LIVIVO - Search results -

Search results

Result 1 - 10 of total 1641

Search options

Article: 6-O-endosulfatases in tumor metastasis: heparan sulfate proteoglycans modification and potential therapeutic targets.

Han, Mengzhen / Zhu, He / Chen, Xiaoping / Luo, Xin

2024 Volume 14, Issue 2, Page(s) 897–916

Abstract: Metastasis is the leading cause of cancer-associated mortality. Although advances in the targeted treatment and immunotherapy have improved the management of some cancers, the prognosis of metastatic cancers remains unsatisfied. Therefore, the specific ... ...

Abstract	Metastasis is the leading cause of cancer-associated mortality. Although advances in the targeted treatment and immunotherapy have improved the management of some cancers, the prognosis of metastatic cancers remains unsatisfied. Therefore, the specific mechanisms in tumor metastasis need further investigation. 6-O-endosulfatases (SULFs), comprising sulfatase1 (SULF1) and sulfatase 2 (SULF2), play pivotal roles in the post-synthetic modifications of heparan sulfate proteoglycans (HSPGs). Consequently, these extracellular enzymes can regulate a variety of downstream pathways by modulating HSPGs function. During the past decades, researchers have detected the expression of SULF1 and SULF2 in most cancers and revealed their roles in tumor progression and metastasis. Herein we reviewed the metastasis steps which SULFs participated in, elucidated the specific roles and mechanisms of SULFs in metastasis process, and discussed the effects of SULFs in different types of cancers. Moreover, we summarized the role of targeting SULFs in combination therapy to treat metastatic cancers, which provided some novel strategies for cancer therapy.
Language	English
Publishing date	2024-02-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: An extensive calcified chronic subdural hematoma.

Wang, Han / Xu, Xiaoping / Yi, Yong / Liu, Bing

Asian journal of surgery

2023 Volume 46, Issue 11, Page(s) 4766–4767

MeSH term(s)	Humans ; Hematoma, Subdural, Chronic ; Calcinosis ; Tomography, X-Ray Computed
Language	English
Publishing date	2023-06-01
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.05.089
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2831: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: [Adoptive bone marrow cells can reduce the liver injury of metabolic-dysfunction-associated fatty liver disease in mice by differentiating into natural killer T (NKT) cells and increasing their own lipid content].

Li, Xiaoping / Geng, Jinke / Han, Mutian

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

2023 Volume 39, Issue 2, Page(s) 124–129

Abstract: Objective To investigate the therapeutic effect of bone marrow cell adoptive therapy on metabolic-dysfunction-associated fatty liver disease (MAFLD) in mice and its possible cell population. Methods The staining was used to detect the liver lesions of ... ...

Abstract	Objective To investigate the therapeutic effect of bone marrow cell adoptive therapy on metabolic-dysfunction-associated fatty liver disease (MAFLD) in mice and its possible cell population. Methods The staining was used to detect the liver lesions of MAFLD in C57BL/6 mice induced by methionine and choline deficiency diet (MCD) and the adoptive therapeutic effect of bone marrow cells on MAFLD was evaluated by detecting the levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The mRNA expressions of low density lipoprotein receptor (LDLR) and interleukin-4 (IL-4) in liver immune cells (including T, NKT, Kupffer cells and other cell populations) were detected by real-time quantitative PCR. The bone marrow cells labeled with 5, 6- carboxyfluorescein diacetate succinimidyl ester (CFSE) were injected into the tail vein of mice. The proportion of CFSE positive cells in liver tissue was observed by the frozen section, and the proportion of labeled cells in the liver and spleen was tracked by flow cytometry. The expression of CD3, CD4, CD8, NK1.1, CD11b and Gr-1 in CFSE labeled adoptive cells was detected by flow cytometry. The intracellular lipid content of NKT cells in liver tissue was evaluated by Nile Red lipid staining. Results The injury of liver tissue and the levels of serum ALT and AST in MAFLD mice were significantly reduced. At the same time, liver immune cells up-regulated the expression of IL-4 and LDLR. LDLR knockout mice induced more severe MAFLD after giving MCD diet. Bone marrow adoptive cells had a significant therapeutic effect and differentiated more NKT cells to colonize the liver. At the same time, the intracellular lipids of these NKT cells increased significantly. Conclusion Bone marrow cell adoptive therapy can reduce liver injury in MAFLD mice by differentiating more NKT cells and increasing the intracellular lipid content of these cells.
MeSH term(s)	Animals ; Mice ; Mice, Inbred C57BL ; Interleukin-4 ; Natural Killer T-Cells ; Non-alcoholic Fatty Liver Disease ; Methionine ; Racemethionine ; Bone Marrow Cells ; Killer Cells, Natural ; Lipids
Chemical Substances	5-(6)-carboxyfluorescein diacetate succinimidyl ester ; Interleukin-4 (207137-56-2) ; Methionine (AE28F7PNPL) ; Racemethionine (73JWT2K6T3) ; Lipids
Language	Chinese
Publishing date	2023-03-06
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1007-8738
ISSN	1007-8738
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets.

