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  1. Article ; Online: The increased hemoglobin oxygen affinity in COVID-19.

    Vogel, Dominik J / Formenti, Federico / Camporota, Luigi

    American journal of physiology. Lung cellular and molecular physiology

    2021  Volume 321, Issue 3, Page(s) L637

    MeSH term(s) COVID-19 ; Hemoglobins ; Humans ; Oxygen ; SARS-CoV-2
    Chemical Substances Hemoglobins ; Oxygen (S88TT14065)
    Language English
    Publishing date 2021-09-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00280.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nutritional interventions to modulate haemoglobin-oxygen affinity in COVID-19 patients.

    Formenti, Federico / Vogel, Dominik J / Camporota, Luigi

    Clinical nutrition (Edinburgh, Scotland)

    2020  Volume 39, Issue 12, Page(s) 3843–3844

    MeSH term(s) COVID-19 ; Hemoglobins ; Humans ; Hypoxia ; Oxygen ; Pandemics ; SARS-CoV-2
    Chemical Substances Hemoglobins ; Oxygen (S88TT14065)
    Keywords covid19
    Language English
    Publishing date 2020-10-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2020.10.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Industrially Relevant Conditions in Lab‐Scale Analysis for Alkaline Water Electrolysis

    Niklas Thissen / Julia Hoffmann / Dr. Sebastian Tigges / Dominik A. M. Vogel / Jil J. Thoede / Stefanie Khan / Nicolai Schmitt / Dr. Saskia Heumann / Prof. Bastian J. M. Etzold / Prof. Anna K. Mechler

    ChemElectroChem, Vol 11, Iss 1, Pp n/a-n/a (2024)

    2024  

    Abstract: Abstract Alkaline water electrolysis remains one of the most promising technologies for the large‐scale production of green hydrogen. However, further increases in efficiency remain elusive, as new electrode materials that are highly efficient in the ... ...

    Abstract Abstract Alkaline water electrolysis remains one of the most promising technologies for the large‐scale production of green hydrogen. However, further increases in efficiency remain elusive, as new electrode materials that are highly efficient in the laboratory cannot maintain their performance under industrial conditions. Within this work, we present a beaker cell setup, in which the industrial relevance of research materials can already be investigated in the laboratory by applying industrial conditions. Thus, the setup allows for testing at 80 °C in 30 wt. % KOH for more than 300 hours. Electrodes are contacted with an in‐house designed Ni tuck‐in holder and two types of reference electrodes are recommended. In addition, a protocol to unify catalyst research is introduced.
    Keywords Alkaline Water Electrolysis ; Benchmarking ; Cell Development ; Industrial Chemistry ; Water splitting ; Industrial electrochemistry ; TP250-261 ; Chemistry ; QD1-999
    Subject code 660
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Wiley-VCH
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.

    Williams, Harry M / Thorkelsson, Sigurdur R / Vogel, Dominik / Milewski, Morlin / Busch, Carola / Cusack, Stephen / Grünewald, Kay / Quemin, Emmanuelle R J / Rosenthal, Maria

    Nucleic acids research

    2023  Volume 51, Issue 3, Page(s) 1424–1442

    Abstract: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a phenuivirus that has rapidly become endemic in several East Asian countries. The large (L) protein of SFTSV, which includes the RNA-dependent RNA polymerase (RdRp), is responsible for ... ...

    Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV) is a phenuivirus that has rapidly become endemic in several East Asian countries. The large (L) protein of SFTSV, which includes the RNA-dependent RNA polymerase (RdRp), is responsible for catalysing viral genome replication and transcription. Here, we present 5 cryo-electron microscopy (cryo-EM) structures of the L protein in several states of the genome replication process, from pre-initiation to late-stage elongation, at a resolution of up to 2.6 Å. We identify how the L protein binds the 5' viral RNA in a hook-like conformation and show how the distal 5' and 3' RNA ends form a duplex positioning the 3' RNA terminus in the RdRp active site ready for initiation. We also observe the L protein stalled in the early and late stages of elongation with the RdRp core accommodating a 10-bp product-template duplex. This duplex ultimately splits with the template binding to a designated 3' secondary binding site. The structural data and observations are complemented by in vitro biochemical and cell-based mini-replicon assays. Altogether, our data provide novel key insights into the mechanism of viral genome replication by the SFTSV L protein and will aid drug development against segmented negative-strand RNA viruses.
    MeSH term(s) Humans ; Severe Fever with Thrombocytopenia Syndrome/genetics ; Cryoelectron Microscopy ; RNA, Viral/genetics ; RNA-Dependent RNA Polymerase/metabolism ; Phlebovirus/genetics ; Virus Replication ; Genome, Viral
    Chemical Substances RNA, Viral ; RNA-Dependent RNA Polymerase (EC 2.7.7.48)
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkac1249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Improved oxygenation with inhaled milrinone in mechanically ventilated patients with severe COVID-19.

