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  1. Article ; Online: Molecular Dynamics Simulation on the Charge Transport Properties in a Salt-in-Ionic Liquid Electrolyte.

    Ren, Xiaozhe / Yan, Tianying

    The journal of physical chemistry. B

    2023  Volume 127, Issue 48, Page(s) 10434–10446

    Abstract: A clear picture of charge transport properties in salt-in-ionic liquid electrolyte (SILE) is indispensable for the applications in lithium-ion batteries. In this study, we applied molecular dynamics (MD) simulations on a typical SILE system, composed of ... ...

    Abstract A clear picture of charge transport properties in salt-in-ionic liquid electrolyte (SILE) is indispensable for the applications in lithium-ion batteries. In this study, we applied molecular dynamics (MD) simulations on a typical SILE system, composed of lithium bis(fluorosulfonyl)imide (LiFSI) with a molar fraction of 0.3 doped in 1-ethyl-3-methylimidazolium bis(fluorosulfonyl)imide (EMIMFSI). Based on the MD simulations, we calculated conductivity spectra from 10
    Language English
    Publishing date 2023-11-26
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.3c05973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hepatic transcriptome analysis reveals that elovl5 deletion promotes PUFA biosynthesis and deposition.

    Wu, Wenpeng / Ren, Tianying / Cao, Xiaojuan / Gao, Jian

    Comparative biochemistry and physiology. Part D, Genomics & proteomics

    2023  Volume 46, Page(s) 101076

    Abstract: The safe and low-cost acquisition of polyunsaturated fatty acids (PUFAs) has become a research hotspot. Fatty acyl elongase 5 (Elovl5), a rate-limiting enzyme for fatty acid elongation, is principally in charge of extending C18 and C20 PUFA substrates. ... ...

    Abstract The safe and low-cost acquisition of polyunsaturated fatty acids (PUFAs) has become a research hotspot. Fatty acyl elongase 5 (Elovl5), a rate-limiting enzyme for fatty acid elongation, is principally in charge of extending C18 and C20 PUFA substrates. However, the role of elovl5 in regulating pathways and genes involved in PUFA synthesis remain largely unknown. Here, hepatic transcriptome analysis of wild-type and elovl5 knockout (elovl5
    MeSH term(s) Animals ; Acetyltransferases/genetics ; Acetyltransferases/metabolism ; Fatty Acid Elongases/genetics ; Fatty Acid Elongases/metabolism ; Zebrafish/genetics ; Zebrafish/metabolism ; Fatty Acids, Unsaturated/metabolism ; Gene Expression Profiling ; Zebrafish Proteins/genetics
    Chemical Substances Acetyltransferases (EC 2.3.1.-) ; Fatty Acid Elongases (EC 2.3.1.-) ; Fatty Acids, Unsaturated ; Elovl5 protein, zebrafish (EC 2.3.1.-) ; Zebrafish Proteins
    Language English
    Publishing date 2023-04-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2212119-5
    ISSN 1878-0407 ; 1744-117X
    ISSN (online) 1878-0407
    ISSN 1744-117X
    DOI 10.1016/j.cbd.2023.101076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The origin of mechanical harmonic distortion within the organ of Corti in living gerbil cochleae

    Wenxuan He / Tianying Ren

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: He and Ren measured sub-nanometer vibrations of the reticular lamina from the apical ends ...

    Abstract He and Ren measured sub-nanometer vibrations of the reticular lamina from the apical ends of the outer hair cells in living gerbil cochleae using a custom-built low-coherence interferometer. Their results indicate that mechanical harmonics are generated by the motile outer hair cells and can propagate to their best-frequency locations.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The origin of mechanical harmonic distortion within the organ of Corti in living gerbil cochleae.

    He, Wenxuan / Ren, Tianying

    Communications biology

    2021  Volume 4, Issue 1, Page(s) 1008

    Abstract: Although auditory harmonic distortion has been demonstrated psychophysically in humans and electrophysiologically in experimental animals, the cellular origin of the mechanical harmonic distortion remains unclear. To demonstrate the outer hair cell- ... ...

