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  1. Article ; Conference proceedings: Einfluss der periinterventionellen Antibiotikagabe auf das Outcome einer endoskopischen Lungenvolumenreduktion

    Darvishi, H / Saccomanno, J / Witzenrath, M / Hübner, R / Pappe, E

    Pneumologie

    2024  Volume 78, Issue S 01

    Event/congress 64. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V., Mannheim, 2024-03-20
    Language German
    Publishing date 2024-03-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/s-0044-1778757
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells.

    Gehring, A / Huebner, K / Rani, H / Erlenbach-Wuensch, K / Merkel, S / Mahadevan, V / Grutzmann, R / Hartmann, A / Schneider-Stock, R

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2683

    Abstract: TROP2 is a powerful cancer driver in colorectal cancer cells. Divergent epigenetic regulation mechanisms for the corresponding TACSTD2 gene exist such as miRNAs or DNA methylation. However, the role of TACSTD2 promoter hypermethylation in colorectal ... ...

    Abstract TROP2 is a powerful cancer driver in colorectal cancer cells. Divergent epigenetic regulation mechanisms for the corresponding TACSTD2 gene exist such as miRNAs or DNA methylation. However, the role of TACSTD2 promoter hypermethylation in colorectal cancer has not been investigated yet. In this study, TROP2 expression strongly correlated with promoter methylation in different colorectal tumor cell lines. Treatment with 5-Azacytidine, a DNMT1 inhibitor, led to demethylation of the TACSTD2 promoter accompanied by an increase in TROP2 protein expression. TROP2 expression correlated with promoter methylation in vivo in human colon tumor tissue, thereby verifying promoter methylation as an important factor in the regulation of TROP2 expression in colorectal cancer. When performing a ChIP-Seq analysis in HCT116 and HT29 cells, we found that TACSTD2 promoter demethylation was accompanied by tri-methylation of H3K4. In silico analysis of GSE156613 data set confirmed that a higher binding of histone mark H3K4me3 around the TACSTD2 promoter was found in TACSTD2 high expressing tumors of colon cancer patients compared to the corresponding adjacent tumor tissue. Moreover, the link between TROP2 and the H3K4me3 code was even evident in tumors showing high intratumoral heterogeneity for TROP2 staining. Our data provide novel evidence for promoter demethylation and simultaneous gains of the active histone mark H3K4me3 across CpG-rich sequences, both being complementary mechanisms in the transcriptional regulation of TACSTD2 in colon cancer. The functional consequences of TROP2 loss in colorectal cancer needs to be further investigated.
    MeSH term(s) Humans ; Epigenesis, Genetic ; DNA Demethylation ; DNA Methylation ; Cell Line, Tumor ; Colonic Neoplasms/genetics ; Gene Expression Regulation, Neoplastic ; Colorectal Neoplasms/pathology ; CpG Islands ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/metabolism
    Chemical Substances TACSTD2 protein, human ; Antigens, Neoplasm ; Cell Adhesion Molecules
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52437-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 57/m mit Hämoptysen : Vorbereitung auf die Facharztprüfung: Fall 122.

    Pappe, E / Hübner, R-H / Raspe, M

    Der Internist

    2021  Volume 63, Issue Suppl 1, Page(s) 110–115

    Title translation 57/m-Hemoptysis : Preparation for the medical specialist examination: part 122.
    MeSH term(s) Hemoptysis/diagnosis ; Hemoptysis/etiology ; Hemoptysis/therapy ; Humans ; Medicine
    Language German
    Publishing date 2021-12-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-021-01224-5
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  4. Article ; Online: 67/m mit langsam zunehmender Dyspnoe und Husten : Vorbereitung auf die Facharztprüfung: Fall 20.

    Raspe, M / Saccomanno, J / Hübner, R-H

    Der Internist

    2021  Volume 62, Issue Suppl 1, Page(s) 110–117

    Title translation 67/m-gradually increasing dyspnea and cough : Preparation for the medical specialist examination: part 20.
    MeSH term(s) Cough/diagnosis ; Dyspnea/diagnosis ; Dyspnea/etiology ; Humans
    Language German
    Publishing date 2021-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-021-00963-9
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  5. Article ; Online: 27/m mit plötzlich einsetzenden thorakalen Schmerzen, Dyspnoe und Hämoptysen : Vorbereitung auf die Facharztprüfung: Fall 3.

    Saccomanno, J / Hübner, R-H / Raspe, M

    Der Internist

    2021  Volume 62, Issue Suppl 1, Page(s) 18–23

    Title translation 27/m-Sudden onset of chest pain, dyspnea and hemoptysis : Preparation for the medical specialist examination: part 3.
    MeSH term(s) Chest Pain/diagnosis ; Chest Pain/etiology ; Dyspnea/diagnosis ; Dyspnea/etiology ; Hemoptysis/diagnosis ; Hemoptysis/etiology ; Humans
    Language German
    Publishing date 2021-02-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-021-00961-x
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  6. Article ; Online: Efficacy of ultrasound vector flow imaging in tracking omnidirectional pulsatile flow.

