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Article ; Online: Relevance of acquired T cell molecular defects in the immunopathogenesis of SLE.

Rosetti, Florencia / Madera-Salcedo, Iris K / Crispín, José C

2024 Volume 263, Page(s) 110225

Abstract: Systemic lupus erythematosus (SLE) and other autoimmune diseases are thought to develop in genetically predisposed individuals when triggered by environmental factors. This paradigm does not fully explain disease development, as it fails to consider the ... ...

Abstract	Systemic lupus erythematosus (SLE) and other autoimmune diseases are thought to develop in genetically predisposed individuals when triggered by environmental factors. This paradigm does not fully explain disease development, as it fails to consider the delay between birth and disease expression. In this review, we discuss observations described in T cells from patients with SLE that are not related to hereditary factors and have therefore been considered secondary to the disease process itself. Here, we contextualize some of those observations and argue that they may represent a pathogenic layer between genetic factors and disease development. Acquired changes in T cell phenotype and function in the setting of SLE may affect the immune system, creating a predisposition towards a more inflammatory and pathogenic system that amplifies autoimmunity and facilitates disease development.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2024.110225
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Article: UNWINDING THE LONG ROAD THAT LEADS TO UNDERSTANDING AUTOIMMUNITY.

Rosetti, Florencia / Crispín, José C

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2021 Volume 73, Issue 5, Page(s) 297–301

Abstract: Systemic autoimmune diseases are complex clinical conditions that arise in genetically predisposed individuals as a result of the interplay between their immune system and their environment. In this perspective, we briefly discuss our current ... ...

Abstract	Systemic autoimmune diseases are complex clinical conditions that arise in genetically predisposed individuals as a result of the interplay between their immune system and their environment. In this perspective, we briefly discuss our current understanding of the pathogenesis of autoimmunity and indicate four research avenues whose exploration will bring us closer to resolving fundamental questions that remain unanswered in this enigmatic field.
MeSH term(s)	Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Autoimmunity/genetics ; Genetic Predisposition to Disease ; Humans
Language	English
Publishing date	2021-10-05
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
DOI	10.24875/RIC.21000294
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Article: Meta-analysis to Implement Alpha-Synuclein in Extracellular Vesicles as a Potential Biomarker for Parkinsons Disease.

Juárez-Vaquera, Víctor H / Rosetti-Sciutto, Marcos F / Morales-Ruiz, Valeria / Adalid-Peralta, Laura V

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2023 Volume 75, Issue 4, Page(s) 193–202

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; alpha-Synuclein ; Biomarkers ; Extracellular Vesicles ; Parkinson Disease/diagnosis
Chemical Substances	alpha-Synuclein ; Biomarkers ; SNCA protein, human
Language	English
Publishing date	2023-08-22
Publishing country	Mexico
Document type	Meta-Analysis ; Journal Article
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
DOI	10.24875/RIC.23000017
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Article ; Online: Understanding the Relationship Between Depression Symptom Severity and Health Care Costs for Patients With Treatment-Resistant Depression.

Lynch, Frances L / Dickerson, John F / O'Keeffe-Rosetti, Maureen / Chow, Wing / Pesa, Jacqueline

The Journal of clinical psychiatry

2022 Volume 83, Issue 2

Abstract: Objective:: Methods:: Results:: Conclusions: ...

Abstract	Objective: Methods: Results: Conclusions:
MeSH term(s)	Adult ; Aged ; Cohort Studies ; Delivery of Health Care, Integrated/economics ; Depressive Disorder, Major/economics ; Depressive Disorder, Treatment-Resistant/economics ; Facilities and Services Utilization/economics ; Female ; Health Care Costs ; Humans ; Male ; Middle Aged ; Patient Acceptance of Health Care ; Patient Acuity ; Patient Health Questionnaire ; Retrospective Studies
Language	English
Publishing date	2022-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	716287-x
ISSN	1555-2101 ; 0160-6689
ISSN (online)	1555-2101
ISSN	0160-6689
DOI	10.4088/JCP.21m13976
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Article: The Tower Building Task: A Behavioral Tool to Evaluate Recreational Risk-Taking.

