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  1. Article ; Online: The forgotten 2S albumin proteins: Importance, structure, and biotechnological application in agriculture and human health.

    Souza, Pedro F N

    International journal of biological macromolecules

    2020  Volume 164, Page(s) 4638–4649

    Abstract: 2S albumin proteins are a group of important seed storage proteins (SSPs) essential to seeds at early and late developmental stages, by providing amino acids and other nutrients during germination and for seed defense. 2S albumins possess a well- ... ...

    Abstract 2S albumin proteins are a group of important seed storage proteins (SSPs) essential to seeds at early and late developmental stages, by providing amino acids and other nutrients during germination and for seed defense. 2S albumins possess a well-conserved cysteine supporting the stability of temperature, pH, and proteolysis. The 3D structure rich in alpha-helices and positively charged is particularly suited for antibacterial and antifungal activity, which is presented by many 2S albumins. However, the hypervariable region present in 2S albumins induces allergenic reactions. Because of that, 2S albumins have never been recognized for their biotechnological potential. However, the development of servers used for the rational design of antimicrobial molecules has now brought a new application to 2S albumins, acting as a model to design antimicrobial molecules without the toxic or allergenic effects of 2S albumins. Therefore, this review is focused on discussing the importance of 2S albumins to seed development and defense and the biochemical, structural and functional properties of these proteins thought to play a role in their antimicrobial activity. Additionally, the application of 2S albumins to design synthetic antimicrobial peptides is discussed, potentially bringing new functions to these forgotten proteins.
    MeSH term(s) 2S Albumins, Plant/chemistry ; 2S Albumins, Plant/pharmacology ; 2S Albumins, Plant/physiology ; 2S Albumins, Plant/therapeutic use ; Agrochemicals ; Allergens/immunology ; Amino Acid Sequence ; Anti-Infective Agents/isolation & purification ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Drug Evaluation, Preclinical ; Humans ; Models, Molecular ; Molecular Structure ; Protein Conformation ; Seeds/chemistry ; Sequence Alignment ; Sequence Homology, Amino Acid ; Structure-Activity Relationship
    Chemical Substances 2S Albumins, Plant ; Agrochemicals ; Allergens ; Anti-Infective Agents
    Keywords covid19
    Language English
    Publishing date 2020-09-13
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2020.09.049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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  2. Article: The forgotten 2S albumin proteins: Importance, structure, and biotechnological application in agriculture and human health

    Souza, Pedro F N

    Int. j. biol. macromol

    Abstract: 2S albumin proteins are a group of important seed storage proteins (SSPs) that are essential to seeds at early and late developmental stages, by providing amino acids and other nutrients during germination and for seed defense. 2S albumins possess a well- ...

    Abstract 2S albumin proteins are a group of important seed storage proteins (SSPs) that are essential to seeds at early and late developmental stages, by providing amino acids and other nutrients during germination and for seed defense. 2S albumins possess a well-conserved cysteine supporting the stability of temperature, pH, and proteolysis. The 3D structure rich in alpha-helices and positively charged is particularly suited for antibacterial and antifungal activity, which is presented by many 2S albumins. However, the hypervariable region present in 2S albumins induces allergenic reactions. Because of that, 2S albumins have never been recognized for their biotechnological potential. However, the development of servers used for the rational design of antimicrobial molecules has now brought a new application to 2S albumins, acting as a model to design antimicrobial molecules without the toxic or allergenic effects of 2S albumins. Therefore, this review is focused on discussing the importance of 2S albumins to seed development and defense and the biochemical, structural and functional properties of these proteins thought to play a role in their antimicrobial activity. Additionally, the application of 2S albumins to design synthetic antimicrobial peptides is discussed, potentially bringing new functions to these forgotten proteins.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32937155
    Database COVID19

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  3. Article ; Online: Tofacitinib and peficitinib inhibitors of Janus kinase for autoimmune disease treatment: a quantum biochemistry approach.

