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Article ; Online: Do budget constraints limit access to health care? Evidence from PCI treatments in Hungary.

Kiss, András / Kiss, Norbert / Váradi, Balázs

International journal of health economics and management

2023 Volume 23, Issue 2, Page(s) 281–302

Abstract: Under Hungary's single payer health care system, hospitals face an annual budget cap on most of their diagnoses-related group based reimbursements. In July 2012, percutaneous coronary intervention (PCI) treatments of acute myocardial infarction were ... ...

Abstract	Under Hungary's single payer health care system, hospitals face an annual budget cap on most of their diagnoses-related group based reimbursements. In July 2012, percutaneous coronary intervention (PCI) treatments of acute myocardial infarction were exempted from that hospital level budget cap. We use countrywide individual-level patient data from 2009 to 2015 to map the effect of such a quasi-experimental change in monetary incentives on health provider decisions and health outcomes. We find that direct admissions into PCI-capable hospitals increase, especially in central Hungary, where there are several hospitals which can compete for patients. The proportion of PCI treatments at PCI-capable hospitals, however, does not increase, and neither does the number of patient transfers from non-PCI hospitals to PCI-capable ones. We conclude that only patient pathways, plausibly influenced by hospital management, were affected by the shift in incentives, while physicians' treatment decisions were not. While average length of stay decreased, we do not find any effect on 30-day readmissions or in-hospital mortality.
MeSH term(s)	Humans ; Hungary ; Percutaneous Coronary Intervention ; Myocardial Infarction/therapy ; Hospitals ; Health Services Accessibility
Language	English
Publishing date	2023-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2817492-6
ISSN	2199-9031 ; 2199-9023
ISSN (online)	2199-9031
ISSN	2199-9023
DOI	10.1007/s10754-023-09349-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: It is all about calcification.

Váradi, András

Cell cycle (Georgetown, Tex.)

2015 Volume 13, Issue 24, Page(s) 3793

MeSH term(s)	ATP-Binding Cassette Transporters/physiology ; Adenosine Triphosphate/metabolism ; Animals ; Diphosphates/blood ; Female ; Humans ; Liver/metabolism ; Male ; Multidrug Resistance-Associated Proteins/physiology
Chemical Substances	ATP-Binding Cassette Transporters ; Diphosphates ; Multidrug Resistance-Associated Proteins ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2015-01-06
Publishing country	United States
Document type	News ; Comment
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/15384101.2014.980706
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Article ; Online: The coronavirus-induced COVID-19 pandemic. Previous experiences and scientific evidences at the end of March, 2020

Váradi, András / Ferenci, Tamás / Falus, András

Orvosi hetilap

2020 Volume 161, Issue 17, Page(s) 644–651

Abstract: The COVID-19 epidemic hit everyone, professionals and civilians alike. The possibility of a worldwide pandemic has long been theorized by epidemiologists, infectologists on the one hand, and sociologists and behavioral scientists dealing with ... ...

Title translation	[A koronavírus okozta COVID–19-pandémia. Korábbi tapasztalatok és tudományos evidenciák 2020. március végén]
Abstract	The COVID-19 epidemic hit everyone, professionals and civilians alike. The possibility of a worldwide pandemic has long been theorized by epidemiologists, infectologists on the one hand, and sociologists and behavioral scientists dealing with communication and social habits on the other. Yet, faced with real-time events, daily infections and mortality statistics, almost everyone feels uninformed or disturbingly inexperienced. This summary aims to provide an overview of the latest scientific evidences. Of course, the incomplete material, compiled in late March 2020, will certainly contain a few elements that likely will be outdated in a few weeks. The authors hope that in the next publication we will all read much better and more hopeful prospects. Orv Hetil. 2020; 161(17): 644–651.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
Keywords	covid19
Language	Hungarian
Publishing date	2020-04-01
Publishing country	Hungary
Document type	Journal Article ; Review
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2020.31830
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Article ; Online: Kezdeti tapasztalataink az infrarenalis aorta atherothromboticus obliteratív megbetegedéseinek sztentgraftokkal történő kezelésében.

Takács, Tibor / Mihalovits, Gábor / Váradi, Rita / Nagy, András / Palásthy, Zsolt

Orvosi hetilap

2022 Volume 163, Issue 34, Page(s) 1353–1361

Abstract: Introduction: Endovascular interventions have become the first-line treatment for peripheral arterial diseases. Atherothrombotic disorders in the infrarenal aorta are also treated with open surgery, especially if it causes critical stenosis or ... ...

