LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 367

Search options

  1. Article: A cost-benefit framework for prosocial motivation-Advantages and challenges.

    Contreras-Huerta, Luis Sebastian

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1170150

    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1170150
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Risking further COVID-19 waves despite vaccination.

    Contreras, Sebastian / Priesemann, Viola

    The Lancet. Infectious diseases

    2021  Volume 21, Issue 6, Page(s) 745–746

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Vaccination
    Language English
    Publishing date 2021-03-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(21)00167-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Describing a landscape we are yet discovering.

    Contreras, Sebastian / Dehning, Jonas / Priesemann, Viola

    Advances in statistical analysis : AStA : a journal of the German Statistical Society

    2022  Volume 106, Issue 3, Page(s) 399–402

    Language English
    Publishing date 2022-06-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2276384-3
    ISSN 1863-818X ; 1863-8171
    ISSN (online) 1863-818X
    ISSN 1863-8171
    DOI 10.1007/s10182-022-00449-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Overexpression of REST Represses the Epithelial-Mesenchymal Transition Process and Decreases the Aggressiveness of Prostate Cancer Cells.

    Indo, Sebastián / Orellana-Serradell, Octavio / Torres, María José / Castellón, Enrique A / Contreras, Héctor R

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: The RE-1 silencing transcription factor (REST) is a repressor factor related to neuroendocrine prostate cancer (PCa) (NEPC), a poor prognostic stage mainly associated with castration-resistant PCa (CRPC). NEPC is associated with cell transdifferentiation ...

    Abstract The RE-1 silencing transcription factor (REST) is a repressor factor related to neuroendocrine prostate cancer (PCa) (NEPC), a poor prognostic stage mainly associated with castration-resistant PCa (CRPC). NEPC is associated with cell transdifferentiation and the epithelial-mesenchymal transition (EMT) in cells undergoing androgen deprivation therapy (ADT) and enzalutamide (ENZ). The effect of REST overexpression in the 22rv1 cell line (xenograft-derived prostate cancer) on EMT, migration, invasion, and the viability for ENZ was evaluated. EMT genes, Twist and Zeb1, and the androgen receptor (AR) were evaluated through an RT-qPCR and Western blot in nuclear and cytosolic fractions of REST-overexpressing 22rv1 cells (22rv1-REST). The migratory and invasive capacities of 22rv1-REST cells were evaluated via Transwell
    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/metabolism ; Androgen Antagonists ; Transcription Factors ; Cell Line, Tumor ; Receptors, Androgen/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Prostatic Neoplasms, Castration-Resistant/pathology ; Benzamides ; Nitriles ; Phenylthiohydantoin
    Chemical Substances enzalutamide (93T0T9GKNU) ; Androgen Antagonists ; Transcription Factors ; Receptors, Androgen ; Benzamides ; Nitriles ; Phenylthiohydantoin (2010-15-3)
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063332
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Cancer Stemness/Epithelial-Mesenchymal Transition Axis Influences Metastasis and Castration Resistance in Prostate Cancer: Potential Therapeutic Target.

    Castellón, Enrique A / Indo, Sebastián / Contreras, Héctor R

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: Prostate cancer (PCa) is a leading cause of cancer death in men, worldwide. Mortality is highly related to metastasis and hormone resistance, but the molecular underlying mechanisms are poorly understood. We have studied the presence and role of cancer ... ...

