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  1. Article ; Online: Temperature Dependence of Nuclear Quadrupole Resonance and the Observation of Metal-Ligand Covalency in Actinide Complexes:

    Park, Sejun / Walter, Eric D / Soderquist, Chuck Z / Sinkov, Sergey I / Cho, Herman

    The journal of physical chemistry. A

    2023  Volume 127, Issue 40, Page(s) 8347–8353

    Abstract: We report a study of the temperature dependence ... ...

    Abstract We report a study of the temperature dependence of
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.3c04657
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  2. Article: Selective Dorsal Rhizotomy For Treatment of Spasticity After Hemispherectomy In Children: A Case Report.

    Park, T S / Joh, Susan / Smyth, Matthew D / Meyer, Nicole L / Walter, Deanna M

    Cureus

    2023  Volume 15, Issue 3, Page(s) e36945

    Abstract: Performing a hemispherotomy or hemispherectomy is known to treat medically intractable epilepsy successfully, yet contralateral hemiparesis and increased muscle tone follow the epilepsy surgery. Spasticity and coexisting dystonia presumably cause the ... ...

    Abstract Performing a hemispherotomy or hemispherectomy is known to treat medically intractable epilepsy successfully, yet contralateral hemiparesis and increased muscle tone follow the epilepsy surgery. Spasticity and coexisting dystonia presumably cause the increased muscle tone in the lower extremity on the opposite side of epilepsy surgery. However, the extent of the role of spasticity and dystonia in high muscle tone is unknown. A selective dorsal rhizotomy is performed to reduce spasticity. If a selective dorsal rhizotomy is performed in the affected patient and muscle tone is reduced, the high muscle tone is not due to dystonia. Two children, who previously underwent a hemispherectomy or hemispherotomy, had a selective dorsal rhizotomy (SDR) performed in our clinic. Both children underwent orthopedic surgery to treat heel cord contractures. To study the extent of the role of spasticity and dystonia in high muscle tone, the mobility of the two children was examined pre- and post-SDR. The children had follow-ups 12 months and 56 months after SDR to study long-term effects. Before SDR, both children showed signs of spasticity. The SDR procedure removed spasticity, and muscle tone in the lower extremity became normal. Importantly, dystonia did not surface after SDR. Patients started independent walking less than two weeks after SDR. Sitting, standing, walking, and balance improved. They could walk longer distances while experiencing less fatigue. Running, jumping, and other more vigorous physical activities became possible. Notably, one child showed voluntary foot dorsiflexion that was absent before SDR. The other child showed improvement in voluntary foot dorsiflexion that was present before SDR. Both children maintained the progress at the 12 and 56-month follow-up visits. The SDR procedure normalized muscle tone and improved ambulation by removing spasticity. The high muscle tone following the epilepsy surgery was not due to dystonia.
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.36945
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  3. Article ; Online: XPA tumor variant leads to defects in NER that sensitize cells to cisplatin.

    Blee, Alexandra M / Gallagher, Kaitlyn S / Kim, Hyun-Suk / Kim, Mihyun / Kharat, Suhas S / Troll, Christina R / D'Souza, Areetha / Park, Jiyoung / Neufer, P Drew / Schärer, Orlando D / Chazin, Walter J

    NAR cancer

    2024  Volume 6, Issue 1, Page(s) zcae013

    Abstract: Nucleotide excision repair (NER) reduces efficacy of treatment with platinum (Pt)-based chemotherapy by removing Pt lesions from DNA. Previous study has identified that missense mutation or loss of the NER genes Excision Repair Cross Complementation ... ...

    Abstract Nucleotide excision repair (NER) reduces efficacy of treatment with platinum (Pt)-based chemotherapy by removing Pt lesions from DNA. Previous study has identified that missense mutation or loss of the NER genes Excision Repair Cross Complementation Group 1 and 2 (
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ISSN 2632-8674
    ISSN (online) 2632-8674
    DOI 10.1093/narcan/zcae013
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  4. Article ; Online: Molecularly thin, two-dimensional all-organic perovskites.

    Choi, Hwa Seob / Lin, Jun / Wang, Gang / Wong, Walter P D / Park, In-Hyeok / Lin, Fang / Yin, Jun / Leng, Kai / Lin, Junhao / Loh, Kian Ping

    Science (New York, N.Y.)

    2024  Volume 384, Issue 6691, Page(s) 60–66

    Abstract: Recently, the emergence of all-organic perovskites with three-dimensional (3D) structures has expanded the potential applications of perovskite materials. However, the synthesis and utilization of all-organic perovskites in 2D form remain largely ... ...

