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  1. Article ; Online: Ingesting probiotic yogurt containing Lactiplantibacillus plantarum OLL2712 improves glycaemic control in adults with prediabetes in a randomized, double-blind, placebo-controlled trial.

    Toshimitsu, Takayuki / Gotou, Ayako / Sashihara, Toshihiro / Hojo, Kenichi / Hachimura, Satoshi / Shioya, Nobuhiko / Iwama, Yoshitaka / Irie, Junichiro / Ichihara, Yoshitatsu

    Diabetes, obesity & metabolism

    2024  

    Abstract: Aim: The ingestion of Lactiplantibacillus plantarum OLL2712 (OLL2712) cells has been shown to improve glucose metabolism by suppressing chronic inflammation in murine models and clinical studies. This study aimed to clarify the effect of OLL2712 on ... ...

    Abstract Aim: The ingestion of Lactiplantibacillus plantarum OLL2712 (OLL2712) cells has been shown to improve glucose metabolism by suppressing chronic inflammation in murine models and clinical studies. This study aimed to clarify the effect of OLL2712 on glycaemic control in healthy adults with prediabetes.
    Materials and methods: The study was a randomized, double-blind, placebo-controlled, parallel-group design. Adult participants with prediabetes [n = 148, glycated haemoglobin (HbA1c) range: 5.6%-6.4%, age range: 20-64 years] were assigned randomly to placebo or OLL2712 groups (n = 74/group) and administered daily for 12 weeks either conventional yogurt or yogurt containing >5 × 10
    Results: The levels of HbA1c and glycoalbumin decreased significantly in both groups at week 12 in comparison with those at week 0, but only in the OLL2712 group at week 16. HbA1c levels decreased significantly at weeks 12 and 16 in the OLL2712 group in comparison with the placebo group (p = .014 and p = .006, respectively). No significant inter- and intragroup differences in HbA1c levels were observed at week 20.
    Conclusions: The ingestion of OLL2712 prevents the deterioration of glycaemic control and maintains the HbA1c levels within the normal range in adults with prediabetes; yogurt probably exhibits similar effects, which may contribute to reducing the risk of developing type 2 diabetes.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5442: Show issues Location:
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  2. Article ; Online: Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men.

    Yamaguchi, Shintaro / Irie, Junichiro / Mitsuishi, Masanori / Uchino, Yuichi / Nakaya, Hideaki / Takemura, Ryo / Inagaki, Emi / Kosugi, Shotaro / Okano, Hideyuki / Yasui, Masato / Tsubota, Kazuo / Hayashi, Kaori / Yoshino, Jun / Itoh, Hiroshi

    Endocrine journal

    2024  Volume 71, Issue 2, Page(s) 153–169

    Abstract: Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide ( ... ...

    Abstract Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD
    MeSH term(s) Male ; Middle Aged ; Animals ; Humans ; NAD/metabolism ; Nicotinamide Mononucleotide/metabolism ; Leukocytes, Mononuclear/metabolism ; Japan ; Obesity ; Sleep ; Hyperinsulinism ; Dietary Supplements
    Chemical Substances NAD (0U46U6E8UK) ; Nicotinamide Mononucleotide (1094-61-7)
    Language English
    Publishing date 2024-01-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1151918-6
    ISSN 1348-4540 ; 0918-8959
    ISSN (online) 1348-4540
    ISSN 0918-8959
    DOI 10.1507/endocrj.EJ23-0431
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  3. Article: [Aging and homeostasis. Age-associated diseases and clinical application of NMN(Nicotinamide Mononucleotide).]

    Irie, Junichiro / Itoh, Hiroshi

    Clinical calcium

    2017  Volume 27, Issue 7, Page(s) 983–990

    Abstract: Sirtuins are ... ...

    Abstract Sirtuins are NAD
    Language Japanese
    Publishing date 2017
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa1707983990
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  4. Article ; Online: Canagliflozin protects the cardiovascular system through effects on the gut environment in non-diabetic nephrectomized rats.

