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Article ; Online: The functional roles of S-adenosyl-methionine and S-adenosyl-homocysteine and their involvement in trisomy 21.

Caracausi, Maria / Ramacieri, Giuseppe / Catapano, Francesca / Cicilloni, Michela / Lajin, Bassam / Pelleri, Maria Chiara / Piovesan, Allison / Vitale, Lorenza / Locatelli, Chiara / Pirazzoli, Gian Luca / Strippoli, Pierluigi / Antonaros, Francesca / Vione, Beatrice

BioFactors (Oxford, England)

2024

Abstract: The one-carbon metabolism pathway is involved in critical human cellular functions such as cell proliferation, mitochondrial respiration, and epigenetic regulation. In the homocysteine-methionine cycle S-adenosyl-methionine (SAM) and S-adenosyl- ... ...

Abstract	The one-carbon metabolism pathway is involved in critical human cellular functions such as cell proliferation, mitochondrial respiration, and epigenetic regulation. In the homocysteine-methionine cycle S-adenosyl-methionine (SAM) and S-adenosyl-homocysteine (SAH) are synthetized, and their levels are finely regulated to ensure proper functioning of key enzymes which control cellular growth and differentiation. Here we review the main biological mechanisms involving SAM and SAH and the known related human diseases. It was recently demonstrated that SAM and SAH levels are altered in plasma of subjects with trisomy 21 (T21) but how this metabolic dysregulation influences the clinical manifestation of T21 phenotype has not been previously described. This review aims at providing an overview of the biological mechanisms which are altered in response to changes in the levels of SAM and SAH observed in DS.
Language	English
Publishing date	2024-02-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	59230-4
ISSN	1872-8081 ; 0951-6433
ISSN (online)	1872-8081
ISSN	0951-6433
DOI	10.1002/biof.2044
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Article ; Online: Reference quantitative transcriptome dataset for adult

Piovesan, Allison / Antonaros, Francesca / Strippoli, Pierluigi / Vitale, Lorenza / Pelleri, Maria Chiara / Caracausi, Maria

Data in brief

2019 Volume 25, Page(s) 104152

Abstract: Caenorhabditis ... ...

Abstract	Caenorhabditis elegans
Language	English
Publishing date	2019-06-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2019.104152
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Article: Higher Integrin Alpha 3 Beta1 Expression in Papillary Thyroid Cancer Is Associated with Worst Outcome.

Mautone, Lorenza / Ferravante, Carlo / Tortora, Anna / Tarallo, Roberta / Giurato, Giorgio / Weisz, Alessandro / Vitale, Mario

Cancers

2021 Volume 13, Issue 12

Abstract: Integrins are cell-extracellular matrix adhesion molecules whose expression level undergoes quantitative changes upon neoplastic transformation and are considered functionally related to the development of cancer metastasis. We analyzed the largest mRNA- ... ...

Abstract	Integrins are cell-extracellular matrix adhesion molecules whose expression level undergoes quantitative changes upon neoplastic transformation and are considered functionally related to the development of cancer metastasis. We analyzed the largest mRNA-seq dataset available to determine the expression pattern of integrin family subunits in papillary thyroid carcinomas (PTC). ITGA2, 3, 6, V, and ITGB1 integrin subunits were overexpressed in PTC compared to normal thyroid tissue. The PTC histology variants "classical" and "tall cell" displayed a similar integrin expression profile with a higher level of ITGA3, ITGAV, and ITGB1, which differed from that of the "follicular" variant. Interestingly, compared to RAS mutations, BRAFV600E mutation was associated with a significantly higher expression of integrins. Some integrin subunits were associated with advanced disease stage, lymph node metastasis, extrathyroidal extension, and high-risk groups. Among them, ITGA3 expression displayed the highest correlation with advanced disease and was associated with a negative prognosis. In vitro scratch assay and Matrigel invasion assay in two different PTC cell lines confirmed α3β1 role in cell motility and invasion, supporting its involvement during tumor progression. These results demonstrate the existence of a PTC-specific integrin expression signature correlated to histopathology, specific driver gene mutations, and aggressiveness of the disease.
Language	English
Publishing date	2021-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13122937
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Polyelectrolyte-Coated Mesoporous Bioactive Glasses via Layer-by-Layer Deposition for Sustained Co-Delivery of Therapeutic Ions and Drugs.

Pontremoli, Carlotta / Pagani, Mattia / Maddalena, Lorenza / Carosio, Federico / Vitale-Brovarone, Chiara / Fiorilli, Sonia

Pharmaceutics

2021 Volume 13, Issue 11

Abstract: In the field of bone regeneration, considerable attention has been addressed towards the use of mesoporous bioactive glasses (MBGs), as multifunctional therapeutic platforms for advanced medical devices. In fact, their extremely high exposed surface area ...

