Y / Shou, Q Y / Sichtermann, E P / Sikora, R / Simko, M / Singh, J / Singha, S / Smirnov, N / Solyst, W / Sorensen, P / Spinka, H M / Srivastava, B / Stanislaus, T D S / Stefaniak, M / Stewart, D J / Strikhanov, M / Stringfellow, B / Suaide, A A P / Sumbera, M / Summa, B / Sun, X M / Sun, X / Sun, Y / Surrow, B / Svirida, D N / Szymanski, P / Tang, A H / Tang, Z / Taranenko, A / Tarnowsky, T / Thomas, J H / Timmins, A R / Tlusty, D / Tokarev, M / Tomkiel, C A / Trentalange, S / Tribble, R E / Tribedy, P / Tripathy, S K / Tsai, O D / Tu, Z / Ullrich, T / Underwood, D G / Upsal, I / Van Buren, G / Vanek, J / Vasiliev, A N / Vassiliev, I / Videbæk, F / Vokal, S / Voloshin, S A / Wang, F / Wang, G / Wang, J S / Wang, P / Wang, Y / Wang, Z / Webb, J C / Weidenkaff, P C / Wen, L / Westfall, G D / Wieman, H / Wissink, S W / Witt, R / Wu, Y / Xiao, Z G / Xie, G / Xie, W / Xu, H / Xu, N / Xu, Q H / Xu, Y F / Xu, Y / Xu, Z / Yang, C / Yang, Q / Yang, S / Yang, Y / Yang, Z / Ye, Z / Yi, L / Yip, K / Yu, Y / Zbroszczyk, H / Zha, W / Zhang, C / Zhang, D / Zhang, S / Zhang, X P / Zhang, Y / Zhang, Z J / Zhang, Z / Zhao, J / Zhong, C / Zhou, C / Zhu, X / Zhu, Z / Zurek, M / Zyzak, M

    Physical review letters

    2021  Volume 127, Issue 9, Page(s) 92301

    Abstract: We report on the first measurement of charm-strange meson D_{s}^{±} production at midrapidity ... in Au+Au collisions at sqrt[s_{NN}]=200  GeV from the STAR experiment. The yield ratio between strange (D ... _{s}^{±}) and nonstrange (D^{0}) open-charm mesons is presented and compared to model calculations ...

    Abstract We report on the first measurement of charm-strange meson D_{s}^{±} production at midrapidity in Au+Au collisions at sqrt[s_{NN}]=200  GeV from the STAR experiment. The yield ratio between strange (D_{s}^{±}) and nonstrange (D^{0}) open-charm mesons is presented and compared to model calculations. A significant enhancement, relative to a pythia simulation of p+p collisions, is observed in the D_{s}^{±}/D^{0} yield ratio in Au+Au collisions over a large range of collision centralities. Model calculations incorporating abundant strange-quark production in the quark-gluon plasma and coalescence hadronization qualitatively reproduce the data. The transverse-momentum integrated yield ratio of D_{s}^{±}/D^{0} at midrapidity is consistent with a prediction from a statistical hadronization model with the parameters constrained by the yields of light and strange hadrons measured at the same collision energy. These results suggest that the coalescence of charm quarks with strange quarks in the quark-gluon plasma plays an important role in D_{s}^{±}-meson production in heavy-ion collisions.
    Language English
    Publishing date 2021-09-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.127.092301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.

    Deng, Liwen / Costa, Flavia / Blake, Kimbria J / Choi, Samantha / Chandrabalan, Arundhasa / Yousuf, Muhammad Saad / Shiers, Stephanie / Dubreuil, Daniel / Vega-Mendoza, Daniela / Rolland, Corinne / Deraison, Celine / Voisin, Tiphaine / Bagood, Michelle D / Wesemann, Lucia / Frey, Abigail M / Palumbo, Joseph S / Wainger, Brian J / Gallo, Richard L / Leyva-Castillo, Juan-Manuel /
    Vergnolle, Nathalie / Price, Theodore J / Ramachandran, Rithwik / Horswill, Alexander R / Chiu, Isaac M

    Cell

    2023  Volume 186, Issue 24, Page(s) 5375–5393.e25

    Abstract: ... activates pruriceptor sensory neurons to drive itch. Epicutaneous S. aureus exposure causes robust itch and ... the S. aureus serine protease V8 as a critical mediator in evoking spontaneous itch and alloknesis. V8 ... and skin damage caused by V8 and S. aureus exposure. Thus, we identify a mechanism of action ...