Abstract	Introduction: Endovascular interventions have become the first-line treatment for peripheral arterial diseases. Atherothrombotic disorders in the infrarenal aorta are also treated with open surgery, especially if it causes critical stenosis or embolization. The use of traditional stents leads to much more complications in such lesions; however, stentgrafts can provide excellent results. Objectives: We retrospectively analyzed our patients undergoing stengraft implantation due to atherothrombotic diseases in the infrarenal aorta and our early experiences. Methods: We included patients undergoing stentgraft implantation at our department due to symptomatic infrarenal aortic atherothrombotic diseases. We established the suitability for endovascular reconstruction with CT-angiography. Control CT-angiography was performed 6 weeks after the intervention. Results: 6 patients underwent successful stentgraft implantation between 25 February 2021 and 15 September 2021 at our department due to infrarenal aorta atherothrombotic diseases. 2 patients had critical limb ischaemia and 4 had claudication. Early postoperative complications did not occur. During the follow-up, the patients reported significant walking improvement. Control CT-angiography showed good stentgraft position without stenosis in all patients. Only 1 late postoperative complication (right iliac stent occlusion) occurred. Peripheral thrombolysis was performed for 24 hours; the stent opened and there was no need to perform further interventions. Conclusions: Both our early experiences and international studies have showed that this method is suitable for the treatment of atherothrombotic diseases in the infrarenal aorta. The use of stentgrafts in the treatment of peripheral atherosclerotic diseases is hindered by the high costs of the device, so at present it is subject to individual funding in Hungary. Orv Hetil. 2022; 163(34): 1353-1361.
MeSH term(s)	Aorta, Abdominal/diagnostic imaging ; Aorta, Abdominal/pathology ; Aorta, Abdominal/surgery ; Aortic Diseases/pathology ; Aortic Diseases/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Constriction, Pathologic/complications ; Constriction, Pathologic/pathology ; Constriction, Pathologic/surgery ; Humans ; Postoperative Complications/etiology ; Retrospective Studies ; Stents/adverse effects ; Treatment Outcome
Language	English
Publishing date	2022-08-21
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2022.32545
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Article ; Online: In gratitude for the collaborative partnership with David E. Minnikin.

Váradi, Orsolya Anna / Marcsik, Antónia / Masson, Muriel / Molnár, Erika / Pap, Ildikó / Spekker, Olga / Szekeres, András / Pálfi, György

Tuberculosis (Edinburgh, Scotland)

2023 Volume 143S, Page(s) 102364

Language	English
Publishing date	2023-11-25
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	2046804-0
ISSN	1873-281X ; 1472-9792
ISSN (online)	1873-281X
ISSN	1472-9792
DOI	10.1016/j.tube.2023.102364
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Article: [A koronavírus okozta COVID19-pandémia. Korábbi tapasztalatok és tudományos evidenciák 2020. március végén]/ The coronavirus-induced COVID-19 pandemic. Previous experiences and scientific evidences at the end of March, 2020

Váradi, András / Ferenci, Tamás / Falus, András

Orv Hetil

Abstract	The COVID-19 epidemic hit everyone, professionals and civilians alike. The possibility of a worldwide pandemic has long been theorized by epidemiologists, infectologists on the one hand, and sociologists and behavioral scientists dealing with communication and social habits on the other. Yet, faced with real-time events, daily infections and mortality statistics, almost everyone feels uninformed or disturbingly inexperienced. This summary aims to provide an overview of the latest scientific evidences. Of course, the incomplete material, compiled in late March 2020, will certainly contain a few elements that likely will be outdated in a few weeks. The authors hope that in the next publication we will all read much better and more hopeful prospects. Orv Hetil. 2020; 161(17): 644651.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32324356
Database	COVID19

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Article ; Online: Paradigm shift in the vascular surgery of the lower extremity at the Department of Vascular Surgery, University of Szeged, Hungary

Takács, Tibor / Mihalovits, Gábor / Váradi, Rita / Nagy, András / Nagy, Endre / Palásthy, Zsolt

Orvosi hetilap

2021 Volume 162, Issue 24, Page(s) 943–951

Title translation	Szemléletváltozás az alsó végtagi érrekonstrukciók gyakorlatában a Szegedi Tudományegyetem Érsebészeti Osztályán.
MeSH term(s)	Humans ; Hungary ; Incidence ; Lower Extremity ; Surgeons ; Vascular Surgical Procedures
Language	Hungarian
Publishing date	2021-06-13
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2021.32099
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Article ; Online: Psychometric properties of the social interaction anxiety scale and the social phobia scale in Hungarian adults and adolescents.

Zsido, Andras N / Varadi-Borbas, Brigitta / Arato, Nikolett

BMC psychiatry

2021 Volume 21, Issue 1, Page(s) 171

Abstract: Background: Although social anxiety disorder is one of the most frequent disorders, it often remained unrecognized. Utilizing brief, yet reliable screening tools, such as the Social Interaction Anxiety Scale (SIAS-6) and the Social Phobia Scale (SPS-6) ... ...

