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  1. Article ; Online: Intercity Mobility Assessment Facing the Demographic Challenge: A Survey-Based Research.

    Vega Naranjo, Juan Miguel / Jiménez-Espada, Montaña / Martínez García, Francisco Manuel / González-Escobar, Rafael / Cortés-Pérez, Juan Pedro

    International journal of environmental research and public health

    2023  Volume 20, Issue 2

    Abstract: The key factor in moving towards a more sustainable travel model is based on improving mobility, especially in rural areas that share territorial dynamics with urban areas and are connected by a daily flow of inhabitants. The purpose of this article is ... ...

    Abstract The key factor in moving towards a more sustainable travel model is based on improving mobility, especially in rural areas that share territorial dynamics with urban areas and are connected by a daily flow of inhabitants. The purpose of this article is to carry out a diagnosis of the daily mobility patterns of the inhabitants of a number of rural municipalities, with the aim of promoting sustainability and mitigating the phenomenon of territorial depopulation in future local planning policies. The research methodology is based on the use of revealed preference surveys together with accessibility analysis using GIS tools, allowing for an in-depth knowledge of the mobility patterns of the municipalities in the area under analysis. In this respect, the reference parameters in terms of territorial accessibility are determined by applying the network analysis procedure to basic public services. The results reflect the existence of an unbalanced modal split with a preponderance of private vehicle use (regardless of the destination or the reason for the journey). In addition, a very weak inter-municipal connection dynamic is observed. There is a knowledge gap in the verification of the long-term suitability of sustainable measures in rural areas implemented after the development of mobility plans (in order to assess their effectiveness).
    MeSH term(s) Humans ; Rural Population ; Cities ; Travel ; Surveys and Questionnaires ; Demography
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20021163
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  2. Article: Repurposing Terfenadine as a Novel Antigiardial Compound.

    Suárez-Rico, Daniel Osmar / Munguía-Huizar, Francisco Javier / Cortés-Zárate, Rafael / Hernández-Hernández, José Manuel / González-Pozos, Sirenia / Perez-Rangel, Armando / Castillo-Romero, Araceli

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 9

    Abstract: ... Giardia ... ...

    Abstract Giardia lamblia
    Language English
    Publishing date 2023-09-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16091332
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  3. Article ; Online: Urinary concentration of Cathepsin D as a relievable marker of preeclampsia.

    Arredondo-Zapien, Rafael / Verdugo-Molinares, Maritza G / Ku Centurion, Marco / Benavides-Diosdado, Rosendo / Lopez-Rojas, Jose F / Gonzalez-Gonzalez, Ricardo / Espinoza-Hernandez, Jose A / Gutierrez-Chavez, Jorge / Cortes Sanabria, Laura / Melo, Zesergio

    Pregnancy hypertension

    2024  Volume 36, Page(s) 101116

    Abstract: Background: The early and accurate diagnosis of preeclampsia is crucial to avoid serious complications for both the mother and baby. However, the current diagnostic methods are limited, and there is a need for new diagnostic biomarkers. Previous studies ...

    Abstract Background: The early and accurate diagnosis of preeclampsia is crucial to avoid serious complications for both the mother and baby. However, the current diagnostic methods are limited, and there is a need for new diagnostic biomarkers. Previous studies have shown that cathepsin D (CTD) participates in the pathophysiology of preeclampsia and is present in urine samples, making it a potential biomarker for the disease. This study aimed to compare urinary and serum levels of CTD in preeclamptic and normotensive women and analyze its potential role as a diagnostic biomarker in preeclampsia.
    Methods: The study included thirty-nine patients with preeclampsia and twelve normotensive pregnant women as controls. Biomarkers were determined using Multiplex Assay kit, and serum prolactin (Prl) and urinary TNF-α levels were also evaluated. Statistical analysis was conducted using the Mann-Whitney U test.
    Results: We found that urinary and serum CTD levels were significantly higher in the preeclampsia group than in the normotensive group, suggesting that CTD could be a diagnostic biomarker for preeclampsia. No significant differences were found in the levels of serum prolactin or urinary TNF-α between the two groups.
    Conclusions: The study provides evidence that non-invasive biological samples such as urine can be used to improve new therapeutic strategies for the early management of preeclampsia.
    Language English
    Publishing date 2024-02-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2584464-7
    ISSN 2210-7797 ; 2210-7789
    ISSN (online) 2210-7797
    ISSN 2210-7789
    DOI 10.1016/j.preghy.2024.101116
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  4. Article ; Online: Primary Photophysics of Nicotinamide Chromophores in Their Oxidized and Reduced Forms.

