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  1. Article ; Online: A low-cost off-the-shelf pressure-controlled mechanical ventilator for a mass respiratory failure scenario.

    Jardim-Neto, Alcendino C / Perlman, Carrie E

    British journal of anaesthesia

    2020  Volume 125, Issue 5, Page(s) e438–e440

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/therapy ; Positive-Pressure Respiration/economics ; Positive-Pressure Respiration/instrumentation ; Positive-Pressure Respiration/methods ; SARS-CoV-2 ; Ventilators, Mechanical/economics
    Keywords covid19
    Language English
    Publishing date 2020-08-20
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.08.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Individualised positive end-expiratory pressure guided by electrical impedance tomography for robot-assisted laparoscopic radical prostatectomy: a prospective, randomised controlled clinical trial.

    Girrbach, Felix / Petroff, David / Schulz, Susann / Hempel, Gunther / Lange, Mirko / Klotz, Carolin / Scherz, Stephanie / Giannella-Neto, Antonio / Beda, Alessandro / Jardim-Neto, Alcendino / Stolzenburg, Jens-Uwe / Reske, Andreas W / Wrigge, Hermann / Simon, Philipp

    British journal of anaesthesia

    2020  Volume 125, Issue 3, Page(s) 373–382

    Abstract: Background: Robot-assisted laparoscopic radical prostatectomy requires general anaesthesia, extreme Trendelenburg positioning and capnoperitoneum. Together these promote impaired pulmonary gas exchange caused by atelectasis and may contribute to ... ...

    Abstract Background: Robot-assisted laparoscopic radical prostatectomy requires general anaesthesia, extreme Trendelenburg positioning and capnoperitoneum. Together these promote impaired pulmonary gas exchange caused by atelectasis and may contribute to postoperative pulmonary complications. In morbidly obese patients, a recruitment manoeuvre (RM) followed by individualised PEEP improves intraoperative oxygenation and end-expiratory lung volume (EELV). We hypothesised that individualised PEEP with initial RM similarly improves intraoperative oxygenation and EELV in non-obese individuals undergoing robot-assisted prostatectomy.
    Methods: Forty males (age, 49-76 yr; BMI <30 kg m
    Results: In 20 males randomised to RM/PEEP
    Conclusion: In non-obese males, an individualised ventilation strategy improved intraoperative oxygenation, which was associated with higher end-expiratory lung volumes during robot-assisted laparoscopic prostatectomy.
    Clinical trial registration: DRKS00004199 (German clinical trials registry).
    MeSH term(s) Aged ; Electric Impedance ; Humans ; Male ; Middle Aged ; Positive-Pressure Respiration/methods ; Prospective Studies ; Prostatectomy/methods ; Robotic Surgical Procedures/methods
    Language English
    Publishing date 2020-07-19
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.05.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.80: Show issues Location:
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  4. Article ; Online: The role of sphingolipid metabolism disruption on lipopolysaccharide-induced lung injury in mice.

    Okuro, Renata Tiemi / Machado, Mariana Nascimento / Casquilho, Natália Vasconcelos / Jardim-Neto, Alcendino / Roncally-Carvalho, Alysson / Atella, Georgia Correa / Zin, Walter Araujo

    Pulmonary pharmacology & therapeutics

    2018  Volume 50, Page(s) 100–110

    Abstract: Aim: This study assessed pulmonary outcomes generated by inhibiting key enzymes of sphingolipid metabolism pathways related to ceramide synthesis in a murine model of lung injury induced by lipopolysaccharide (LPS).: Methods: C57BL/6 male adult mice ... ...

    Abstract Aim: This study assessed pulmonary outcomes generated by inhibiting key enzymes of sphingolipid metabolism pathways related to ceramide synthesis in a murine model of lung injury induced by lipopolysaccharide (LPS).
    Methods: C57BL/6 male adult mice received LPS intratracheally and the expressions of acid sphingomyelinase (ASM), neutral sphingomyelinase (NSM), serine palmitoyl transferase (SPT) and dihydroceramide synthase (DS) were assessed at 2, 4, 6, 12 and 24 h after LPS instillation in lung homogenate (n = 30). The pharmacological inhibition of ASM, NSM, SPT and DS were assayed in other mice groups by three different doses of desipramine, GW4869, myriocin and fumonisin, respectively (n = 90). Their most effective doses were administered intraperitoneally 1 or 2 h before LPS to different animal groups (n = 120). Mice underwent determination of pulmonary mechanics, lung histopathological aspects and apoptosis.
    Results: The expression levels of the enzymes reached their peak at 2-4 h after LPS administration. ASM inhibition attenuated alveolar collapse and GW4869 decreased lung elastance, proinflammatory cytokines' levels and was more effective to improve alveolar collapse than desipramine. On the other hand, SPT blockage aggravated lung lesion and no effects it was observed with fumonisin. Moreover, simultaneous administration of inhibitors (desipramine + GW4869, myriocin + fumonisin and all inhibitors together) resulted in no changes.
    Conclusion: Blockage of sphingomyelinases and the de novo pathways improved and aggravated lung injury, respectively, putatively suggesting specific targets to therapeutic strategies in LPS-induced lung injury.
    MeSH term(s) Aniline Compounds/pharmacology ; Animals ; Benzylidene Compounds/pharmacology ; Enzyme Activation/drug effects ; Enzyme Inhibitors/pharmacology ; Lipopolysaccharides/pharmacology ; Lung/drug effects ; Lung/enzymology ; Lung/metabolism ; Lung/pathology ; Lung Injury/chemically induced ; Lung Injury/enzymology ; Lung Injury/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Oxidoreductases/antagonists & inhibitors ; Oxidoreductases/metabolism ; Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Serine C-Palmitoyltransferase/antagonists & inhibitors ; Serine C-Palmitoyltransferase/metabolism ; Sphingolipids/metabolism ; Sphingomyelin Phosphodiesterase/antagonists & inhibitors ; Sphingomyelin Phosphodiesterase/metabolism
    Chemical Substances Aniline Compounds ; Benzylidene Compounds ; Enzyme Inhibitors ; GW 4869 ; Lipopolysaccharides ; Sphingolipids ; Oxidoreductases (EC 1.-) ; dihydroceramide synthase (EC 1.3.-) ; Serine C-Palmitoyltransferase (EC 2.3.1.50) ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; sphingosine kinase (EC 2.7.1.-) ; ceramide kinase (EC 2.7.1.138) ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
    Language English
    Publishing date 2018-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1399707-5
    ISSN 1522-9629 ; 1094-5539
    ISSN (online) 1522-9629
    ISSN 1094-5539
    DOI 10.1016/j.pupt.2018.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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