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  1. Article ; Online: Genetic variants causing G6PD deficiency: Clinical and biochemical data support new WHO classification.

    Nannelli, Caterina / Bosman, Andrea / Cunningham, Jane / Dugué, Pierre-Antoine / Luzzatto, Lucio

    British journal of haematology

    2023  Volume 202, Issue 5, Page(s) 1024–1032

    Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency in erythrocytes causes acute haemolytic anaemia upon exposure to fava beans, drugs, or infection; and it predisposes to neonatal jaundice. The polymorphism of the X-linked G6PD gene has been studied ... ...

    Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency in erythrocytes causes acute haemolytic anaemia upon exposure to fava beans, drugs, or infection; and it predisposes to neonatal jaundice. The polymorphism of the X-linked G6PD gene has been studied extensively: allele frequencies of up to 25% of different G6PD deficient variants are known in many populations; variants that cause chronic non-spherocytic haemolytic anaemia (CNSHA) are instead all rare. WHO recommends G6PD testing to guide 8-aminoquinolines administration to prevent relapse of Plasmodium vivax infection. From a literature review focused on polymorphic G6PD variants we have retrieved G6PD activity values of 2291 males, and for the mean residual red cell G6PD activity of 16 common variants we have obtained reliable estimates, that range from 1.9% to 33%. There is variation in different datasets: for most variants most G6PD deficient males have a G6PD activity below 30% of normal. There is a direct relationship between residual G6PD activity and substrate affinity (K
    MeSH term(s) Male ; Infant, Newborn ; Humans ; Glucosephosphate Dehydrogenase Deficiency/genetics ; Glucosephosphate Dehydrogenase/genetics ; Erythrocytes ; Polymorphism, Genetic ; Hemolysis ; World Health Organization
    Chemical Substances Glucosephosphate Dehydrogenase (EC 1.1.1.49)
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18943
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  2. Article ; Online: The vocal tract as a time machine: inferences about past speech and language from the anatomy of the speech organs.

    Dediu, Dan / Moisik, Scott R / Baetsen, W A / Bosman, Abel Marinus / Waters-Rist, Andrea L

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2021  Volume 376, Issue 1824, Page(s) 20200192

    Abstract: While speech and language do not fossilize, they still leave traces that can be extracted and interpreted. Here, we suggest that the shape of the hard structures of the vocal tract may also allow inferences about the speech of long-gone humans. These ... ...

    Abstract While speech and language do not fossilize, they still leave traces that can be extracted and interpreted. Here, we suggest that the shape of the hard structures of the vocal tract may also allow inferences about the speech of long-gone humans. These build on recent experimental and modelling studies, showing that there is extensive variation between individuals in the precise shape of the vocal tract, and that this variation affects speech and language. In particular, we show that detailed anatomical information concerning two components of the vocal tract (the lower jaw and the hard palate) can be extracted and digitized from the osteological remains of three historical populations from The Netherlands, and can be used to conduct three-dimensional biomechanical simulations of vowel production. We could recover the signatures of inter-individual variation between these vowels, in acoustics and articulation. While 'proof-of-concept', this study suggests that older and less well-preserved remains could be used to draw inferences about historic and prehistoric languages. Moreover, it forces us to clarify the meaning and use of the uniformitarian principle in linguistics, and to consider the wider context of language use, including the anatomy, physiology and cognition of the speakers. This article is part of the theme issue 'Reconstructing prehistoric languages'.
    MeSH term(s) Adult ; Cultural Evolution ; Female ; History, 15th Century ; History, 16th Century ; History, 19th Century ; History, Medieval ; Humans ; Language ; Male ; Middle Aged ; Netherlands ; Speech/physiology ; Speech Production Measurement ; Young Adult
    Language English
    Publishing date 2021-03-22
    Publishing country England
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2020.0192
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  3. Article ; Online: Comprehensive framework for integrated action on the prevention, diagnosis, and management of anemia: An introduction.

