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  1. Article ; Online: How To Manage T3b Prostate Cancer in the Contemporary Era: The Benefits of Surgery.

    Peyrottes, Arthur / Achard, Verane / Dariane, Charles

    European urology open science

    2023  Volume 53, Page(s) 55–57

    Language English
    Publishing date 2023-05-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2023.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: High-risk biochemical recurrence of locally treated prostate cancer after EMBARK. An end to decades of conventional wisdom?

    Achard, Vérane / Tombal, Bertrand

    Prostate cancer and prostatic diseases

    2023  

    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-023-00767-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prostate cancer intensity-modulated radiotherapy and long term genitourinary toxicity: an evolving therapeutic landscape.

    Achard, Vérane / Zilli, Thomas

    Prostate cancer and prostatic diseases

    2022  Volume 26, Issue 1, Page(s) 1–2

    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/drug therapy ; Radiotherapy, Intensity-Modulated/adverse effects ; Dose Fractionation, Radiation ; Radiotherapy Dosage ; Treatment Outcome
    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Editorial
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-022-00535-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Stereotactic body radiation therapy for prostate cancer after surgical treatment of prostatic obstruction

    Constance Huck / Vérane Achard / Priyamvada Maitre / Vedang Murthy / Thomas Zilli

    Clinical and Translational Radiation Oncology, Vol 45, Iss , Pp 100709- (2024)

    Impact on urinary morbidity and mitigation strategies

    1481  

    Abstract: In the past decade, stereotactic body radiation therapy (SBRT) has emerged as a valid treatment option for patients with localized prostate cancer. Despite the promising results of ultra-hypofractionation in terms of tolerance and disease control, the ... ...

    Abstract In the past decade, stereotactic body radiation therapy (SBRT) has emerged as a valid treatment option for patients with localized prostate cancer. Despite the promising results of ultra-hypofractionation in terms of tolerance and disease control, the toxicity profile of SBRT for prostate cancer patients with a history of surgical treatment of benign prostate hyperplasia is still underreported. Here we present an overview of the available data on urinary morbidity for prostate cancer patients treated with SBRT after prior surgical treatments for benign prostate hyperplasia. Technical improvements useful to minimize toxicity and possible treatments for radiation-induced urethritis are discussed.
    Keywords Prostate cancer ; Radiotherapy ; Stereotactic body radiation therapy ; Transurethral resection ; Adenomectomy ; Toxicity ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Language English
    Publishing date 2024-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: How To Manage T3b Prostate Cancer in the Contemporary Era: Is Radiotherapy the Standard of Care?

    Achard, Vérane / Peyrottes, Arthur / Sargos, Paul

    European urology open science

    2023  Volume 53, Page(s) 60–62

    Language English
    Publishing date 2023-05-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2023.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Stereotactic body radiation therapy for prostate cancer after surgical treatment of prostatic obstruction: Impact on urinary morbidity and mitigation strategies.

    Huck, Constance / Achard, Vérane / Maitre, Priyamvada / Murthy, Vedang / Zilli, Thomas

    Clinical and translational radiation oncology

    2023  Volume 45, Page(s) 100709

    Abstract: In the past decade, stereotactic body radiation therapy (SBRT) has emerged as a valid treatment option for patients with localized prostate cancer. Despite the promising results of ultra-hypofractionation in terms of tolerance and disease control, the ... ...

    Abstract In the past decade, stereotactic body radiation therapy (SBRT) has emerged as a valid treatment option for patients with localized prostate cancer. Despite the promising results of ultra-hypofractionation in terms of tolerance and disease control, the toxicity profile of SBRT for prostate cancer patients with a history of surgical treatment of benign prostate hyperplasia is still underreported. Here we present an overview of the available data on urinary morbidity for prostate cancer patients treated with SBRT after prior surgical treatments for benign prostate hyperplasia. Technical improvements useful to minimize toxicity and possible treatments for radiation-induced urethritis are discussed.
    Language English
    Publishing date 2023-12-10
    Publishing country Ireland
    Document type Journal Article
    ISSN 2405-6308
    ISSN (online) 2405-6308
    DOI 10.1016/j.ctro.2023.100709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: ONE SHOT - single shot radiotherapy for localized prostate cancer: 18-month results of a single arm, multicenter phase I/II trial.

