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Article: Unraveling the mystery: congenital absence of the portal vein and its cardiac implications.

Xu, Zhanwen / Yin, Xiaoping

Revista espanola de enfermedades digestivas

2024

Abstract: A 25-year-old male with tachycardia and right heart enlargement was diagnosed with atrial-ventricular nodal reentrant tachycardia (AVNRT) and successfully treated with radiofrequency ablation. Cardiac MRI confirmed right heart enlargement but ruled out ... ...

Abstract	A 25-year-old male with tachycardia and right heart enlargement was diagnosed with atrial-ventricular nodal reentrant tachycardia (AVNRT) and successfully treated with radiofrequency ablation. Cardiac MRI confirmed right heart enlargement but ruled out cardiomyopathy. Further imaging revealed a rare congenital absence of the portal vein (CAPV) with an associated portosystemic shunt. This case highlights the importance of considering CAPV in unexplained cardiac symptoms and structural heart changes.
Language	English
Publishing date	2024-03-07
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2024.10323/2024
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Zs.B 199: Show issues

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Article ; Online: Total cholesterol mediates the association between history of gestational diabetes mellitus and bone mineral density in US women aged 20-49 years.

Zeng, Yan / Yin, Li / Yin, Xiaoping / Zhao, Danqing

BMC public health

2024 Volume 24, Issue 1, Page(s) 81

Abstract: Objective: The aim of this study is to investigate the potential association between a history of gestational diabetes mellitus (GDM) and lumbar bone mineral density (BMD) among premenopausal women, with an additional examination of the mediating role ... ...

Abstract	Objective: The aim of this study is to investigate the potential association between a history of gestational diabetes mellitus (GDM) and lumbar bone mineral density (BMD) among premenopausal women, with an additional examination of the mediating role of serum total cholesterol (TC). Methods: In this cross-sectional study, 1809 women aged 20-49 years with at least one live birth between 2011 and 2018, drawn from the NHANES dataset, were analyzed. GDM history was identified through questionnaires. Using weighted multiple linear regression, we assessed the relationship between GDM history and lumbar BMD. Additionally, mediation analysis was performed to investigate the potential mediating role of TC. Results: The fully adjusted linear regression model revealed a negative association between a history of GDM and lumbar BMD, indicating a reduction in lumbar BMD (β = -0.023, 95% CI: -0.043, -0.003, P = 0.0275). Subgroup analysis highlighted a more pronounced trend in individuals aged ≥ 35 years and with a body mass index ≥ 30 kg/m². Furthermore, mediation analysis demonstrated a significant direct effect of a history of GDM on lumbar BMD (P < 0.0001), with serum TC playing a partial mediating role in this interaction (5.33%, P = 0.028). Conclusions: In women aged 20-49 years within the United States, a history of GDM was associated with diminished lumbar BMD, potentially mediated through serum TC.
MeSH term(s)	Female ; Humans ; Pregnancy ; Absorptiometry, Photon ; Bone Density ; Cholesterol ; Cross-Sectional Studies ; Diabetes, Gestational/epidemiology ; Nutrition Surveys ; United States/epidemiology
Chemical Substances	Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-17609-0
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Article ; Online: Total cholesterol mediates the association between history of gestational diabetes mellitus and bone mineral density in US women aged 20–49 years

Yan Zeng / Li Yin / Xiaoping Yin / Danqing Zhao

BMC Public Health, Vol 24, Iss 1, Pp 1-

2024 Volume 9

Abstract: Abstract Objective The aim of this study is to investigate the potential association between a history of gestational diabetes mellitus (GDM) and lumbar bone mineral density (BMD) among premenopausal women, with an additional examination of the mediating ...