    Amaral, Jackson L / Lucredi, Naiara C / França, Victor L B / Santos, Samuel J M / Maia, Francisco F / Morais, Pablo A / Souza, Pedro F N / Comar, Jurandir F / Freire, Valder N

    Physical chemistry chemical physics : PCCP

    2024  

    Abstract: Autoimmune inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis, are associated with an uncontrolled production of cytokines leading to the pronounced inflammatory response of these disorders. Their therapy is currently focused ...

    Abstract Autoimmune inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis, are associated with an uncontrolled production of cytokines leading to the pronounced inflammatory response of these disorders. Their therapy is currently focused on the inhibition of cytokine receptors, such as the Janus kinase (JAK) protein family. Tofacitinib and peficitinib are JAK inhibitors that have been recently approved to treat rheumatoid arthritis. In this study, an in-depth analysis was carried out through quantum biochemistry to understand the interactions involved in the complexes formed by JAK1 and tofacitinib or peficitinib. Computational analyses provided new insights into the binding mechanisms between tofacitinib or peficitinib and JAK1. The essential amino acid residues that support the complex are also identified and reported. Additionally, we report new interactions, such as van der Waals; hydrogen bonds; and alkyl, pi-alkyl, and pi-sulfur forces, that stabilize the complexes. The computational results revealed that peficitinib presents a similar affinity to JAK1 compared to tofacitinib based on their interaction energies.
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp06332a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The forgotten 2S albumin proteins: Importance, structure, and biotechnological application in agriculture and human health

    Souza, Pedro F.N

    International journal of biological macromolecules. 2020 Dec. 01, v. 164

    2020  

    Abstract: 2S albumin proteins are a group of important seed storage proteins (SSPs) essential to seeds at early and late developmental stages, by providing amino acids and other nutrients during germination and for seed defense. 2S albumins possess a well- ... ...

    Abstract 2S albumin proteins are a group of important seed storage proteins (SSPs) essential to seeds at early and late developmental stages, by providing amino acids and other nutrients during germination and for seed defense. 2S albumins possess a well-conserved cysteine supporting the stability of temperature, pH, and proteolysis. The 3D structure rich in alpha-helices and positively charged is particularly suited for antibacterial and antifungal activity, which is presented by many 2S albumins. However, the hypervariable region present in 2S albumins induces allergenic reactions. Because of that, 2S albumins have never been recognized for their biotechnological potential. However, the development of servers used for the rational design of antimicrobial molecules has now brought a new application to 2S albumins, acting as a model to design antimicrobial molecules without the toxic or allergenic effects of 2S albumins. Therefore, this review is focused on discussing the importance of 2S albumins to seed development and defense and the biochemical, structural and functional properties of these proteins thought to play a role in their antimicrobial activity. Additionally, the application of 2S albumins to design synthetic antimicrobial peptides is discussed, potentially bringing new functions to these forgotten proteins.
    Keywords albumins ; allergenicity ; antifungal properties ; antimicrobial peptides ; cysteine ; germination ; human health ; pH ; proteolysis ; seed development ; seed storage ; temperature ; toxicity
    Language English
    Dates of publication 2020-1201
    Size p. 4638-4649.
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2020.09.049
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: No Chance to Survive:

    Aguiar, Tawanny K B / Mesquita, Felipe P / Neto, Nilton A S / Gomes, Francisco Í R / Freitas, Cleverson D T / Carneiro, Rômulo F / Nagano, Celso S / Alencar, Luciana M R / Santos-Oliveira, Ralph / Oliveira, Jose T A / Souza, Pedro F N

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Multidrug- ... ...

    Abstract Multidrug-resistant
    Language English
    Publishing date 2023-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12020378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A historical, economic, and technical-scientific approach to the current crisis in the development of antibacterial drugs: Promising role of antibacterial peptides in this scenario.

    Guevara, Yeimer A S / Santos, Maria H C / Gomes, Francisco I R / Sheheryar / Mesquita, Felipe P / Souza, Pedro F N

    Microbial pathogenesis

    2023  Volume 179, Page(s) 106108

    Abstract: The emergence of antibiotic resistance (AMR) is a global public health problem. According to estimates, drug-resistant bacteria infect 2 million patients and perish 23,000 annually. To overcome this problem, antimicrobial peptides became a potential ... ...

    Abstract The emergence of antibiotic resistance (AMR) is a global public health problem. According to estimates, drug-resistant bacteria infect 2 million patients and perish 23,000 annually. To overcome this problem, antimicrobial peptides became a potential solution based on a new mechanism of action against bacteria. This article addresses the phenomenon of antibacterial resistance in most of its nuances, responding to historical, technical-scientific, and economic aspects. Likewise, it explores new therapeutic approaches to combat multi-resistant pathogens, specifically concerning antibacterial peptides, as a potential therapeutic tool to mitigate the current crisis of antibacterial drugs. It is expected that, with technological advances, especially with the advent and adoption of artificial intelligence, there will be an increase in diversified synthetic peptide production, which can face the challenges that we have in terms of antibacterial drugs.
    MeSH term(s) Humans ; Artificial Intelligence ; Anti-Bacterial Agents/pharmacology ; Bacteria ; Peptides ; Drug Resistance, Bacterial
    Chemical Substances Anti-Bacterial Agents ; Peptides
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2023.106108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: United we stand, divided we fall: in-depth proteomic evaluation of the synergistic effect of

    Neto, Nilton A S / Aguiar, Tawanny K B / Costa, Rayara J P / Mesquita, Felipe P / Oliveira, Lais L B de / Moraes, Maria E A de / Montenegro, Raquel C / Carneiro, Rômulo F / Nagano, Celso S / Freitas, Cleverson D T / Souza, Pedro F N

    Biofouling

    2023  Volume 39, Issue 8, Page(s) 838–852

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    MeSH term(s) Humans ; Ciprofloxacin/pharmacology ; Staphylococcus aureus ; Proteomics ; Biofilms ; Staphylococcal Infections ; DNA
    Chemical Substances Ciprofloxacin (5E8K9I0O4U) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1029-2454
    ISSN (online) 1029-2454
    DOI 10.1080/08927014.2023.2279992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Giving a Hand: Synthetic Peptides Boost the Antifungal Activity of Itraconazole against

    Aguiar, Tawanny K B / Feitosa, Ricardo M / Neto, Nilton A S / Malveira, Ellen A / Gomes, Francisco I R / Costa, Ana C M / Freitas, Cleverson D T / Mesquita, Felipe P / Souza, Pedro F N

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Cryptococcus ... ...

    Abstract Cryptococcus neoformans
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12020256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Behind the Curtain: In Silico and In Vitro Experiments Brought to Light New Insights into the Anticryptococcal Action of Synthetic Peptides.

    Aguiar, Tawanny K B / Neto, Nilton A S / Silva, Romério R S / Freitas, Cleverson D T / Mesquita, Felipe P / Alencar, Luciana M R / Santos-Oliveira, Ralph / Goldman, Gustavo H / Souza, Pedro F N

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 1

    Abstract: Cryptococcus ... ...

    Abstract Cryptococcus neoformans
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12010153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Antimicrobial Activity the Essential Oil from

    Carvalho, Rayara J P / Souza, Pedro F N / Malveira, Ellen A / Neto, Nilton A S / Silva, Romério R S / Melo, Gabriel L C / Silva, Ayrles F B / Lima, Leandro B / de Albuquerque, Cynthia C / Bastos, Rafael W / Goldman, Gustavo H / de Freitas, Cleverson D T

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 7

    Abstract: Multiresistant pathogens pose a serious threat to human health. The ... ...

    Abstract Multiresistant pathogens pose a serious threat to human health. The genus
    Language English
    Publishing date 2023-07-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9070756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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