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Article: Effects of Yi Jin Jing on juvenile cervical spondylopathy in China: A parallel, randomized, assessor-blinded clinical trial.

Guo, W / Xing, H / Gong, X / He, L / Zhang, Z / Jia, C

2023 Volume 26, Issue 9, Page(s) 1234–1241

Abstract: ... the efficacy of Chinese fitness exercise Yi Jin Jing exercise in intervening the cervical spondylopathy ... Jing exercise, and the control group took the brisk walking exercise. The first week was ... at follow-up, while the reduction in scores of the Yi Jin Jing group was more significant. Cervical ...

Abstract	Background: Cervical spondylopathy is a common musculo-articular disorder, multiple exercises are recommended. Chinese fitness exercises are prevalent and used to treat various diseases. Aim: To explore the efficacy of Chinese fitness exercise Yi Jin Jing exercise in intervening the cervical spondylopathy in adolescents. Patients and methods: The study was conducted in 60 adolescent patients with cervical spondylopathy, with 30 patients in each group. Methods: The study was conducted in 60 adolescent patients with cervical spondylopathy, with 30 patients in each group. The observation group was required to take Yi Jin Jing exercise, and the control group took the brisk walking exercise. The first week was the preparatory period for the patients, and then the participants were required to do exercises three times a week for at least 30 minutes in the later 3 weeks. Before and after treatment, Neck Disability Index (NDI) scores, pain visual analog scale (VAS) scores, and cervical curvature in both groups were observed, and the incidence of adverse events in both groups was recorded during the trial. Results: The NDI and VAS scores in both groups statistically decreased after intervention and mildly increased at follow-up, while the reduction in scores of the Yi Jin Jing group was more significant. Cervical curvature in both groups improved on day 28 compared to day 0. There were no adverse reactions during the evaluation period. Conclusion: The Chinese health-care qigong Yi Jin Jing exercise is more effective than brisk walking in improving the cervical range of motion and relieving pain in adolescents with cervical spondylopathy. Trial registration/Protocol registration: Clinical Trial Registry (ChiCTR2000030723).
MeSH term(s)	Humans ; Adolescent ; Neck ; Exercise ; China ; Exercise Therapy ; Pain ; Treatment Outcome ; Cervical Vertebrae
Language	English
Publishing date	2023-10-04
Publishing country	India
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1458330-6
ISSN	1119-3077
ISSN	1119-3077
DOI	10.4103/njcp.njcp_410_22
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Article: Bloodletting Acupuncture at Jing-Well Points on Hand Induced Autophagy to Alleviate Brain Injury in Acute Altitude Hypoxic Rats by Activating PINK1/Parkin Pathway.

Li, Yong-Ping / Li, Meng-Xin / Wang, Chao / Li, Yun-di / Sa, Yu-Ping / Guo, Yi

Chinese journal of integrative medicine

2023 Volume 29, Issue 10, Page(s) 932–940

Abstract: Objective: To explore the protective effect of bloodletting acupuncture at twelve Jing-well points ...