    Abstract Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly exposed to microbes and their products. However, the role of microbes in itch generation is unknown. Here, we show that Staphylococcus aureus, a bacterial pathogen associated with itchy skin diseases, directly activates pruriceptor sensory neurons to drive itch. Epicutaneous S. aureus exposure causes robust itch and scratch-induced damage. By testing multiple isogenic bacterial mutants for virulence factors, we identify the S. aureus serine protease V8 as a critical mediator in evoking spontaneous itch and alloknesis. V8 cleaves proteinase-activated receptor 1 (PAR1) on mouse and human sensory neurons. Targeting PAR1 through genetic deficiency, small interfering RNA (siRNA) knockdown, or pharmacological blockade decreases itch and skin damage caused by V8 and S. aureus exposure. Thus, we identify a mechanism of action for a pruritogenic bacterial factor and demonstrate the potential of inhibiting V8-PAR1 signaling to treat itch.
    MeSH term(s) Animals ; Humans ; Mice ; Peptide Hydrolases/metabolism ; Pruritus/microbiology ; Receptor, PAR-1/metabolism ; Staphylococcus aureus/enzymology ; Staphylococcus aureus/pathogenicity ; Staphylococcus aureus/physiology ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/pathology
    Chemical Substances Peptide Hydrolases (EC 3.4.-) ; Receptor, PAR-1
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.10.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Development of double-layer metamaterial with high effective medium ratio values for S- and C-band applications

    Rasheduzzaman Sifat / Mohammad Rashed Iqbal Faruque / Tayaallen Ramachandran / Mardina Abdullah / Mohammad Tariqul Islam / K.S. Al-Mugren

    Heliyon, Vol 10, Iss 1, Pp e23851- (2024)

    1481  

    Abstract: ... material that is highly suitable for microwave S and C band covering applications. The popular low-loss ...

    Abstract This study introduces a compact double negative metamaterial (DNM) composed of three split rings connected slab resonator (TSRCSR) based double-layer design with a high 13.9 EMR (effective medium ratio) value. A double-layer patch is introduced to achieve the novel double negative properties, including negative behaviours of effective medium parameters, including refractive index, permittivity, and permeability with a high effective medium ratio for the miniaturised size of the introduced unconventional material that is highly suitable for microwave S and C band covering applications. The popular low-loss Rogers RT5880 (thickness 1.575 mm) substrate and copper resonator materials are utilized to develop the metamaterial unit cell that offers triple resonance between frequencies from 1 to 8 GHz. Therefore, the proposed metamaterial exhibits resonance peaks at 2.75, 5.2, and 6.3 GHz, suitable for radar, communication satellite, and long-distance telecommunication applications, respectively. The commercially available simulator known as Computer Simulation Technology (CST) is adopted to develop and simulate the 8 × 8 mm2 metamaterial design. The simulation results of the introduced TSRCSR design structure were verified by adopting the Ansys High-Frequency Structure Simulator (HFSS). Furthermore, it was then proved with the help of equivalent circuit model findings gained from the Advanced Design Structure (ADS) software. On the other hand, the analytical results were further validated by measuring the TSRCSR design utilizing a Vector Network Analyzer (VNA). These analyses become one of the novelties of this work, where the compact TSRCSR metamaterial successfully gained small discrepancies in transmission coefficient values when compared to both analytical and measurement results. The proposed metamaterial is highly suggested for communication devices for its extensive effective characteristics and compactness.
    Keywords Double negative metamaterial ; Split ring resonator ; Electromagnetism ; EMR ; ASR application ; Satellite application ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 600
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A junior doctor’s experience of critical illness

    Ramachandran, S.

