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Article ; Online: APTC-C-SA01

Sha Liu / Karen Hon / George Spyro Bouras / Alkis James Psaltis / Keith Shearwin / Peter-John Wormald / Sarah Vreugde

International Journal of Molecular Sciences, Vol 23, Iss 6116, p

A Novel Bacteriophage Cocktail Targeting Staphylococcus aureus and MRSA Biofilms

2022 Volume 6116

Abstract: ... into the phage cocktail APTC-C-SA01 than for bacteria exposed to each of the phages alone. In conclusion, APTC-C ...

Abstract	The high infection and mortality rate of methicillin-resistant Staphylococcus aureus (MRSA) necessitates the urgent development of new treatment strategies. Bacteriophages (phages) have several advantages compared to antibiotics for the treatment of multi-drug-resistant bacterial infections, and thus provide a promising alternative to antibiotics. Here, S. aureus phages were isolated from patients and environmental sources. Phages were characterized for stability, morphology and genomic sequence and their bactericidal activity against the biofilm form of methicillin-susceptible Staphylococcus aureus (MSSA) and MRSA was investigated. Four S. aureus phages were isolated and tested against 51 MSSA and MRSA clinical isolates and reference strains. The phages had a broad host range of 82–94% individually and of >98% when combined and could significantly reduce the viability of S. aureus biofilms. The phages had a latent period of ≤20 min and burst size of >11 plaque forming units (PFU)/infected cell. Transmission electron microscopy (TEM) identified phages belonging to the family of Myoviridae . Genomic sequencing indicated the lytic nature of all four phages, with no identified resistance or virulence genes. The 4 phages showed a high complementarity with 49/51 strains (96%) sensitive to at least 2/4 phages tested. Furthermore, the frequency of bacteriophage insensitive mutant (BIM) generation was lower when the phages were combined into the phage cocktail APTC-C-SA01 than for bacteria exposed to each of the phages alone. In conclusion, APTC-C-SA01, containing four lytic S. aureus phages has the potential for further development as a treatment against MSSA and MRSA infections.
Keywords	S. aureus ; antimicrobial ; bacteriophage ; biofilm ; phage cocktail ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	630
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: APTC-C-SA01: A Novel Bacteriophage Cocktail Targeting

Liu, Sha / Hon, Karen / Bouras, George Spyro / Psaltis, Alkis James / Shearwin, Keith / Wormald, Peter-John / Vreugde, Sarah

International journal of molecular sciences

2022 Volume 23, Issue 11

Abstract: ... into the phage cocktail APTC-C-SA01 than for bacteria exposed to each of the phages alone. In conclusion, APTC-C ...

Abstract	The high infection and mortality rate of methicillin-resistant Staphylococcus aureus (MRSA) necessitates the urgent development of new treatment strategies. Bacteriophages (phages) have several advantages compared to antibiotics for the treatment of multi-drug-resistant bacterial infections, and thus provide a promising alternative to antibiotics. Here, S. aureus phages were isolated from patients and environmental sources. Phages were characterized for stability, morphology and genomic sequence and their bactericidal activity against the biofilm form of methicillin-susceptible Staphylococcus aureus (MSSA) and MRSA was investigated. Four S. aureus phages were isolated and tested against 51 MSSA and MRSA clinical isolates and reference strains. The phages had a broad host range of 82−94% individually and of >98% when combined and could significantly reduce the viability of S. aureus biofilms. The phages had a latent period of ≤20 min and burst size of >11 plaque forming units (PFU)/infected cell. Transmission electron microscopy (TEM) identified phages belonging to the family of Myoviridae. Genomic sequencing indicated the lytic nature of all four phages, with no identified resistance or virulence genes. The 4 phages showed a high complementarity with 49/51 strains (96%) sensitive to at least 2/4 phages tested. Furthermore, the frequency of bacteriophage insensitive mutant (BIM) generation was lower when the phages were combined into the phage cocktail APTC-C-SA01 than for bacteria exposed to each of the phages alone. In conclusion, APTC-C-SA01, containing four lytic S. aureus phages has the potential for further development as a treatment against MSSA and MRSA infections.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Biofilms ; Humans ; Methicillin-Resistant Staphylococcus aureus/genetics ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/therapy ; Staphylococcus Phages/genetics ; Staphylococcus aureus
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23116116
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; E-Book: Innovation in byzantine medicine

Bouras-Vallianatos, Petros

the writings of John Zacharias Aktouarios (c.1275-c.1330)

(Oxford studies in Byzantium)

2020

Abstract: Byzantine medicine is the biggest unknown quantity in both the study of medieval medicine and science and in Byzantine studies. This volume aims to redress this gap by presenting a comprehensive examination of the medical corpus of John Zacharias ... ...