Abstract	In the field of bone regeneration, considerable attention has been addressed towards the use of mesoporous bioactive glasses (MBGs), as multifunctional therapeutic platforms for advanced medical devices. In fact, their extremely high exposed surface area and pore volume allow to load and the release of several drugs, while their framework can be enriched with specific therapeutic ions allowing to boost the tissue regeneration. However, due to the open and easily accessible mesopore structure of MBG, the release of the incorporated therapeutic molecules shows an initial burst effect leading to unsuitable release kinetics. Hence, a still open challenge in the design of drug delivery systems based on MBGs is the control of their release behavior. In this work, Layer-by-layer (LbL) deposition of polyelectrolyte multi-layers was exploited as a powerful and versatile technique for coating the surface of Cu-substituted MBG nanoparticles with innovative multifunctional drug delivery systems for co-releasing of therapeutic copper ions (exerting pro-angiogenic and anti-bacterial effects) and an anti-inflammatory drug (ibuprofen). Two different routes were investigated: in the first strategy, chitosan and alginate were assembled by forming the multi-layered surface, and, successively, ibuprofen was loaded by incipient wetness impregnation, while in the second approach, alginate was replaced by ibuprofen, introduced as polyelectrolyte layer. Zeta-potential, TGA and FT-IR spectroscopy were measured after the addition of each polyelectrolyte layer, confirming the occurrence of the stepwise deposition. In addition, the in vitro bioactivity and the ability to modulate the release of the cargo were evaluated. The polyelectrolyte coated-MBGs were proved to retain the peculiar ability to induce hydroxyapatite formation after 7 days of soaking in Simulated Body Fluid. Both copper ions and ibuprofen were co-released over time, showing a sustained release profile up to 14 days and 24 h, respectively, with a significantly lower burst release compared to the bare MBG particles.
Language	English
Publishing date	2021-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13111952
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Article ; Online: Estimating survival in patients with melanoma brain metastases: prognostic value of lactate dehydrogenase.

Pelizzari, Giacomo / Bertoli, Elisa / Buriolla, Silvia / Vitale, Maria Grazia / Basile, Debora / Palmero, Lorenza / Zara, Diego / Iacono, Donatella / Andrea, Freschi / Pascoletti, Gaetano / Bolzonello, Silvia / Garutti, Mattia / Fasola, Gianpiero / Puglisi, Fabio / Minisini, Alessandro Marco

Melanoma research

2023 Volume 33, Issue 5, Page(s) 398–405

Abstract: Patients with melanoma brain metastases (MBM) have poor prognosis, albeit advances in locoregional and systemic treatments. The melanoma-specific Graded Prognostic Assessment (GPA) effectively stratifies survival for patients with MBM. Nevertheless, ... ...

Abstract	Patients with melanoma brain metastases (MBM) have poor prognosis, albeit advances in locoregional and systemic treatments. The melanoma-specific Graded Prognostic Assessment (GPA) effectively stratifies survival for patients with MBM. Nevertheless, lactate dehydrogenase (LDH), a well known prognostic factor for patients with melanoma, is not represented in the GPA scores and might add prognostic information for patients with MBM. In this study, 150 consecutive patients with MBM were retrospectively analyzed with the aim of evaluating independent prognostic factors for MBM patients, including LDH. Furthermore, we implemented a disease-specific prognostic score and estimated survival according to treatment modalities. On the basis of multivariable Cox regression analyses, six prognostic factors (age, BRAF status, number of MBM, number of extracranial metastatic sites, performance status, and LDH level) resulted statistically significant in terms of survival and were combined in a prognostic score to stratify patients in distinct prognostic groups ( P < 0.0001). Among treatment modalities, a multimodal approach with stereotactic radiosurgery or neurosurgery associated with systemic therapy showed the best outcome (median overall survival: 12.32 months, 95% confidence interval, 7.92-25.30). This is the first study to demonstrate that LDH has independent prognostic value for patients with MBM and might be used to improve prognostic stratification, albeit external validation is mandatory. Survival of patients with MBM is affected by both disease-specific risk factors and treatment modalities, with locoregional treatments associated with better outcomes.
MeSH term(s)	Humans ; Prognosis ; Melanoma/pathology ; Retrospective Studies ; L-Lactate Dehydrogenase ; Skin Neoplasms/surgery ; Brain Neoplasms/secondary ; Radiosurgery
Chemical Substances	L-Lactate Dehydrogenase (EC 1.1.1.27)
Language	English
Publishing date	2023-07-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1095779-0
ISSN	1473-5636 ; 0960-8931
ISSN (online)	1473-5636
ISSN	0960-8931
DOI	10.1097/CMR.0000000000000907
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Zs.A 3378: Show issues

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Article ; Online: Sustained increase in physical fitness independently predicts improvements in cardiometabolic risk profile in type 2 diabetes.