    Anaesthesia Reports

    from treating patients to becoming a patient with COVID‐19

    2020  Volume 8, Issue 1, Page(s) 59–62

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ISSN 2637-3726
    DOI 10.1002/anr3.12052
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Social, Behavioral, and Metabolic Risk Factors and Racial Disparities in Cardiovascular Disease Mortality in U.S. Adults : An Observational Study.

    He, Jiang / Bundy, Joshua D / Geng, Siyi / Tian, Ling / He, Hua / Li, Xingyan / Ferdinand, Keith C / Anderson, Amanda H / Dorans, Kirsten S / Vasan, Ramachandran S / Mills, Katherine T / Chen, Jing

    Annals of internal medicine

    2023  Volume 176, Issue 9, Page(s) 1200–1208

    Abstract: ... with adjustment for social determinants of health in the U.S. population.: Primary funding source: National Institutes ...

    Abstract Background: Cardiovascular disease (CVD) mortality is persistently higher in the Black population than in other racial and ethnic groups in the United States.
    Objective: To examine the degree to which social, behavioral, and metabolic risk factors are associated with CVD mortality and the extent to which racial differences in CVD mortality persist after these factors are accounted for.
    Design: Prospective cohort study.
    Setting: NHANES (National Health and Nutrition Examination Survey) 1999 to 2018.
    Participants: A nationally representative sample of 50 808 persons aged 20 years or older.
    Measurements: Data on social, behavioral, and metabolic factors were collected in each NHANES survey using standard methods. Deaths from CVD were ascertained from linkage to the National Death Index with follow-up through 2019.
    Results: Over an average of 9.4 years of follow-up, 2589 CVD deaths were confirmed. The age- and sex-standardized rates of CVD mortality were 484.7 deaths per 100 000 person-years in Black participants, 384.5 deaths per 100 000 person-years in White participants, 292.4 deaths per 100 000 person-years in Hispanic participants, and 255.1 deaths per 100 000 person-years in other race groups. In a multiple Cox regression analysis adjusted for all measured risk factors simultaneously, several social (unemployment, low family income, food insecurity, lack of home ownership, and unpartnered status), behavioral (current smoking, lack of leisure-time physical activity, and sleep <6 or >8 h/d), and metabolic (obesity, hypertension, and diabetes) risk factors were associated with a significantly higher risk for CVD death. After adjustment for these metabolic, behavioral, and social risk factors separately, hazard ratios of CVD mortality for Black compared with White participants were attenuated from 1.54 (95% CI, 1.34 to 1.77) to 1.34 (CI, 1.16 to 1.55), 1.31 (CI, 1.15 to 1.50), and 1.04 (CI, 0.90 to 1.21), respectively.
    Limitation: Causal contributions of social, behavioral, and metabolic risk factors to racial and ethnic disparities in CVD mortality could not be established.
    Conclusion: The Black-White difference in CVD mortality diminished after adjustment for behavioral and metabolic risk factors and completely dissipated with adjustment for social determinants of health in the U.S. population.
    Primary funding source: National Institutes of Health.
    MeSH term(s) Adult ; Humans ; United States/epidemiology ; Cardiovascular Diseases ; Nutrition Surveys ; Prospective Studies ; Risk Factors ; Racial Groups
    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Observational Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M23-0507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Erratum: Global Polarization of Ξ and Ω Hyperons in Au+Au Collisions at sqrt[s_{NN}]=200  GeV [Phys. Rev. Lett. 126, 162301 (2021)].