Author's details	Petros Bouras-Vallianatos
Series title	Oxford studies in Byzantium
Abstract	Byzantine medicine is the biggest unknown quantity in both the study of medieval medicine and science and in Byzantine studies. This volume aims to redress this gap by presenting a comprehensive examination of the medical corpus of John Zacharias Aktouarios, arguably the most important Late Byzantine physician.
Keywords	Medicine, Medieval
Subject code	610
Language	English
Size	1 online resource :, illustrations (black and white, and colour).
Edition	First edition.
Publisher	Oxford Univeristy Press
Publishing place	Oxford, England
Document type	Book ; Online ; E-Book
Note	This edition also issued in print: 2020.
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-19-259108-8 ; 0-19-188563-0 ; 0-19-259107-X ; 0-19-885068-9 ; 978-0-19-259108-1 ; 978-0-19-188563-1 ; 978-0-19-259107-4 ; 978-0-19-885068-7
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Light-Induced Vitamin C Accumulation in Tomato Fruits is Independent of Carbohydrate Availability.

Ntagkas, Nikolaos / Woltering, Ernst / Bouras, Sofoklis / de Vos, Ric Ch / Dieleman, J Anja / Nicole, Celine Cs / Labrie, Caroline / Marcelis, Leo Fm

Plants (Basel, Switzerland)

2019 Volume 8, Issue 4

Abstract: L-ascorbate (ASC) is essential for human health. Therefore, there is interest in increasing the ASC content of crops like tomato. High irradiance induces accumulation of ASC in green tomato fruits. The D-mannose/L-galactose biosynthetic pathway accounts ... ...

Abstract	L-ascorbate (ASC) is essential for human health. Therefore, there is interest in increasing the ASC content of crops like tomato. High irradiance induces accumulation of ASC in green tomato fruits. The D-mannose/L-galactose biosynthetic pathway accounts for the most ASC in plants. The myo-inositol and galacturonate pathways have been proposed to exist but never identified in plants. The D-mannose/L-galactose starts from D-glucose. In a series of experiments, we tested the hypothesis that ASC levels depend on soluble carbohydrate content when tomato fruits ripen under irradiances that stimulate ASC biosynthesis. We show that ASC levels considerably increased when fruits ripened under light, but carbohydrate levels did not show a parallel increase. When carbohydrate levels in fruits were altered by flower pruning, no effects on ASC levels were observed at harvest or after ripening under irradiances that induce ASC accumulation. Artificial feeding of trusses with sucrose increased carbohydrate levels, but did not affect the light-induced ASC levels. We conclude that light-induced accumulation of ASC is independent of the carbohydrate content in tomato fruits. In tomato fruit treated with light, the increase in ASC was preceded by a concomitant increase in myo-inositol.
Language	English
Publishing date	2019-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants8040086
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Article ; Online: Cystatin C: an emerging biomarker in cardiovascular disease.

Angelidis, Christos / Deftereos, Spyridon / Giannopoulos, Georgios / Anatoliotakis, Nikolaos / Bouras, Georgios / Hatzis, Georgios / Panagopoulou, Vasiliki / Pyrgakis, Vlasios / Cleman, Michael W

Current topics in medicinal chemistry

2013 Volume 13, Issue 2, Page(s) 164–179

Abstract: Cystatin C (cys-C) is a small protein molecule (120 amino acid peptide chain, approximately 13kDa ... in the pathophysiology of CVD inspired researchers to explore the potential association of cys-C with CVD ... coronary artery disease) adverse outcomes and risk stratification have been associated with high plasma levels of cys-C ...

