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Article ; Online: Antifibrotic action of Yifei Sanjie formula enhanced autophagy via PI3K-AKT-mTOR signaling pathway in mouse model of pulmonary fibrosis.

Yu, Jing-Ze / Ying, Yi / Liu, Yang / Sun, Chun-Bin / Dai, Chen / Zhao, Shan / Tian, Shou-Zheng / Peng, Jing / Han, Ni-Ping / Yuan, Jia-Li / Yan, Jin-Yuan / Yang, Zhong-Shan

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2019 Volume 118, Page(s) 109293

Abstract: ... with a high mortality rate, but its origin is unknown and there is no effective treatment. Yifei Sanjie ...

Abstract	Pulmonary fibrosis (PF) is a crippling disease characterized by progressive dyspnea and associated with a high mortality rate, but its origin is unknown and there is no effective treatment. Yifei Sanjie formula (YFSJF) is a Chinese medicine that is widely used for treatment of respiratory systems disease. However, the molecular basis for the function of YFSJF has not been determined. Here we investigate the contribution of YFSJF in BLM-induced PF mice. Administration with YFSJF significantly alleviated the degree of BLM-induced collagen I and III deposition and the inflammatory injuring in the lungs and suppressed hydroxyproline release in PF animals. The active components of YFSJF are comprised with flavonoid, amino acids, saponins, oligosaccharide, organic acid, vitamin, esters, purine nucleosides. Additionally, there was a significant increase in autophagosomes, after treatment with YFSJF in PF animals. Interestingly, autophagy dysfunction by the blocker chloroquine (CQ) resulted in collagen deposition and inducing the expression of fibrosis-related genes. In addition, YFSJF-induced autophagy is mediated by the PI3K-AKT-mTOR pathway, and knockdown of PI3K by siRNA up-regulated the expression of autophagy-related genes and down-regulated the expression of collagen in human lung fibroblasts (HLF). Our findings provide a detailed understanding that YFSJF-antifibrotic effects are mainly mediated by triggering autophagy, and suppressing phosphorylation of the PI3K-AKT-mTOR pathway is required for YFSJF-curative effect.
MeSH term(s)	Animals ; Autophagosomes/metabolism ; Autophagosomes/ultrastructure ; Autophagy/drug effects ; Collagen/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal ; Humans ; Inflammation/complications ; Inflammation/pathology ; Lung/pathology ; Male ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Pulmonary Fibrosis/complications ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/pathology ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Transforming Growth Factor beta1/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Transforming Growth Factor beta1 ; Collagen (9007-34-5) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2019-08-08
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2019.109293
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Article ; Online: Analysis of the Progressive Collapse Resistance Mechanism of an RC Frame Structure with an L-Shaped Plane

Yifei Dai / Lei Qin

Applied Sciences, Vol 13, Iss 7216, p

2023 Volume 7216

Abstract: In order to improve the progressive collapse resistance of an RC frame structure with an L-shaped plane under local component failure, X-tension reinforcement and steel trusses are applied to the progressive collapse resistance design. In this paper, the ...

Abstract	In order to improve the progressive collapse resistance of an RC frame structure with an L-shaped plane under local component failure, X-tension reinforcement and steel trusses are applied to the progressive collapse resistance design. In this paper, the finite element software MIDAS Gen v2.1 is used to establish the RC frame structure with 6-story X-type tension strengthening and the RC frame structure with a steel truss at the top. Nonlinear dynamic analysis and a comparison of the two structures after local structural failure are carried out. The results show that both X-tension reinforcement and steel trusses can improve the integrity of the RC frame structure with an L-shaped plane and reduce the risk of progressive collapse in the event of single-column failure, but the steel trusses have the best effect. After component failure, adding a steel truss to the top layer can transfer the load above the failure column to other columns and reduce some beam resistance, providing a more effective alternative load transfer path for the structure.
Keywords	progressive collapse ; numerical simulation ; steel truss ; nonlinear dynamic analysis ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	621
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Overexpression of a Ramie (

Bao, Yaning / Zou, Yifei / An, Xia / Liao, Yiwen / Dai, Lunjin / Liu, Lijun / Peng, Dingxiang / Huang, Xing / Wang, Bo

Plants (Basel, Switzerland)

2024 Volume 13, Issue 3

Abstract: Plants face multiple stresses in their natural habitats. ...