    Adam, J / Adamczyk, L / Adams, J R / Adkins, J K / Agakishiev, G / Aggarwal, M M / Ahammed, Z / Alekseev, I / Anderson, D M / Aparin, A / Aschenauer, E C / Ashraf, M U / Atetalla, F G / Attri, A / Averichev, G S / Bairathi, V / Barish, K / Behera, A / Bellwied, R /
    Bhasin, A / Bielcik, J / Bielcikova, J / Bland, L C / Bordyuzhin, I G / Brandenburg, J D / Brandin, A V / Butterworth, J / Caines, H / Calderón de la Barca Sánchez, M / Cebra, D / Chakaberia, I / Chaloupka, P / Chan, B K / Chang, F-H / Chang, Z / Chankova-Bunzarova, N / Chatterjee, A / Chen, D / Chen, J / Chen, J H / Chen, X / Chen, Z / Cheng, J / Cherney, M / Chevalier, M / Choudhury, S / Christie, W / Chu, X / Crawford, H J / Csanád, M / Daugherity, M / Dedovich, T G / Deppner, I M / Derevschikov, A A / Didenko, L / Dong, X / Drachenberg, J L / Dunlop, J C / Edmonds, T / Elsey, N / Engelage, J / Eppley, G / Esumi, S / Evdokimov, O / Ewigleben, A / Eyser, O / Fatemi, R / Fazio, S / Federic, P / Fedorisin, J / Feng, C J / Feng, Y / Filip, P / Finch, E / Fisyak, Y / Francisco, A / Fulek, L / Gagliardi, C A / Galatyuk, T / Geurts, F / Ghimire, N / Gibson, A / Gopal, K / Gou, X / Grosnick, D / Guryn, W / Hamad, A I / Hamed, A / Harabasz, S / Harris, J W / He, S / He, W / He, X H / He, Y / Heppelmann, S / Herrmann, N / Hoffman, E / Holub, L / Hong, Y / Horvat, S / Hu, Y / Huang, H Z / Huang, S L / Huang, T / Huang, X / Humanic, T J / Huo, P / Igo, G / Isenhower, D / Jacobs, W W / Jena, C / Jentsch, A / Ji, Y / Jia, J / Jiang, K / Jowzaee, S / Ju, X / Judd, E G / Kabana, S / Kabir, M L / Kagamaster, S / Kalinkin, D / Kang, K / Kapukchyan, D / Kauder, K / Ke, H W / Keane, D / Kechechyan, A / Kelsey, M / Khyzhniak, Y V / Kikoła, D P / Kim, C / Kimelman, B / Kincses, D / Kinghorn, T A / Kisel, I / Kiselev, A / Kocan, M / Kochenda, L / Kosarzewski, L K / Kramarik, L / Kravtsov, P / Krueger, K / Kulathunga Mudiyanselage, N / Kumar, L / Kumar, S / Kunnawalkam Elayavalli, R / Kwasizur, J H / Lacey, R / Lan, S / Landgraf, J M / Lauret, J / Lebedev, A / Lednicky, R / Lee, J H / Leung, Y H / Li, C / Li, W / Li, X / Li, Y / Liang, Y / Licenik, R / Lin, T / Lin, Y / Lisa, M A / Liu, F / Liu, H / Liu, P / Liu, T / Liu, X / Liu, Y / Liu, Z / Ljubicic, T / Llope, W J / Longacre, R