    Haniel, Jonathas / Yiu, Billy Y S / Chee, Adrian J Y / Huebner, Rudolf / Yu, Alfred C H

    Medical physics

    2023  Volume 50, Issue 3, Page(s) 1699–1714

    Abstract: ... The mean percentage error (MPE) and the coefficient of determination (R: Results: Pulsatile flow ... correlation exists between VFI measurements and simulated flow vectors (lateral velocity: R: Conclusion ...

    Abstract Background: Ultrasound vector flow imaging (VFI) shows potential as an emerging non-invasive modality for time-resolved flow mapping. However, its efficacy in tracking multidirectional pulsatile flow with temporal resolvability has not yet been systematically evaluated because of the lack of an appropriate test protocol.
    Purpose: We present the first systematic performance investigation of VFI in tracking pulsatile flow in a meticulously designed scenario with time-varying, omnidirectional flow fields (with flow angles from 0° to 360°).
    Methods: Ultrasound VFI was performed on a three-loop spiral flow phantom (4 mm diameter; 5 mm pitch) that was configured to operate under pulsatile flow conditions (10 ml/s peak flow rate; 1 Hz pulse rate; carotid pulse shape). The spiral lumen geometry was designed to simulate recirculatory flow dynamics observed in the heart and in curvy blood vessel segments such as the carotid bulb. The imaging sequence was based on steered plane wave pulsing (-10°, 0°, +10° steering angles; 5 MHz imaging frequency; 3.3 kHz interleaved pulse repetition frequency). VFI's pulsatile flow estimation performance and its ability to detect secondary flow were comparatively assessed against flow fields derived from computational fluid dynamics (CFD) simulations that included consideration of fluid-structure interactions (FSI). The mean percentage error (MPE) and the coefficient of determination (R
    Results: Pulsatile flow patterns rendered by VFI agreed with the flow profiles computed from CFD-FSI simulations (average MPE: -5.3%). The shape of the VFI-measured velocity magnitude profile generally matched the inlet flow profile. High correlation exists between VFI measurements and simulated flow vectors (lateral velocity: R
    Conclusion: VFI can consistently track omnidirectional pulsatile flow on a time-resolved basis. This systematic investigation serves well as a quality assurance test of VFI.
    MeSH term(s) Pulsatile Flow ; Pulse Wave Analysis ; Ultrasonography/methods ; Carotid Arteries/diagnostic imaging ; Heart ; Phantoms, Imaging ; Blood Flow Velocity
    Language English
    Publishing date 2023-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.16168
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  7. Article ; Online: Single-Polymer Friction Force Microscopy of dsDNA Interacting with a Nanoporous Membrane.

    Schellnhuber, Kordula / Blass, Johanna / Hübner, Hanna / Gallei, Markus / Bennewitz, Roland

    Langmuir : the ACS journal of surfaces and colloids

    2023  Volume 40, Issue 1, Page(s) 968–974

    Abstract: Surface-grafted polymers can reduce friction between solids in liquids by compensating the normal load with osmotic pressure, but they can also contribute to friction when fluctuating polymers entangle with the sliding counter face. We have measured ... ...

    Abstract Surface-grafted polymers can reduce friction between solids in liquids by compensating the normal load with osmotic pressure, but they can also contribute to friction when fluctuating polymers entangle with the sliding counter face. We have measured forces acting on a single fluctuating double-stranded DNA polymer, which is attached to the tip of an atomic force microscope and interacts intermittently with nanometer-scale methylated pores of a self-assembled polystyrene-
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c03190
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  8. Article ; Online: Development of Photoswitchable Tethered Ligands that Target the μ-Opioid Receptor.

    Lahmy, Ranit / Hübner, Harald / Lachmann, Daniel / Gmeiner, Peter / König, Burkhard

    ChemMedChem

    2023  Volume 18, Issue 23, Page(s) e202300228

    Abstract: Converting known ligands into photoswitchable derivatives offers the opportunity to modulate compound structure with light and hence, biological activity. In doing so, these probes provide unique control when evaluating G-protein-coupled receptor (GPCR) ... ...