Gracia-Garrido, Santiago / Rosetti, Marcos F / Muñoz Navarrete, Kevin / Hudson, Robyn

Behavioral sciences (Basel, Switzerland)

2022 Volume 12, Issue 9

Abstract: Risk-taking is a fundamental aspect of life spanning diverse contexts. Despite many tests being readily available, the behavioral assessment of risk propensity in recreational contexts, where decisions are not necessarily motivated by monetary gains or ... ...

Abstract	Risk-taking is a fundamental aspect of life spanning diverse contexts. Despite many tests being readily available, the behavioral assessment of risk propensity in recreational contexts, where decisions are not necessarily motivated by monetary gains or losses, is not well represented. As the tower building task (TBT) shares features of recreational activities, we evaluated whether it could assess risk-taking in this type of scenario. In the TBT, participants use standard-size wooden blocks to build the tallest tower they can within a 10 min period. In the current study we (i) examined methodological modifications to the task to either promote or reduce risky behavior and (ii) tested possible associations between the TBT scores and those of two commonly used risk-taking evaluations: The Balloon Analogue Risk Task (BART) and the Sensation Seeking Scale (SSS). We found that limiting the number of permitted collapses decreased the willingness to take risks, whereas challenging participants to exceed a "record" height increased risk-taking. TBT scores of one of the conditions correlated with scores of the BART and the SSS, particularly with the subscale addressing recreational activities. These findings suggest that the TBT offers a potentially useful means of evaluating risk-taking behaviors akin to those of the recreational domain.
Language	English
Publishing date	2022-09-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs12090325
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Article ; Online: Regulation of activated T cell survival in rheumatic autoimmune diseases.

Rosetti, Florencia / Madera-Salcedo, Iris K / Rodríguez-Rodríguez, Noé / Crispín, José C

Nature reviews. Rheumatology

2022 Volume 18, Issue 4, Page(s) 232–244

Abstract: Adaptive immune responses rely on the proliferation of T lymphocytes able to recognize and eliminate pathogens. The magnitude and duration of the expansion of activated T cell clones are finely regulated to minimize immunopathology and avoid autoimmunity. ...

Abstract	Adaptive immune responses rely on the proliferation of T lymphocytes able to recognize and eliminate pathogens. The magnitude and duration of the expansion of activated T cell clones are finely regulated to minimize immunopathology and avoid autoimmunity. In patients with rheumatic autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, activated lymphocytes survive and exert effector functions for prolonged periods, defying the mechanisms that normally curb their capacities during acute and chronic infections. Here, we review the molecular mechanisms that limit the duration of immune responses in health and discuss the factors that alter such regulation in the setting of systemic lupus erythematosus and rheumatoid arthritis. We highlight defects that could contribute to the development and progression of autoimmune disease and describe how chronic inflammation can alter the regulation of activated lymphocyte survival, promoting its perpetuation. These concepts might contribute to the understanding of the mechanisms that underlie the chronicity of inflammation in the context of autoimmunity.
MeSH term(s)	Arthritis, Rheumatoid ; Autoimmune Diseases ; Autoimmunity ; Cell Survival ; Humans ; Inflammation ; Lupus Erythematosus, Systemic ; Rheumatic Diseases ; T-Lymphocytes
Language	English
Publishing date	2022-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2491532-4
ISSN	1759-4804 ; 1759-4790
ISSN (online)	1759-4804
ISSN	1759-4790
DOI	10.1038/s41584-021-00741-9
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Article ; Online: Intrathecal anti-suprabasin antibodies in SLE, a cause of local concern?

Rosetti, Florencia / Crispín, José C

Clinical immunology (Orlando, Fla.)

2017 Volume 193, Page(s) 131–132

MeSH term(s)	Autoantibodies ; Humans ; Lupus Erythematosus, Systemic ; Lupus Vasculitis, Central Nervous System
Chemical Substances	Autoantibodies
Language	English
Publishing date	2017-11-29
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2017.11.013
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Article ; Online: Transient inhibition of sodium-glucose cotransporter 2 after ischemia/reperfusion injury ameliorates chronic kidney disease.