Abstract	Abstract Objective The aim of this study is to investigate the potential association between a history of gestational diabetes mellitus (GDM) and lumbar bone mineral density (BMD) among premenopausal women, with an additional examination of the mediating role of serum total cholesterol (TC). Methods In this cross-sectional study, 1809 women aged 20–49 years with at least one live birth between 2011 and 2018, drawn from the NHANES dataset, were analyzed. GDM history was identified through questionnaires. Using weighted multiple linear regression, we assessed the relationship between GDM history and lumbar BMD. Additionally, mediation analysis was performed to investigate the potential mediating role of TC. Results The fully adjusted linear regression model revealed a negative association between a history of GDM and lumbar BMD, indicating a reduction in lumbar BMD (β = -0.023, 95% CI: -0.043, -0.003, P = 0.0275). Subgroup analysis highlighted a more pronounced trend in individuals aged ≥ 35 years and with a body mass index ≥ 30 kg/m². Furthermore, mediation analysis demonstrated a significant direct effect of a history of GDM on lumbar BMD (P < 0.0001), with serum TC playing a partial mediating role in this interaction (5.33%, P = 0.028). Conclusions In women aged 20–49 years within the United States, a history of GDM was associated with diminished lumbar BMD, potentially mediated through serum TC.
Keywords	History of gestational diabetes mellitus ; Bone mineral density ; Serum total cholesterol ; Mediation effect ; Premenopausal women ; Public aspects of medicine ; RA1-1270
Subject code	900
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Delayed cardiotoxicity following osimertinib therapy in non-small cell lung cancer: a unique case report.

Xu, Zhanwen / Jia, Haiyan / Yin, Xiaoping

Anti-cancer drugs

2024

Abstract: This case report features a 62-year-old male with stage IB lung adenocarcinoma harboring an epidermal growth factor receptor exon 19 deletion, who underwent treatment with osimertinib following a left upper lobectomy and lymph node dissection. Despite a ... ...

Abstract	This case report features a 62-year-old male with stage IB lung adenocarcinoma harboring an epidermal growth factor receptor exon 19 deletion, who underwent treatment with osimertinib following a left upper lobectomy and lymph node dissection. Despite a history of smoking and well-managed type 2 diabetes, the patient developed heart failure 18 months post-initiation of osimertinib therapy, marking one of the latest occurrences of heart failure following osimertinib treatment documented in limited literature. Cardiac MRI revealed significant left ventricular enlargement, lateral wall myocardial thinning, and localized myocardial fibrosis without perfusion defects, a finding not previously reported in literature. This case underscores the severe and unusual cardiac effects of osimertinib in patients with latent risk factors, highlighting the importance of vigilant cardiac monitoring and a multidisciplinary management approach.
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1065301-6
ISSN	1473-5741 ; 0959-4973
ISSN (online)	1473-5741
ISSN	0959-4973
DOI	10.1097/CAD.0000000000001595
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Article ; Online: Chronic exposure to low concentrations of microplastics causing gut tissue damage but non-significant changes in the microbiota of marine medaka larvae (Oryzias melastigma).

Wen, Shaobai / Yin, Xiuran / Zhang, Yankun / Diao, Xiaoping

Marine environmental research

2024 Volume 195, Page(s) 106381

Abstract: Microplastics (MPs) have become a popular research topic due to their potential ramifications on aquatic organisms. To evaluate the ecotoxicological impacts of chronic exposure to different microplastics on marine medaka larvae, we exposed medaka larvae ... ...

Abstract	Microplastics (MPs) have become a popular research topic due to their potential ramifications on aquatic organisms. To evaluate the ecotoxicological impacts of chronic exposure to different microplastics on marine medaka larvae, we exposed medaka larvae to 200 μg/L of polyethylene (PE-200) and polylactic acid (PLA-200) microplastics for 60 days, respectively. The results indicated that both exposures had no significant effect on fish length/weight and did not result in fish mortality. Notably, the structure of intestinal microbiota was not disrupted either. However, microscopy observations of intestinal tissue suggested that exposure to MPs resulted in inflammation of the intestinal tract of fish and significant atrophy and shedding of small intestinal villus. Linear discriminant analysis Effect Size (LEfSe) showed that intestinal enrichment of Streptomyces occurred in marine medaka larvae in both MPs treatments, while the PE-200 treatment exhibited a significant enrichment. In addition, the PICRUSt2 prediction indicated significant upregulation of the Novobiocin biosynthesis function in gut microbiota in the PE-200 treatment. Overall, multi-level assessment is necessary to determine the risk of exposure of aquatic organisms to MPs.
MeSH term(s)	Animals ; Microplastics/toxicity ; Plastics ; Oryzias/physiology ; Larva ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/analysis ; Aquatic Organisms ; Microbiota
Chemical Substances	Microplastics ; Plastics ; Water Pollutants, Chemical
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1502505-6
ISSN	1879-0291 ; 0141-1136
ISSN (online)	1879-0291
ISSN	0141-1136
DOI	10.1016/j.marenvres.2024.106381
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Article: Association of triglyceride-glucose index levels with gestational diabetes mellitus in the US pregnant women: a cross-sectional study.

