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Article ; Online: Circadian clock synchrony and chronotherapy opportunities in cancer treatment.

Damato, Anna R / Herzog, Erik D

Seminars in cell & developmental biology

2021 Volume 126, Page(s) 27–36

Abstract: Cell-autonomous, tissue-specific circadian rhythms in gene expression and cellular processes have been observed throughout the human body. Disruption of daily rhythms by mistimed exposure to light, food intake, or genetic mutation has been linked to ... ...

Abstract	Cell-autonomous, tissue-specific circadian rhythms in gene expression and cellular processes have been observed throughout the human body. Disruption of daily rhythms by mistimed exposure to light, food intake, or genetic mutation has been linked to cancer development. Some medications are also more effective at certain times of day. However, a limited number of clinical studies have examined daily rhythms in the patient or drug timing as treatment strategies. This review highlights advances and challenges in cancer biology as a function of time of day. Recent evidence for daily rhythms and their entrainment in tumors indicate that personalized medicine should include understanding and accounting for daily rhythms in cancer patients.
MeSH term(s)	Chronotherapy ; Circadian Clocks/genetics ; Circadian Rhythm/genetics ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Time Factors
Language	English
Publishing date	2021-08-03
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2021.07.017
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Article: Maternal-Fetal Circadian Communication During Pregnancy.

Bates, Keenan / Herzog, Erik D

Frontiers in endocrinology

2020 Volume 11, Page(s) 198

Abstract: This article reviews evidence for maternal-fetal communication about the time of day. We explore the hypothesis that key maternal hormones synchronize daily rhythms in the fetus to regulate gestation duration. These findings may help to predict and ... ...

Abstract	This article reviews evidence for maternal-fetal communication about the time of day. We explore the hypothesis that key maternal hormones synchronize daily rhythms in the fetus to regulate gestation duration. These findings may help to predict and prevent preterm birth.
MeSH term(s)	Animals ; Circadian Rhythm/physiology ; Female ; Humans ; Maternal-Fetal Exchange/physiology ; Pregnancy ; Premature Birth/diagnosis ; Premature Birth/physiopathology ; Premature Birth/prevention & control ; Prognosis
Language	English
Publishing date	2020-04-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2020.00198
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Article: Kv12-Encoded K

Hermanstyne, Tracey O / Yang, Nien-Du / Granados-Fuentes, Daniel / Li, Xiaofan / Mellor, Rebecca L / Jegla, Timothy / Herzog, Erik D / Nerbonne, Jeanne M

bioRxiv : the preprint server for biology

2023

Abstract: Considerable evidence suggests that day-night rhythms in the functional expression of subthreshold potassium ( ... ...

Abstract	Considerable evidence suggests that day-night rhythms in the functional expression of subthreshold potassium (K
Language	English
Publishing date	2023-02-02
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.30.526323
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Article ; Online: Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly.

Hastings, Michael H / Brancaccio, Marco / Gonzalez-Aponte, Maria F / Herzog, Erik D

Annual review of neuroscience

2023 Volume 46, Page(s) 123–143

Abstract: This review explores the interface between circadian timekeeping and the regulation of brain function by astrocytes. Although astrocytes regulate neuronal activity across many time domains, their cell-autonomous circadian clocks exert a particular role ... ...

Abstract	This review explores the interface between circadian timekeeping and the regulation of brain function by astrocytes. Although astrocytes regulate neuronal activity across many time domains, their cell-autonomous circadian clocks exert a particular role in controlling longer-term oscillations of brain function: the maintenance of sleep states and the circadian ordering of sleep and wakefulness. This is most evident in the central circadian pacemaker, the suprachiasmatic nucleus, where the molecular clock of astrocytes suffices to drive daily cycles of neuronal activity and behavior. In Alzheimer's disease, sleep impairments accompany cognitive decline. In mouse models of the disease, circadian disturbances accelerate astroglial activation and other brain pathologies, suggesting that daily functions in astrocytes protect neuronal homeostasis. In brain cancer, treatment in the morning has been associated with prolonged survival, and gliomas have daily rhythms in gene expression and drug sensitivity. Thus, circadian time is fast becoming critical to elucidating reciprocal astrocytic-neuronal interactions in health and disease.
MeSH term(s)	Mice ; Animals ; Astrocytes/physiology ; Circadian Rhythm/physiology ; Circadian Clocks/genetics ; Sleep ; Suprachiasmatic Nucleus/metabolism
Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	282459-0
ISSN	1545-4126 ; 0147-006X
ISSN (online)	1545-4126
ISSN	0147-006X
DOI	10.1146/annurev-neuro-100322-112249
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Article ; Online: Synchronization, clustering, and weak chimeras in a densely coupled transcription-based oscillator model for split circadian rhythms.

Ocampo-Espindola, Jorge Luis / Nikhil, K L / Li, Jr-Shin / Herzog, Erik D / Kiss, István Z

Chaos (Woodbury, N.Y.)

2023 Volume 33, Issue 8

Abstract: The synchronization dynamics for the circadian gene expression in the suprachiasmatic nucleus is investigated using a transcriptional circadian clock gene oscillator model. With global coupling in constant dark (DD) conditions, the model exhibits a one- ... ...