Martínez-Rojas, Miguel Ángel / Balcázar, Hiram / González-Soria, Isaac / González-Rivera, Jesús Manuel / Rodríguez-Vergara, Mauricio E / Velazquez-Villegas, Laura A / León-Contreras, Juan Carlos / Pérez-Villalva, Rosalba / Correa, Francisco / Rosetti, Florencia / Bobadilla, Norma A

JCI insight

2024 Volume 9, Issue 6

Abstract: Sodium-glucose cotransporter 2 (SGLT2) inhibitor, dapagliflozin (Dapa), exhibited nephroprotective effects in patients with chronic kidney disease (CKD). We assessed the efficacy of short-term Dapa administration following acute kidney injury (AKI) in ... ...

Abstract	Sodium-glucose cotransporter 2 (SGLT2) inhibitor, dapagliflozin (Dapa), exhibited nephroprotective effects in patients with chronic kidney disease (CKD). We assessed the efficacy of short-term Dapa administration following acute kidney injury (AKI) in preventing CKD. Male Wistar rats were randomly assigned to Sham surgery, bilateral ischemia for 30 minutes (abbreviated as IR), and IR + Dapa groups. Daily treatment with Dapa was initiated just 24 hours after IR and maintained for only 10 days. Initially, rats were euthanized at this point to study early renal repair. After severe AKI, Dapa promptly restored creatinine clearance (CrCl) and significantly reduced renal vascular resistance compared with the IR group. Furthermore, Dapa effectively reversed the mitochondrial abnormalities, including increased fission, altered mitophagy, metabolic dysfunction, and proapoptotic signaling. To study this earlier, another set of rats was studied just 5 days after AKI. Despite persistent renal dysfunction, our data reveal a degree of mitochondrial protection. Remarkably, a 10-day treatment with Dapa demonstrated effectiveness in preventing CKD transition in an independent cohort monitored for 5 months after AKI. This was evidenced by improvements in proteinuria, CrCl, glomerulosclerosis, and fibrosis. Our findings underscore the potential of Dapa in preventing maladaptive repair following AKI, emphasizing the crucial role of early intervention in mitigating AKI long-term consequences.
MeSH term(s)	Animals ; Humans ; Male ; Rats ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/prevention & control ; Acute Kidney Injury/metabolism ; Glucose ; Rats, Wistar ; Renal Insufficiency, Chronic/drug therapy ; Reperfusion Injury/complications ; Reperfusion Injury/metabolism ; Sodium/metabolism ; Sodium-Glucose Transporter 2/drug effects ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Benzhydryl Compounds/pharmacology ; Benzhydryl Compounds/therapeutic use
Chemical Substances	Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27) ; Sodium-Glucose Transporter 2 ; dapagliflozin (1ULL0QJ8UC) ; Sodium-Glucose Transporter 2 Inhibitors ; Benzhydryl Compounds
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.173675
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Article ; Online: The many faces of Mac-1 in autoimmune disease.

Rosetti, Florencia / Mayadas, Tanya N

Immunological reviews

2016 Volume 269, Issue 1, Page(s) 175–193

Abstract: Mac-1 (CD11b/CD18) is a β2 integrin classically regarded as a pro-inflammatory molecule because of its ability to promote phagocyte cytotoxic functions and enhance the function of several effector molecules such as FcγR, uPAR, and CD14. Nevertheless, ... ...