S / Lukow, N S / Luo, S / Luo, X / Ma, G L / Ma, L / Ma, R / Ma, Y G / Magdy, N / Majka, R / Mallick, D / Margetis, S / Markert, C / Matis, H S / Mazer, J A / Minaev, N G / Mioduszewski, S / Mohanty, B / Mooney, I / Moravcova, Z / Morozov, D A / Nagy, M / Nam, J D / Nasim, Md / Nayak, K / Neff, D / Nelson, J M / Nemes, D B / Nie, M / Nigmatkulov, G / Niida, T / Nogach, L V / Nonaka, T / Nunes, A S / Odyniec, G / Ogawa, A / Oh, S / Okorokov, V A / Page, B S / Pak, R / Pandav, A / Panebratsev, Y / Pawlik, B / Pawlowska, D / Pei, H / Perkins, C / Pinsky, L / Pintér, R L / Pluta, J / Pokhrel, B R / Porter, J / Posik, M / Pruthi, N K / Przybycien, M / Putschke, J / Qiu, H / Quintero, A / Radhakrishnan, S K / Ramachandran, S / Ray, R L / Reed, R / Ritter, H G / Rogachevskiy, O V / Romero, J L / Ruan, L / Rusnak, J / Sahoo, N R / Sako, H / Salur, S / Sandweiss, J / Sato, S / Schmidke, W B / Schmitz, N / Schweid, B R / Seck, F / Seger, J / Sergeeva, M / Seto, R / Seyboth, P / Shah, N / Shahaliev, E / Shanmuganathan, P V / Shao, M / Sheikh, A I / Shen, W Q / Shi, S S / Shi, Y / Shou, Q Y / Sichtermann, E P / Sikora, R / Simko, M / Singh, J / Singha, S / Smirnov, N / Solyst, W / Sorensen, P / Spinka, H M / Srivastava, B / Stanislaus, T D S / Stefaniak, M / Stewart, D J / Strikhanov, M / Stringfellow, B / Suaide, A A P / Sumbera, M / Summa, B / Sun, X M / Sun, X / Sun, Y / Surrow, B / Svirida, D N / Szymanski, P / Tang, A H / Tang, Z / Taranenko, A / Tarnowsky, T / Thomas, J H / Timmins, A R / Tlusty, D / Tokarev, M / Tomkiel, C A / Trentalange, S / Tribble, R E / Tribedy, P / Tripathy, S K / Tsai, O D / Tu, Z / Ullrich, T / Underwood, D G / Upsal, I / Van Buren, G / Vanek, J / Vasiliev, A N / Vassiliev, I / Videbæk, F / Vokal, S / Voloshin, S A / Wang, F / Wang, G / Wang, J S / Wang, P / Wang, Y / Wang, Z / Webb, J C / Weidenkaff, P C / Wen, L / Westfall, G D / Wieman, H / Wissink, S W / Witt, R / Wu, Y / Xiao, Z G / Xie, G / Xie, W / Xu, H / Xu, N / Xu, Q H / Xu, Y F / Xu, Y / Xu, Z / Yang, C / Yang, Q / Yang, S / Yang, Y / Yang, Z / Ye, Z / Yi, L / Yip, K / Yu, Y / Zbroszczyk, H / Zha, W / Zhang, C / Zhang, D / Zhang, S / Zhang, X P / Zhang, Y / Zhang, Z J / Zhang, Z / Zhao, J / Zhong, C / Zhou, C / Zhu, X / Zhu, Z / Zurek, M / Zyzak, M