    Zilli, Thomas / Franzese, Ciro / Guckenberger, Matthias / Giaj-Levra, Niccolò / Mach, Nicolas / Koutsouvelis, Nikolaos / Achard, Verane / Mcdonald, Andrew / Alongi, Filippo / Scorsetti, Marta / Constantin, Guillaume / Bertaut, Aurelie / Miralbell, Raymond

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2024  Volume 194, Page(s) 110181

    Abstract: Purpose: To assess in a prospective, multicenter, single-arm phase I/II study the early safety and efficacy profile of single fraction urethra-sparing stereotactic body radiotherapy (SBRT) for men with localized prostate cancer.: Material and methods!# ...

    Abstract Purpose: To assess in a prospective, multicenter, single-arm phase I/II study the early safety and efficacy profile of single fraction urethra-sparing stereotactic body radiotherapy (SBRT) for men with localized prostate cancer.
    Material and methods: Patients with low- and intermediate-risk localized prostate cancer without significant tumor in the transitional zone were recruited. A single-fraction of 19 Gy was delivered to the prostate, with 17 Gy dose-reduction to the urethra. Intrafraction motion was monitored using intraprostatic electromagnetic transponders with intra-fraction correction of displacements exceeding 3 mm. Genitourinary (GU), gastrointestinal (GI), and sexual toxicity during the first 18 months were evaluated using the CTCAE v4.0 grading scale. Quality of life was assessed using the International Prostate Symptom Score, the Expanded Prostate Cancer Index composite 26 score, and the International Index of Erectile Function score.
    Results: Among the 45 patients recruited in 5 centers between 2017 and 2022, 43 received the single fraction without protocol deviations, and 34 had a minimal follow-up of 18 months. The worst GU toxicity was observed at day-5 after SBRT (42.5 % and 20 % with grade 1 and 2, respectively), returning to baseline at week-12 and month-6 (<3% with grade 2), with a 12 % grade 2 flare at month 18. Gl toxicity was mild in the acute phase, with no grade ≥ 2 events (12 % grade 1 at month 6). Grade-3 proctitis was observed in one patient at month 12, with < 3 % grade 2 toxicity at month 18. Mean GU and GI bother scores showed a decline at day 5, a complete recovery at month 6, and a flare between month 12 and 18. Mean PSA dropped from 6.2 ng/ml to 1.2 ng/ml at month 18 and 0.7 ng/ml at month 24. After a median follow-up time of 26 months, 3 biochemical failures (7 %) were observed at month 17, 21 and 30.
    Conclusions: In this multicenter phase I/II trial, we demonstrated that a 19 Gy single-fraction urethra-sparing SBRT is feasible and associated with an acceptable toxicity rate, mostly returning to the baseline at week-12 and with a symptoms flare between months 12 and 18. Longer follow-up is needed to assess the potential long-term adverse effects and the disease control efficacy.
    MeSH term(s) Humans ; Male ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Aged ; Middle Aged ; Prospective Studies ; Radiosurgery/methods ; Radiosurgery/adverse effects ; Aged, 80 and over ; Quality of Life ; Urethra/radiation effects ; Organ Sparing Treatments/methods ; Radiation Injuries/etiology
    Language English
    Publishing date 2024-02-24
    Publishing country Ireland
    Document type Journal Article ; Clinical Trial, Phase II ; Multicenter Study ; Clinical Trial, Phase I ; Research Support, Non-U.S. Gov't
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2024.110181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Intraprostatic Urethra: The New Kid on the Block for Prostate Cancer Radiation Therapy?

    Zilli, Thomas / Achard, Vérane / Guevelou, Jennifer Le

    International journal of radiation oncology, biology, physics

    2022  Volume 113, Issue 1, Page(s) 92–95

    MeSH term(s) Brachytherapy ; Humans ; Male ; Prostate ; Prostatic Neoplasms/radiotherapy ; Urethra
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2022.01.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Five fractions of SBRT for prostate cancer.

    Achard, Vérane / Bosetti, Davide / Pesce, Gianfranco / Zilli, Thomas

    The Lancet. Oncology

    2022  Volume 23, Issue 12, Page(s) e530

    MeSH term(s) Male ; Humans ; Radiosurgery/adverse effects ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery
    Language English
    Publishing date 2022-11-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00615-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: In Regard to Qi et al.

    Achard, Vérane / Zilli, Thomas

    International journal of radiation oncology, biology, physics

    2020  Volume 106, Issue 4, Page(s) 887–888

    MeSH term(s) Drugs, Chinese Herbal ; Humans ; Male ; Postoperative Period ; Prostatic Neoplasms
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2020-02-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2019.11.407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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