    Reza, Mariana M / Durán-Hernández, Jesús / González-Cano, Beatriz / Jara-Cortés, Jesús / López-Arteaga, Rafael / Cadena-Caicedo, Andrea / Muñoz-Rugeles, Leonardo / Hernández-Trujillo, Jesús / Peon, Jorge

    The journal of physical chemistry. B

    2023  Volume 127, Issue 39, Page(s) 8432–8445

    Abstract: Nicotinamide adenine dinucleotide (NADH) is an important enzyme cofactor with emissive properties that allow it to be used in fluorescence microscopies to study cell metabolism. Its oxidized form ... ...

    Abstract Nicotinamide adenine dinucleotide (NADH) is an important enzyme cofactor with emissive properties that allow it to be used in fluorescence microscopies to study cell metabolism. Its oxidized form NAD
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.3c03246
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  5. Article ; Online: Costos médicos directos de la atención médica de pacientes con cáncer de mama.

    de la Cruz-Aguirre, Karla / Cortés-Sanabria, Laura / Salas-González, Efraín / Canales-Muñoz, José Luis / Aguayo-Alcaraz, Guadalupe / Ayala-Cortés, Rafael Adalid / Palomares-Hernández, Carmen Yuritzi

    Revista medica del Instituto Mexicano del Seguro Social

    2022  Volume 60, Issue 2, Page(s) 107–115

    Abstract: Background: The economic cost of breast cancer (BC) treatment and the increase in incidence and prevalence challenges the financial stability of any healthcare system.: Objective: To determine direct medical costs (DMC) of BC treatment and factors ... ...

    Title translation Direct medical costs in a cohort of patients with breast cancer.
    Abstract Background: The economic cost of breast cancer (BC) treatment and the increase in incidence and prevalence challenges the financial stability of any healthcare system.
    Objective: To determine direct medical costs (DMC) of BC treatment and factors associated with DMC.
    Material and methods: Partial economic evaluation in a retrospective cohort of 160 patients with a confirmed diagnosis of BC. DMC was considered from the IMSS perspective. Bootstrapping analysis was used to deal with uncertainty and generalized linear model to identify factors associated with DCM.
    Results: The total average annual cost of BC treatment was $251,018 mexican pesos. In clinical stage I was $116,123, stage II $242,132, stage III $287,946, and stage IV $358,792 pesos. In progression disease, DMC were more elevate ($380,117) vs. without progression ($172,897), (p < 0.0001). In patients who died, DMC were $357,579 mexican pesos compared to those who survived ($218,699) (p < 0.0001).
    Conclusions: The average annual cost of CM treatment was $251,018 pesos. DMCs increase significantly as patients present more advanced stages of the disease. Factors associated with costs were age, stages II, III and the progression of BC.
    MeSH term(s) Breast Neoplasms/therapy ; Cohort Studies ; Cost-Benefit Analysis ; Female ; Health Care Costs ; Humans ; Retrospective Studies
    Language Spanish
    Publishing date 2022-03-01
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 732133-8
    ISSN 2448-5667 ; 0443-5117 ; 0484-7849
    ISSN (online) 2448-5667
    ISSN 0443-5117 ; 0484-7849
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  6. Article ; Online: Expanding the Clinical Spectrum of