Abstract	Mac-1 (CD11b/CD18) is a β2 integrin classically regarded as a pro-inflammatory molecule because of its ability to promote phagocyte cytotoxic functions and enhance the function of several effector molecules such as FcγR, uPAR, and CD14. Nevertheless, recent reports have revealed that Mac-1 also plays significant immunoregulatory roles, and genetic variants in ITGAM, the gene that encodes CD11b, confer risk for the autoimmune disease systemic lupus erythematosus (SLE). This has renewed interest in the physiological roles of this integrin and raised new questions on how its seemingly opposing biological functions may be regulated. Here, we provide an overview of the CD18 integrins and how their activation may be regulated as this may shed light on how the opposing roles of Mac-1 may be elicited. We then discuss studies that exemplify Mac-1's pro-inflammatory versus regulatory roles particularly in the context of IgG immune complex-mediated inflammation. This includes a detailed examination of molecular mechanisms that could explain the risk-conferring effect of rs1143679, a single nucleotide non-synonymous Mac-1 polymorphism associated with SLE.
MeSH term(s)	Animals ; CD11b Antigen/genetics ; CD11b Antigen/metabolism ; Genetic Predisposition to Disease ; Humans ; Immune Complex Diseases/immunology ; Immunomodulation ; Lupus Erythematosus, Systemic/immunology ; Phagocytosis ; Polymorphism, Genetic ; Risk
Chemical Substances	CD11b Antigen ; ITGAM protein, human
Language	English
Publishing date	2016-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	391796-4
ISSN	1600-065X ; 0105-2896
ISSN (online)	1600-065X
ISSN	0105-2896
DOI	10.1111/imr.12373
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Article ; Online: Sexually Transmitted Infection Testing, Prevalence, and Treatment Among Individuals Receiving HIV Preexposure Prophylaxis Within an Integrated Healthcare Delivery System.

Schmidt, Mark A / Dickerson, John F / O'Keeffe-Rosetti, Maureen C / Salas, Suzanne B / Donald, Judy L / Tao, Guoyu

Sexually transmitted diseases

2022 Volume 49, Issue 9, Page(s) 616–621

Abstract: Background: Initial and follow-up sexually transmitted infection (STI) and human immunodeficiency virus (HIV) testing are recommended when taking HIV preexposure prophylaxis (PrEP). We assessed STI services before and after PrEP initiation among persons ...

Abstract	Background: Initial and follow-up sexually transmitted infection (STI) and human immunodeficiency virus (HIV) testing are recommended when taking HIV preexposure prophylaxis (PrEP). We assessed STI services before and after PrEP initiation among persons 18 years or older. Methods: We conducted this retrospective cohort study at a US integrated healthcare delivery system. We measured HIV/STI testing rates, STI prevalence and treatment at 3 time points: (1) at PrEP initiation, (2) at 120 days, and (3) at 210 days. Results: Of 685 PrEP initiators, 67.2% continued PrEP use at 120 days and 49.5% at 210 days. Of PrEP users, HIV and STI testing were greater than 85% and greater than 80%, respectively, at all 3 time points. Prevalence for any chlamydia, rectal chlamydia, and any gonorrhea, rectal gonorrhea, or pharyngeal gonorrhea was always high at the 120 days and 210 days (eg, 6.9%, 10.5%, 6.7%, 5.0%, and 5.2%, respectively, at the 120 days for continuous PrEP users). Over 90% of all individuals who tested positive for chlamydia and gonorrhea received antibiotic pharmacy fills within 7 days at 120 and 210 days. Monthly PrEP-related pharmacy cost was about $2259 to $2659. The proportion of the total medical cost that was PrEP-related pharmacy was about 82% for PrEP continuous users. Conclusions: Although HIV/STI testing rates were high, they can still be improved during HIV PrEP management. High STI prevalence after PrEP initiation in this study suggests that patients taking PrEP are at risk of acquiring an STI. Interventions to improve STI services during PrEP management are continuously needed.
MeSH term(s)	Delivery of Health Care, Integrated ; Gonorrhea/diagnosis ; Gonorrhea/drug therapy ; Gonorrhea/epidemiology ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Homosexuality, Male ; Humans ; Male ; Pre-Exposure Prophylaxis ; Prevalence ; Retrospective Studies ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/drug therapy ; Sexually Transmitted Diseases/epidemiology
Language	English
Publishing date	2022-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	435191-5
ISSN	1537-4521 ; 0148-5717
ISSN (online)	1537-4521
ISSN	0148-5717
DOI	10.1097/OLQ.0000000000001665
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