Han, Mengzhen / Huang, Qibo / Li, Xinxin / Chen, Xiaoping / Zhu, He / Pan, Yonglong / Zhang, Bixiang

International journal of biological sciences

2024 Volume 20, Issue 4, Page(s) 1238–1255

Abstract: RNA modifications play a pivotal role in regulating cellular biology by exerting influence over distribution features and molecular functions at the post-transcriptional level. Among these modifications, N7-methylguanosine (m7G) stands out as one of the ... ...

Abstract	RNA modifications play a pivotal role in regulating cellular biology by exerting influence over distribution features and molecular functions at the post-transcriptional level. Among these modifications, N7-methylguanosine (m7G) stands out as one of the most prevalent. Over recent years, significant attention has been directed towards understanding the implications of m7G modification. This modification is present in diverse RNA molecules, including transfer RNAs, messenger RNAs, ribosomal RNAs, and other noncoding RNAs. Its regulation occurs through a series of specific methyltransferases and m7G-binding proteins. Notably, m7G modification has been implicated in various diseases, prominently across multiple cancer types. Earlier studies have elucidated the significance of m7G modification in the context of immune biology regulation within the tumor microenvironment. This comprehensive review culminates in a synthesis of findings related to the modulation of immune cells infiltration, encompassing T cells, B cells, and various innate immune cells, all orchestrated by m7G modification. Furthermore, the interplay between m7G modification and its regulatory proteins can profoundly affect the efficacy of diverse adjuvant therapeutics, thereby potentially serving as a pivotal biomarker and therapeutic target for combinatory interventions in diverse cancer types.
MeSH term(s)	Humans ; Adjuvants, Immunologic ; B-Lymphocytes ; Neoplasms/genetics ; Neoplasms/therapy ; RNA ; Tumor Microenvironment/genetics
Chemical Substances	Adjuvants, Immunologic ; RNA (63231-63-0)
Language	English
Publishing date	2024-01-27
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.90382
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: High-frequency ultrasound imaging findings in the diagnosis of segmental schwannomatosis of the ulnar nerve: case report and literature review.

Li, Shuang / Han, Jingwen / Zhang, Xiaoping / Qi, Yunfeng / Du, Jie / Zhao, Lirong

Skeletal radiology

2024

Abstract: Schwannomatosis is characterized by the development of multiple schwannomas without evidence of vestibular tumors. Segmental schwannomatosis is defined as being limited to one limb or five or fewer contiguous segments of the spine. We report a case of a ... ...