    Wilson, Shelby E / Rogers, Lisa M / Garcia-Casal, Maria Nieves / Barreix, María / Bosman, Andrea / Cunningham, Jane / Goga, Ameena / Montresor, Antonio / Tunçalp, Özge

    Annals of the New York Academy of Sciences

    2023  Volume 1524, Issue 1, Page(s) 5–9

    Abstract: The World Health Organization (WHO) announced in 2021 a commitment to develop a comprehensive framework for integrated action on the prevention, diagnosis, and management of anemia and to establish an Anaemia Action Alliance to support the implementation ...

    Abstract The World Health Organization (WHO) announced in 2021 a commitment to develop a comprehensive framework for integrated action on the prevention, diagnosis, and management of anemia and to establish an Anaemia Action Alliance to support the implementation of the framework. WHO commissioned four background papers to provide reflections about the most pressing issues to be addressed for accelerating reductions in the prevalence of anemia. Here, we provide a complete vision of the framework.
    MeSH term(s) Humans ; Anemia/diagnosis ; Anemia/prevention & control ; World Health Organization
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.14999
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  4. Article ; Online: Malaria kills more than Ebola virus disease.

    Pagnoni, Franco / Bosman, Andrea

    The Lancet. Infectious diseases

    2015  Volume 15, Issue 9, Page(s) 988–989

    MeSH term(s) Community Health Centers/statistics & numerical data ; Delivery of Health Care/statistics & numerical data ; Epidemics ; Female ; Hemorrhagic Fever, Ebola/epidemiology ; Hospitals/statistics & numerical data ; Humans ; Malaria/drug therapy
    Keywords covid19
    Language English
    Publishing date 2015-06-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(15)00075-4
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  5. Article: Smartphone assisted fieldwork: Towards the digital transition of geoscience fieldwork using LiDAR-equipped iPhones

    Tavani, Stefano / Billi, Andrea / Corradetti, Amerigo / Mercuri, Marco / Bosman, Alessandro / Cuffaro, Marco / Seers, Thomas / Carminati, Eugenio

    Earth-science reviews. 2022 Apr., v. 227

    2022  

    Abstract: Major advances in smartphones and tablets in terms of their built-in sensors (esp. cameras), available computational power and on-board memory are transforming the role of such devices into the key digital platform around which geological fieldwork is ... ...

    Abstract Major advances in smartphones and tablets in terms of their built-in sensors (esp. cameras), available computational power and on-board memory are transforming the role of such devices into the key digital platform around which geological fieldwork is redesigning itself. This digital transition is changing how geoscientists collect and share multimodal-multidimensional field datasets, which can now be readily distributed via standardized exchange formats and online data repositories. The increased accessibility of digital field datasets means that such data products are no longer the sole preserve of geospatial/geoscience specialists, but also students, stakeholders and the general public alike, providing great opportunities for knowledge transfer over the entirety of the research value chain. In the wake of this digital transition, the geological community has welcomed with enthusiasm and curiosity the introduction during 2020 of a native LiDAR scanner equipped on both the iPad Pro and the iPhone 12 Pro. This scanner offers a potential paradigm shift in digital geological fieldwork and puts these devices at the forefront of smartphone assisted fieldwork. In this work, we review progress in smartphone/tablet assisted geological fieldwork and test the iPhone 12 Pro's effectiveness as a replacement for conventional geological field tools. Specifically, we evaluate the geo-location accuracy of the iPhone's Global Navigation Satellite System (GNSS) receiver, the effectiveness of its inertial measurement unit (IMU) and magnetometer for orientation data collection, its photo-video imaging capabilities, and the performance of the device's newly equipped LiDAR in the field. We demonstrate that the performance of the iPhone for orientation and raster image data capture is high, being comparable to analog compass-clinometers and reflex/mirrorless cameras. Whilst location error is within the order of a few meters, the level of accuracy and the fast stabilization of the signal means that, beyond survey grade applications, the iPhone's geo-location capabilities are acceptable for most field cases. With regards to the iPhone's built-in LiDAR scanner, it is an excellent tool for depth assisted camera focusing and for casual 3D outcrop sharing, especially for ‘soft’ applications such as geo-heritage documentation and the production of teaching materials (here we also propose a simple mode of uploading outcrops models in Google Maps). However, the generated 3D models in some cases may be considered overly crude for detailed interrogation, particularly where the fidelity of the surface reconstruction is critical to the analysis (e.g. mesh facet orientation estimation). Based on our review of the evolution of digital field acquisition technologies and on our extensive field testing of the sensor suite integrated within the iPhone 12 Pro, it is clear that the digital transition of geological fieldwork is already mature, whereby smartphone devices have become as indispensable in the field as the geologists' traditional hammer and hand lens.
    Keywords cameras ; data collection ; global positioning systems ; lidar ; mobile telephones ; scanners ; stakeholders ; supply chain ; surveys
    Language English
    Dates of publication 2022-04
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1792-9
    ISSN 0012-8252
    ISSN 0012-8252
    DOI 10.1016/j.earscirev.2022.103969
    Database NAL-Catalogue (AGRICOLA)