    Vogel, Dominik J / Brame, Aimee / Hanks, Fraser / Remmington, Chris / Chung, Natali / Camporota, Luigi

    British journal of anaesthesia

    2021  Volume 127, Issue 3, Page(s) e111–e113

    MeSH term(s) Administration, Inhalation ; Aged ; COVID-19/therapy ; Female ; Humans ; Hypertension, Pulmonary ; Male ; Middle Aged ; Milrinone/administration & dosage ; Milrinone/therapeutic use ; Oxygen Inhalation Therapy/methods ; Respiration, Artificial/methods ; Respiratory Dead Space ; Vasodilator Agents/administration & dosage ; Vasodilator Agents/therapeutic use
    Chemical Substances Vasodilator Agents ; Milrinone (JU9YAX04C7)
    Language English
    Publishing date 2021-06-08
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2021.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: De novo variants in GABRA4 are associated with a neurological phenotype including developmental delay, behavioral abnormalities and epilepsy.

    Sajan, Samin A / Gradisch, Ralph / Vogel, Florian D / Coffey, Alison J / Salyakina, Daria / Soler, Diana / Jayakar, Parul / Jayakar, Anuj / Bianconi, Simona E / Cooper, Annina H / Liu, Shuxi / William, Nancy / Benkel-Herrenbrück, Ira / Maiwald, Robert / Heller, Corina / Biskup, Saskia / Leiz, Steffen / Westphal, Dominik S / Wagner, Matias /
    Clarke, Amy / Stockner, Thomas / Ernst, Margot / Kesari, Akanchha / Krenn, Martin

    European journal of human genetics : EJHG

    2024  

    Abstract: Nine out of 19 genes encoding ... ...

    Abstract Nine out of 19 genes encoding GABA
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-024-01600-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Policy makers believe money motivates more than it does.

    Jilke, Sebastian / Keppeler, Florian / Ternovski, John / Vogel, Dominik / Yoeli, Erez

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1901

    Abstract: To motivate contributions to public goods, should policy makers employ financial incentives like taxes, fines, subsidies, and rewards? While these are widely considered as the classic policy approach, a substantial academic literature suggests the impact ...

    Abstract To motivate contributions to public goods, should policy makers employ financial incentives like taxes, fines, subsidies, and rewards? While these are widely considered as the classic policy approach, a substantial academic literature suggests the impact of financial incentives is not always positive; they can sometimes fail or even backfire. To test whether policy makers are overly bullish about financial incentives, we asked county heads, mayors, and municipal government representatives of medium-to-large towns in Germany to predict the effects of a financial incentive on COVID-19 vaccination, and tested the exact same incentive in a field experiment involving all 41,548 inhabitants (clustered in 10,032 addresses) of the German town of Ravensburg. Whereas policy makers overwhelmingly predict that the financial incentive will increase vaccination-by 15.3 percentage points on average-the same financial incentive yielded a precisely estimated null effect on vaccination. We discuss when financial incentives are most likely to fail, and conclude that it is critical to educate policy makers on the potential pitfalls of employing financial incentives to promote contributions to public goods.
    MeSH term(s) Humans ; COVID-19 Vaccines ; Administrative Personnel ; Germany ; Local Government ; Policy
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-51590-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Nutritional interventions to modulate haemoglobin-oxygen affinity in COVID-19 patients

    Formenti, Federico / Vogel, Dominik J. / Camporota, Luigi

    Clinical Nutrition ; ISSN 0261-5614

    2020  

    Keywords Nutrition and Dietetics ; Critical Care and Intensive Care Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.clnu.2020.10.047
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Liberté, Égalité, Crédibilité: An experimental study of citizens' perceptions of government responses to COVID-19 in eight countries.

    Amirkhanyan, Anna A / Meier, Kenneth J / Song, Miyeon / Roberts, Fei W / Park, Joohyung / Vogel, Dominik / Bellé, Nicola / Molina, Angel Luis / Guul, Thorbjørn Sejr

    Public administration review

    2023  

    Abstract: During a global pandemic, individual views of government can be linked to citizens' trust and cooperation with government and their propensity to resist state policies or to take action that influences the course of a pandemic. This article explores ... ...

    Abstract During a global pandemic, individual views of government can be linked to citizens' trust and cooperation with government and their propensity to resist state policies or to take action that influences the course of a pandemic. This article explores citizens' assessments of government responses to COVID-19 as a function of policy substance (restrictions on civil liberties), information about performance, and socioeconomic inequity in outcomes. We conducted a survey experiment and analyzed data on over 7000 respondents from eight democratic countries. We find that across countries, citizens are less favorable toward COVID-19 policies that are more restrictive of civil liberties. Additionally, citizens' views of government performance are significantly influenced by objective performance information from reputable sources and information on the disproportionate impacts of COVID-19 on low-income groups. This study reinforces the importance of policy design and outcomes and the consideration of multiple public values in the implementation of public policies.
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2045553-7
    ISSN 1540-6210 ; 0033-3352
    ISSN (online) 1540-6210
    ISSN 0033-3352
    DOI 10.1111/puar.13588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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