Abstract	Schwannomatosis is characterized by the development of multiple schwannomas without evidence of vestibular tumors. Segmental schwannomatosis is defined as being limited to one limb or five or fewer contiguous segments of the spine. We report a case of a 20-year-old male with the painful masses of the left upper extremity with associated numbness and paresthesia in the ulnar nerve distribution. The high-frequency ultrasound showed that the ulnar nerve fascicles were enlarged and expanded with beadlike growth. The patient underwent surgery twice and all the tumors were pathologically confirmed to be schwannomas. Together, the medical history, imaging, and pathology findings indicated the diagnosis of segmental schwannomatosis. By the imaging diagnostic tools, MRI is the most commonly used in assistance with diagnosis of segmental schwannomatosis while high-frequency ultrasonography is rare. In this paper, we discuss the value of high-frequency ultrasonography in the diagnosis of this rare disease. This case report provides a deeper understanding of segmental schwannomatosis and may help improve the accuracy of preoperative diagnosis.
Language	English
Publishing date	2024-03-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-024-04645-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1304: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Synthesis of carbon dot based Schiff bases and selective anticancer activity in glioma cells.

Zhuang, Yafeng / Zhu, Liping / Chen, Xiaoping / Chen, Jing / Ye, Zhoujie / Kang, Jie / Wang, Xinrui / Han, Zhizhong

RSC advances

2024 Volume 14, Issue 3, Page(s) 1952–1961

Abstract: Schiff bases have remarkable anticancer activity and are used for glioma therapy. However, the poor water solubility/dispersibility limits their therapeutic potential in biological systems. To address this issue, carbon dots (CDs) have been utilized to ... ...

Abstract	Schiff bases have remarkable anticancer activity and are used for glioma therapy. However, the poor water solubility/dispersibility limits their therapeutic potential in biological systems. To address this issue, carbon dots (CDs) have been utilized to enhance the dispersibility in water and biological efficacy of Schiff bases. The amino groups on the surface of CDs were conjugated effectively with the aldehyde group of terephthalaldehyde to form novel CD-based Schiff bases (CDSBs). The results of the MTT assays demonstrate that CDSBs have significant anticancer activity in glioma GL261 cells and U251 cells, with IC50 values of 17.9 μg mL
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra06411e
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Exploring the mediating role of utilitarian value and hedonic value in the formation of oppositional loyalty in online communities

Yangguang / Chen, Han / Lang, Xiaoping / Li, Tieshan

International Journal of Consumer Studies. 2023 July, v. 47, no. 4 p.1500-1515

2023

Abstract: Our research expands the scope of the research on oppositional loyalty from brands to online communities. Online communities allow members to freely express their opinions and promote the occurrence of oppositional loyalty behaviours towards the ... ...

Abstract	Our research expands the scope of the research on oppositional loyalty from brands to online communities. Online communities allow members to freely express their opinions and promote the occurrence of oppositional loyalty behaviours towards the communities. Oppositional loyalty is defined in this article that, for the purpose of strengthening the market position of their preferred community, members of the online community may express negative views or even show oppositional behaviour towards adversarial communities. In view of social capital theory, the study examines the effect of hedonic value and utilitarian value on oppositional loyalty in online communities. The results show that only hedonic value significantly affects oppositional loyalty; hedonic value mediates the effect of the three dimensions of social capital (network ties, identification, and common language) on oppositional loyalty. The study identifies that community type moderates the impact of social capital (identification and common language) on hedonic value but does not moderate the effect of social capital on utilitarian value. Finally, we find that members' oppositional loyalty towards their community can promote their community participation. This research provides recommendations for online community managers to manage and benefit from members' oppositional loyalty.
Keywords	community service ; hedonic scales ; markets ; social capital
Language	English
Dates of publication	2023-07
Size	p. 1500-1515.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2045189-1
ISSN	1470-6423
ISSN	1470-6423
DOI	10.1111/ijcs.12929
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 6399: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Photonic time-frequency filter based on the software-defined time-frequency prism.

Han, Guanyu / Li, Shangyuan / Xue, Xiaoxiao / Zheng, Xiaoping

Optics letters

2022 Volume 47, Issue 14, Page(s) 3576–3579

Abstract: We propose a microwave photonic 2D time-frequency filter based on a photonic time-frequency prism. A time-varying frequency response is realized by deviating the passband of a 1D ordinary frequency filter in the 2D time-frequency plane. The proposed time- ...