Abstract	Cystatin C (cys-C) is a small protein molecule (120 amino acid peptide chain, approximately 13kDa) produced by virtually all nucleated cells in the human body. It belongs to the family of papain-like cysteine proteases and its main biological role is the extracellular inhibition of cathepsins. It's near constant production rate, the fact that it is freely filtered from the glomerular membrane and then completely reabsorbed without being secreted from the proximal tubular cells, made it an almost perfect candidate for estimating renal function. The strong correlation between chronic kidney disease (CKD) and cardiovascular disease (CVD) along with the growing understanding of the role of cysteinyl cathepsins in the pathophysiology of CVD inspired researchers to explore the potential association of cys-C with CVD. Throughout the spectrum of CVD (peripheral arterial disease, stroke, abdominal aortic aneurysm, heart failure, coronary artery disease) adverse outcomes and risk stratification have been associated with high plasma levels of cys-C. The exact mechanisms behind the observed correlations have not been comprehensively clarified. Plausible links between high cys-C levels and poor cardiovascular outcome could be impaired renal function, atherogenesis and inflammatory mediators, remodeling of myocardial tissue and others (genetic factors, aging and social habits). The scope of the present article is to systematically review the current knowledge about cys-C biochemistry, metabolism, methods of detection and quantification and pathophysiological associations with different aspects of CVD.
MeSH term(s)	Amino Acid Sequence ; Animals ; Aortic Aneurysm, Abdominal/metabolism ; Biomarkers/blood ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Cathepsins/metabolism ; Cystatin C/blood ; Cystatin C/chemistry ; Cystatin C/metabolism ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Humans ; Kidney/metabolism ; Molecular Sequence Data ; Peripheral Arterial Disease/metabolism ; Peripheral Arterial Disease/physiopathology ; Predictive Value of Tests ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/metabolism ; Stroke/metabolism
Chemical Substances	Biomarkers ; Cystatin C ; Cathepsins (EC 3.4.-)
Language	English
Publishing date	2013-03-02
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/1568026611313020006
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Article ; Online: Light-Induced Vitamin C Accumulation in Tomato Fruits is Independent of Carbohydrate Availability

Ntagkas, N. / Woltering, E.J. / Bouras, Sofoklis / de Vos, C.H. / Dieleman, J.A. / Nicole, Celine / Labrie, C.W. / Marcelis, L.F.M.

Plants

2019 Volume 8, Issue 4

Abstract	L-ascorbate (ASC) is essential for human health. Therefore, there is interest in increasing the ASC content of crops like tomato. High irradiance induces accumulation of ASC in green tomato fruits. The D-mannose/L-galactose biosynthetic pathway accounts for the most ASC in plants. The myo-inositol and galacturonate pathways have been proposed to exist but never identified in plants. The D-mannose/L-galactose starts from D-glucose. In a series of experiments, we tested the hypothesis that ASC levels depend on soluble carbohydrate content when tomato fruits ripen under irradiances that stimulate ASC biosynthesis. We show that ASC levels considerably increased when fruits ripened under light, but carbohydrate levels did not show a parallel increase. When carbohydrate levels in fruits were altered by flower pruning, no effects onASC levels were observed at harvest or after ripening under irradiances that induce ASC accumulation. Artificial feeding of trusses with sucrose increased carbohydrate levels, but did not affect the light-induced ASC levels. We conclude that light-induced accumulation of ASC is independent of the carbohydrate content in tomato fruits. In tomato fruit treated with light, the increase in ASC was preceded by a concomitant increase in myo-inositol.
Keywords	Ascorbic acid ; Carbohydrates ; Galacturonate ; Irradiance ; Myo-inositol ; Vitamin C
Subject code	333
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Light-Induced Vitamin C Accumulation in Tomato Fruits is Independent of Carbohydrate Availability

Ntagkas, Nikolaos / Woltering, Ernst / Bouras, Sofoklis / de Vos, Ric C. H / Dieleman, J Anja / Nicole, Celine C. S / Labrie, Caroline / Marcelis, Leo F. M