Abstract	Plants face multiple stresses in their natural habitats.
Language	English
Publishing date	2024-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13030379
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Article ; Online: Hernia uterine inguinale associated with Mayer-Rokitansky-Küster-Hauser syndrome: Three case reports and literature review.

Dai, Yifei / Qin, Chenglu / Zhu, Linling / Luo, Guangnan

Medicine

2023 Volume 102, Issue 5, Page(s) e32802

Abstract: Rationale: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH syndrome) present with genital inguinal hernia was rare and probably under reported, on account of lack in typical gynecological symptom. It should be regarded with care.Here 3 cases diagnosed at ... ...

Abstract	Rationale: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH syndrome) present with genital inguinal hernia was rare and probably under reported, on account of lack in typical gynecological symptom. It should be regarded with care.Here 3 cases diagnosed at our institution with detailed clinical information were present, and the literature was reviewed to paint a comprehensive profile of hernia uterine inguinale associated with MRKH syndrome. Patient concerns: Case no. 1 was a 36-year-old female with recurrent dragalgia for 5 years. Left rudimentary uterus at the left groin area was revealed by sonography scan and confirmed by diagnostic laparoscopy.Case no. 2 was a 27-year-old woman diagnosed with MRKH syndrome and her MRI examination suggested a suspicious swelling measuring 2.0cm×2.0cm in left groin. The left nonfunctionally rudimentary uterus and adnexa were incarcerated in the left inguinal hernial sac, which was revealed by laparoscopy.Case no. 3 was a 29-year-old woman, admitted with right abdominal pain with a provisional diagnosis of appendicitis. After appendicectomy, pelvic exploration showed a part of left rudimentary uterus and elongated oviduct herniated through the left internal inguinal ring. Diagnoses: Hernia uterine inguinale associated with MRKH syndrome. Interventions and outcomes: Case no.1: When the rudimentary uterus was pulled out from the hernia sac, it appearance dark ocher. Then the left rudimentary uterus was removed and the indirect defect of inguinal duct was closed.The patient was followed up for 18 months with no recurrence of abdominal pain.Case no.2 and 3:The left rudimentary uterus were replaced from the hernia sac, and the indirect defect was fixed with sutures.The patients recovered smoothly without complications for 12-month follow-up. Lessons: Left involvement of rudimentary uterus was frequently observed in patients with MRKH syndrome, along with ipsilateral ovary and/or fallopian tube horned in the hernia. Abdominal pain or inguinale mass could be the chief complaints while some individuals were asymptomatic. Either surgical removal or replacement of rudimentary uterus was an effectively optional treatment strategy for hernia uterine inguinale.When a patient with MRKH syndrome presented with abdominal pain of unknown cause or inguinal mass, rudimentary uterine inguinal hernia should be suspected.
MeSH term(s)	Humans ; Female ; Adult ; Abnormalities, Multiple/diagnosis ; Hernia, Inguinal/etiology ; Uterus/surgery ; Mullerian Ducts ; Abdominal Pain ; Congenital Abnormalities/diagnosis
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000032802
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Article ; Online: Sucrose Osmotic Self-Oscillation Drives Membrane Permeability.

Chen, Lichun / Xue, Songwen / Dai, Binhao / Wang, Yifei / Zhao, Huimin

Journal of agricultural and food chemistry

2023 Volume 71, Issue 19, Page(s) 7557–7565

Abstract: Molecular permeation through phospholipid membranes is a fundamental biological process for small molecules. Sucrose is one of the most widely used sweeteners and a key factor in the pathogenesis of obesity and diabetes, yet a detailed understanding of ... ...

Abstract	Molecular permeation through phospholipid membranes is a fundamental biological process for small molecules. Sucrose is one of the most widely used sweeteners and a key factor in the pathogenesis of obesity and diabetes, yet a detailed understanding of its mechanism involved in permeability into phospholipid membranes is still lacking. Here, using giant unimolecular vesicles (GUVs) reconstituting membrane properties, we compared the osmotic behavior of sucrose in GUVs and HepG2 cells to explore the effect of sucrose on membrane stability in the absence of protein enhancers. The results suggested that the particle size and potential of GUVs and the cellular membrane potential changed significantly with increasing the sucrose concentration (
MeSH term(s)	Sucrose/metabolism ; Unilamellar Liposomes/metabolism ; Cell Membrane/metabolism ; Phospholipids/metabolism ; Permeability
Chemical Substances	Sucrose (57-50-1) ; Unilamellar Liposomes ; Phospholipids
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c00794
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Article ; Online: Metabolic Glycan Labeling in Primary Neurons Enabled by Unnatural Sugars with No