    Matsui, Ayumi / Yoshifuji, Ayumi / Irie, Junichiro / Tajima, Takaya / Uchiyama, Kiyotaka / Itoh, Tomoaki / Wakino, Shu / Itoh, Hiroshi

    Clinical and experimental nephrology

    2023  Volume 27, Issue 4, Page(s) 295–308

    Abstract: Background: The gut produces toxins that contribute to the cardiovascular complications of chronic kidney disease. Canagliflozin, a sodium glucose cotransporter (SGLT) 2 inhibitor that is used as an anti-diabetic drug, has a weak inhibitory effect ... ...

    Abstract Background: The gut produces toxins that contribute to the cardiovascular complications of chronic kidney disease. Canagliflozin, a sodium glucose cotransporter (SGLT) 2 inhibitor that is used as an anti-diabetic drug, has a weak inhibitory effect against SGLT1 and may affect the gut glucose concentration and environment.
    Methods: Here, we determined the effect of canagliflozin on the gut microbiota and the serum gut-derived uremic toxin concentrations in 5/6th nephrectomized (Nx) rats.
    Results: Canagliflozin increased the colonic glucose concentration and restored the number of Lactobacillus bacteria, which was low in Nx rats. In addition, the expression of tight junction proteins in the ascending colon was low in Nx rats, and this was partially restored by canagliflozin. Furthermore, the serum concentrations of gut-derived uremic toxins were significantly increased by Nx and reduced by canagliflozin. Finally, the wall of the thoracic aorta was thicker and there was more cardiac interstitial fibrosis in Nx rats, and these defects were ameliorated by canagliflozin.
    Conclusions: The increases in colonic glucose concentration, Lactobacillus numbers and tight junction protein expression, and the decreases in serum uremic toxin concentrations and cardiac interstitial fibrosis may have been caused by the inhibition of SGLT1 by canagliflozin because similar effects were not identified in tofogliflozin-treated rats.
    MeSH term(s) Rats ; Animals ; Canagliflozin/pharmacology ; Canagliflozin/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Cardiovascular System ; Glucose ; Fibrosis
    Chemical Substances Canagliflozin (0SAC974Z85) ; Sodium-Glucose Transporter 2 Inhibitors ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-01-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-022-02312-y
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  5. Article ; Online: Dysbiosis in the Pathophysiology of Coronary Artery Disease.

    Irie, Junichiro / Itoh, Hiroshi

    Journal of atherosclerosis and thrombosis

    2016  Volume 23, Issue 8, Page(s) 901–902

    MeSH term(s) Coronary Artery Disease/etiology ; Coronary Artery Disease/physiopathology ; Dysbiosis/complications ; Humans ; Risk Factors
    Language English
    Publishing date 2016-06-15
    Publishing country Japan
    Document type Editorial
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.ED052
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  6. Article ; Online: Host metabolic benefits of prebiotic exopolysaccharides produced by

    Miyamoto, Junki / Shimizu, Hidenori / Hisa, Keiko / Matsuzaki, Chiaki / Inuki, Shinsuke / Ando, Yuna / Nishida, Akari / Izumi, Ayano / Yamano, Mayu / Ushiroda, Chihiro / Irie, Junichiro / Katayama, Takane / Ohno, Hiroaki / Itoh, Hiroshi / Yamamoto, Kenji / Kimura, Ikuo

    Gut microbes

    2023  Volume 15, Issue 1, Page(s) 2161271

    Abstract: Fermented foods demonstrate remarkable health benefits owing to probiotic bacteria or microproducts produced via bacterial fermentation. Fermented foods are produced by the fermentative action of several lactic acid bacteria, ... ...

    Abstract Fermented foods demonstrate remarkable health benefits owing to probiotic bacteria or microproducts produced via bacterial fermentation. Fermented foods are produced by the fermentative action of several lactic acid bacteria, including
    MeSH term(s) Prebiotics ; Leuconostoc mesenteroides ; Gastrointestinal Microbiome ; Probiotics ; Lactobacillales/metabolism ; Bacteria ; Fermentation
    Chemical Substances Prebiotics
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2022.2161271
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  7. Article: [The Cutting-edge of Medicine; Human gut microbiome and its implication in endocrinology and metabolism].