    Sivera, Rafael / Pelayo-Negro, Ana L / Jericó, Ivonne / Domínguez-González, Cristina / Horga, Alejandro / Rodriguez De Rivera, Francisco J / Gallardo, Elena / Tembl, Jose Ignacio / Bermejo-Guerrero, Laura / Pagola Lorz, Maria Inmaculada / Azorín, Inmaculada / Cordoba, Marta / Fenollar-Cortés, María Del Mar / Millet, Elvira / Vilchez, Juan J / Espinós, Carmen / Apellániz-Ruiz, María / Sevilla, Teresa

    Neurology

    2024  Volume 102, Issue 7, Page(s) e209174

    Abstract: Background and objectives: Germline truncating variants in the : Methods: This cross-sectional retrospective observational study includes 9 patients with Charcot-Marie-Tooth disease (CMT) with : Results: We identified 7 Spanish families with 4 ... ...

    Abstract Background and objectives: Germline truncating variants in the
    Methods: This cross-sectional retrospective observational study includes 9 patients with Charcot-Marie-Tooth disease (CMT) with
    Results: We identified 7 Spanish families with 4 different
    Discussion: Our findings support the causality of
    MeSH term(s) Female ; Humans ; Male ; Charcot-Marie-Tooth Disease/genetics ; Charcot-Marie-Tooth Disease/pathology ; Myelin Sheath/pathology ; Peripheral Nerves/diagnostic imaging ; Phenotype ; Germ-Line Mutation ; Cross-Sectional Studies ; Retrospective Studies ; Pedigree ; Young Adult ; Middle Aged ; Aged
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000209174
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Influence of plant domestication on plant‐pollinator interactions: Floral attributes and floral visitor communities in wild and cultivated squash plants

    Glasser, Sonja K. / de Santiago‐Hernández, Martín Hesajim / Delgado‐Carrillo, Oliverio / Espino, Luis Alberto Villanueva / Pérez, Adonaji Cortés / González‐Rodríguez, Antonio / Lira‐Saade, Rafael / Quesada, Mauricio

    American Journal of Botany. 2023 May, v. 110, no. 5 p.e16170-

    2023  

    Abstract: PREMISE: Domestication of plant species results in phenotypic modifications and changes in biotic interactions. Most studies have compared antagonistic plant‐herbivore interactions of domesticated plants and their wild relatives, but little attention has ...

    Abstract PREMISE: Domestication of plant species results in phenotypic modifications and changes in biotic interactions. Most studies have compared antagonistic plant‐herbivore interactions of domesticated plants and their wild relatives, but little attention has been given to how domestication influences plant‐pollinator interactions. Floral attributes and interactions of floral visitors were compared between sister taxa of the genus Cucurbita (Cucurbitaceae), the domesticated C. moschata, C. argyrosperma ssp. argyrosperma and its wild progenitor C. argyrosperma ssp. sororia in the place of origin. METHODS: We conducted univariate and multivariate analyses to compare floral morphological traits and analyzed floral reward (nectar and pollen) quantity and quality between flowers of wild and domesticated Cucurbita taxa. Staminate and pistillate flowers of all three taxa were video recorded, and visitation and behavior of floral visitors were registered and analyzed. RESULTS: Most floral morphological characteristics of flowers of domesticated taxa were larger in both staminate and pistillate flowers. Staminate and pistillate flowers presented distinct correlations between floral traits and integration indices between domesticated and wild species. Additionally, pollen quantity and protein to lipid ratio were greater in domesticated species. Cucurbit pollen specialists, Eucera spp., had the highest probability of visit for all Cucurbita taxa. CONCLUSIONS: We provide evidence that floral traits of domesticated and wild Cucurbita species experienced different selection pressures. Domesticated Cucurbita species may have more resources invested towards floral traits, thereby increasing attractiveness to pollinators and potentially plant reproductive success. Wild ancestor plant populations should be conserved in their centers of origin to preserve plant‐pollinator interactions.
    Keywords Cucurbita ; Eucera ; ancestry ; domestication ; lipids ; nectar ; phenotype ; pollen ; probability ; reproductive success ; squashes
    Language English
    Dates of publication 2023-05
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2935-x
    ISSN 1537-2197 ; 0002-9122
    ISSN (online) 1537-2197
    ISSN 0002-9122
    DOI 10.1002/ajb2.16170
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    Z 4' 49/55: Show issues