    Abstract Although auditory harmonic distortion has been demonstrated psychophysically in humans and electrophysiologically in experimental animals, the cellular origin of the mechanical harmonic distortion remains unclear. To demonstrate the outer hair cell-generated harmonics within the organ of Corti, we measured sub-nanometer vibrations of the reticular lamina from the apical ends of the outer hair cells in living gerbil cochleae using a custom-built heterodyne low-coherence interferometer. The harmonics in the reticular lamina vibration are significantly larger and have broader spectra and shorter latencies than those in the basilar membrane vibration. The latency of the second harmonic is significantly greater than that of the fundamental at low stimulus frequencies. These data indicate that the mechanical harmonics are generated by the outer hair cells over a broad cochlear region and propagate from the generation sites to their own best-frequency locations.
    MeSH term(s) Animals ; Biomechanical Phenomena ; Cochlea/physiology ; Gerbillinae/physiology ; Hair Cells, Auditory, Outer/physiology ; Interferometry ; Organ of Corti/physiology ; Vibration
    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-021-02540-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hepatic transcriptome analysis reveals that elovl5 deletion promotes PUFA biosynthesis and deposition

    Wu, Wenpeng / Ren, Tianying / Cao, Xiaojuan / Gao, Jian

    Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 2023 June, v. 46 p.101076-

    2023  

    Abstract: The safe and low-cost acquisition of polyunsaturated fatty acids (PUFAs) has become a research hotspot. Fatty acyl elongase 5 (Elovl5), a rate-limiting enzyme for fatty acid elongation, is principally in charge of extending C18 and C20 PUFA substrates. ... ...

    Abstract The safe and low-cost acquisition of polyunsaturated fatty acids (PUFAs) has become a research hotspot. Fatty acyl elongase 5 (Elovl5), a rate-limiting enzyme for fatty acid elongation, is principally in charge of extending C18 and C20 PUFA substrates. However, the role of elovl5 in regulating pathways and genes involved in PUFA synthesis remain largely unknown. Here, hepatic transcriptome analysis of wild-type and elovl5 knockout (elovl5⁻/⁻) zebrafish was performed to identify the potential regulatory targets related to PUFA deposition and synthesis. There were 1579 differentially expressed genes (DEGs), of which 787 had their expression levels increased while 792 had the opposite effect. Peroxisome proliferators-activated receptors (PPAR) signaling pathway was considerably enriched in DEGs, according to the KEGG analysis, in which fatp2, fabp7, and pparδ were engaged in PUFA absorption and deposition. Additionally, transcriptome analysis also revealed that cyp46a1 and cyp2r1 were implicated in the synthesis of bile acids and the metabolism of vitamin D, thus indirectly participating in PUFA biosynthesis and deposition. Finally, the DEGs, which improve PUFA level following elovl5 deletion, were verified through feeding experiment with two prepared diets soybean oil diet and linolenic acid oil diet. This study revealed potential regulatory targets that improve PUFA level after elovl5 deletion in teleosts.
    Keywords Danio rerio ; absorption ; bile ; biosynthesis ; diet ; enzymes ; gene expression regulation ; genomics ; linolenic acid ; peroxisome proliferator-activated receptors ; proteomics ; soybean oil ; transcriptomics ; Polyunsaturated fatty acids ; elovl5 ; Knockout ; Zebrafish
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 2212119-5
    ISSN 1878-0407 ; 1744-117X
    ISSN (online) 1878-0407
    ISSN 1744-117X
    DOI 10.1016/j.cbd.2023.101076
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6254: Show issues Location:
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  6. Article ; Online: Multi-DNA-Modified Double-Network Hydrogel with Customized Microstructure: A Novel System for Living Circulating Tumor Cells Capture and Real-Time Detection.

    Chen, Dongliang / Li, Yonggang / Liu, Xiaoqiu / Zhao, Yali / Ren, Tianying / Guo, Jing / Yang, Dawei / Li, Shenghai

    ACS applied materials & interfaces

    2024  Volume 16, Issue 7, Page(s) 8301–8309

    Abstract: The precise and effective isolation of living circulating tumor cells (CTCs) from peripheral blood, followed by their real-time monitoring, is crucial for diagnosing cancer patients. In this study, a cell-imprinted double-network (DN) hydrogel modified ... ...

    Abstract The precise and effective isolation of living circulating tumor cells (CTCs) from peripheral blood, followed by their real-time monitoring, is crucial for diagnosing cancer patients. In this study, a cell-imprinted double-network (DN) hydrogel modified with circular multi-DNA (CMD), coined the CMD-imprinted hydrogel with fixed cells as templates (CMD-CIDH), was developed. The hydrogel featured a customized surface for proficient capture of viable CTCs and
    MeSH term(s) Humans ; HeLa Cells ; Neoplastic Cells, Circulating/pathology ; Hydrogels ; MCF-7 Cells ; DNA ; Cell Separation ; Cell Line, Tumor
    Chemical Substances Hydrogels ; DNA (9007-49-2)
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c15432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Two-tone distortion in reticular lamina vibration of the living cochlea

    Tianying Ren / Wenxuan He

    Communications Biology, Vol 3, Iss 1, Pp 1-

    2020  Volume 8

    Abstract: Ren et al. used an in house heterodyne low-coherence interferometer to measure sub-nanometer ...