Abstract	Objective: To explore the protective effect of bloodletting acupuncture at twelve Jing-well points on hand (BAJP) on acute hypobaric hypoxia (AHH)-induced brain injury in rats and its possible mechanisms. Methods: Seventy-five Sprague Dawley rats were divided into 5 groups by a random number table (n=15), including control, model, BAJP, BAJP+3-methyladenine (3-MA), and bloodletting acupuncture at non-acupoint (BANA, tail tip blooding) groups. After 7-day pre-treatment, AHH models were established using hypobaric oxygen chambers. The levels of S100B, glial fibrillary acidic protein (GFAP), superoxide dismutase (SOD), and malondialdehyde (MDA) in serum were measured by enzyme-linked immunosorbent assay. Hematoxylin-eosin staining and the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling method were used to assess hippocampal histopathology and apoptosis. Transmission electron microscopy assay was used to observe mitochondrial damage and autophagosomes in hippocampal tissues. Flow cytometry was used to detect mitochondrial membrane potential (MMP). The mitochondrial respiratory chain complexes I, III and IV activities and ATPase in hippocampal tissue were evaluated, respectively. Western blot analysis was used to detect the protein expressions of Beclin1, autophagy protein 5 (ATG5), microtubule-associated protein 1 light chain 3 beta (LC3B), phosphatase and tensin homolog induced kinase 1 (PINK1), and Parkin in hippocampal tissues. The mRNA expressions of Beclin1, ATG5 and LC3-II were analyzed by quantitative real-time polymerase chain reaction. Results: BAJP treatment reduced hippocampal tissue injury and inhibited hippocampal cell apoptosis in AHH rats. BAJP reduced oxidative stress by decreasing S100B, GFAP and MDA levels and increasing SOD level in the serum of AHH rats (P<0.05 or P<0.01). Then, BAJP increased MMP, the mitochondrial respiratory chain complexes I, III and IV activities, and the mitochondrial ATPase activity in AHH rats (all P<0.01). BAJP improved mitochondrial swelling and increased the autophagosome number in hippocampal tissue of AHH rats. Moreover, BAJP treatment increased the protein and mRNA expressions of Beclin1 and ATG5 and LC3-II/LC3-I ratio in AHH rats (all P<0.01) and activated the PINK1/Parkin pathway (P<0.01). Finally, 3-MA attenuated the therapeutic effect of BAJP on AHH rats (P<0.05 or P<0.01). Conclusion: BAJP was an effective treatment for AHH-induced brain injury, and the mechanism might be through reducing hippocampal tissue injury via increasing the PINK1/Parkin pathway and enhancement of mitochondrial autophagy.
Language	English
Publishing date	2023-07-12
Publishing country	China
Document type	Journal Article
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-023-3597-0
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Article: Chinese herbal medicine Jia Wei Jing Xie Yin (JWJXY) ameliorates psoriasis via suppressing the Th17 cell response.

Yang, Dengke / Guo, Yiyu / Wu, Jun / Qin, Jianping / Wu, Jie / Lu, Yu / Xiao, Yan / Zhang, Xiaolin / Ye, Jianzhou

Annals of translational medicine

2022 Volume 10, Issue 6, Page(s) 332

Abstract: ... advantages. The Chinese herbal medicine Jia Wei Jing Xie Yin (JWJXY) has its origins in Jing Xie Yin ...

Abstract	Background: Psoriasis is a chronic autoimmune disease. At present, it is very difficult to treat; however, clinical trials have shown that the traditional Chinese medicine (TCM) treatment of psoriasis has certain advantages. The Chinese herbal medicine Jia Wei Jing Xie Yin (JWJXY) has its origins in Jing Xie Yin, a medicine created by the TCM doctor Wu Jun. Previous studies have shown that JWJXY has good clinical efficacy for patients with blood-heat type psoriasis, but its mechanism is unknown. Methods: This paper aimed to further study the therapeutic effect and mechanism of JWJXY on an imiquimod (IMQ)-induced, psoriasis-like mouse model (0.4 mL, i.g., 6 days). The histopathological skin changes were observed by hematoxylin and eosin (HE) staining, the infiltration of cluster of differentiation 11B (CD11b) and cluster of differentiation 4 (CD4) cells was observed by immunohistochemistry, lymphocyte subsets were detected by flow cytometry, T helper (Th)17 cell expression was perceived by flow cytometry, and Th17 cell-related gene expression was detected by real-time quantitative polymerase chain reaction (qPCR). Results: JWJXY significantly reduced the skin thickness of the IMQ-induced model mouse. Compared with that in the vehicle group, the skin tissue of the mice in the JWJXY group showed significantly reduced infiltration of CD11b Conclusions: The study confirmed the therapeutic effect of JWJXY on psoriasis. Its mechanism of action might be to inhibit the Th17 cell response but not the Th1 and Treg response.
Language	English
Publishing date	2022-04-01
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-22-967
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Article ; Online: Cluster analysis of Qian Jing-hua's experience in treatment of lung cancer

Zhi-Li Guo / Jing-Hua Qian / Yi-Ping Fan / Kai-Tao Luo / Hong-Sheng Ding

TMR Theory and Hypothesis, Vol 1, Iss 3, Pp 54-

2018 Volume 62

Abstract: Objective to analyze the rule of drug use in treating lung cancer disease by using the theory of fuzheng and dispelling evil in traditional Chinese medicine by data mining. Methods: By following Dr. Qianjinghua's outpatient department, we collected the ... ...

