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Article ; Online: Effects of sex and hydration status on kappa opioid receptor-mediated diuresis in rats.

Lalji, Hasnain M / Bailey, Christopher P / Husbands, Stephen M / Bailey, Sarah J

Basic & clinical pharmacology & toxicology

2024

Abstract: Understanding the function of the kappa opioid receptor (KOP) is crucial for the development of novel therapeutic interventions that target KOP for the treatment of pain, stress-related disorders and other indications. Activation of KOP produces diuretic ...

Abstract	Understanding the function of the kappa opioid receptor (KOP) is crucial for the development of novel therapeutic interventions that target KOP for the treatment of pain, stress-related disorders and other indications. Activation of KOP produces diuretic effects in rodents and man. Sex is a vital factor to consider when assessing drug response in pre-clinical and clinical studies. In this study, the diuretic effect of the KOP agonist, U50488 (1-10 mg/kg), was investigated in both adult female and male Wistar rats that were either normally hydrated or water-loaded. The KOP antagonist norbinaltorphimine (norBNI, 10 mg/kg) was administered 24 h prior to U50488 to confirm the involvement of KOP. U50488 elicited a significant diuretic response at doses ≥ 3 mg/kg in both female and male rats independent of hydration status. U50488 diuretic effects were inhibited by norBNI pre-administration. Water-loading reduced data variability for urine volume in males, but not in females, compared with normally hydrated rats. Sex differences were also evident in U50488 eliciting a significant increase in sodium and potassium ion excretion only in males. This may suggest different mechanisms of U50488 diuretic action in males where renal excretion mechanisms are directly affected more than in females.
Language	English
Publishing date	2024-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2134679-3
ISSN	1742-7843 ; 1742-7835
ISSN (online)	1742-7843
ISSN	1742-7835
DOI	10.1111/bcpt.14008
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Article ; Online: Telomeres and aging: on and off the planet!

Mason, Christopher E / Sierra, Maria A / Feng, Henry J / Bailey, Susan M

Biogerontology

2024 Volume 25, Issue 2, Page(s) 313–327

Abstract: Improving human healthspan in our rapidly aging population has never been more imperative. Telomeres, protective "caps" at the ends of linear chromosomes, are essential for maintaining genome stability of eukaryotic genomes. Due to their physical ... ...

Abstract	Improving human healthspan in our rapidly aging population has never been more imperative. Telomeres, protective "caps" at the ends of linear chromosomes, are essential for maintaining genome stability of eukaryotic genomes. Due to their physical location and the "end-replication problem" first envisioned by Dr. Alexey Olovnikov, telomeres shorten with cell division, the implications of which are remarkably profound. Telomeres are hallmarks and molecular drivers of aging, as well as fundamental integrating components of the cumulative effects of genetic, lifestyle, and environmental factors that erode telomere length over time. Ongoing telomere attrition and the resulting limit to replicative potential imposed by cellular senescence serves a powerful tumor suppressor function, and also underlies aging and a spectrum of age-related degenerative pathologies, including reduced fertility, dementias, cardiovascular disease and cancer. However, very little data exists regarding the extraordinary stressors and exposures associated with long-duration space exploration and eventual habitation of other planets, nor how such missions will influence telomeres, reproduction, health, disease risk, and aging. Here, we briefly review our current understanding, which has advanced significantly in recent years as a result of the NASA Twins Study, the most comprehensive evaluation of human health effects associated with spaceflight ever conducted. Thus, the Twins Study is at the forefront of personalized space medicine approaches for astronauts and sets the stage for subsequent missions. We also extrapolate from current understanding to future missions, highlighting potential biological and biochemical strategies that may enable human survival, and consider the prospect of longevity in the extreme environment of space.
MeSH term(s)	Humans ; Aging/genetics ; Cellular Senescence ; Longevity/genetics ; Planets ; Telomere ; Twin Studies as Topic
Language	English
Publishing date	2024-04-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2047160-9
ISSN	1573-6768 ; 1389-5729
ISSN (online)	1573-6768
ISSN	1389-5729
DOI	10.1007/s10522-024-10098-7
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Article: The impact of the COVID-19 pandemic on a recreational rainbow trout (

Bunt, Christopher M / Jacobson, Bailey

Environmental biology of fishes

2022 Volume 105, Issue 4, Page(s) 499–507

Abstract: There has been a recent flurry of publications describing the potential effects of the COVID-19 pandemic on both commercial and recreational fisheries. As of yet, studies have only provided insights from researchers or industry experts detailing ... ...

Abstract	There has been a recent flurry of publications describing the potential effects of the COVID-19 pandemic on both commercial and recreational fisheries. As of yet, studies have only provided insights from researchers or industry experts detailing perceived consequences, or from survey data indicating modifications in angler activity levels and behaviours. Using real recreational fisheries data from an ongoing radio telemetry study (2018-present), we explored changes in the relative exploitation rates of rainbow trout (
Language	English
Publishing date	2022-04-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	196790-3
ISSN	1573-5133 ; 0378-1909
ISSN (online)	1573-5133
ISSN	0378-1909
DOI	10.1007/s10641-022-01250-8
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Article ; Online: Understanding and Appreciating Burnout in Radiologists.