    Abstract Prostate cancer (PCa) is a leading cause of cancer death in men, worldwide. Mortality is highly related to metastasis and hormone resistance, but the molecular underlying mechanisms are poorly understood. We have studied the presence and role of cancer stem cells (CSCs) and the Epithelial-Mesenchymal transition (EMT) in PCa, using both in vitro and in vivo models, thereby providing evidence that the stemness-mesenchymal axis seems to be a critical process related to relapse, metastasis and resistance. These are complex and related processes that involve a cooperative action of different cancer cell subpopulations, in which CSCs and mesenchymal cancer cells (MCCs) would be responsible for invading, colonizing pre-metastatic niches, initiating metastasis and an evading treatments response. Manipulating the stemness-EMT axis genes on the androgen receptor (AR) may shed some light on the effect of this axis on metastasis and castration resistance in PCa. It is suggested that the EMT gene SNAI2/Slug up regulates the stemness gene Sox2, and vice versa, inducing AR expression, promoting metastasis and castration resistance. This approach will provide new sight about the role of the stemness-mesenchymal axis in the metastasis and resistance mechanisms in PCa and their potential control, contributing to develop new therapeutic strategies for patients with metastatic and castration-resistant PCa.
    Language English
    Publishing date 2022-11-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232314917
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Cancer Stemness/Epithelial–Mesenchymal Transition Axis Influences Metastasis and Castration Resistance in Prostate Cancer

    Enrique A. Castellón / Sebastián Indo / Héctor R. Contreras

    International Journal of Molecular Sciences, Vol 23, Iss 14917, p

    Potential Therapeutic Target

    2022  Volume 14917

    Abstract: Prostate cancer (PCa) is a leading cause of cancer death in men, worldwide. Mortality is highly related to metastasis and hormone resistance, but the molecular underlying mechanisms are poorly understood. We have studied the presence and role of cancer ... ...

    Abstract Prostate cancer (PCa) is a leading cause of cancer death in men, worldwide. Mortality is highly related to metastasis and hormone resistance, but the molecular underlying mechanisms are poorly understood. We have studied the presence and role of cancer stem cells (CSCs) and the Epithelial–Mesenchymal transition (EMT) in PCa, using both in vitro and in vivo models, thereby providing evidence that the stemness–mesenchymal axis seems to be a critical process related to relapse, metastasis and resistance. These are complex and related processes that involve a cooperative action of different cancer cell subpopulations, in which CSCs and mesenchymal cancer cells (MCCs) would be responsible for invading, colonizing pre-metastatic niches, initiating metastasis and an evading treatments response. Manipulating the stemness–EMT axis genes on the androgen receptor (AR) may shed some light on the effect of this axis on metastasis and castration resistance in PCa. It is suggested that the EMT gene SNAI2/Slug up regulates the stemness gene Sox2, and vice versa, inducing AR expression, promoting metastasis and castration resistance. This approach will provide new sight about the role of the stemness–mesenchymal axis in the metastasis and resistance mechanisms in PCa and their potential control, contributing to develop new therapeutic strategies for patients with metastatic and castration-resistant PCa.
    Keywords prostate cancer ; Epithelial–Mesenchymal transition ; cancer stem cell ; castration resistance ; metastasis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Conference proceedings: 3D-Analyse einer Glenoiddysplasie-Korrektur mit einer augmentierten Basisplatte

    Navas Contreras, Luis Alfredo / Schmidt, Sebastian / Gühring, Thorsten

    2023  , Page(s) AB67–3135

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2023); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2023
    Keywords Medizin, Gesundheit ; Glenoidbasisplatte ; Schultergelenkpfanne ; Schultergelenkpfannenneigung ; Skapularkerbe ; präoperative Planung ; umgekehrte Schulterarthroplastik
    Publishing date 2023-10-23
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkou340
    Database German Medical Science

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Rethinking COVID-19 vaccine allocation

    Sebastian Contreras / Álvaro Olivera-Nappa / Viola Priesemann

    The Lancet Regional Health. Europe, Vol 12, Iss , Pp 100277- (2022)

    it is time to care about our neighbours

    2022  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: 2‐D Vp and Vs Models of the Indian Oceanic Crust Adjacent to the NinetyEast Ridge

    Contreras‐Reyes, Eduardo / Obando‐Orrego, Sebastián / Grevemeyer, Ingo

    Journal of Geophysical Research: Solid Earth. 2023 Mar., v. 128, no. 3 p.e2022JB025701-

    2023  

    Abstract: Until now, few offshore seismic studies have acquired simultaneously P‐ and S‐ wave data to derive in detail the seismic structure of the oceanic crust. We present 2‐D Vₚ and Vₛ models using wide‐angle seismic data at the Indian basin adjacent to the ... ...