Sun, Jiayu / Huang, Zhimin / Du, Yifei / Lv, Pinou / Fan, Xinqi / Dai, Peng / Chen, Xing

ACS chemical biology

2023 Volume 18, Issue 6, Page(s) 1416–1424

Abstract: It is of great interest to probe glycosylation in primary neuron cultures. However, per- ...

Abstract	It is of great interest to probe glycosylation in primary neuron cultures. However, per-
MeSH term(s)	Sugars ; Glycoproteins/metabolism ; Polysaccharides/metabolism ; Neurons/metabolism
Chemical Substances	N-azidoacetylmannosamine ; Sugars ; Glycoproteins ; Polysaccharides
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/acschembio.3c00152
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Article: Bootstrapping Semi-supervised Medical Image Segmentation with Anatomical-Aware Contrastive Distillation.

You, Chenyu / Dai, Weicheng / Min, Yifei / Staib, Lawrence / Duncan, James S

Information processing in medical imaging : proceedings of the ... conference

2023 Volume 13939, Page(s) 641–653

Abstract: Contrastive learning has shown great promise over annotation scarcity problems in the context of medical image segmentation. Existing approaches typically assume a balanced class distribution for both labeled and unlabeled medical images. However, ... ...

Abstract	Contrastive learning has shown great promise over annotation scarcity problems in the context of medical image segmentation. Existing approaches typically assume a balanced class distribution for both labeled and unlabeled medical images. However, medical image data in reality is commonly imbalanced (
Language	English
Publishing date	2023-06-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	50782-9
ISSN	1011-2499
ISSN	1011-2499
DOI	10.1007/978-3-031-34048-2_49
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Article: Safety and Efficacy of Inactivated SARS-CoV-2 Vaccine in Patients with Rheumatic Diseases and Serum Antibody Changes Post-Omicron Variant Infection.

Zhang, Xiaowei / Li, Yifei / Dai, Chunqing / Chu, Yaya / Luan, Chaoqi / Wang, Guihong

Rheumatology and therapy

2024 Volume 11, Issue 1, Page(s) 191–200

Abstract: Introduction: The purpose of this study was to investigate whether the inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine has a similar effectiveness and safety profile in patients with rheumatic and musculoskeletal ... ...

Abstract	Introduction: The purpose of this study was to investigate whether the inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine has a similar effectiveness and safety profile in patients with rheumatic and musculoskeletal diseases (RMDs) and healthy controls (HCs). Methods: Between August 10, 2021 and September 30, 2021, 134 HCs and 269 patients with RMDs were recruited. All participants who tested negative for COVID-19 were vaccinated with SARS-CoV-2 inactivated vaccine. Next, 150 patients with RMDs and 30 HCs infected with the SARS-CoV-2 Omicron variant within the previous 12 weeks were recruited between February 20, 2023 and March 1, 2023. Serum samples were collected from each participant, and the serum immunoglobulin G (IgG) and immunoglobulin M (IgM) antibody titers against SARS-CoV-2 were determined using a chemiluminescence assay. Results: No statistically significant difference was found in the titer of anti-SARS-CoV-2 IgG and IgM antibodies, or in the incidence of vaccination-related adverse events between the RMD and HC groups (P = 0.183, P = 0.903, and P = 0.27, respectively). Serum IgG titers of SARS-CoV-2 neutralizing antibodies were significantly higher in patients who received two or more doses of inactivated vaccine than in patients who were unvaccinated or had received one dose of vaccine (244.36 ± 109.79 vs. 66.20 ± 82.50; P < 0.001). Conclusions: SARS-CoV-2 inactivated vaccines have similar protective effects in HCs and patients with RMDs, with an appreciable safety profile. Fully vaccinated patients with RMDs infected with the Omicron variant were able to produce effective neutralizing antibody concentrations.
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2783278-8
ISSN	2198-6584 ; 2198-6576
ISSN (online)	2198-6584
ISSN	2198-6576
DOI	10.1007/s40744-023-00630-5
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Article ; Online: Accurate leukocyte detection based on deformable-DETR and multi-level feature fusion for aiding diagnosis of blood diseases.