Bailey, Christopher R / Bailey, Allison M / McKenney, Anna Sophia / Weiss, Clifford R

Radiographics : a review publication of the Radiological Society of North America, Inc

2022 Volume 42, Issue 5, Page(s) E137–E139

MeSH term(s)	Burnout, Professional ; Burnout, Psychological ; Humans ; Radiologists ; Surveys and Questionnaires
Language	English
Publishing date	2022-07-15
Publishing country	United States
Document type	Editorial
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.220037
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Article: The impact of the COVID-19 pandemic on a recreational rainbow trout (Oncorhynchus mykiss) fishery

Bunt, Christopher M. / Jacobson, Bailey

Environmental biology of fishes. 2022 Apr., v. 105, no. 4

2022

Abstract	There has been a recent flurry of publications describing the potential effects of the COVID-19 pandemic on both commercial and recreational fisheries. As of yet, studies have only provided insights from researchers or industry experts detailing perceived consequences, or from survey data indicating modifications in angler activity levels and behaviours. Using real recreational fisheries data from an ongoing radio telemetry study (2018–present), we explored changes in the relative exploitation rates of rainbow trout (Oncorhynchus mykiss; Walbaum 1792) in the Saugeen River, Ontario, a tributary to Lake Huron, before compared to during the pandemic. Restrictions on site access that affected the implementation of important management activities that usually support this popular fishery are also discussed. During the initial phase of complete public lock-downs imposed during spring 2020, angler exploitation rates decreased to half that reported prior to the pandemic. Fishway operations were temporarily suspended and hatchery efforts were interrupted. Once restrictions began to ease in fall 2020, there was an eight-fold increase in overall exploitation rate and a four and a half-fold increase in harvest rate compared to seasons prior to the pandemic. While the full impact of the ongoing pandemic on the Lake Huron fishery is not likely to be fully realized for several years, the potential effects on future return run sizes may need to be considered by fisheries managers monitoring trends in population escapement.
Keywords	COVID-19 infection ; Oncorhynchus mykiss ; fish ladders ; fisheries ; hatcheries ; pandemic ; radio telemetry ; rivers ; spring ; surveys ; Lake Huron ; Ontario
Language	English
Dates of publication	2022-04
Size	p. 499-507.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	196790-3
ISSN	1573-5133 ; 0378-1909
ISSN (online)	1573-5133
ISSN	0378-1909
DOI	10.1007/s10641-022-01250-8
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Article: Monitoring Genomic Structural Rearrangements Resulting from Gene Editing.

Bailey, Susan M / Cross, Erin M / Kinner-Bibeau, Lauren / Sebesta, Henry C / Bedford, Joel S / Tompkins, Christopher J

Journal of personalized medicine

2024 Volume 14, Issue 1

Abstract: The cytogenomics-based methodology of directional genomic hybridization (dGH) enables the detection and quantification of a more comprehensive spectrum of genomic structural variants than any other approach currently available, and importantly, does so ... ...

Abstract	The cytogenomics-based methodology of directional genomic hybridization (dGH) enables the detection and quantification of a more comprehensive spectrum of genomic structural variants than any other approach currently available, and importantly, does so on a single-cell basis. Thus, dGH is well-suited for testing and/or validating new advancements in CRISPR-Cas9 gene editing systems. In addition to aberrations detected by traditional cytogenetic approaches, the strand specificity of dGH facilitates detection of otherwise cryptic intra-chromosomal rearrangements, specifically small inversions. As such, dGH represents a powerful, high-resolution approach for the quantitative monitoring of potentially detrimental genomic structural rearrangements resulting from exposure to agents that induce DNA double-strand breaks (DSBs), including restriction endonucleases and ionizing radiations. For intentional genome editing strategies, it is critical that any undesired effects of DSBs induced either by the editing system itself or by mis-repair with other endogenous DSBs are recognized and minimized. In this paper, we discuss the application of dGH for assessing gene editing-associated structural variants and the potential heterogeneity of such rearrangements among cells within an edited population, highlighting its relevance to personalized medicine strategies.
Language	English
Publishing date	2024-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm14010110
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Article: FABRICATION OF MULTILUMEN MICROFLUIDIC TUBING FOR

Felix, Bailey M / Young, Olivia M / Andreou, Jordi T / Sarker, Sunandita / Fuge, Mark D / Krieger, Axel / Weiss, Clifford R / Bailey, Christopher R / Sochol, Ryan D

Proceedings. IEEE International Conference on Micro Electro Mechanical Systems

2024 Volume 2024, Page(s) 1158–1161

Abstract: Among the numerous additive manufacturing or "three-dimensional (3D) printing" techniques, two-photon Direct Laser Writing (DLW) is distinctively suited for applications that demand high geometric versatility with micron-to-submicron-scale feature ... ...

Abstract	Among the numerous additive manufacturing or "three-dimensional (3D) printing" techniques, two-photon Direct Laser Writing (DLW) is distinctively suited for applications that demand high geometric versatility with micron-to-submicron-scale feature resolutions. Recently, "
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ISSN	1084-6999
ISSN	1084-6999
DOI	10.1109/mems58180.2024.10439522
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Article ; Online: Penicillin allergy reassessment for treatment improvement: A dental office tool to support appropriate penicillin allergy labeling.

Kunz Coyne, Ashlan J / Holger, Dana / Kennedy, Erinne / Connell, Mackenzie / Binienda, Juliann / Giuliano, Christopher / Bailey, Elaine M

Journal of the American Dental Association (1939)

2024

Abstract: Background: Dental appointments offer an opportunity to evaluate a documented penicillin (PCN) allergy and determine whether the patient might be a candidate for medical reassessment of their allergy. The authors gathered feedback on the Penicillin ... ...

Abstract	Background: Dental appointments offer an opportunity to evaluate a documented penicillin (PCN) allergy and determine whether the patient might be a candidate for medical reassessment of their allergy. The authors gathered feedback on the Penicillin Allergy Reassessment for Treatment Improvement (PARTI) tool, designed to enhance dentist-patient communications regarding PCN allergies. Methods: From January 2022 through May 2023, the authors conducted a mixed-methods study, collecting focus group data from patients with PCN allergies and surveying health care workers (HCWs) regarding the PARTI tool. Feedback focused on reassessment procedures, patient-centered allergy information, and medical records updates. Thematic analysis was used for focus group data. Results: The study included 15 patients in focus groups and 50 HCW survey respondents representing diverse US regions. Patient demographic characteristics included varied races, the mean age was 52 years, and most of the patients were female (53.3%). Most patients had health care interactions within the preceding year, at which 86.6% of patients were asked about drug allergies. HCW respondents primarily consisted of pharmacists (30%) and dentists, dental hygienists, and dental assistants (28%). Feedback on the PARTI tool was constructive, with both patients and HCWs recognizing its potential benefits and providing insights for improvement. Many HCWs (68%) highlighted the importance of step 3 of the PARTI tool, that is, the section on PCN allergy testing. Feedback from participants was incorporated into the final PARTI tool. Conclusions: Patient and HCW feedback on the PARTI tool was used to finalize a tool for the dental office to provide to patients who are candidates for PCN allergy reassessment. The feedback will also be used to inform an upcoming pilot study in US dental offices, focused on the process for PCN allergy reassessment and health record documentation. Practical implications: Deploying the PARTI tool in dental offices is pivotal, as mislabeling patients with PCN allergies could have severe consequences, such as hindering the prescription of lifesaving antibiotics for conditions like endocarditis, in the future. This implementation not only enhances communication between dentists and patients, but it is also crucial for ensuring improved patient safety and maintaining accurate medical records among health care settings.
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	220622-5
ISSN	1943-4723 ; 0002-8177 ; 1048-6364
ISSN (online)	1943-4723
ISSN	0002-8177 ; 1048-6364
DOI	10.1016/j.adaj.2023.12.007
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Article ; Online: Hidradenitis Suppurativa in Older Adults.

Blum, Franklin R / DeBarmore, Bailey M / Sayed, Christopher J

JAMA dermatology

2022 Volume 159, Issue 2, Page(s) 216–219

MeSH term(s)	Humans ; Aged ; Hidradenitis Suppurativa/diagnosis ; Hidradenitis Suppurativa/therapy ; Retrospective Studies
Language	English
Publishing date	2022-12-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2701761-8
ISSN	2168-6084 ; 2168-6068
ISSN (online)	2168-6084
ISSN	2168-6068
DOI	10.1001/jamadermatol.2022.5390
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Article: How Will You Feel on Valentine's Day? Affective Forecasting and Recall Biases as a Function of Anxiety, Depression, and Borderline Personality Disorder Features.

Hughes, Christopher D / King, Alexandra M / Bailey, Katharine / Alba, Maria C / Hoelscher, Elizabeth / Rizvi, Shireen L

Journal of social and clinical psychology

2023 Volume 41, Issue 5, Page(s) 491–516

Abstract: Introduction: The prediction of affective experiences, also known as affective forecasting, is an integral component of individuals' decision-making processes. Yet, research consistently demonstrates that affective forecasts (AF) and recollections (AR) ... ...

Abstract	Introduction: The prediction of affective experiences, also known as affective forecasting, is an integral component of individuals' decision-making processes. Yet, research consistently demonstrates that affective forecasts (AF) and recollections (AR) are generally inaccurate. Recent research has demonstrated distinct patterns of AF/R bias related to psychopathology. The present study examined the relationship between AF/R and features of Borderline Personality Disorder (BPD), anxiety, and depression using Valentine's Day as the target event. Methods: Undergraduate students (N=263; 33% white; 63% female; Results: Results indicate that higher BPD symptomatology predicted a significant overestimation of negative affect ( Discussion: Results were in line with prior research indicating that unique patterns of AF biases are associated with symptoms of psychopathology. However, results failed to support prior research linking AR biases to symptoms of psychopathology. Implications for future studies of affective biases and psychopathology more generally are discussed.
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	226817-6
ISSN	0736-7236
ISSN	0736-7236
DOI	10.1521/jscp.2022.41.5.491
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