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  6. Book ; Online: Malaria kills more than Ebola virus disease

    Bosman, Andrea / Pagnoni, Franco

    2015  

    Abstract: Comment ... Journal ... ...

    Abstract Comment

    Journal Article
    Language English
    Publishing date 2015-06-23
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Tumor-Induced Osteomalacia: A Systematic Clinical Review of 895 Cases.

    Bosman, Ariadne / Palermo, Andrea / Vanderhulst, Julien / De Beur, Suzanne M Jan / Fukumoto, Seiji / Minisola, Salvatore / Xia, Weibo / Body, Jean-Jacques / Zillikens, M Carola

    Calcified tissue international

    2022  Volume 111, Issue 4, Page(s) 367–379

    Abstract: Tumor-induced osteomalacia (TIO) is a rare and largely underdiagnosed paraneoplastic condition. Previous reviews often reported incomplete data on clinical aspects, diagnosis or prognosis. The aim of this study was to present a systematic clinical review ...

    Abstract Tumor-induced osteomalacia (TIO) is a rare and largely underdiagnosed paraneoplastic condition. Previous reviews often reported incomplete data on clinical aspects, diagnosis or prognosis. The aim of this study was to present a systematic clinical review of all published cases of TIO. A search was conducted in Pubmed, Embase, Web of Science from inception until April 23rd, 2020. We selected case reports and case series of patients diagnosed with TIO, with information on tumor localization and serum phosphate concentration. Two reviewers independently extracted data on biochemical and clinical characteristics including bone involvement, tumor localization and treatment. 468 articles with 895 unique TIO cases were included. Median age was 46 years (range 9 months-90 years) and 58.3% were males. Hypophosphatemia and inappropriately low or normal 1,25-dihydroxyvitamin D levels, characteristic for TIO, were present in 98% of cases. Median tumor size was 2.7 cm (range 0.5 to 25.0 cm). Serum fibroblast growth factor 23 was related to tumor size (r = 0.344, P < 0.001). In 32% of the cases the tumor was detected by physical examination. Data on bone phenotype confirmed skeletal involvement: 62% of cases with BMD data had a T-score of the lumbar spine ≤ - 2.5 (n = 61/99) and a fracture was reported in at least 39% of all cases (n = 346/895). Diagnostic delay was longer than 2 years in more than 80% of cases. 10% were reported to be malignant at histology. In conclusion, TIO is a debilitating disease characterized by a long diagnostic delay leading to metabolic disturbances and skeletal impairment. Increasing awareness of TIO should decrease its diagnostic delay and the clinical consequences.
    MeSH term(s) Delayed Diagnosis/adverse effects ; Female ; Fibroblast Growth Factors ; Humans ; Hypophosphatemia ; Male ; Osteomalacia/diagnosis ; Osteomalacia/etiology ; Osteomalacia/pathology ; Paraneoplastic Syndromes/diagnosis
    Chemical Substances Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 304266-2
    ISSN 1432-0827 ; 0944-0747 ; 0008-0594 ; 0171-967X
    ISSN (online) 1432-0827
    ISSN 0944-0747 ; 0008-0594 ; 0171-967X
    DOI 10.1007/s00223-022-01005-8
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  8. Article: [No title information]

    Abarca, Andrea Águila / Bosman, Karin Lagos

    Acta bioethica

    2010  Volume 3, Page(s) 403–411

    Title translation Actualización de registros de comités de ética y regulaciones en países de Latinoamérica y el Caribe.
    Language French
    Publishing date 2010-07-20
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 2122084-0
    ISSN 1726-569X ; 0717-5906
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    ISSN 0717-5906
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  9. Article ; Online: Een vrouw met klachten na een diclofenac-injectie.