Abstract	The synchronization dynamics for the circadian gene expression in the suprachiasmatic nucleus is investigated using a transcriptional circadian clock gene oscillator model. With global coupling in constant dark (DD) conditions, the model exhibits a one-cluster phase synchronized state, in dim light (dim LL), bistability between one- and two-cluster states and in bright LL, a two-cluster state. The two-cluster phase synchronized state, where some oscillator pairs synchronize in-phase, and some anti-phase, can explain the splitting of the circadian clock, i.e., generation of two bouts of daily activities with certain species, e.g., with hamsters. The one- and two-cluster states can be reached by transferring the animal from DD or bright LL to dim LL, i.e., the circadian synchrony has a memory effect. The stability of the one- and two-cluster states was interpreted analytically by extracting phase models from the ordinary differential equation models. In a modular network with two strongly coupled oscillator populations with weak intragroup coupling, with appropriate initial conditions, one group is synchronized to the one-cluster state and the other group to the two-cluster state, resulting in a weak-chimera state. Computational modeling suggests that the daily rhythms in sleep-wake depend on light intensity acting on bilateral networks of suprachiasmatic nucleus (SCN) oscillators. Addition of a network heterogeneity (coupling between the left and right SCN) allowed the system to exhibit chimera states. The simulations can guide experiments in the circadian rhythm research to explore the effect of light intensity on the complexities of circadian desynchronization.
MeSH term(s)	Cricetinae ; Animals ; Circadian Rhythm ; Suprachiasmatic Nucleus ; Computer Simulation ; Darkness ; Cluster Analysis
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1472677-4
ISSN	1089-7682 ; 1054-1500
ISSN (online)	1089-7682
ISSN	1054-1500
DOI	10.1063/5.0156135
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Article: Circadian clock synchrony and chronotherapy opportunities in cancer treatment

Damato, Anna R. / Herzog, Erik D.

Seminars in cell & developmental biology. 2022 June, v. 126

2022

Abstract	Cell-autonomous, tissue-specific circadian rhythms in gene expression and cellular processes have been observed throughout the human body. Disruption of daily rhythms by mistimed exposure to light, food intake, or genetic mutation has been linked to cancer development. Some medications are also more effective at certain times of day. However, a limited number of clinical studies have examined daily rhythms in the patient or drug timing as treatment strategies. This review highlights advances and challenges in cancer biology as a function of time of day. Recent evidence for daily rhythms and their entrainment in tumors indicate that personalized medicine should include understanding and accounting for daily rhythms in cancer patients.
Keywords	cancer therapy ; carcinogenesis ; circadian clocks ; drugs ; food intake ; gene expression ; humans ; mutation ; patients ; precision medicine
Language	English
Dates of publication	2022-06
Size	p. 27-36.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2021.07.017
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids.

Jones, Jeff R / Chaturvedi, Sneha / Granados-Fuentes, Daniel / Herzog, Erik D

Nature communications

2021 Volume 12, Issue 1, Page(s) 5763

Abstract: Signals from the central circadian pacemaker, the suprachiasmatic nucleus (SCN), must be decoded to generate daily rhythms in hormone release. Here, we hypothesized that the SCN entrains rhythms in the paraventricular nucleus (PVN) to time the daily ... ...

Abstract	Signals from the central circadian pacemaker, the suprachiasmatic nucleus (SCN), must be decoded to generate daily rhythms in hormone release. Here, we hypothesized that the SCN entrains rhythms in the paraventricular nucleus (PVN) to time the daily release of corticosterone. In vivo recording revealed a critical circuit from SCN vasoactive intestinal peptide (SCN
MeSH term(s)	Animals ; CLOCK Proteins/genetics ; CLOCK Proteins/metabolism ; Calcium/metabolism ; Circadian Rhythm/drug effects ; Circadian Rhythm/genetics ; Circadian Rhythm/physiology ; Corticosterone/pharmacology ; Corticotropin-Releasing Hormone/metabolism ; Feces/chemistry ; Gene Expression Regulation/drug effects ; Gene Silencing/drug effects ; Glucocorticoids/metabolism ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/drug effects ; Neurons/physiology ; Paraventricular Hypothalamic Nucleus/drug effects ; Paraventricular Hypothalamic Nucleus/physiology ; Photometry ; Suprachiasmatic Nucleus/physiology ; Mice
Chemical Substances	Glucocorticoids ; Corticotropin-Releasing Hormone (9015-71-8) ; CLOCK Proteins (EC 2.3.1.48) ; Calcium (SY7Q814VUP) ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2021-10-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-25959-9
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Article ; Online: Different Roles for VIP Neurons in the Neonatal and Adult Suprachiasmatic Nucleus.

Mazuski, Cristina / Chen, Samantha P / Herzog, Erik D

Journal of biological rhythms

2020 Volume 35, Issue 5, Page(s) 465–475

Abstract: The suprachiasmatic nucleus (SCN) drives circadian rhythms in locomotion through coupled, single-cell oscillations. Global genetic deletion of the ... ...