    Abstract Converting known ligands into photoswitchable derivatives offers the opportunity to modulate compound structure with light and hence, biological activity. In doing so, these probes provide unique control when evaluating G-protein-coupled receptor (GPCR) mechanism and function. Further conversion of such compounds into covalent probes, known as photoswitchable tethered ligands (PTLs), offers additional advantages. These include localization of the PTLs to the receptor binding pocket. Covalent localization increases local ligand concentration, improves site selectivity and may improve the biological differences between the respective isomers. This work describes chemical, photophysical and biochemical characterizations of a variety of PTLs designed to target the μ-opioid receptor (μOR). These PTLs were modeled on fentanyl, with the lead disulfide-containing agonist found to covalently interact with a cysteine-enriched mutant of this medically-relevant receptor.
    MeSH term(s) Ligands ; Receptors, Opioid, mu/metabolism ; Fentanyl/chemistry ; Protein Binding ; Cysteine/metabolism
    Chemical Substances Ligands ; Receptors, Opioid, mu ; Fentanyl (UF599785JZ) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2023-10-31
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218496-X
    ISSN 1860-7187 ; 1860-7179
    ISSN (online) 1860-7187
    ISSN 1860-7179
    DOI 10.1002/cmdc.202300228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of CytoSorb Hemoadsorption Therapy on Fluid Balance in Patients with Septic Shock

    Klaus Kogelmann / Tobias Hübner / Matthias Drüner / Dominik Jarczak

    Journal of Clinical Medicine, Vol 13, Iss 1, p

    2024  Volume 294

    Abstract: ... reduction in fluid balance at 72 h (T 72 ) compared to both baseline (T 0 ) and the 24 h mark (T 24 ). Fluid ...

    Abstract Recent in vitro studies have investigated the effects of hemoadsorption therapy on endothelial function in sepsis showing a reduction in markers of endothelial dysfunction, but, to this day, there are no clinical studies proving whether this approach could actually positively influence the disturbed vascular barrier function in septic conditions. We retrospectively analyzed data on administered fluid volumes and catecholamines in 124 septic shock patients. We collected catecholamine and volume requirements and calculated the volume balance within different time periods to obtain an assumption on the stability of the vascular barrier. Regarding the entire study cohort, our findings revealed a significant reduction in fluid balance at 72 h (T 72 ) compared to both baseline (T 0 ) and the 24 h mark (T 24 ). Fluid balances from T 72 –T 0 were significantly lower in hospital survivors compared with non-survivors. Patients who received a second catecholamine had a significantly lower in-hospital mortality. Our findings suggest that the applied treatment regimen including hemoadsorption therapy is associated with a reduced positive fluid balance paralleled by reductions in vasopressor needs, suggesting a potential positive effect on endothelial integrity. These results, derived from a large cohort of patients, provide valuable insights on the multiple effects of hemoadsorption treatment in septic shock patients.
    Keywords inflammation ; septic shock ; CytoSorb ; hemoadsorption ; fluid balance ; vasopressors ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Interventions to promote health literacy among working-age populations experiencing socioeconomic disadvantage: systematic review.

    Singh, Himal / Samkange-Zeeb, Florence / Kolschen, Jonathan / Herrmann, Ruben / Hübner, Wiebke / Barnils, Núria Pedrós / Brand, Tilman / Zeeb, Hajo / Schüz, Benjamin

    Frontiers in public health

    2024  Volume 12, Page(s) 1332720

    Abstract: Background: Experiencing financial insecurity and being underserved is often associated with low health literacy, i.e., the ability to identify, obtain, interpret and act upon health information, which may result in poor health outcomes. Little is known ...

    Abstract Background: Experiencing financial insecurity and being underserved is often associated with low health literacy, i.e., the ability to identify, obtain, interpret and act upon health information, which may result in poor health outcomes. Little is known about effective interventions for promoting health literacy among underserved populations. The objective of this systematic review is to summarize the literature on such interventions and identify characteristics that differentiate more effective interventions.
    Methods: Following PRISMA guidelines we searched the databases SCOPUS, Pubmed, Web of Science core collection and CINAHL. We included primary studies with a quantitative study design and control groups testing interventions to increase health literacy or health knowledge in underserved populations between 18 and 65 years. Where possible, we converted effect sizes into Cohen's d and compared mean differences of intervention and control groups. Albatross plots were created to summarize the results according to different health literacy and health knowledge outcomes.
    Results: We screened 3,696 titles and abstracts and 206 full texts. In total, 86 articles were analyzed, of which 55 were summarized in seven albatross plots. The majority of the studies (
    Discussion: Although the outcomes addressed in the included studies were heterogeneous, effective intervention approaches were often culturally sensitive and developed tailored educational materials. Interventions aiming to promote health literacy in underserved populations should hence consider applying similar approaches.
    MeSH term(s) Humans ; Exercise ; Health Literacy ; Health Promotion ; Randomized Controlled Trials as Topic ; Socioeconomic Disparities in Health
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article ; Systematic Review
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1332720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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