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  1. Book: San Giovanni Battista dei Genovesi

    Kouma, Chryso / Paganelli, Danilo

    (Le Chiese di Roma illustrate ; N.S.,18)

    1986  

    Author's details Chryso Kouma; Danilo Paganelli
    Series title Le Chiese di Roma illustrate ; N.S.,18
    Language Italian
    Size 99 S, Ill., graph. Darst, 17 cm
    Publisher Istituto nazionale di studi romani
    Publishing place Roma
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  2. Article: Development of sentinel node biopsy, ROLL and IART in early breast cancer at the European Institute of Oncology, Milan (IEO).

    Paganelli, Giovanni

    Ecancermedicalscience

    2017  Volume 11, Page(s) 744

    Abstract: The problem of unnecessary axillary clearance in many patients with early breast cancer was certainly a major issue at IEO when we started working with Prof. Umberto Veronesi in 1994. At that time, axillary dissection in EBC was offered to all patients ... ...

    Abstract The problem of unnecessary axillary clearance in many patients with early breast cancer was certainly a major issue at IEO when we started working with Prof. Umberto Veronesi in 1994. At that time, axillary dissection in EBC was offered to all patients and this procedure was often hotly debated during our multidisciplinary breast cancer meetings. The question as to whether we could avoid axillary dissection by using PET scans or other nuclear medicine methods was frequently asked by Veronesi. This eventually prompted us to investigate whether, as for melanoma patients, the sentinel node biopsy (SNB) approach could reliably be applied to breast cancer. In December 1995, we proposed a new lymphoscintigraphy protocol to detect the SN in early breast cancer patients to our Ethic Committee, and it was approved. The pilot study was published in 1997 and after only 6 years, the first randomised trial comparing SNB and axillary clearance in breast cancer patients was published. During the pilot study, we optimised the lymphoscintigraphy technique by comparing different radiotracers and different injection modalities. Following the observation that the majority of the radiocolloids injected into the tumour did not migrate to lymph nodes, a new method called ROLL or Radio-guided Occult Lesion Localisation was developed for the localisation of non-palpable breast lesions. This technique was introduced into clinical practice at the European Institute of Oncology in 1996. Several studies showed that the ROLL procedure enabled the surgeon to remove non-palpable breast lesions easily and accurately, overcoming some disadvantages of other methods such as wire-guided localisation (WGL). In addition to SNB and ROLL, other protocols such as the IART (intraoperative avidination for radionuclide therapy)-ARTHE (avidinated radiotherapy) procedure were developed at the IEO Nuclear Medicine Division during the period 1994-2013. I remember that time as the most professionally productive of my career and it would not have been possible without the help, suggestions and encouragement given to me by Umberto Veronesi.
    Language English
    Publishing date 2017-06-08
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1754-6605
    ISSN 1754-6605
    DOI 10.3332/ecancer.2017.744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 177Lu-PSMA therapy in metastatic prostate cancer: An updated review of prognostic and predictive biomarkers.

    Giunta, Emilio Francesco / Brighi, Nicole / Gurioli, Giorgia / Matteucci, Federica / Paganelli, Giovanni / De Giorgi, Ugo

    Cancer treatment reviews

    2024  Volume 125, Page(s) 102699

    Abstract: 177Lu-PSMA has been approved for the treatment of PSMA-positive metastatic castration-resistant (mCRPC) patients who progressed to androgen receptor pathway inhibitors (ARPIs) and taxane-based chemotherapy. However, a higher proportion of patients do not ...