Abstract	The suprachiasmatic nucleus (SCN) drives circadian rhythms in locomotion through coupled, single-cell oscillations. Global genetic deletion of the neuropeptide
MeSH term(s)	Aging/metabolism ; Animals ; Animals, Newborn/metabolism ; Circadian Clocks/genetics ; Circadian Rhythm/genetics ; Glucocorticoids/metabolism ; Male ; Mice ; Neurons/metabolism ; Receptors, Vasoactive Intestinal Peptide, Type II/metabolism ; Suprachiasmatic Nucleus/metabolism ; Vasoactive Intestinal Peptide/metabolism
Chemical Substances	Glucocorticoids ; Receptors, Vasoactive Intestinal Peptide, Type II ; Vipr2 protein, mouse ; Vasoactive Intestinal Peptide (37221-79-7)
Language	English
Publishing date	2020-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	896387-3
ISSN	1552-4531 ; 0748-7304
ISSN (online)	1552-4531
ISSN	0748-7304
DOI	10.1177/0748730420932073
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Article ; Online: The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep.

Herz, Rachel S / Herzog, Erik D / Merrow, Martha / Noya, Sara B

Journal of biological rhythms

2021 Volume 36, Issue 5, Page(s) 423–431

Abstract: Daily rhythms of behavior and neurophysiology are integral to the circadian clocks of all animals. Examples of circadian clock regulation in the human brain include daily rhythms in sleep-wake, cognitive function, olfactory sensitivity, and risk for ... ...

Abstract	Daily rhythms of behavior and neurophysiology are integral to the circadian clocks of all animals. Examples of circadian clock regulation in the human brain include daily rhythms in sleep-wake, cognitive function, olfactory sensitivity, and risk for ischemic stroke, all of which overlap with symptoms displayed by many COVID-19 patients. Motivated by the relatively unexplored, yet pervasive, overlap between circadian functions and COVID-19 neurological symptoms, this perspective piece uses daily variations in the sense of smell and the timing of sleep and wakefulness as illustrative examples. We propose that time-stamping clinical data and testing may expand and refine diagnosis and treatment of COVID-19.
MeSH term(s)	Animals ; Brain ; COVID-19 ; Circadian Clocks ; Circadian Rhythm ; Humans ; SARS-CoV-2 ; Sleep ; Smell ; Wakefulness
Language	English
Publishing date	2021-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	896387-3
ISSN	1552-4531 ; 0748-7304
ISSN (online)	1552-4531
ISSN	0748-7304
DOI	10.1177/07487304211031206
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Article ; Online: Hyperammonaemia disrupts daily rhythms reversibly by elevating glutamate in the central circadian pacemaker.

Granados-Fuentes, Daniel / Cho, Kevin / Patti, Gary J / Costa, Rodolfo / Herzog, Erik D / Montagnese, Sara

Liver international : official journal of the International Association for the Study of the Liver

2022 Volume 43, Issue 3, Page(s) 673–683

Abstract: Patients with cirrhosis exhibit features of circadian disruption. Hyperammonaemia has been suggested to impair both homeostatic and circadian sleep regulation. Here, we tested if hyperammonaemia directly disrupts circadian rhythm generation in the ... ...

Abstract	Patients with cirrhosis exhibit features of circadian disruption. Hyperammonaemia has been suggested to impair both homeostatic and circadian sleep regulation. Here, we tested if hyperammonaemia directly disrupts circadian rhythm generation in the central pacemaker, the suprachiasmatic nuclei (SCN) of the hypothalamus. Wheel-running activity was recorded from mice fed with a hyperammonaemic or normal diet for ~35 days in a 12:12 light-dark (LD) cycle followed by ~15 days in constant darkness (DD). The expression of the clock protein PERIOD2 (PER2) was recorded from SCN explants before, during and after ammonia exposure, ±glutamate receptor antagonists. In LD, hyperammonaemic mice advanced their daily activity onset time by ~1 h (16.8 ± 0.3 vs. 18.1 ± 0.04 h, p = .009) and decreased their total activity, concentrating it during the first half of the night. In DD, hyperammonaemia reduced the amplitude of daily activity (551.5 ± 27.7 vs. 724.9 ± 59 counts, p = .007), with no changes in circadian period. Ammonia (≥0.01 mM) rapidly and significantly reduced PER2 amplitude, and slightly increased circadian period. The decrease in PER2 amplitude correlated with decreased synchrony among circadian cells in the SCN and increased extracellular glutamate, which was rescued by AMPA glutamate receptor antagonists. These data suggest that hyperammonaemia affects circadian regulation of rest-activity behaviour by increasing extracellular glutamate in the SCN.
MeSH term(s)	Mice ; Animals ; Glutamic Acid ; Ammonia ; Excitatory Amino Acid Antagonists ; Hyperammonemia ; Circadian Rhythm/physiology
Chemical Substances	Glutamic Acid (3KX376GY7L) ; Ammonia (7664-41-7) ; Excitatory Amino Acid Antagonists
Language	English
Publishing date	2022-11-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.15476
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