    Physical review letters

    2023  Volume 131, Issue 8, Page(s) 89901

    Abstract: This corrects the article DOI: 10.1103/PhysRevLett.126.162301. ...

    Abstract This corrects the article DOI: 10.1103/PhysRevLett.126.162301.
    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.131.089901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The relationship between medical marijuana use and prescription pain reliever use among U.S. adults: A retrospective analysis utilizing the 2015-2019 National Survey on Drug Use and Health (NSDUH).

    Dunn, Tyler J / Holmes, Erin / Yang, Yi / Bentley, John P / Kashmiri, Saim / Ramachandran, Sujith

    Exploratory research in clinical and social pharmacy

    2023  Volume 12, Page(s) 100368

    Abstract: Background: Despite a number of states in the U.S. enacting medical marijuana policies, there is ... of this study was to assess the prevalence of medical marijuana use in the U.S. and to identify clinical, social ... in the adult U.S. population while adjusting for substance use factors, psychiatric factors, and demographic ...

    Abstract Background: Despite a number of states in the U.S. enacting medical marijuana policies, there is currently a lack of research outlining the role that individual-level factors play in predicting medical marijuana use, especially regarding use and misuse of prescription pain relievers. The overall aim of this study was to assess the prevalence of medical marijuana use in the U.S. and to identify clinical, social, and demographic predictors.
    Methods: A retrospective secondary database analysis was conducted utilizing five years of the National Survey on Drug Use and Health (NSUDH). A multivariable logistic regression model assessed the association between prescription pain reliever use and medical marijuana in the adult U.S. population while adjusting for substance use factors, psychiatric factors, and demographic characteristics.
    Results: Within the U.S. adult population from 2015 to 2019, medical marijuana use increased from 1.6% to 2.4%, while appropriate prescription pain reliever use decreased from 33.4% to 27.5%, and prescription pain reliever misuse decreased from 4.7% to 3.7%. Of all marijuana users, 15.1% resided within non-medical marijuana states. Medical marijuana users are more likely to have a serious mental illness (14.0% vs. 4.4%) and a non-marijuana related substance dependence (5.3% vs. 1.2%). Past-year medical marijuana use was significantly more likely to be reported among appropriate users of prescription pain relievers (OR = 1.99,
    Conclusions: Prescription pain reliever appropriate use and misuse were associated with higher odds of medical marijuana use. This study identified a potential treatment gap among individuals residing in states with no medical marijuana availability. These study findings highlight the potential benefits of medical marijuana legalization that future research can build on to guide policy making decisions.
    Language English
    Publishing date 2023-11-11
    Publishing country United States
    Document type Journal Article
    ISSN 2667-2766
    ISSN (online) 2667-2766
    DOI 10.1016/j.rcsop.2023.100368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: [Fe-S] biogenesis and unusual assembly of the ISC scaffold complex in the Plasmodium falciparum mitochondrion.

    Mohammad Sadik / Mohammad Afsar / Ramachandran, Ravishankar / Habib, Saman

    Molecular microbiology

    2021  Volume 116, Issue 2, Page(s) 606–623

    Abstract: The malaria parasite harbors two [Fe-S] biogenesis pathways of prokaryotic origin-the SUF and ISC ... of Plasmodium falciparum ISC proteins followed by analyses of cysteine desulfurase, scaffold, and [Fe-S]-carrier components ...

    Abstract The malaria parasite harbors two [Fe-S] biogenesis pathways of prokaryotic origin-the SUF and ISC systems in the apicoplast and mitochondrion, respectively. While the SUF machinery has been delineated, there is little experimental evidence on the ISC pathway. We confirmed mitochondrial targeting of Plasmodium falciparum ISC proteins followed by analyses of cysteine desulfurase, scaffold, and [Fe-S]-carrier components. PfIscU functioned as the scaffold in complex with the PfIscS-PfIsd11 cysteine desulfurase and could directly assemble [4Fe-4S] without prior [2Fe-2S] formation seen in other homologs. Small angle X-ray scattering and spectral studies showed that PfIscU, a trimer, bound one [4Fe-4S]. In a deviation from reported complexes from other organisms, the P. falciparum desulfurase-scaffold complex assembled around a PfIscS tetramer instead of a dimer, resulting in a symmetric hetero-hexamer [2× (2PfIscS-2PfIsd11-2PfIscU)]. PfIscU directly transferred [4Fe-4S] to the apo-protein aconitase B thus abrogating the requirement of intermediary proteins for conversion of [2Fe-2S] to [4Fe-4S] before transfer to [4Fe-4S]-recipients. Among the putative cluster-carriers, PfIscA2 was more efficient than PfNifU-like protein; PfIscA1 primarily bound iron, suggesting its potential role as a Fe
    MeSH term(s) Aconitate Hydratase/metabolism ; Carbon-Sulfur Lyases/metabolism ; Carrier Proteins/metabolism ; Humans ; Iron-Sulfur Proteins/biosynthesis ; Malaria, Falciparum/pathology ; Mitochondria/metabolism ; Plasmodium falciparum/metabolism ; Protein Multimerization
    Chemical Substances Carrier Proteins ; Iron-Sulfur Proteins ; Aconitate Hydratase (EC 4.2.1.3) ; Carbon-Sulfur Lyases (EC 4.4.-) ; cysteine desulfurase (EC 4.4.1.-)
    Language English
    Publishing date 2021-06-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.14735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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