Abstract	Background: Although social anxiety disorder is one of the most frequent disorders, it often remained unrecognized. Utilizing brief, yet reliable screening tools, such as the Social Interaction Anxiety Scale (SIAS-6) and the Social Phobia Scale (SPS-6) are helping to solve this problem in parts of Western Europe and the US. Still some countries, like Hungary, lag behind. For this purpose, previous studies call for further evidence on the applicability of the scales in various populations and cultures, as well as the elaborative validity of the short forms. Here, we aimed to provide a thorough analysis of the scales in five studies. We employed item response theory (IRT) to explore the psychometric properties of the SIAS-6 and the SPS-6 in Hungarian adults (n = 3213, age range:19-80) and adolescents (n = 292, age range:14-18). Results: In both samples, IRT analyses demonstrated that the items of SIAS-6 and SPS-6 had high discriminative power and cover a wide range of the latent trait. Using various subsamples, we showed that (1) the scales had excellent convergent and divergent validity in relation to domains of anxiety, depression, and cognitive emotion regulation in both samples. Further, that (2) the scales discriminated those with a history of fainting or avoidance from those without such history. Lastly, (3) the questionnaires can discriminate people diagnosed with social anxiety disorder (n = 30, age range:13-71) and controls. Conclusions: These findings suggest that the questionnaires are suitable for screening for SAD in adults and adolescents. Although the confirmation of the two-factor structure may be indicative of the validity of the "performance only" specifier of SAD in DSM-V, the high correlation between the factors and the similar patter of convergent validity might indicate that it is not a discrete entity but rather a part of SAD; and that SAD is latently continuous.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anxiety/diagnosis ; Europe ; Humans ; Hungary ; Middle Aged ; Phobia, Social/diagnosis ; Psychiatric Status Rating Scales ; Psychometrics ; Reproducibility of Results ; Social Interaction ; Young Adult
Language	English
Publishing date	2021-03-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-021-03174-6
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Article: PXE, a Mysterious Inborn Error Clarified.

Borst, Piet / Váradi, András / van de Wetering, Koen

Trends in biochemical sciences

2018 Volume 44, Issue 2, Page(s) 125–140

Abstract: Ever since Garrod deduced the existence of inborn errors in 1901, a vast array of metabolic diseases has been identified and characterized in molecular terms. In 2018 it is difficult to imagine that there is any uncharted backyard left in the metabolic ... ...

Abstract	Ever since Garrod deduced the existence of inborn errors in 1901, a vast array of metabolic diseases has been identified and characterized in molecular terms. In 2018 it is difficult to imagine that there is any uncharted backyard left in the metabolic disease landscape. Nevertheless, it took until 2013 to identify the cause of a relatively frequent inborn error, pseudoxanthoma elasticum (PXE), a disorder resulting in aberrant calcification. The mechanism found was not only biochemically interesting but also points to possible new treatments for PXE, a disease that has remained untreatable. In this review we sketch the tortuous road that led to the biochemical understanding of PXE and to new ideas for treatment. We also discuss some of the controversies still haunting the field.
MeSH term(s)	Humans ; Metabolism, Inborn Errors/genetics ; Metabolism, Inborn Errors/metabolism ; Metabolism, Inborn Errors/therapy ; Pseudoxanthoma Elasticum/genetics ; Pseudoxanthoma Elasticum/metabolism ; Pseudoxanthoma Elasticum/therapy
Language	English
Publishing date	2018-11-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	194216-5
ISSN	1362-4326 ; 0968-0004 ; 0376-5067
ISSN (online)	1362-4326
ISSN	0968-0004 ; 0376-5067
DOI	10.1016/j.tibs.2018.10.005
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Article ; Online: In vitro transport of methotrexate by Drosophila Multidrug Resistance-associated Protein.

Karasik, Agnes / Váradi, András / Szeri, Flóra

PloS one

2018 Volume 13, Issue 10, Page(s) e0205657

Abstract: Methotrexate (MTX) is a widely used chemotherapeutic agent, immune suppressant and antimalarial drug. It is a substrate of several human ABC proteins that confer multidrug resistance to cancer cells and determine compartmentalization of a wide range of ... ...

Abstract	Methotrexate (MTX) is a widely used chemotherapeutic agent, immune suppressant and antimalarial drug. It is a substrate of several human ABC proteins that confer multidrug resistance to cancer cells and determine compartmentalization of a wide range of physiological metabolites and endo or xenobiotics, by their primary active transport across biological membranes. The substrate specificity and tissue distribution of these promiscuous human ABC transporters show a high degree of redundancy, providing robustness to these key physiological and pharmacological processes, such as the elimination of toxins, e.g. methotrexate from the body. A similar network of proteins capable of transporting methotrexate has been recently suggested to exist in Drosophila melanogaster. One of the key players of this putative network is Drosophila Multidrug-resistance Associated Protein (DMRP). DMRP has been shown to be a highly active and promiscuous ABC transporter, capable of transporting various organic anions. Here we provide the first direct evidence that DMRP, expressed alone in a heterologous system lacking other, potentially functionally overlapping D. melanogaster organic anion transporters, is indeed able to transport methotrexate. Our in vitro results support the hypothesized but debated role of DMRP in in vivo methotrexate excretion.
MeSH term(s)	ATP-Binding Cassette Transporters/metabolism ; Adenosine Triphosphatases/metabolism ; Animals ; Biological Transport, Active ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; In Vitro Techniques ; Methotrexate/metabolism
Chemical Substances	ATP-Binding Cassette Transporters ; Drosophila Proteins ; MRP protein, Drosophila ; Adenosine Triphosphatases (EC 3.6.1.-) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2018-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0205657
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