Chen, Yifei / Zhang, Chenyan / Chen, Ben / Huang, Yiyu / Sun, Yifei / Wang, Changmiao / Fu, Xianjun / Dai, Yuxing / Qin, Feiwei / Peng, Yong / Gao, Yu

Computers in biology and medicine

2024 Volume 170, Page(s) 107917

Abstract: In standard hospital blood tests, the traditional process requires doctors to manually isolate leukocytes from microscopic images of patients' blood using microscopes. These isolated leukocytes are then categorized via automatic leukocyte classifiers to ... ...

Abstract	In standard hospital blood tests, the traditional process requires doctors to manually isolate leukocytes from microscopic images of patients' blood using microscopes. These isolated leukocytes are then categorized via automatic leukocyte classifiers to determine the proportion and volume of different types of leukocytes present in the blood samples, aiding disease diagnosis. This methodology is not only time-consuming and labor-intensive, but it also has a high propensity for errors due to factors such as image quality and environmental conditions, which could potentially lead to incorrect subsequent classifications and misdiagnosis. Contemporary leukocyte detection methods exhibit limitations in dealing with images with fewer leukocyte features and the disparity in scale among different leukocytes, leading to unsatisfactory results in most instances. To address these issues, this paper proposes an innovative method of leukocyte detection: the Multi-level Feature Fusion and Deformable Self-attention DETR (MFDS-DETR). To tackle the issue of leukocyte scale disparity, we designed the High-level Screening-feature Fusion Pyramid (HS-FPN), enabling multi-level fusion. This model uses high-level features as weights to filter low-level feature information via a channel attention module and then merges the screened information with the high-level features, thus enhancing the model's feature expression capability. Further, we address the issue of leukocyte feature scarcity by incorporating a multi-scale deformable self-attention module in the encoder and using the self-attention and cross-deformable attention mechanisms in the decoder, which aids in the extraction of the global features of the leukocyte feature maps. The effectiveness, superiority, and generalizability of the proposed MFDS-DETR method are confirmed through comparisons with other cutting-edge leukocyte detection models using the private WBCDD, public LISC and BCCD datasets. Our source code and private WBCCD dataset are available at https://github.com/JustlfC03/MFDS-DETR.
MeSH term(s)	Humans ; Pregnancy ; Female ; Hematologic Diseases ; Leukocytes ; Hospitals ; Labor, Obstetric ; Piperazines
Chemical Substances	RHC 3281 (33353-30-9) ; Piperazines
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2024.107917
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Article ; Online: Blood Urea Nitrogen as a Prognostic Marker in Severe Acute Pancreatitis.

Dai, Minhui / Fan, Yifei / Pan, Pinhua / Tan, Yun

Disease markers

2022 Volume 2022, Page(s) 7785497

Abstract: Objectives: To explore independent risk factors with good and early predictive power for SAP severity and prognosis.: Methods: Patients with SAP were enrolled at Central South University Xiangya Hospital between April 2017 and May 2021 and used as ... ...

Abstract	Objectives: To explore independent risk factors with good and early predictive power for SAP severity and prognosis. Methods: Patients with SAP were enrolled at Central South University Xiangya Hospital between April 2017 and May 2021 and used as the training cohort. From June 2021 to February 2022, all patients with SAP were defined as external patients for validation. Patients were grouped by survival status at a 30-day posthospital admission and then compared in terms of basic information and laboratory tests to screen the independent risk factors. Results: A total of 249 patients with SAP were enrolled in the training cohort. The all-cause mortality rate at a 30-day postadmission was 25.8% (51/198). Blood urea nitrogen (BUN) levels were significantly higher in the mortality group (20.45 [interquartile range (IQR), 19.7] mmol/L) than in the survival group (6.685 [IQR, 6.3] mmol/L; Conclusions: Our results showed that BUN levels within 24 h after hospital admission were independent risk factors for a 30-day all-cause death in patients with SAP.
MeSH term(s)	Acute Disease ; Blood Urea Nitrogen ; Humans ; Pancreatitis/diagnosis ; Prognosis ; ROC Curve ; Retrospective Studies
Language	English
Publishing date	2022-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2022/7785497
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