    Abstract 177Lu-PSMA has been approved for the treatment of PSMA-positive metastatic castration-resistant (mCRPC) patients who progressed to androgen receptor pathway inhibitors (ARPIs) and taxane-based chemotherapy. However, a higher proportion of patients do not respond to this type of radioligand therapy (RLT). To date, there is a lack of validated prognostic and predictive biomarkers for 177Lu-PSMA therapy in prostate cancer. Several studies have investigated the prognostic and predictive role of clinical and molecular factors and also the metabolic features of PET imaging. In this review, we aim to take stock of the current scenario, focusing on new emerging data from retrospective/prospective series and clinical trials. Given the high costs and the possibility of primary resistance, it seems essential to identify clinical and molecular characteristics that could allow clinicians to choose the right patient to treat with 177Lu-PSMA. Biomarker-based clinical trials are urgently needed in this field.
    MeSH term(s) Male ; Humans ; Prognosis ; Retrospective Studies ; Treatment Outcome ; Prostate-Specific Antigen ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/radiotherapy ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Dipeptides/therapeutic use ; Lutetium ; Radioisotopes
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77) ; Dipeptides ; Lutetium-177 (BRH40Y9V1Q) ; Lutetium (5H0DOZ21UJ) ; Radioisotopes
    Language English
    Publishing date 2024-02-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2024.102699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 611: Show issues

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  4. Article: From Cellulite to Post-liposuction Skin Irregularities: A Proposal for Definition and Classification.

    Guida, Stefania / Zerbinati, Nicola / Conforti, Claudio / Paganelli, Alessia / Pellacani, Giovanni / Galadari, Hassan

    The Journal of clinical and aesthetic dermatology

    2024  Volume 17, Issue 4, Page(s) 24–27

    Abstract: Background: Post-liposuction skin irregularities (PLSI) represent a complication of liposuction, even though literature does not report specific data on their characteristics.: Objective: Considering the expanding request of treatment of PLSI and ... ...

    Abstract Background: Post-liposuction skin irregularities (PLSI) represent a complication of liposuction, even though literature does not report specific data on their characteristics.
    Objective: Considering the expanding request of treatment of PLSI and their similarities to cellulite, the aim of this study is to provide a definition or classification of their appearance according to a previously described cellulite scale and to highlight eventual novel features, in patients undergoing previous liposuction and a control group.
    Methods: A total of 47 women, of which 47 percent performed a previous liposuction, were included in this study. Pictures of gluteal area and postero-lateral thighs were analyzed according to number and depth of depressions, skin laxity, asymmetry and v-sign by three investigators. The correlation between parameters and previous liposuction was explored with statistical analysis.
    Results: Our results show good to excellent intraobserver agreement and moderate to good agreement between the evaluators. Additionally, we showed that PLSI can appear as marked cellulite signs (depth of evident depression) or as specific previously not reported features including asymmetry and v-sign.
    Conclusion: Our findings provide information about the previously unreported morphology of PLSI. Further studies will apply validated features of PLSI proposed herein to clinical practice.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2571623-2
    ISSN 1941-2789
    ISSN 1941-2789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: PET/CT in Multiple Myeloma: Beyond FDG.

    Matteucci, Federica / Paganelli, Giovanni / Martinelli, Giovanni / Cerchione, Claudio

    Frontiers in oncology

    2021  Volume 10, Page(s) 622501

    Abstract: Recent advances in the diagnosis and treatment of multiple myeloma (MM) have highlighted the importance of imaging methods, not only in the localization and extent of the disease but also in prognostic stratification and assessment of response to therapy. ...

    Abstract Recent advances in the diagnosis and treatment of multiple myeloma (MM) have highlighted the importance of imaging methods, not only in the localization and extent of the disease but also in prognostic stratification and assessment of response to therapy. In this context, PET/CT, combining both morphological and functional information, is particularly useful in this pathology. The tracer mostly used is 18F-FDG, a glucose analog, which provides extremely accurate information with a sensitivity ranging from 80 to 100%. However, this tracer has some limitations, mostly related to the physiological uptake of FDG in the bone marrow and brain, which reduce its effectiveness. For this reason, some studies in the literature have evaluated the effectiveness of other PET tracers, which provide information on protein metabolism or the synthesis of metabolic plasma membranes, such as choline and methionine, as well as innovative radiopharmaceuticals, directed against receptors expressed by cells of myeloma, including tracers directed to the chemokine receptor. This review analyzes the characteristics and accuracy of non-FDG tracers in the management of patients with multiple myeloma.
    Language English
    Publishing date 2021-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.622501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Importance of PET with

    Paganelli, Giovanni / Matteucci, Federica

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2020  Volume 61, Issue Suppl 2, Page(s) 187S–188S

    MeSH term(s) Gallium Radioisotopes/chemistry ; Humans ; Isotope Labeling ; Positron-Emission Tomography/methods ; Somatostatin/chemistry
    Chemical Substances Gallium Radioisotopes ; Somatostatin (51110-01-1) ; Gallium-68 (98B30EPP5S)
    Language English
    Publishing date 2020-11-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.254631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 114: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 328: Show issues

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  7. Article ; Online: [

    Paganelli, Giovanni / De Giorgi, Ugo

    The Lancet. Oncology

    2018  Volume 19, Issue 6, Page(s) 725–726

    Language English
    Publishing date 2018-05-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(18)30268-7
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    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  8. Article ; Online: A Novel Injectable Hydrogel Matrix Loaded With 90Y Microspheres for the Treatment of Solid Tumors.

    Amato, Antonino / Carriero, Pier Luigi / McVie, Gordon / Paganelli, Giovanni

    Anticancer research

    2022  Volume 42, Issue 2, Page(s) 827–836

    Abstract: Background/aim: The need to concentrate the anti-tumoral activity of : Materials and methods: This in vivo randomized study was planned to assess the efficacy, safety, and biodistribution of BAT-90 in 46 rabbits implanted with a VX2 tumor. The ... ...

    Abstract Background/aim: The need to concentrate the anti-tumoral activity of
    Materials and methods: This in vivo randomized study was planned to assess the efficacy, safety, and biodistribution of BAT-90 in 46 rabbits implanted with a VX2 tumor. The effects of BAT-90 were compared to those of
    Results: BAT-90 localized effectively the
    Conclusion: BAT-90 can be administered as an adjuvant treatment to clear surgical margins from any potential minimal residual disease, or as an alternative to other loco-regional treatments for non-resectable tumors.
    MeSH term(s) Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Chemoradiotherapy, Adjuvant ; Hydrogels/administration & dosage ; Hydrogels/chemistry ; Hydrogels/pharmacokinetics ; Injections ; Kidney Neoplasms/therapy ; Male ; Microspheres ; Neoplasm, Residual ; Neoplasms, Experimental ; Rabbits ; Tissue Distribution ; Treatment Outcome ; Yttrium Radioisotopes/administration & dosage ; Yttrium Radioisotopes/chemistry ; Yttrium Radioisotopes/pharmacokinetics
    Chemical Substances Antineoplastic Agents ; Hydrogels ; Yttrium Radioisotopes ; Yttrium-90 (1K8M7UR6O1)
    Language English
    Publishing date 2022-01-29
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.15540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio. Results from InCHIANTI follow-up study.

    Pellegrino, Raffaello / Paganelli, Roberto / Di Iorio, Angelo / Bandinelli, Stefania / Moretti, Antimo / Iolascon, Giovanni / Sparvieri, Eleonora / Tarantino, Domiziano / Ferrucci, Luigi

    Research square

    2023  

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3111431/v2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: On the Way for Patients with Prostate Cancer to the Best Use of PSMA.

    von Eyben, Finn Edler / Bauman, Glenn / Kapp, Daniel S / Virgolini, Irene / Paganelli, Giovanni

    International journal of molecular sciences

    2022  Volume 23, Issue 5

    Abstract: In recent years, the prostate-specific membrane antigen (PSMA) has achieved a significant role in the diagnostics and treatments of patients with prostate cancer [ ... ]. ...

    Abstract In recent years, the prostate-specific membrane antigen (PSMA) has achieved a significant role in the diagnostics and treatments of patients with prostate cancer [...].
    MeSH term(s) Humans ; Male ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/therapy
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2022-02-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23052478
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