    Abstract Until now, few offshore seismic studies have acquired simultaneously P‐ and S‐ wave data to derive in detail the seismic structure of the oceanic crust. We present 2‐D Vₚ and Vₛ models using wide‐angle seismic data at the Indian basin adjacent to the NinetyEast Ridge. Here, an outcrop basement located at the middle of the seismic line presents uppermost crustal Poisson's ratios (ν) of 0.28–0.29 (Vₚ ∼ 4.2 km/s and Vₛ ∼ 2.3 km/s). At the flanks of the outcrop basement, the sediment cover is 200–300 m thick and ν values are similar (0.28–0.3), but Vₚ and Vₛ values are higher (4.5–4.8 and 2.4–2.6 km/s, respectively). We interpret the relatively lower Vₚ and Vₛ around the basement outcrop in terms of hydrothermal alteration, while at the flanks of the basement outcrop, hydrothermal alteration has most likely ceased by sedimentation and compaction processes. Across the seismic layer 2, the Vₚ–Vₛ trend is linear and follows a ν value of 0.28–0.29, however, at the seismic layer 2/3 transition, the Vₚ–Vₛ trend abruptly changes following a ν value of 0.25–0.26. These reduced observed ν values at the layer 2/3 transition are lower than those reported by laboratory measurements for gabbro (ν ∼ 0.293) and are interpreted in terms of epidotization at the dike‐gabbro contact and/or crack‐change properties around the lower part of the intrusive sheeted dike section.
    Keywords basins ; geophysics ; research ; sediments
    Language English
    Dates of publication 2023-03
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ISSN 2169-9313
    DOI 10.1029/2022JB025701
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: 2‐D V p and V s Models of the Indian Oceanic Crust Adjacent to the NinetyEast Ridge

    Contreras‐Reyes, Eduardo / Obando‐Orrego, Sebastián / Grevemeyer, Ingo

    2023  

    Abstract: Until now, few offshore seismic studies have acquired simultaneously P- and S- wave data to derive in detail the seismic structure of the oceanic crust. We present 2-D Vp and Vs models using wide-angle seismic data at the Indian basin adjacent to the ... ...

    Abstract Until now, few offshore seismic studies have acquired simultaneously P- and S- wave data to derive in detail the seismic structure of the oceanic crust. We present 2-D Vp and Vs models using wide-angle seismic data at the Indian basin adjacent to the NinetyEast Ridge. Here, an outcrop basement located at the middle of the seismic line presents uppermost crustal Poisson's ratios (ν) of 0.28–0.29 (Vp ∼ 4.2 km/s and Vs ∼ 2.3 km/s). At the flanks of the outcrop basement, the sediment cover is 200–300 m thick and ν values are similar (0.28–0.3), but Vp and Vs values are higher (4.5–4.8 and 2.4–2.6 km/s, respectively). We interpret the relatively lower Vp and Vs around the basement outcrop in terms of hydrothermal alteration, while at the flanks of the basement outcrop, hydrothermal alteration has most likely ceased by sedimentation and compaction processes. Across the seismic layer 2, the Vp–Vs trend is linear and follows a ν value of 0.28–0.29, however, at the seismic layer 2/3 transition, the Vp–Vs trend abruptly changes following a ν value of 0.25–0.26. These reduced observed ν values at the layer 2/3 transition are lower than those reported by laboratory measurements for gabbro (ν ∼ 0.293) and are interpreted in terms of epidotization at the dike-gabbro contact and/or crack-change properties around the lower part of the intrusive sheeted dike section. Key Points We obtain 2-D Vp and Vs models from active seismic data for the Indian oceanic crust The seismic models suggest hydrothermal alteration near a basement outcrop Poisson's ratios change at the layer 2/3 transition from 0.28–0.29 to 0.25–0.26
    Subject code 550
    Language English
    Publishing date 2023-03-08
    Publisher Wiley
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top