Zeng, Yan / Yin, Li / Yin, Xiaoping / Zhao, Danqing

Frontiers in endocrinology

2023 Volume 14, Page(s) 1241372

Abstract: Objective: This investigation aimed to assess the correlation between the triglyceride-glucose (TyG) index and gestational diabetes mellitus (GDM) in pregnant women in the United States.: Methods: We calculated the TyG index utilizing data from ... ...

Abstract	Objective: This investigation aimed to assess the correlation between the triglyceride-glucose (TyG) index and gestational diabetes mellitus (GDM) in pregnant women in the United States. Methods: We calculated the TyG index utilizing data from pregnant women who participated in the National Health and Nutrition Examination Survey (NHANES) through 1999 to March 2020, and then employed multivariate logistic regression, smoothed curve fitting, and subgroup analysis to investigate the association between the TyG index and gestational diabetes during pregnancy. Results: Logistic regression models revealed a positive association between the TyG index and GDM, remaining significant even after adjusting for all confounding variables (OR=3.43, 95% CI: 1.20-9.85, Conclusion: The TyG index correlates positively with the GDM, however its diagnostic efficacy is limited. Further research on the TyG index as an early predictor of GDM is required.
MeSH term(s)	Pregnancy ; Humans ; Female ; Diabetes, Gestational/diagnosis ; Diabetes, Gestational/epidemiology ; Cross-Sectional Studies ; Pregnant Women ; Nutrition Surveys ; Glucose ; Triglycerides
Chemical Substances	Glucose (IY9XDZ35W2) ; Triglycerides
Language	English
Publishing date	2023-10-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1241372
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Article ; Online: Advances in diagnosis and treatment of talaromycosis in patients with AIDS

Pengle Guo / Linghua Li / Xiaoping Tang / Yanjie Yin

Chinese Medical Journal, Vol 135, Iss 22, Pp 2687-

2022 Volume 2689

Keywords	Medicine ; R
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
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Article ; Online: Albumin and C-reactive protein as diagnostic markers for neonatal sepsis: a retrospective study.

Yin, Wei / Fang, ChengChao / Fan, Xiaoping / Chen, YanLin

The Journal of international medical research

2024 Volume 52, Issue 3, Page(s) 3000605241238993

Abstract: Objective: To assess the applicability of albumin (ALB) and C-reactive protein (CRP) concentrations in the diagnosis of sepsis in neonates on the day of admission, and to help with early identification and intervention in the development of sepsis.: ... ...

Abstract	Objective: To assess the applicability of albumin (ALB) and C-reactive protein (CRP) concentrations in the diagnosis of sepsis in neonates on the day of admission, and to help with early identification and intervention in the development of sepsis. Methods: This retrospective study included all neonates who were admitted to the neonatal intensive care unit from January 2020 to June 2023. We studied 160 full-term neonates, including 80 with sepsis and 80 healthy controls. A multivariate analysis was conducted to evaluate the associations between ALB, CRP, and sepsis. Results: CRP concentrations were significantly higher in neonates with sepsis than in controls (26.5 ± 8.6 vs. 3.6 ± 1.2 ng/L). At a cut-off point of 10.8 ng/L, CRP showed a sensitivity of 74.3% and a specificity of 80%. Moreover, ALB concentrations were significantly lower in neonates with sepsis than in controls (25.4 ± 2.5 g/L vs. 29.2 ± 2.6 g/L). At a cut-off point of 26.8, ALB showed a sensitivity of 75.6% and a specificity of 84.2%. Conclusions: Our findings suggest that ALB and CRP concentrations on the first day of admission are different between neonates who do and those who do not develop sepsis. Higher CRP concentrations and lower ALB concentrations may indicate an increased risk of sepsis.
MeSH term(s)	Infant, Newborn ; Humans ; C-Reactive Protein/analysis ; Neonatal Sepsis/diagnosis ; Retrospective Studies ; ROC Curve ; Sepsis/diagnosis ; Biomarkers
Chemical Substances	C-Reactive Protein (9007-41-4) ; Biomarkers
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605241238993
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Zs.A 925: Show issues

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Article ; Online: Differentiating HCC from ICC and prediction of ICC grade based on MRI deep-radiomics: Using lesions and their extended regions.