    Geerts, Jan-Willem H J / Siegel, Andrea M / Bosman, Anne

    Nederlands tijdschrift voor geneeskunde

    2014  Volume 158, Page(s) A7351

    Abstract: A 61-year-old woman came to the Emergency Department with a skin lesion located at her right upper leg. At the site of the lesion a subcutaneous injection of diclofenac had been administered for pain from nephrolithiasis. CT revealed a large infiltrate ... ...

    Title translation A woman with complaints after an injection of diclofenac.
    Abstract A 61-year-old woman came to the Emergency Department with a skin lesion located at her right upper leg. At the site of the lesion a subcutaneous injection of diclofenac had been administered for pain from nephrolithiasis. CT revealed a large infiltrate proximal in the right upper leg; histologic evaluation of the tissue showed an acute necrotizing inflammation. These findings are typical for Nicolau syndrome.
    MeSH term(s) Diclofenac/administration & dosage ; Female ; Humans ; Injections, Intramuscular/adverse effects ; Leg ; Middle Aged ; Nicolau Syndrome/diagnosis ; Nicolau Syndrome/etiology ; Nicolau Syndrome/surgery
    Chemical Substances Diclofenac (144O8QL0L1)
    Language Dutch
    Publishing date 2014
    Publishing country Netherlands
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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    Ua VI Zs.18: Show issues Location:
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  10. Article ; Online: Sexual function of adult long-term survivors and their partners after allogeneic hematopoietic cell transplantation in Europe (S-FAST): a study from the Transplant Complications Working Party and Nurses Group of the EBMT.

    Gjærde, Lars Klingen / Eeltink, Corien / Stringer, Jacqui / Mooyaart, Jarl / Bosman, Paul / Kenyon, Michelle / Liptrott, Sarah / Greenfield, Diana M / Linke, Andrea / Turlure, Pascal / Botti, Stefano / Dzaferagic, Dzenana / Sica, Simona / Welsh, Lorna / Kisch, Annika / Perić, Zinaida / Schoemans, Hélène / Murray, John

    Bone marrow transplantation

    2022  Volume 58, Issue 2, Page(s) 195–202

    Abstract: Sexual dysfunction after allogeneic hematopoietic cell transplantation (allo-HCT) is a common long-term complication. We conducted a European multicenter cross-sectional study of adult allo-HCT recipients who had survived >2 years and their partners to ... ...

    Abstract Sexual dysfunction after allogeneic hematopoietic cell transplantation (allo-HCT) is a common long-term complication. We conducted a European multicenter cross-sectional study of adult allo-HCT recipients who had survived >2 years and their partners to investigate sexual functioning after HCT and to evaluate whether discussion about sexual functioning between the transplant team and the survivor and partner was perceived to have taken place. In total, 136 survivors (77 males, 59 females) and 81 partners (34 males, 47 females) participated. Median age was 56 and 54 years in male and female survivors, respectively. Forty-seven percent of male and 65% of female survivors and 57% of male and 59% of female partners reported clinically relevant sexual problems. Sixty-two percent of survivors and 79% of partners reported that sexual functioning had not been discussed with them during transplant. Standardized sexual functioning scores were correlated with self-reported health status in survivors (rho = 0.24, p = 0.009). The high prevalence of sexual dysfunction warrants additional studies focusing on the impact of changes in sexuality for patients as well as their partners. Future studies should also investigate which methods that are effective in preventing or treating sexual problems after allo-HCT.
    MeSH term(s) Humans ; Adult ; Male ; Female ; Cross-Sectional Studies ; Hematopoietic Stem Cell Transplantation/adverse effects ; Survivors ; Sexual Behavior ; Sexual Dysfunction, Physiological/etiology
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-022-01869-2
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