    Irie, Junichiro / Itoh, Hiroshi

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2016  Volume 103, Issue 11, Page(s) 2813–2819

    MeSH term(s) Diabetes Mellitus/metabolism ; Diabetes Mellitus/microbiology ; Endocrine System/metabolism ; Energy Metabolism ; Gastrointestinal Microbiome ; Humans ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/microbiology ; Microbiota ; Obesity/metabolism ; Obesity/microbiology
    Language Japanese
    Publishing date 2016-07-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.103.2813
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  8. Article ; Online: Author Correction: CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake.

    Kobayashi, Nana / Okazaki, Shogo / Sampetrean, Oltea / Irie, Junichiro / Itoh, Hiroshi / Saya, Hideyuki

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 6084

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2020-04-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-63111-7
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  9. Article ; Online: Intestinal Epithelial NAD+ Biosynthesis Regulates GLP-1 Production and Postprandial Glucose Metabolism in Mice.

    Nagahisa, Taichi / Yamaguchi, Shintaro / Kosugi, Shotaro / Homma, Koichiro / Miyashita, Kazutoshi / Irie, Junichiro / Yoshino, Jun / Itoh, Hiroshi

    Endocrinology

    2022  Volume 163, Issue 4

    Abstract: Obesity is associated with perturbations in incretin production and whole-body glucose metabolism, but the precise underlying mechanism remains unclear. Here, we tested the hypothesis that nicotinamide phosphoribosyltransferase (NAMPT), which mediates ... ...

    Abstract Obesity is associated with perturbations in incretin production and whole-body glucose metabolism, but the precise underlying mechanism remains unclear. Here, we tested the hypothesis that nicotinamide phosphoribosyltransferase (NAMPT), which mediates the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a key regulator of cellular energy metabolism, plays a critical role in obesity-associated intestinal pathophysiology and systemic metabolic complications. To this end, we generated a novel mouse model, namely intestinal epithelial cell-specific Nampt knockout (INKO) mice. INKO mice displayed diminished glucagon-like peptide-1 (GLP-1) production, at least partly contributing to reduced early-phase insulin secretion and postprandial hyperglycemia. Mechanistically, loss of NAMPT attenuated the Wnt signaling pathway, resulting in insufficient GLP-1 production. We also found that diet-induced obese mice had compromised intestinal NAMPT-mediated NAD+ biosynthesis and Wnt signaling pathway, associated with impaired GLP-1 production and whole-body glucose metabolism, resembling the INKO mice. Finally, administration of a key NAD+ intermediate, nicotinamide mononucleotide (NMN), restored intestinal NAD+ levels and obesity-associated metabolic derangements, manifested by a decrease in ileal Proglucagon expression and GLP-1 production as well as postprandial hyperglycemia in INKO and diet-induced obese mice. Collectively, our study provides mechanistic and therapeutic insights into intestinal NAD+ biology related to obesity-associated dysregulation of GLP-1 production and postprandial hyperglycemia.
    MeSH term(s) Animals ; Cytokines/metabolism ; Glucagon-Like Peptide 1 ; Glucose/metabolism ; Mice ; NAD/metabolism ; Nicotinamide Mononucleotide/pharmacology ; Postprandial Period
    Chemical Substances Cytokines ; NAD (0U46U6E8UK) ; Nicotinamide Mononucleotide (1094-61-7) ; Glucagon-Like Peptide 1 (89750-14-1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqac023
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  10. Article: [The Update of Obesity Syndrome: Molecular Mechanism. Pathophysiology and Therapies. Topics: I. Recent Topics of Diagnosis and Pathophysiology of the Obesity Syndrome; 3. Gut microbiome and obesity].

    Irie, Junichiro / Itoh, Hiroshi

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2015  Volume 104, Issue 4, Page(s) 703–709

    MeSH term(s) Animals ; Chronic Disease ; Dysbiosis/microbiology ; Endocrine System ; Gastrointestinal Microbiome ; Humans ; Inflammation ; Obesity/metabolism ; Obesity/microbiology
    Language Japanese
    Publishing date 2015-10-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.104.703
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