Abstract	Objective to analyze the rule of drug use in treating lung cancer disease by using the theory of fuzheng and dispelling evil in traditional Chinese medicine by data mining. Methods: By following Dr. Qianjinghua's outpatient department, we collected the prescription for the treatment of lung cancer by using frequency analysis, association rule analysis and cluster analysis. Results: 746 prescriptions were included in this study, commonly used drugs 170 flavors. Traditional Chinese medicine with a high frequency of use were Baihuasheshecao (Hedyotis diffusa), Maorenshen (Actinidia valvata Dunn), Shishangbai (Selaginella doederleinii Hieron), Shijianchuan (Salvia chinensis Benth), Huangqi (Astragali Radix), Sanyeqing (Tetrastlgma hemsleyanum), Baimaoteng (HerbaSolani), Zhuling (Polyporus), Nvzhenzi (Ligustrum lucidum Ait) etc. Through the analysis of association rule, we find out the core prescription according to the support degree (10 %, 20 %, 30 %) and the confidence degree, and set the correlation degree to 8 and punishment degree to 2. Finally: The core prescription efficacy of the drug group was analyzed and the theoretical connotation of preventive treatment of disease was obtained. Conclusion: The core prescription of preventive treatment of disease is to clear up heat and detoxification on the basis of strengthening the spleen, replenishing qi and tonifying kidney. The use of blood supplements and yin tonics throughout the course is reduced during treatments. The treatments also pay attention to the function of spleen and stomach of lung cancer patients, and adjust heat and detoxification force according to different conditions of patients and pay attention to the relief of patients’ emotions.
Keywords	Data mining technology ; Lung cancer ; Help the right and remove evil spirits ; Association rules ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	TMR publishing group
Document type	Article ; Online
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Article: Sheng Jing Decoction Can Promote Spermatogenesis and Increase Sperm Motility of the Oligozoospermia Mouse Model.

Yan, Guang / Tian, Fang / Liu, Peng / Sun, Jianming / Mao, Jianmin / Han, Wenjun / Mo, Ran / Guo, Shishuai / Yu, Quanyao

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 3686494

Abstract: Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used ...

Abstract	Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used to treat male infertility. However, the pharmacological functions and molecular mechanisms of SJD are poorly understood. In this study, we investigated the functions of SJD on spermatogenesis and sperm motility and explored the potential mechanisms involved. Here, we demonstrated that high, medium, and low doses of SJD are effective in restoring the impairments of the whole body and testicular tissue by cyclophosphamide inducing and to rescue the damage of testicular tissue cells including Sertoli cells and germ cells. SJD can partly restore the decrease in sperm concentration, sperm vitality, sperm motility, and normal sperm morphology rate in oligozoospermic mouse models. Ki67 staining analyses confirm SJD can promote testicular tissue cell proliferation. Real-time RT-PCR analyses also reveal that SJD can upregulate the expression of proliferation-associated gene
Language	English
Publishing date	2021-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/3686494
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Zs.A 5995: Show issues

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Article: Botrytis cinerea causing gray mold of Polygonatum sibiricum (Huang Jing) in China

Chen, Jin / Zhu, Jun Zi / Li, Xiao Gang / He, Ai Guo / Xia, Shi Tou / Zhong, Jie

Crop protection. 2021 Feb., v. 140

2021

Abstract: Polygonatum sibiricum is a traditional Chinese medicinal herb and can also be used as tea and ornamental plant. During 2016 to 2018, a disease with symptoms similar to gray mold was extensively observed on leaves of P. sibiricum in the Sichuan Province ... ...

Abstract	Polygonatum sibiricum is a traditional Chinese medicinal herb and can also be used as tea and ornamental plant. During 2016 to 2018, a disease with symptoms similar to gray mold was extensively observed on leaves of P. sibiricum in the Sichuan Province of China. The pathogen was isolated from the diseased plants and identified as Botrytis cinerea based on the morphological features and Internal transcribed spacer (ITS), DNA dependent RNA polymerase subunit II gene (RPB2), heat-shock protein 60 gene (HSP60) and ATP-dependent RNA helicase DBP7 gene (MS547) all of which showed 99.89%–99.91% identities to the reported B. cinerea strains. Pathogenicity was confirmed through inoculation experiments fulfilling Koch's postulates. To our knowledge, this is the first report of B. cinerea causing gray mold disease on P. sibiricum in China.
Keywords	Botrytis cinerea ; DNA ; DNA-directed RNA polymerase ; Polygonatum sibiricum ; RNA helicases ; genes ; gray mold ; heat shock proteins ; internal transcribed spacers ; medicinal plants ; ornamental plants ; pathogenicity ; pathogens ; plant protection ; tea ; China
Language	English
Dates of publication	2021-02
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	786839-x
ISSN	1873-6904 ; 0261-2194
ISSN (online)	1873-6904
ISSN	0261-2194
DOI	10.1016/j.cropro.2020.105424
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Inequality and collaboration in north China urban agglomeration: Evidence from embodied cultivated land in Jing-Jin-Ji's interregional trade.