Plants. 2019 Apr. 03, v. 8, no. 4

2019

Abstract	L-ascorbate (ASC) is essential for human health. Therefore, there is interest in increasing the ASC content of crops like tomato. High irradiance induces accumulation of ASC in green tomato fruits. The D-mannose/L-galactose biosynthetic pathway accounts for the most ASC in plants. The myo-inositol and galacturonate pathways have been proposed to exist but never identified in plants. The D-mannose/L-galactose starts from D-glucose. In a series of experiments, we tested the hypothesis that ASC levels depend on soluble carbohydrate content when tomato fruits ripen under irradiances that stimulate ASC biosynthesis. We show that ASC levels considerably increased when fruits ripened under light, but carbohydrate levels did not show a parallel increase. When carbohydrate levels in fruits were altered by flower pruning, no effects on ASC levels were observed at harvest or after ripening under irradiances that induce ASC accumulation. Artificial feeding of trusses with sucrose increased carbohydrate levels, but did not affect the light-induced ASC levels. We conclude that light-induced accumulation of ASC is independent of the carbohydrate content in tomato fruits. In tomato fruit treated with light, the increase in ASC was preceded by a concomitant increase in myo-inositol.
Keywords	ascorbic acid ; biochemical pathways ; biosynthesis ; carbohydrate content ; crops ; flowers ; fruits ; galactose ; glucose ; human health ; light intensity ; mannose ; myo-inositol ; nutritional support ; pruning ; ripening ; sucrose ; tomatoes
Language	English
Dates of publication	2019-0403
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants8040086
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Glycerin-Grafted Starch as Corrosion Inhibitor of C-Mn Steel in 1 M HCl solution

Sihem Lahrour / Abderrahim Benmoussat / Brahim Bouras / Asma Mansri / Lahcene Tannouga / Stefania Marzorati

Applied Sciences, Vol 9, Iss 21, p

2019 Volume 4684

Abstract: C-Mn steels, commonly employed in structural applications, are often exposed to near-neutral ... or coating. This work focuses on the C-Mn steel corrosion protection in the presence of HCl ...

Abstract	C-Mn steels, commonly employed in structural applications, are often exposed to near-neutral aerated environments and hence subjected to general corrosion. In broader contexts, for example during pickling, acidizing treatments, or acid-releasing processes, where steel comes in contact with more aggressive solutions, the use of corrosion inhibitors is a supplementary strategy to cathodic protection and/or coating. This work focuses on the C-Mn steel corrosion protection in the presence of HCl, either as process fluid or by product. In order to avoid the toxicological issues related to conventional synthetic products, a bio-copolymer containing glycerin-grafted starch, synthesized by modification of maize starch, was studied as a “green” corrosion inhibitor by the weight loss method and electrochemical techniques (open circuit potential, potentiodynamic polarization and electrochemical impedance spectroscopy). Corrosion-related parameters, such as inhibitor concentration and temperature, were varied and optimized to characterize the corrosion process. Results showed that inhibition efficiency increases with increasing bio-copolymer concentration, reaching a maximum of 94%at the concentration of 300 mg L −1 . The kinetic and thermodynamic parameters were determined and discussed. The obtained values of corrosion potential and corrosion current density, E corr and i corr , obtained by potentiodynamic polarization, are in agreement with the weight loss method. The corrosion current densities decrease when the concentration of the inhibitor increases.
Keywords	c-mnsteel ; corrosion inhibitors ; bio-copolymer ; starch ; glycerin ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	669 ; 621
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Combined effects of smoking and interleukin-6 and C-reactive protein genetic variants on endothelial function, inflammation, thrombosis and incidence of coronary artery disease.

Hatzis, George / Tousoulis, Dimitris / Papageorgiou, Nikolaos / Bouras, George / Oikonomou, Evangelos / Miliou, Antigoni / Siasos, Gerasimos / Toutouzas, Kostas / Papaioannou, Spyridon / Tsiamis, Eleftherios / Antoniades, Charalambos / Stefanadis, Christodoulos

International journal of cardiology

2014 Volume 176, Issue 1, Page(s) 254–257

MeSH term(s)	Adult ; Aged ; C-Reactive Protein/genetics ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/genetics ; Endothelium, Vascular/pathology ; Female ; Genetic Variation/genetics ; Humans ; Incidence ; Inflammation/diagnosis ; Inflammation/epidemiology ; Inflammation/genetics ; Interleukin-6/genetics ; Male ; Middle Aged ; Smoking/epidemiology ; Smoking/genetics ; Thrombosis/diagnosis ; Thrombosis/epidemiology ; Thrombosis/genetics
Chemical Substances	IL6 protein, human ; Interleukin-6 ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2014-09
Publishing country	Netherlands
Document type	Letter
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2014.06.058
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Book ; Online: Trends in Telecommunications Technologies

J Bouras, Christos

2010

Keywords	Mobile phone technology ; WAP (wireless) technology
Size	1 electronic resource (780 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021048963
ISBN	9789535158776 ; 9535158775
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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