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  1. Book: Microbe

    Swanson, Michele / Joyce, Elizabeth A. / Horak, Rachel E. A.

    Michele Swanson, Elizabeth A. Joyce, Rachel E. A. Horak

    2022  

    Keywords Microbiology
    Subject code 579
    Language English
    Size xiii, 738 Seiten, Illustrationen, 28 cm
    Edition Third edition
    Publisher ASM Press
    Publishing place Washington, DC
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT021458626
    ISBN 978-1-68367-370-5 ; 9781683673729 ; 1-68367-370-0 ; 1683673727
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 A 1004 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Bacterial pathogenesis: An angel of death fights infection.

    Swanson, Michele S

    Nature microbiology

    2016  Volume 1, Page(s) 16012

    MeSH term(s) Apoptosis ; Humans ; Legionnaires' Disease/drug therapy ; Macrophages ; bcl-X Protein/drug effects
    Chemical Substances bcl-X Protein
    Language English
    Publishing date 2016-02-24
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/nmicrobiol.2016.12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: How

    Hughes, Elisa D / Swanson, Michele S

    eLife

    2019  Volume 8

    Abstract: Communities of bacteria that cause Legionnaires' disease repel other bacteria by secreting an acid called HGA. ...

    Abstract Communities of bacteria that cause Legionnaires' disease repel other bacteria by secreting an acid called HGA.
    MeSH term(s) Environmental Microbiology ; Humans ; Legionella pneumophila/genetics ; Legionella pneumophila/metabolism ; Legionella pneumophila/pathogenicity ; Legionnaires' Disease/metabolism ; Legionnaires' Disease/microbiology ; Phenylalanine/biosynthesis ; Phenylalanine/metabolism ; Tyrosine/biosynthesis ; Tyrosine/metabolism
    Chemical Substances Tyrosine (42HK56048U) ; Phenylalanine (47E5O17Y3R)
    Language English
    Publishing date 2019-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.48695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Functional characterization of the HMP-P synthase of Legionella pneumophila (Lpg1565).

    Paxhia, Michael D / Swanson, Michele S / Downs, Diana M

    Molecular microbiology

    2020  Volume 115, Issue 4, Page(s) 539–553

    Abstract: ... the Fe-S cluster protein ThiC. An alternative pathway utilizes Thi5, a novel enzyme that uses PLP ...

    Abstract The production of the pyrimidine moiety in thiamine synthesis, 2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate (HMP-P), has been described to proceed through the Thi5-dependent pathway in Saccharomyces cerevisiae and other yeast. Previous work found that ScThi5 functioned poorly in a heterologous context. Here we report a bacterial ortholog to the yeast HMP-P synthase (Thi5) was necessary for HMP synthesis in Legionella pneumophila. Unlike ScThi5, LpThi5 functioned in vivo in Salmonella enterica under multiple growth conditions. The protein LpThi5 is a dimer that binds pyridoxal-5'-phosphate (PLP), apparently without a solvent-exposed Schiff base. A small percentage of LpThi5 protein co-purifies with a bound molecule that can be converted to HMP. Analysis of variant proteins both in vivo and in vitro confirmed that residues in sequence motifs conserved across bacterial and eukaryotic orthologs modulate the function of LpThi5. IMPORTANCE: Thiamine is an essential vitamin for the vast majority of organisms. There are multiple strategies to synthesize and salvage this vitamin. The predominant pathway for synthesis of the pyrimidine moiety of thiamine involves the Fe-S cluster protein ThiC. An alternative pathway utilizes Thi5, a novel enzyme that uses PLP as a substrate. The Thi5-dependent pathway is poorly characterized in yeast and has not been characterized in Bacteria. Here we demonstrate that a Thi5-dependent pathway is necessary for thiamine biosynthesis in Legionella pneumophila and provide biochemical data to extend knowledge of the Thi5 enzyme, the corresponding biosynthetic pathway, and the role of metabolic network architecture in optimizing its function.
    MeSH term(s) Amino Acid Sequence ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biosynthetic Pathways ; Iron/metabolism ; Iron-Sulfur Proteins/metabolism ; Legionella pneumophila/chemistry ; Legionella pneumophila/enzymology ; Legionella pneumophila/genetics ; Legionella pneumophila/metabolism ; Phylogeny ; Protein Binding ; Protein Conformation ; Pyridoxal Phosphate/metabolism ; Pyrimidines/biosynthesis ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Salmonella enterica/metabolism ; Thiamine/biosynthesis
    Chemical Substances Bacterial Proteins ; Iron-Sulfur Proteins ; Pyrimidines ; ThiC protein, Bacteria ; Pyridoxal Phosphate (5V5IOJ8338) ; Iron (E1UOL152H7) ; toxopyrimidine (G62V17J09J) ; pyrimidine (K8CXK5Q32L) ; Thiamine (X66NSO3N35)
    Language English
    Publishing date 2020-11-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.14622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Two-Component System That Modulates Cyclic di-GMP Metabolism Promotes Legionella pneumophila Differentiation and Viability in Low-Nutrient Conditions.