    Abstract Ren et al. used an in house heterodyne low-coherence interferometer to measure sub-nanometer vibrations, a proxy for distortion products, in living cochleae of gerbils. They were able to locate the generation source of the outer hair cell in the reticular lamina versus the basilar membrane in vivo.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Two-tone distortion in reticular lamina vibration of the living cochlea.

    Ren, Tianying / He, Wenxuan

    Communications biology

    2020  Volume 3, Issue 1, Page(s) 35

    Abstract: It has been demonstrated that isolated auditory sensory cells, outer hair cells, can generate distortion products at low frequencies. It remains unknown, however, whether or not motile outer hair cells are able to generate two-tone distortion at high ... ...

    Abstract It has been demonstrated that isolated auditory sensory cells, outer hair cells, can generate distortion products at low frequencies. It remains unknown, however, whether or not motile outer hair cells are able to generate two-tone distortion at high frequencies in living cochleae under the mechanical loads caused by surounding tissues and fluids. By measuring sub-nanometer vibration directly from the apical ends of outer hair cells using a custom-built heterodyne low-coherence interferometer, here we show outer hair cell-generated two-tone distortion in reticular lamina motion in the living cochlea. Reticular-lamina distortion is significantly greater and occurs at a broader frequency range than that of the basilar membrane. Contrary to expectations, our results indicate that motile outer hair cells are capable of generating two-tone distortion in vivo not only at the locations tuned to primary tones but also at a broad region basal to these locations.
    MeSH term(s) Acoustic Stimulation ; Animals ; Basilar Membrane/physiology ; Cochlea/physiology ; Female ; Gerbillinae ; Hair Cells, Auditory/physiology ; Male ; Organ of Corti/physiology ; Vibration
    Language English
    Publishing date 2020-01-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-020-0762-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Catalytic Electrolyte Additive Modulating Molecular Orbital Energy Levels of Lithium Polysulfides for High-Performance Lithium-Sulfur Batteries.

    Liu, Jing / Zhou, Yuhao / Xiao, Zhenxue / Ren, Xiaozhe / Liu, Sheng / Yan, Tianying

    ACS applied materials & interfaces

    2023  Volume 15, Issue 48, Page(s) 55608–55619

    Abstract: Lithium-sulfur (Li-S) batteries have ultrahigh theoretical specific capacity, but the practical application is hindered by the severe shuttle effect and the sluggish redox kinetics of the intermediate lithium polysulfides (LiPSs). Effectively enhancing ... ...

    Abstract Lithium-sulfur (Li-S) batteries have ultrahigh theoretical specific capacity, but the practical application is hindered by the severe shuttle effect and the sluggish redox kinetics of the intermediate lithium polysulfides (LiPSs). Effectively enhancing the conversion kinetics of LiPSs is essential for addressing these issues. Herein, the redox kinetics of LiPSs are effectively improved by introducing 6-azauracil (6-AU) molecules to the organic electrolyte to modulate the molecular orbital energy level of LiPSs. The 6-AU as a soluble catalyst can form complexes with LiPSs via Li-O bonds. These complexes are liable to transform because of the elevated HOMO and the reduced LUMO energy levels as compared to the dissociative LiPSs, resulting in small energy gaps (
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c10163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Validation of combined AFP, AFP-L3, and PIVKA II for diagnosis and monitoring of hepatocellular carcinoma in Chinese patients.

    Ren, Tianying / Hou, Xu / Zhang, Xin / Chen, Dongliang / Li, Juan / Zhu, Yingnan / Liu, Zhiheng / Yang, Dawei

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e21906

    Abstract: Background: In this study, we aimed to investigate the performance of GALAD, GALAD-C, and GAAP models in Chinese population in comparison to our newly build statistical model.: Methods: In this study, we built the AALP model based on age, α- ... ...

    Abstract Background: In this study, we aimed to investigate the performance of GALAD, GALAD-C, and GAAP models in Chinese population in comparison to our newly build statistical model.
    Methods: In this study, we built the AALP model based on age, α-fetoprotein (AFP), AFP-L3, and prothrombin induced by vitamin K absence-II (PIVKA II) to differentiate between patients with HCC and patients with CLD. We then compared the serum levels of AFP-L3 and PIVKA II in patients with HCC who were defined as remission or progression and showed the prognostic value of combined biomarkers.
    Results: The AUC value of the AALP model for HCC detection was 0.939 and AALP model exhibited a sensitivity of 81 % and a high specificity of 95 %. AALP model also exhibited good performance in the subgroups of patients with CLD. Furthermore, we demonstrated the consistency between imaging results and serum levels of AFP-L3 and PIVKA II.
    Conclusions: The AALP model achieved a good diagnostic performance and a high sensitivity for predicting HCC patients. Our research also showed that AFP-L3 and PIVKA II are complementary to each other but irreplaceable in the clinical detection and monitoring of HCC.
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e21906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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