    Abstract Recently, the emergence of all-organic perovskites with three-dimensional (3D) structures has expanded the potential applications of perovskite materials. However, the synthesis and utilization of all-organic perovskites in 2D form remain largely unexplored because the design principle has not been developed. We present the successful synthesis of a metal-free 2D layered perovskite, denoted as the Choi-Loh van der Waals phase (CL-v phase), with the chemical formula A
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adk8912
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    Zs.MG 77: Show issues

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  5. Article ; Online: Multiple abnormal peripheral blood gene expression assay results are correlated with subsequent graft loss after kidney transplantation.

    Heilman, Raymond L / Fleming, James N / Mai, Martin / Smith, Byron / Park, Walter D / Holman, John / Stegall, Mark D

    Clinical transplantation

    2023  Volume 37, Issue 8, Page(s) e14987

    Abstract: Background: The aim of this study was to correlate peripheral blood gene expression profile (GEP) results during the first post-transplant year with outcomes after kidney transplantation.: Methods: We conducted a prospective, multicenter ... ...

    Abstract Background: The aim of this study was to correlate peripheral blood gene expression profile (GEP) results during the first post-transplant year with outcomes after kidney transplantation.
    Methods: We conducted a prospective, multicenter observational study of obtaining peripheral blood at five timepoints during the first post-transplant year to perform a GEP assay. The cohort was stratified based on the pattern of the peripheral blood GEP results: Tx-all GEP results normal, 1 Not-TX had one GEP result abnormal and >1 Not-TX two or more abnormal GEP results. We correlated the GEP results with outcomes after transplantation.
    Results: We enrolled 240 kidney transplant recipients. The cohort was stratified into the three groups: TX n = 117 (47%), 1 Not-TX n = 59 (25%) and >1 Not-TX n = 64 (27%). Compared to the TX group, the >1 Not-TX group had lower eGFR (p < .001) and more chronic changes on 1-year surveillance biopsy (p = .007). Death censored graft survival showed inferior graft survival in the >1 Not-TX group (p < .001) but not in the 1 Not-TX group. All graft losses in the >1 Not-TX group occurred after 1-year post-transplant.
    Conclusions: We conclude that a pattern of persistently Not-TX GEP assay correlates with inferior graft survival.
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Prospective Studies ; Gene Expression ; Graft Survival ; Graft Rejection/etiology ; Graft Rejection/genetics
    Language English
    Publishing date 2023-04-07
    Publishing country Denmark
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14987
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  6. Article ; Online: Association of Nonuveitic Retinal Vasculitis and Tractional Retinoschisis With Cystoid Macular Edema With Fabry Disease.

    Wisely, C Ellis / Park, Jong G / Walter, Scott D / Postel, Eric A / Ali, Mohsin H

    JAMA ophthalmology

    2019  Volume 137, Issue 9, Page(s) 1086–1088

    Language English
    Publishing date 2019-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2019.2170
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  7. Article: XPA tumor variants lead to defects in NER that sensitize cells to cisplatin.

    Blee, Alexandra M / Gallagher, Kaitlyn S / Kim, Hyun-Suk / Kim, Mihyun / Troll, Christina R / D'Souza, Areetha / Park, Jiyoung / Neufer, P Drew / Schärer, Orlando D / Chazin, Walter J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Nucleotide excision repair (NER) neutralizes treatment with platinum (Pt)-based chemotherapy by removing Pt lesions from DNA. Previous study has identified that missense mutation or loss of either of the NER genes Excision Repair Cross Complementation ... ...

    Abstract Nucleotide excision repair (NER) neutralizes treatment with platinum (Pt)-based chemotherapy by removing Pt lesions from DNA. Previous study has identified that missense mutation or loss of either of the NER genes Excision Repair Cross Complementation Group 1 and 2 (
    Significance: A destabilized, readily degraded tumor variant identified in the NER scaffold protein XPA sensitizes cells to cisplatin, suggesting that XPA variants can be used to predict response to chemotherapy.
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.29.547124
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  8. Article ; Online: Electrocardiography-based Artificial Intelligence Algorithms Aid in Prediction of Long-term Mortality After Kidney Transplantation.

    Pencovich, Niv / Smith, Byron H / Attia, Zachi I / Jimenez, Francisco Lopez / Bentall, Andrew J / Schinstock, Carrie A / Khamash, Hasan A / Jadlowiec, Caroline C / Jarmi, Tambi / Mao, Shennen A / Park, Walter D / Diwan, Tayyab S / Friedman, Paul A / Stegall, Mark D

    Transplantation

    2024  

    Abstract: Background: Predicting long-term mortality postkidney transplantation (KT) using baseline clinical data presents significant challenges. This study aims to evaluate the predictive power of artificial intelligence (AI)-enabled analysis of preoperative ... ...