Guo, Shan / Wang, Yang / Wang, Yao / Wang, Mengxun / He, Ping / Feng, Lei

Journal of environmental management

2020 Volume 275, Page(s) 111050

Abstract: ... should be systematically explored. This study analyzes the virtual cultivated land flows of the Jing-Jin-Ji ...

Abstract	An urban agglomeration is a highly connected city group, which is nested in complex trading networks. Ignoring the intercity connections and regional inequality may lead to the unsustainability of the urban agglomeration. The misuse and overuse of cultivated land resources are threatening environmental sustainability and causing global climate change. Facing the inequality and environment pressures in the urban agglomeration, the cultivated land resource reallocation within the complex urban agglomeration trading network should be systematically explored. This study analyzes the virtual cultivated land flows of the Jing-Jin-Ji (JJJ) region embodied in China's interregional trade network using a multiregional input-output model. Results show that the average virtual cultivated land intensity of the JJJ region is 1.59 ha/million yuan, which is below the national average. The JJJ region has 10.74 million ha of embodied cultivated land in consumption, accounting for 7.82% of the country's total amount. JJJ region is an import-oriented region and it receives virtual cultivated land from surrounding underdeveloped regions, such as Heilongjiang and Inner Mongolia. Beijing and Tianjin are typical net importers of virtual cultivated land, while Zhangjiakou, Xingtai, Hengshui, Baoding, and Cangzhou are net exporters in the interior of the JJJ region. This study could provide a systematical perspective and data supporting system for formulating the sustainable cultivated land use policies and collaborated development policies in the JJJ region to mitigate regional inequality. Policy suggestions concerning the eco-compensation mechanism, collaborative innovation mode, and uniform management platform in JJJ are given.
MeSH term(s)	Beijing ; China ; Cities ; Socioeconomic Factors
Language	English
Publishing date	2020-08-28
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2020.111050
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Article: Macromitrium maolanense Zeyou Zhang, D.D.Li, Jing Yu & S.L.Guo, a new species from China based on molecular and morphological evidence

Zhang, Zeyou / Li, Dandan / Yu, Jing / Guo, Shuiliang

Journal of bryology. 2019 July 3, v. 41, no. 3

2019

Abstract: ... species. Conclusions. A new moss species, Macromitrium maolanense Zeyou Zhang, D.D.Li, Jing Yu & S.L.Guo ...

Abstract	Introduction. During a field excursion in Guizhou Province, China, we collected some interesting moss specimens with branch leaves subulate in the upper part, partially and variably bistratose laminae, and a Macromitrium-like epiphytic growth habit on tree trunks. We present morphological and phylogenetic arguments for recognising these plants as a new moss species in the genus Macromitrium Brid. (Orthotrichaceae). Methods. We compared the morphology of the potential new species with closely related species of Macromitrium, and constructed a phylogenetic tree based on ITS2, trnL and trnG including sampling from 14 other morphologically similar species of Macromitrium. Key results. The proposed new species belongs to the genus Macromitrium (Orthotrichaceae, Musci). It is closely related to M. gymnostomum Sull. & Lesq. in the phylogenetic tree and according to gametophytic morphological features, represents a hitherto undescribed species. Conclusions. A new moss species, Macromitrium maolanense Zeyou Zhang, D.D.Li, Jing Yu & S.L.Guo, is described and illustrated. The new species can be distinguished from all congeners by the combination of the following features of the branch leaves: (1) oblong-lanceolate, lanceolate to linear-lanceolate, gradually narrowed to an easily broken subula; (2) rather obscure upper and medial cells, often with blackish stains among cells, densely pluripapillose; (3) variably and partially bistratose laminae in the upper 1/3 portion; (4) basal cells clear, hyaline and smooth, those near costae forming a ‘cancellina region’; and (5) with numerous brownish, clavate gemmae on upper portion. We also discuss the principal distinctive characters separating the new species from its nearest congeners.
Keywords	Macromitrium ; bryology ; epiphytes ; gametophytes ; growth habit ; mosses and liverworts ; new species ; phylogeny ; trees ; China
Language	English
Dates of publication	2019-0703
Size	p. 263-273.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2080324-2
ISSN	1743-2820 ; 0373-6687
ISSN (online)	1743-2820
ISSN	0373-6687
DOI	10.1080/03736687.2019.1623517
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Sheng Jing Decoction Can Promote Spermatogenesis and Increase Sperm Motility of the Oligozoospermia Mouse Model

Guang Yan / Fang Tian / Peng Liu / Jianming Sun / Jianmin Mao / Wenjun Han / Ran Mo / Shishuai Guo / Quanyao Yu

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used ...