Wang, Shuping / Wang, Xuehu / Yin, Xiaoping / Lv, Xiaoyan / Cai, Jianming

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

2024 Volume 120, Page(s) 103322

Abstract: Purpose: This study aimed to evaluate the ability of MRI-based intratumoral and peritumoral radiomics features of liver tumors to differentiate between hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) and to predict ICC ... ...

Abstract	Purpose: This study aimed to evaluate the ability of MRI-based intratumoral and peritumoral radiomics features of liver tumors to differentiate between hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) and to predict ICC differentiation. Methods: This study retrospectively collected 87 HCC patients and 75 ICC patients who were confirmed pathologically. The standard region of interest (ROI) of the lesion drawn by the radiologist manually shrank inward and expanded outward to form multiple ROI extended regions. A three-step feature selection method was used to select important radiomics features and convolution features from extended regions. The predictive performance of several machine learning classifiers on dominant feature sets was compared. The extended region performance was assessed by area under the curve (AUC), specificity, sensitivity, F1-score and accuracy. Results: The performance of the model is further improved by incorporating convolution features. Compared with the standard ROI, the extended region obtained better prediction performance, among which 6 mm extended region had the best prediction ability (Classification: AUC = 0.96, F1-score = 0.94, Accuracy: 0.94; Grading: AUC = 0.94, F1-score = 0.93, Accuracy = 0.89). Conclusion: Larger extended region and fusion features can improve tumor predictive performance and have potential value in tumor radiology.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular ; Liver Neoplasms/pathology ; Retrospective Studies ; Radiomics ; Magnetic Resonance Imaging/methods ; Cholangiocarcinoma ; Bile Ducts, Intrahepatic/pathology ; Bile Duct Neoplasms
Language	English
Publishing date	2024-03-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1122650-x
ISSN	1724-191X ; 1120-1797
ISSN (online)	1724-191X
ISSN	1120-1797
DOI	10.1016/j.ejmp.2024.103322
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Article ; Online: Gemtuzumab ozogamicin (GO) as monotherapy and in combination with hypomethylation agents in the treatment of acute myeloid leukemia: a systematic meta-analysis.

Li, Jun / Yin, Xiaoping

Hematology (Amsterdam, Netherlands)

2022 Volume 27, Issue 1, Page(s) 300–309

Abstract: Objectives: To explore whether the addition of HMA to GO could bring additional clinical benefits to AML patients.: Background: Several studies have shown the HMA plus GO combination showed exciting results. However, the comparison of the clinical ... ...

Abstract	Objectives: To explore whether the addition of HMA to GO could bring additional clinical benefits to AML patients. Background: Several studies have shown the HMA plus GO combination showed exciting results. However, the comparison of the clinical efficacy and safety profile of this combination with GO monotherapy has not been witnessed. Methods: We performed a systematic review and meta-analysis of 18 clinical trials regarding the mono-GO therapy alone or the HMA + GO combination. The random-effect model or fixed-effect model was applied to the study based on heterogeneity. Results: Pooled data of HMA + GO combination are more effective than mono-GO therapy among the unfit acute myeloid leukemia (AML) patients, based on the evaluation of overall response rate (ORR) (HMA + GO vs. mono-GO, 48% vs. 25%), composite complete remission (CRc) (HMA + GO vs. mono-GO, 42% vs. 25%). But pooled data of CRc and ORR showed no notable difference among R/R AML patients. Safety profiles have demonstrated that the HMA + GO combination was tolerable, considering the relatively low toxicities. Conclusion: HMA + GO combination, more effective and better tolerated than mono-GO therapy should be recommended to treat unfit AML patients instead of R/R AML patients.
MeSH term(s)	Gemtuzumab/pharmacology ; Gemtuzumab/therapeutic use ; Humans ; Leukemia, Myeloid, Acute/drug therapy
Chemical Substances	Gemtuzumab (93NS566KF7)
Language	English
Publishing date	2022-02-26
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1341428-8
ISSN	1607-8454 ; 1024-5332 ; 1024-5340
ISSN (online)	1607-8454
ISSN	1024-5332 ; 1024-5340
DOI	10.1080/16078454.2022.2042964
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