    Abstract Background: Predicting long-term mortality postkidney transplantation (KT) using baseline clinical data presents significant challenges. This study aims to evaluate the predictive power of artificial intelligence (AI)-enabled analysis of preoperative electrocardiograms (ECGs) in forecasting long-term mortality following KT.
    Methods: We analyzed preoperative ECGs from KT recipients at three Mayo Clinic sites (Minnesota, Florida, and Arizona) between January 1, 2006, and July 30, 2021. The study involved 6 validated AI algorithms, each trained to predict future development of atrial fibrillation, aortic stenosis, low ejection fraction, hypertrophic cardiomyopathy, amyloid heart disease, and biological age. These algorithms' outputs based on a single preoperative ECG were correlated with patient mortality data.
    Results: Among 6504 KT recipients included in the study, 1764 (27.1%) died within a median follow-up of 5.7 y (interquartile range: 3.00-9.29 y). All AI-ECG algorithms were independently associated with long-term all-cause mortality (P < 0.001). Notably, few patients had a clinical cardiac diagnosis at the time of transplant, indicating that AI-ECG scores were predictive even in asymptomatic patients. When adjusted for multiple clinical factors such as recipient age, diabetes, and pretransplant dialysis, AI algorithms for atrial fibrillation and aortic stenosis remained independently associated with long-term mortality. These algorithms also improved the C-statistic for predicting overall (C = 0.74) and cardiac-related deaths (C = 0.751).
    Conclusions: The findings suggest that AI-enabled preoperative ECG analysis can be a valuable tool in predicting long-term mortality following KT and could aid in identifying patients who may benefit from enhanced cardiac monitoring because of increased risk.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000005023
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    Zs.A 488: Show issues Location:
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    Zs.MO 509: Show issues

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  9. Article ; Online: Liver mesenchymal stem cells are superior inhibitors of NK cell functions through differences in their secretome compared to other mesenchymal stem cells.

    Yigitbilek, Furkan / Ozdogan, Elif / Abrol, Nitin / Park, Walter D / Hansen, Michael J / Dasari, Surendra / Stegall, Mark D / Taner, Timucin

    Frontiers in immunology

    2022  Volume 13, Page(s) 952262

    Abstract: Liver-resident mesenchymal stem cells (L-MSCs) are superior inhibitors of alloreactive T cell responses compared to their counterparts from bone marrow (BM-MSCs) or adipose tissue (A-MSCs), suggesting a role in liver's overall tolerogenic ... ...

    Abstract Liver-resident mesenchymal stem cells (L-MSCs) are superior inhibitors of alloreactive T cell responses compared to their counterparts from bone marrow (BM-MSCs) or adipose tissue (A-MSCs), suggesting a role in liver's overall tolerogenic microenvironment. Whether L-MSCs also impact NK cell functions differently than other MSCs is not known. We generated and characterized L-MSCs, A-MSCs and BM-MSCs from human tissues. The mass spectrometry analysis demonstrated that L-MSC secretome is uniquely different than that of A-MSC/BM-MSC, with enriched protein sets involved in IFNγ responses and signaling. When co-cultured with primary human NK cells, L-MSCs but not other MSCs, decreased surface expression of activating receptors NKp44 and NKG2D. L-MSCs also decreased IFNγ secretion by IL-2-stimulated NK cells more effectively than other MSCs. Cytolytic function of NK cells were reduced significantly when co-cultured with L-MSCs, whereas A-MSCs or BM-MSCs did not have a major impact. Mechanistic studies showed that the L-MSC-mediated reduction in NK cell cytotoxicity is not through changes in secretion of the cytotoxic proteins Perforin, Granzyme A or B, but through increased production of HLA-C1 found in L-MSC secretome that inhibits NK cells by stimulating their inhibitory receptor KIRDL2/3. L-MSCs are more potent inhibitors of NK cell functions than A-MSC or BM-MSC. Combined with their T cell inhibitory features, these results suggest L-MSCs contribute to the tolerogenic liver microenvironment and liver-induced systemic tolerance often observed after liver transplantation.
    MeSH term(s) Granzymes/metabolism ; Humans ; Interleukin-2/metabolism ; Killer Cells, Natural/metabolism ; Liver/metabolism ; Mesenchymal Stem Cells/metabolism ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Perforin/metabolism ; Secretome
    Chemical Substances Interleukin-2 ; NK Cell Lectin-Like Receptor Subfamily K ; Perforin (126465-35-8) ; Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.952262
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  10. Article ; Online: Equatorial Electronic Structure in the Uranyl Ion: Cs

    Sergentu, Dumitru-Claudiu / Gendron, Frédéric / Walter, Eric D / Park, Sejun / Capan, Cigdem / Surbella, R Gian / Soderquist, Chuck Z / Hall, Gabriel B / Sinkov, Sergey I / Autschbach, Jochen / Cho, Herman

    Inorganic chemistry

    2021  Volume 61, Issue 9, Page(s) 3821–3831

    Abstract: Electric field gradient (EFG) tensors in the equatorial plane of the linear ... ...

    Abstract Electric field gradient (EFG) tensors in the equatorial plane of the linear UO
    Language English
    Publishing date 2021-11-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.1c02832
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