Balducci, Stefano / Haxhi, Jonida / Vitale, Martina / Mattia, Lorenza / Sacchetti, Massimo / Orlando, Giorgio / Cardelli, Patrizia / Iacobini, Carla / Bollanti, Lucilla / Conti, Francesco / Zanuso, Silvano / Nicolucci, Antonio / Pugliese, Giuseppe

Diabetes/metabolism research and reviews

2023 Volume 39, Issue 6, Page(s) e3671

Abstract: Aims: To investigate the relationship between changes in physical fitness and cardiovascular risk factors and scores in patients with type 2 diabetes receiving either a behavioural counselling intervention to increase moderate-to-vigorous-intensity ... ...

Abstract	Aims: To investigate the relationship between changes in physical fitness and cardiovascular risk factors and scores in patients with type 2 diabetes receiving either a behavioural counselling intervention to increase moderate-to-vigorous-intensity physical activity (MVPA) and decrease sedentary-time (SED-time) or standard care. Materials and methods: This is a pre-specified ancillary analysis of the Italian Diabetes and Exercise Study_2, a 3-year randomized clinical trial in which 300 physically inactive and sedentary patients were randomized 1:1 to receive either a one-month theoretical and practical counselling each year or standard care. Mean changes from baseline throughout the 3-year period in MVPA, SED-time, cardiorespiratory fitness (VO Results: Haemoglobin (Hb) A Conclusions: Improvement in physical fitness predicts favourable changes in cardiometabolic risk profile, independent of changes not only in (central) adiposity or body composition but also in MVPA and SED-time. Trial registration: ClinicalTrials.gov; NCT01600937; URL https://clinicaltrials.gov/ct2/show/NCT01600937.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; Risk Factors ; Exercise/physiology ; Physical Fitness ; Glycated Hemoglobin ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Waist Circumference
Chemical Substances	Glycated Hemoglobin
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1470192-3
ISSN	1520-7560 ; 1520-7552
ISSN (online)	1520-7560
ISSN	1520-7552
DOI	10.1002/dmrr.3671
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Zs.A 2119: Show issues

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Article: Structural Characterization of the Highly Restricted Down Syndrome Critical Region on 21q22.13: New

Antonaros, Francesca / Pitocco, Margherita / Abete, Domenico / Vione, Beatrice / Piovesan, Allison / Vitale, Lorenza / Strippoli, Pierluigi / Caracausi, Maria / Pelleri, Maria Chiara

Frontiers in genetics

2021 Volume 12, Page(s) 770359

Abstract: Down syndrome (DS) is caused by trisomy of chromosome 21 and it is the most common genetic cause of intellectual disability (ID) in humans. Subjects with DS show a typical phenotype marked by facial dysmorphisms and ID. Partial trisomy 21 (PT21) is a ... ...

Abstract	Down syndrome (DS) is caused by trisomy of chromosome 21 and it is the most common genetic cause of intellectual disability (ID) in humans. Subjects with DS show a typical phenotype marked by facial dysmorphisms and ID. Partial trisomy 21 (PT21) is a rare genotype characterized by the duplication of a delimited chromosome 21 (Hsa21) portion and it may or may not be associated with DS diagnosis. The highly restricted Down syndrome critical region (HR-DSCR) is a region of Hsa21 present in three copies in all individuals with PT21 and a diagnosis of DS. This region, located on distal 21q22.13, is 34 kbp long and does not include characterized genes. The HR-DSCR is annotated as an intergenic region between
Language	English
Publishing date	2021-12-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.770359
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Article ; Online: Spinal 'flip-flop' effect in anorexia nervosa: A case report.

Varotto, Alessia / Vitale, Valerio / Mansour, Mariam / Di Pascoli, Lorenza / Iannucci, Giuseppe

Journal of medical imaging and radiation oncology

2020 Volume 64, Issue 4, Page(s) 534–536

Abstract: Anorexia nervosa is a psychiatric eating disorder related to malnutrition and consequent altered metabolism. A 48-year-old female with a history of anorexia in the last 2 years referred to our hospital with spinal pain. She underwent spinal X-ray and ... ...