Abstract	We propose a microwave photonic 2D time-frequency filter based on a photonic time-frequency prism. A time-varying frequency response is realized by deviating the passband of a 1D ordinary frequency filter in the 2D time-frequency plane. The proposed time-frequency filter features highly reconfigurable frequency-sweeping speed and bandwidth, thanks to the software-defined photonic time-frequency prism. With the proposed technique, separation of multiple linear and nonlinear chirp signals with overlapped spectra is experimentally demonstrated.
Language	English
Publishing date	2022-07-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.457157
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Quantitative analysis of the impact of climate change and human activities on vegetation NPP in the Qilian Mountain

Yang, Anle / Zhang, Han / Yang, Xuejie / Zhang, Xiaoping

Human and Ecological Risk Assessment: An International Journal. 2023 Feb. 1, v. 29, no. 1 p.202-221

2023

Abstract: Qilian Mountain as an important ecological security barrier and water connotation area in China, Research on its vegetation NPP driving mechanism can provide reference for ecological security protection in northwest China. Based on Qilian Mountain ... ...

Abstract	Qilian Mountain as an important ecological security barrier and water connotation area in China, Research on its vegetation NPP driving mechanism can provide reference for ecological security protection in northwest China. Based on Qilian Mountain MOD17A3 remote sensing data from 2000-2019, using one-dimensional linear regression, partial correlation analysis, multiple linear regression, residual analysis and land transfer matrix. The spatial and temporal dynamics of vegetation NPP in the Qilian Mountain and its correlation with precipitation, temperature and human activities were analyzed, and quantified the effects of climate change and human activities on vegetation NPP. The results show that: 1) from 2000 to 2019 vegetation NPP in Qilian Mountains had an overall fluctuating upward trend and decreased from east to west, with a multi-year average of 138.54 g C·m⁻²·a⁻¹ and an average annual increase of 1.67 g C·m⁻²·a⁻¹; 2) vegetation NPP was positively correlated with precipitation and temperature, with precipitation having a more significant effect on it; 3) the area of grassland in LUCC increased the most and contributed 183.12% to vegetation NPP, while the area of unused land decreased the most and its contribution to vegetation NPP was −119.6%; 4) In the vegetation recovery area, climate change and human activities explained 89% and 11% of the vegetation recovery, respectively. While in the vegetation degradation area, they explained 22% and 78% of the vegetation degradation, respectively.
Keywords	climate change ; environmental assessment ; grasslands ; humans ; quantitative analysis ; regression analysis ; temperature ; temporal variation ; China ; Qilian Mountains ; vegetation NPP ; human activities ; land use changes
Language	English
Dates of publication	2023-0201
Size	p. 202-221.
Publishing place	Taylor & Francis
Document type	Article ; Online
ISSN	1549-7860
DOI	10.1080/10807039.2022.2152774
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Effective of phage cocktail against Klebsiella pneumoniae infection of murine mammary glands.

Liang, Bingchun / Han, Bo / Shi, Yuxiang / Li, Xiaoping / Zhao, Wenpeng / Kastelic, John / Gao, Jian

Microbial pathogenesis

2023 Volume 182, Page(s) 106218

Abstract: Phage therapy has potential to combat antibiotic-resistant bacteria causing bovine mastitis. Our objective was to use 3 Klebsiella lytic phages to create a phage cocktail, and to compare bactericidal activity of this phage cocktail versus an individual ... ...

Abstract	Phage therapy has potential to combat antibiotic-resistant bacteria causing bovine mastitis. Our objective was to use 3 Klebsiella lytic phages to create a phage cocktail, and to compare bactericidal activity of this phage cocktail versus an individual phage, both in vitro and in vivo. Based on transmission electron microscopy, phage CM_Kpn_HB154724 belonged to Podoviridae and on double agar plates, it formed translucent plaques on the bacterial lawn of Klebsiella pneumoniae KPHB154724. In one-step growth curves, this phage had a latent period of 40 min, an outbreak period of 40 min, a burst size of 1.2 × 10
Language	English
Publishing date	2023-07-07
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2023.106218
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2136: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito