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  1. Article ; Online: From spirometry to spatial omics in pursuit of asthma endotypes.

    Hinks, Timothy S C

    Clinical and translational medicine

    2022  Volume 12, Issue 9, Page(s) e878

    MeSH term(s) Asthma/genetics ; Humans ; Spirometry
    Language English
    Publishing date 2022-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Azithromycin for mild-to-moderate COVID-19 - Authors' reply.

    Hinks, Timothy S C

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 10, Page(s) e100–e101

    MeSH term(s) Azithromycin ; Humans ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Azithromycin (83905-01-5)
    Language English
    Publishing date 2021-09-09
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00376-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
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  3. Article ; Online: Editorial: MAIT cells come of age.

    Corbett, Alexandra J / Ussher, James E / Hinks, Timothy S C

    Frontiers in immunology

    2023  Volume 14, Page(s) 1281881

    MeSH term(s) Mucosal-Associated Invariant T Cells
    Language English
    Publishing date 2023-09-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1281881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Boosting MAIT cells as immunotherapy: context is everything.

    Hinks, Timothy S C

    Mucosal immunology

    2020  Volume 14, Issue 1, Page(s) 1–3

    MeSH term(s) Humans ; Immunotherapy ; Mucosal-Associated Invariant T Cells ; Tuberculosis
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1038/s41385-020-00337-8
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    Zs.A 6796: Show issues Location:
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  5. Article: MAIT Cells in Respiratory Viral Infections in Mouse and Human.

    Long, Yuqing / Hinks, Timothy S C

    Critical reviews in immunology

    2022  Volume 41, Issue 5, Page(s) 19–35

    Abstract: Mucosal associated invariant T (MAIT) cells were first identified as specific for bacterial, mycobacterial, and fungal organisms, which detect microbially-derived biosynthetic ligands presented by MHC-related protein 1 (MR1). More recently two unexpected, ...

    Abstract Mucosal associated invariant T (MAIT) cells were first identified as specific for bacterial, mycobacterial, and fungal organisms, which detect microbially-derived biosynthetic ligands presented by MHC-related protein 1 (MR1). More recently two unexpected, additional roles have been identified for these ancient and abundant cells: a TCR-depen-dent role in tissue repair and a TCR-independent role in antiviral host defence. Data from several classes of viral disease shows their capability for activation by the cytokines interleukin (IL)-12, IL-15, IL-18, and type I interferon. MAIT cells are abundant at mucosal surfaces, particularly in the lung, and it seems likely a primary reason for their striking evolutionary conservation is an important role in early innate defence against respiratory infections, including both bacteria and viruses. Here we review evidence for their TCR-independent activation, observational human data for their activation in influenza A virus, and in vivo murine evidence of their protection against severe influenza A infection, mediated at least partially via IFN-gamma. We then survey evidence emerging from other respiratory viral infections including recent evidence for an important adjuvant role in adenovirus infection, specifically chimpanzee adenoviruses used in recent coronavirus vaccines, and data for strong associations between MAIT cell responses and adverse outcomes from coronavirus-19 (COVID-19) disease. We speculate on potential translational implications of these findings, either using corticosteroids or inhibitory ligands to suppress deleterious MAIT cell responses, or the potential utility of stimulatory MR1 ligands to boost MAIT cell frequencies to enhance innate viral defences.
    MeSH term(s) Animals ; COVID-19 ; Humans ; Lymphocyte Activation ; Mice ; Mucosal-Associated Invariant T Cells ; Virus Diseases ; Viruses
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1353116-5
    ISSN 1040-8401
    ISSN 1040-8401
    DOI 10.1615/CritRevImmunol.2021040877
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1699: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: MAIT cells and the microbiome.

    Jabeen, Maisha F / Hinks, Timothy S C

    Frontiers in immunology

    2023  Volume 14, Page(s) 1127588

    Abstract: Mucosal associated invariant T (MAIT) cells are innate-like T lymphocytes, strikingly enriched at mucosal surfaces and characterized by a semi-invariant αβ T cell receptor (TCR) recognizing microbial derived intermediates of riboflavin synthesis ... ...

    Abstract Mucosal associated invariant T (MAIT) cells are innate-like T lymphocytes, strikingly enriched at mucosal surfaces and characterized by a semi-invariant αβ T cell receptor (TCR) recognizing microbial derived intermediates of riboflavin synthesis presented by the MHC-Ib molecule MR1. At barrier sites MAIT cells occupy a prime position for interaction with commensal microorganisms, comprising the microbiota. The microbiota is a rich source of riboflavin derived antigens required in early life to promote intra-thymic MAIT cell development and sustain a life-long population of tissue resident cells. A symbiotic relationship is thought to be maintained in health whereby microbes promote maturation and homeostasis, and in turn MAIT cells can engage a TCR-dependent "tissue repair" program in the presence of commensal organisms conducive to sustaining barrier function and integrity of the microbial community. MAIT cell activation can be induced in a MR1-TCR dependent manner or through MR1-TCR independent mechanisms
    MeSH term(s) Humans ; Mucosal-Associated Invariant T Cells ; Histocompatibility Antigens Class I ; Dysbiosis ; Minor Histocompatibility Antigens/metabolism ; Receptors, Antigen, T-Cell ; Riboflavin ; Microbiota
    Chemical Substances Histocompatibility Antigens Class I ; Minor Histocompatibility Antigens ; Receptors, Antigen, T-Cell ; Riboflavin (TLM2976OFR)
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1127588
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  7. Article ; Online: Are biologics for chronic rhinosinusitis effective and safe?

    Rampersad, Anjali / Banerjee, Nandini / Hinks, Timothy S C

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2021  Volume 51, Issue 7, Page(s) 870–872

    MeSH term(s) Biological Products/adverse effects ; Chronic Disease ; Humans ; Rhinitis/drug therapy ; Sinusitis/drug therapy
    Chemical Substances Biological Products
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.13904
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 767: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Non-typeable

    Brown, Mary Ashley / Jabeen, Maisha / Bharj, Gurpreet / Hinks, Timothy S C

    European respiratory review : an official journal of the European Respiratory Society

    2022  Volume 31, Issue 165

    Abstract: Asthma is a complex, heterogeneous condition that affects over 350 million people globally. It is characterised by bronchial hyperreactivity and airways inflammation. A subset display marked airway neutrophilia, associated with worse lung function, ... ...

    Abstract Asthma is a complex, heterogeneous condition that affects over 350 million people globally. It is characterised by bronchial hyperreactivity and airways inflammation. A subset display marked airway neutrophilia, associated with worse lung function, higher morbidity and poor response to treatment. In these individuals, recent metagenomic studies have identified persistent bacterial infection, particularly with non-encapsulated strains of the Gram-negative bacterium
    MeSH term(s) Asthma/complications ; Asthma/diagnosis ; Asthma/drug therapy ; Cell Adhesion Molecule-1 ; Cytokines ; Haemophilus influenzae ; Humans ; Inflammasomes ; Interleukin-12 ; Interleukin-17/metabolism ; Interleukin-6 ; Interleukin-8 ; Macrolides ; NLR Family, Pyrin Domain-Containing 3 Protein ; Pulmonary Disease, Chronic Obstructive/metabolism ; Respiratory System ; Tumor Necrosis Factors
    Chemical Substances Cell Adhesion Molecule-1 ; Cytokines ; Inflammasomes ; Interleukin-17 ; Interleukin-6 ; Interleukin-8 ; Macrolides ; NLR Family, Pyrin Domain-Containing 3 Protein ; Tumor Necrosis Factors ; Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2022-09-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0008-2022
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    Zs.A 3265: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Treatment options in type-2 low asthma.

    Hinks, Timothy S C / Levine, Stewart J / Brusselle, Guy G

    The European respiratory journal

    2021  Volume 57, Issue 1

    Abstract: Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13 are proving highly effective in reducing exacerbations and symptoms in people with severe allergic and eosinophilic asthma, respectively. However, these ... ...

    Abstract Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13 are proving highly effective in reducing exacerbations and symptoms in people with severe allergic and eosinophilic asthma, respectively. However, these therapies are not appropriate for 30-50% of patients in severe asthma clinics who present with non-allergic, non-eosinophilic, "type-2 low" asthma. These patients constitute an important and common clinical asthma phenotype, driven by distinct, yet poorly understood pathobiological mechanisms. In this review we describe the heterogeneity and clinical characteristics of type-2 low asthma and summarise current knowledge on the underlying pathobiological mechanisms, which includes neutrophilic airway inflammation often associated with smoking, obesity and occupational exposures and may be driven by persistent bacterial infections and by activation of a recently described IL-6 pathway. We review the evidence base underlying existing treatment options for specific treatable traits that can be identified and addressed. We focus particularly on severe asthma as opposed to difficult-to-treat asthma, on emerging data on the identification of airway bacterial infection, on the increasing evidence base for the use of long-term low-dose macrolides, a critical appraisal of bronchial thermoplasty, and evidence for the use of biologics in type-2 low disease. Finally, we review ongoing research into other pathways including tumour necrosis factor, IL-17, resolvins, apolipoproteins, type I interferons, IL-6 and mast cells. We suggest that type-2 low disease frequently presents opportunities for identification and treatment of tractable clinical problems; it is currently a rapidly evolving field with potential for the development of novel targeted therapeutics.
    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Bronchial Thermoplasty ; Humans ; Hypersensitivity ; Pulmonary Eosinophilia
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2021-01-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00528-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 292: Show issues

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  10. Article ; Online: Sub-stratification of type-2 high airway disease for therapeutic decision-making: A 'bomb' (blood eosinophils) meets 'magnet' (FeNO) framework.

    Couillard, Simon / Pavord, Ian D / Heaney, Liam G / Petousi, Nayia / Hinks, Timothy S C

    Respirology (Carlton, Vic.)

    2022  Volume 27, Issue 8, Page(s) 573–577

    MeSH term(s) Asthma/drug therapy ; Biomarkers ; Breath Tests ; Eosinophils ; Exhalation ; Humans ; Leukocyte Count ; Nitric Oxide
    Chemical Substances Biomarkers ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2022-05-19
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14294
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    Zs.A 4957: Show issues Location:
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