Abstract	Anorexia nervosa is a psychiatric eating disorder related to malnutrition and consequent altered metabolism. A 48-year-old female with a history of anorexia in the last 2 years referred to our hospital with spinal pain. She underwent spinal X-ray and magnetic resonance imaging (MRI) showing multiple vertebral collapses in dorsal and lumbar spine with inversion of normal bone marrow and soft tissue signal in T1-weighted and STIR images. We describe this case of spinal 'flip-flop' phenomenon, underlining how what seems a technical failure is actually a specific imaging pattern related to the clinical context.
MeSH term(s)	Anorexia Nervosa/pathology ; Bone Marrow/diagnostic imaging ; Bone Marrow/pathology ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Middle Aged ; Radiography/methods ; Spine/diagnostic imaging ; Spine/pathology
Language	English
Publishing date	2020-02-09
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	2389687-5
ISSN	1754-9485 ; 1440-1673 ; 1754-9477 ; 0004-8461
ISSN (online)	1754-9485 ; 1440-1673
ISSN	1754-9477 ; 0004-8461
DOI	10.1111/1754-9485.12985
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Zs.B 66: Show issues

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Article ; Online: Dataset of differential gene expression between total normal human thyroid and histologically normal thyroid adjacent to papillary thyroid carcinoma.

Vitale, Lorenza / Piovesan, Allison / Antonaros, Francesca / Strippoli, Pierluigi / Pelleri, Maria Chiara / Caracausi, Maria

Data in brief

2019 Volume 24, Page(s) 103835

Abstract: This article contains further data and information from our published manuscript [1]. We aim to identify significant transcriptome alterations of total normal human thyroid vs. histologically normal thyroid adjacent to papillary thyroid carcinoma. We ... ...

Abstract	This article contains further data and information from our published manuscript [1]. We aim to identify significant transcriptome alterations of total normal human thyroid vs. histologically normal thyroid adjacent to papillary thyroid carcinoma. We performed a systematic meta-analysis of all the available gene expression profiles for the whole organ also collecting gene expression data for the normal thyroid adjacent to papillary thyroid carcinoma. A differential quantitative transcriptome reference map was generated by using TRAM (Transcriptome Mapper) software able to combine, normalize and integrate a total of 35 datasets from total normal thyroid and 40 datasets from histologically normal thyroid adjacent to papillary thyroid carcinoma from different sources. This analysis identified genes and genome segments that significantly discriminated the two groups of samples. Differentially expressed genes were grouped and enrichment function analyses were performed identifying the main features of the differentially expressed genes between total normal thyroid and histologically normal thyroid adjacent to papillary thyroid carcinoma. The search for housekeeping genes retrieved 414 loci.
Language	English
Publishing date	2019-03-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2019.103835
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Article ; Online: Sustained decreases in sedentary time and increases in physical activity are associated with preservation of estimated β-cell function in individuals with type 2 diabetes.

Balducci, Stefano / Haxhi, Jonida / Vitale, Martina / Mattia, Lorenza / Bollanti, Lucilla / Conti, Francesco / Cardelli, Patrizia / Sacchetti, Massimo / Orlando, Giorgio / Zanuso, Silvano / Nicolucci, Antonio / Pugliese, Giuseppe

Diabetes research and clinical practice

2022 Volume 193, Page(s) 110140

Abstract: Aims: In the Italian Diabetes and Exercise Study_2, a counselling intervention produced modest but sustained increments in moderate-to vigorous-intensity physical activity (MVPA), with reallocation of sedentary-time (SED-time) to light-intensity ... ...

Abstract	Aims: In the Italian Diabetes and Exercise Study_2, a counselling intervention produced modest but sustained increments in moderate-to vigorous-intensity physical activity (MVPA), with reallocation of sedentary-time (SED-time) to light-intensity physical activity (LPA). This post hoc analysis evaluated the impact of intervention on estimated β-cell function and insulin sensitivity. Methods: Patients with type 2 diabetes were randomized to one-month counselling once-a-year or standard care for 3 years. The HOmeostatic Model Assessment-2 (HOMA-2) method was used for estimating indices of β-cell function (HOMA-B%), insulin sensitivity (HOMA-S%), and insulin resistance (HOMA-IR); the disposition index (DI) was estimated as HOMA-β%/HOMA-IR; MVPA, LPA, and SED-time were objectively measured by accelerometer. Results: HOMA-B% and DI decreased in control group, whereas HOMA-B% remained stable and DI increased in intervention group. Between-group differences were significant for almost all insulin secretion and sensitivity indices. Changes in HOMA-B% and DI correlated with SED-time, MVPA and LPA. Changes in HOMA-B%, DI, and all indices were independently predicted by changes in SED-time (or LPA), MVPA, and BMI (or waist circumference), respectively. Conclusions: In individuals with type 2 diabetes, increasing MVPA, even without achieving the recommended target, is effective in maintaining estimated β-cell function if sufficient amounts of SED-time are reallocated to LPA.
MeSH term(s)	Humans ; Sedentary Behavior ; Diabetes Mellitus, Type 2 ; Insulin Resistance/physiology ; Exercise/physiology ; Waist Circumference
Language	English
Publishing date	2022-11-01
Publishing country	Ireland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2022.110140
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