    Hughes, Elisa D / Byrne, Brenda G / Swanson, Michele S

    Journal of bacteriology

    2019  Volume 201, Issue 17

    Abstract: During its life cycle, the environmental ... ...

    Abstract During its life cycle, the environmental pathogen
    MeSH term(s) Amino Acids/metabolism ; Bacterial Proteins/metabolism ; Culture Media ; Cyclic GMP/analogs & derivatives ; Cyclic GMP/genetics ; Cyclic GMP/metabolism ; Gene Expression Regulation, Bacterial ; Hydroxybutyrates/metabolism ; Legionella pneumophila/genetics ; Legionella pneumophila/physiology ; Microbial Viability ; Polyesters/metabolism ; Signal Transduction
    Chemical Substances Amino Acids ; Bacterial Proteins ; Culture Media ; Hydroxybutyrates ; Polyesters ; poly-beta-hydroxybutyrate (26063-00-3) ; bis(3',5')-cyclic diguanylic acid (61093-23-0) ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2019-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00253-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Implementing Psychiatric Advance Directives: The Transmitter and Receiver Problem and the Neglected Right to Be Deemed Incapable.

    Swartz, Marvin S / Swanson, Jeffrey W / Easter, Michele M / Robertson, Allison G

    Psychiatric services (Washington, D.C.)

    2020  Volume 72, Issue 2, Page(s) 219–221

    Abstract: Psychiatric advance directives (PADs) can help adults with serious mental illnesses preserve their autonomy and avoid involuntary interventions during an incapacitating mental health crisis. A PAD is a legal document prepared while mentally competent and ...

    Abstract Psychiatric advance directives (PADs) can help adults with serious mental illnesses preserve their autonomy and avoid involuntary interventions during an incapacitating mental health crisis. A PAD is a legal document prepared while mentally competent and states the person's treatment preferences to be implemented during a future crisis, ideally with the advocacy of an authorized proxy decision maker. PADs have been available in the United States for more than three decades but have yet to be robustly implemented in practice. This Open Forum describes PADs metaphorically as a device for remote communication among the person with mental illness, a proxy decision maker, and health care providers. Barriers to PAD usage occur on both "transmitter" and "receiver" sides and must be addressed to advance PAD implementation.
    MeSH term(s) Adult ; Advance Directives ; Communication ; Humans ; Mental Disorders/therapy ; United States
    Language English
    Publishing date 2020-12-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.202000659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: How Legionella defend their turf

    Elisa D Hughes / Michele S Swanson

    eLife, Vol

    2019  Volume 8

    Abstract: Communities of bacteria that cause Legionnaires' disease repel other bacteria by secreting an acid called ... ...

    Abstract Communities of bacteria that cause Legionnaires' disease repel other bacteria by secreting an acid called HGA
    Keywords Legionella pneumophila ; Legionella micdadei ; homogentisic acid ; pyomelanin ; inter-bacterial competition ; antimicrobial ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Appropriateness of psychiatric advance directives facilitated by peer support specialists and clinicians on Assertive Community Treatment teams.

    Belden, Charles M / Gilbert, Allison R / Easter, Michele M / Swartz, Marvin S / Swanson, Jeffrey W

    Journal of mental health (Abingdon, England)

    2021  Volume 31, Issue 2, Page(s) 239–245

    Abstract: Background: Psychiatric advance directives (PADs) are used to document a person's treatment preferences for a future mental health crisis. Peer support specialists have been proposed to facilitate PADs, but little is known about the quality of peer ... ...

    Abstract Background: Psychiatric advance directives (PADs) are used to document a person's treatment preferences for a future mental health crisis. Peer support specialists have been proposed to facilitate PADs, but little is known about the quality of peer versus clinician facilitated PADs.
    Aims: This study examined whether PAD documents facilitated by peer specialists and non-peer clinicians differed in the mix of treatment requests and refusals and expert ratings of feasibility and consistency.
    Methods: Analyses were conducted of content and expert ratings of 72 PAD documents from a randomized trial of PAD facilitation by peers and clinicians on Assertive Community Treatment (ACT) teams. A count of treatment refusals and requests was used to classify documents as predominantly prescriptive, proscriptive, or balanced. Regression was used to estimate relationships between PAD facilitator type and content.
    Results: Peer-facilitated PADs were significantly more likely to be predominantly prescriptive than were PADs facilitated by non-peer clinicians. Prescriptive PADs were more likely to receive expert ratings of high feasibility and consistency.
    Conclusions: Results should alleviate some clinicians' apprehensions regarding the appropriateness of peer-facilitated PADs, such as the concern that people with lived experience with mental illness might encourage other consumers to use their PAD primarily for treatment refusals.
    MeSH term(s) Advance Directives/psychology ; Community Mental Health Services ; Counseling ; Humans ; Mental Disorders/psychology ; Mental Disorders/therapy ; Mental Health
    Language English
    Publishing date 2021-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1145439-8
    ISSN 1360-0567 ; 0963-8237
    ISSN (online) 1360-0567
    ISSN 0963-8237
    DOI 10.1080/09638237.2021.1952946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Adult criminal outcomes of juvenile justice involvement.

    Copeland, William E / Tong, Guangyu / Gifford, Elizabeth J / Easter, Michele M / Shanahan, Lilly / Swartz, Marvin S / Swanson, Jeffrey W

    Psychological medicine

    2022  Volume 53, Issue 8, Page(s) 3711–3718

    Abstract: Background: The juvenile justice system in the USA adjudicates over seven hundred thousand youth in the USA annually with significant behavioral offenses. This study aimed to test the effect of juvenile justice involvement on adult criminal outcomes.: ...

    Abstract Background: The juvenile justice system in the USA adjudicates over seven hundred thousand youth in the USA annually with significant behavioral offenses. This study aimed to test the effect of juvenile justice involvement on adult criminal outcomes.
    Methods: Analyses were based on a prospective, population-based study of 1420 children followed up to eight times during childhood (ages 9-16; 6674 observations) about juvenile justice involvement in the late 1990 and early 2000s. Participants were followed up years later to assess adult criminality, using self-report and official records. A propensity score (i.e. inverse probability) weighting approach was used that approximated an experimental design by balancing potentially confounding characteristics between children with
    Results: Between-groups differences on variables that elicit a juvenile justice referral (e.g. violence, property offenses, status offenses, and substance misuse) were attenuated after applying propensity-based inverse probability weights. Participants with a history of juvenile justice involvement were more likely to have later official and violent felony charges, and to self-report police contact and spending time in jail (ORs from 2.5 to 3.3). Residential juvenile justice involvement was associated with the highest risk of both, later official criminal records and self-reported criminality (ORs from 5.1 to 14.5). Sensitivity analyses suggest that our findings are likely robust to potential unobserved confounders.
    Conclusions: Juvenile justice involvement was associated with increased risk of adult criminality, with residential services associated with highest risk. Juvenile justice involvement may catalyze rather than deter from adult offending.
    MeSH term(s) Adolescent ; Child ; Humans ; Adult ; Criminals ; Prospective Studies ; Juvenile Delinquency ; Crime ; Violence
    Language English
    Publishing date 2022-03-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291722000393
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  10. Article ; Online: Impact of psychiatric advance directive facilitation on mental health consumers: empowerment, treatment attitudes and the role of peer support specialists.

    Easter, Michele M / Swanson, Jeffrey W / Robertson, Allison G / Moser, Lorna L / Swartz, Marvin S

    Journal of mental health (Abingdon, England)

    2020  Volume 30, Issue 5, Page(s) 585–593

    Abstract: Background: A psychiatric advance directive (PAD) is designed to prevent involuntary mental health interventions by enabling people with serious mental illnesses to plan ahead for their own treatment during a future incapacitating crisis. This study ... ...

    Abstract Background: A psychiatric advance directive (PAD) is designed to prevent involuntary mental health interventions by enabling people with serious mental illnesses to plan ahead for their own treatment during a future incapacitating crisis. This study implemented PAD facilitation in assertive community treatment (ACT) teams.
    Aims: We examined ACT clients' attitudes toward PAD facilitators, satisfaction with PAD facilitation, the short-term impact of PAD completion on subjective sense of empowerment and attitudes toward treatment, and whether the type of PAD facilitator made a difference.
    Methods: Participants were randomly assigned to be offered PAD facilitation by a peer support specialist or non-peer ACT team clinician, and interviewed at baseline (
    Results: There was no evidence of bias against peer-facilitators. There was a modest positive impact of PAD facilitation on treatment attitudes and empowerment.
    Conclusions: PAD facilitation by peer support specialists and others working in community mental health settings supports recovery.
    MeSH term(s) Advance Directives/psychology ; Attitude ; Attitude of Health Personnel ; Empowerment ; Health Knowledge, Attitudes, Practice ; Humans ; Mental Disorders/diagnosis ; Mental Disorders/psychology ; Mental Disorders/therapy ; Mental Health ; Patient Care Planning ; Patient Satisfaction ; Peer Group ; Specialization
    Language English
    Publishing date 2020-02-04
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1145439-8
    ISSN 1360-0567 ; 0963-8237
    ISSN (online) 1360-0567
    ISSN 0963-8237
    DOI 10.1080/09638237.2020.1714008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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