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  8. Article ; Online: Effect of Pepper Rootstocks as a Sustainable Alternative to Improve Yield and Fruit Quality

    Luna-Garcia, Laura Raquel / Robledo-Torres, Valentin / Gonzalez-Cortes, Areli / Mendoza-Villarreal, Rosalinda / Paredes-Jacome, Jose Rafael

    Horticulturae. 2023 July 12, v. 9, no. 7

    2023  

    Abstract: Sustainable agriculture is a good alternative for the healthy production of food in the present, without the risk to global agriculture in the future. Therefore, feasible production techniques have been sought, such as the use of rootstocks, which ... ...

    Abstract Sustainable agriculture is a good alternative for the healthy production of food in the present, without the risk to global agriculture in the future. Therefore, feasible production techniques have been sought, such as the use of rootstocks, which provide tolerance to biotic and/or abiotic stresses, to avoid an excessive use of agrochemicals and damage from pathogens, without affecting crop production. The objective of this study was to analyze the morphological and productive adaptation of three commercial hybrids (Avante, DiCaprio and Ucumari) grafted onto three rootstocks (Fundación, Yaocali and UAN), in order to evaluate and determine their effect on the quality and yield of bell pepper fruit, which has a high demand and great economic potential. Significant differences were found between the rootstocks and hybrids for the commercial classification of the fruits, with Yaocali producing larger fruits, which have the highest value in the export market, surpassing the UAN with 63.9%. The DiCaprio graft outperformed the Ucumari interactions by 231.5%, and the Avante interactions by 142.8%, for the extra-large (XL) fruit production. Based on the results obtained, it is possible to conclude that the grafted plants improved the quantity of the fruits of higher classification. However, they did not have a significant influence on the yield and quality of the fruits, which could be attributed to the lack of compatibility between them; therefore, the vigor of the plant was not expressed. This study showed that the rootstock did not influence the yield and fruit quality components of the grafts.
    Keywords agrochemicals ; crop production ; exports ; fruit quality ; fruits ; markets ; pepper ; risk ; rootstocks ; sustainable agriculture ; sweet peppers ; vigor
    Language English
    Dates of publication 2023-0712
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2813983-5
    ISSN 2311-7524
    ISSN 2311-7524
    DOI 10.3390/horticulturae9070795
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  9. Article ; Online: A multicenter national survey of children with SARS-CoV-2 infection admitted to Spanish Pediatric Intensive Care Units.

    González Cortés, Rafael / García-Salido, Alberto / Roca Pascual, David / Slöcker Barrio, María / de Carlos Vicente, Juan Carlos

    Intensive care medicine

    2020  Volume 46, Issue 9, Page(s) 1774–1776

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/epidemiology ; Humans ; Intensive Care Units, Pediatric ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Surveys and Questionnaires
    Keywords covid19
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-020-06146-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1089: Show issues Location:
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  10. Article ; Online: Ultrasound-guided central venous catheter placement in children: what is a really good practice?

    Hosokawa, Koji / Shime, Nobuaki / Oulego-Erroz, Ignacio / González-Cortes, Rafael / Rodríguez-Núñez, Antonio

    Intensive care medicine

    2018  Volume 44, Issue 4, Page(s) 546–547

    MeSH term(s) Catheterization, Central Venous ; Central Venous Catheters ; Child ; Humans ; Ultrasonography ; Ultrasonography, Interventional
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-018-5101-4
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