Abstract	Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used to treat male infertility. However, the pharmacological functions and molecular mechanisms of SJD are poorly understood. In this study, we investigated the functions of SJD on spermatogenesis and sperm motility and explored the potential mechanisms involved. Here, we demonstrated that high, medium, and low doses of SJD are effective in restoring the impairments of the whole body and testicular tissue by cyclophosphamide inducing and to rescue the damage of testicular tissue cells including Sertoli cells and germ cells. SJD can partly restore the decrease in sperm concentration, sperm vitality, sperm motility, and normal sperm morphology rate in oligozoospermic mouse models. Ki67 staining analyses confirm SJD can promote testicular tissue cell proliferation. Real-time RT-PCR analyses also reveal that SJD can upregulate the expression of proliferation-associated gene Lin28a and differentiation-associated genes Kit, Sohlh2, and Stra8. SJD can also reduce the impairment of mitochondrial membrane potential (MMP) and sperm plasma membrane integrity by cyclophosphamide inducing. Our results reveal that SJD is effective in improving both sperm quantity and quality by increasing the sperm concentration, sperm vitality, sperm motility, and normal sperm morphology rate. SJD can promote spermatogenesis by upregulating the expression of the proliferation-associated gene Lin28a and the differentiation-associated genes (Kit, Sohlh2, and Stra8). SJD can sustain MMP and sperm plasma membrane integrity to increase sperm motility.
Keywords	Other systems of medicine ; RZ201-999
Subject code	572
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article: Wake-Promoting Effect of Bloodletting Puncture at Hand Twelve Jing-Well Points in Acute Stroke Patients: A Multi-center Randomized Controlled Trial.

Yu, Nan-Nan / Xu, Zhi-Fang / Gao, Yang / Zhou, Zhi-Liang / Zhao, Xue / Zhou, Dan / Wang, Zhen-Guo / Chen, Ze-Lin / Pan, Xing-Fang / Guo, Yi

Chinese journal of integrative medicine

2020 Volume 27, Issue 8, Page(s) 570–577

Abstract: Objective: To assess the effect and safety of bloodletting puncture at hand twelve Jing-Well ...

Abstract	Objective: To assess the effect and safety of bloodletting puncture at hand twelve Jing-Well points (HTWPs) in acute stroke patients with conscious disturbance. Methods: In this multi-center and randomized controlled trial, 360 patients suffered from ischemic or hemorrhagic stroke with conscious disturbance within 48 h from the onset of symptom were divided into bloodletting (180 cases) and control (180 cases) groups using a block randomization. Patients in both groups received routine Western medicine, and patients in the bloodletting group received additional bloodletting puncture at HTWPs on admission immediately before conventional treatment. The primary outcome measure was Glasgow Coma Scale (GCS) score and the secondary outcomes included blood pressure, respiratory rate and pulse rate. All variables were evaluated at baseline (before bloodletting), 0 (after bloodletting immediately), 15, 30, 50 and 80 min post bloodletting. Results: At 80 min post bloodletting, the proportion of patients with improved consciousness in the bloodletting group was greater than the control group (P<0.05). In the separate analysis of moderate consciousness disturbance subgroup, bloodletting therapy benefited ischemic patients, and improved the eye and language response of GCS score at 15, 30, 50, 80 min post bloodletting (P<0.05 or P<0.01). No significant differences were observed regarding the secondary outcomes between two groups (P>0.05). Conclusion: The bloodletting puncture at HTWPs was safe and could improve conscious levels of ischemic stroke patients, highlighting a first-aid intervention for acute stroke. (Registration No. ChiCTR-INR-16009530).
MeSH term(s)	Acupuncture Points ; Bloodletting ; Consciousness ; Humans ; Random Allocation ; Stroke/therapy ; Treatment Outcome
Language	English
Publishing date	2020-09-11
Publishing country	China
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-020-3093-8
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