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Article ; Online: Biological risk in Italian prisons: data analysis from the second to the fourth wave of COVID-19 pandemic.

Franchi, Cristiano / Rossi, Riccardo / Malizia, Andrea / Gaudio, Pasqualino / Di Giovanni, Daniele

2023 Volume 80, Issue 5, Page(s) 273–279

Abstract: Background: The management of COVID-19 in Italian prisons triggered considerable concern at the beginning of the pandemic due to numerous riots which resulted in inmate deaths, damages and prison breaks. The aim of this study is to shed some light, ... ...

Abstract	Background: The management of COVID-19 in Italian prisons triggered considerable concern at the beginning of the pandemic due to numerous riots which resulted in inmate deaths, damages and prison breaks. The aim of this study is to shed some light, through analysis of the infection and relevant disease parameters, on the period spanning from the second to the fourth wave of the outbreak in Italy's prisons. Methods: Reproductive number (Rt) and Hospitalisation were calculated through a Eulerian approach applied to differential equations derived from compartmental models. Comparison between trends was performed through paired t-test and linear regression analyses. Results: The infection trends (prevalence and Rt) show a high correlation between the prison population and the external community. Both the indices appear to be lagging 1 week in prison. The prisoners' Rt values are not statistically different from those of the general population. The hospitalisation trend of inmates strongly correlates with the external population's, with a delay of 2 weeks. The magnitude of hospitalisations in prison is less than in the external community for the period analysed. Conclusions: The comparison with the external community revealed that in prison the infection prevalence was greater, although Rt values showed no significant difference, and the hospitalisation rate was lower. These results suggest that the consistent monitoring of inmates results in a higher infection prevalence while a wide vaccination campaign leads to a lower hospitalisation rate. All three indices demonstrate a lag of 1 or 2 weeks in prison. This delay could represent a useful time-window to strengthen planned countermeasures.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Pandemics ; Prisons ; Prevalence ; Data Analysis
Language	English
Publishing date	2023-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1180733-7
ISSN	1470-7926 ; 1351-0711
ISSN (online)	1470-7926
ISSN	1351-0711
DOI	10.1136/oemed-2022-108599
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Article ; Online: Estimation of the transpulmonary pressure from the central venous pressure in mechanically ventilated patients.

Franchi, Federico / Detti, Emanuele / Fogagnolo, Alberto / Spadaro, Savino / Cevenini, Gabriele / Cataldo, Gennaro / Addabbo, Tommaso / Biuzzi, Cesare / Marianello, Daniele / Volta, Carlo Alberto / Taccone, Fabio Silvio / Scolletta, Sabino

Journal of clinical monitoring and computing

2024

Abstract: Transpulmonary pressure ( ... ...

Abstract	Transpulmonary pressure (P
Language	English
Publishing date	2024-03-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1418733-4
ISSN	1573-2614 ; 1387-1307 ; 0748-1977
ISSN (online)	1573-2614
ISSN	1387-1307 ; 0748-1977
DOI	10.1007/s10877-024-01150-5
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Article: Impact of Pre-Liver Transplant Treatments on the Imaging Accuracy of HCC Staging and Their Influence on Outcomes.

Franchi, Eloisa / Dondossola, Daniele Eliseo / Marini, Giulia Maria Francesca / Iavarone, Massimo / Del Prete, Luca / Di Benedetto, Clara / Donato, Maria Francesca / Antonelli, Barbara / Lampertico, Pietro / Caccamo, Lucio

Cancers

2024 Volume 16, Issue 5

Abstract: The outcome of liver transplantation (LT) for hepatocarcinoma (HCC) is strongly influenced by HCC staging, which is based on radiological examinations in a pre-LT setting; concordance between pre-LT radiological and definitive pathological staging ... ...

Abstract	The outcome of liver transplantation (LT) for hepatocarcinoma (HCC) is strongly influenced by HCC staging, which is based on radiological examinations in a pre-LT setting; concordance between pre-LT radiological and definitive pathological staging remains controversial. To address this issue, we retrospectively analyzed our LT series to assess concordance between radiology and pathology and to explore the factors associated with poor concordance and outcomes. We included all LTs with an HCC diagnosis performed between 2013 and 2018. Concordance (Co group) was defined as a comparable tumor burden in preoperative imaging and post-transplant pathology; otherwise, non-concordance was diagnosed (nCo group). Concordance between radiology and pathology was observed in 32/134 patients (Co group, 24%). The number and diameter of the nodules were higher when nCo was diagnosed, as was the number of pre-LT treatments. Although concordance did not affect survival, more than three pre-LT treatments led to a lower disease-free survival. Patients who met the Milan Criteria (Milan-in patients) were more likely to receive ≥three prior treatments, leading to a lower survival in multi-treated Milan-in patients than in other Milan-in patients. In conclusion, the concordance rate between the pre-LT imaging and histopathological results was low in patients with a high number of nodules. Multiple bridging therapies reduce the accuracy of pre-LT imaging in predicting HCC stages and negatively affect outcomes after LT.
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16051043
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Article ; Online: Effect of chemotherapy on tumour-vessel relationship in colorectal liver metastases.

Vigano, Luca / Terrone, Alfonso / Costa, Guido / Franchi, Eloisa / Cimino, Matteo / Procopio, Fabio / Del Fabbro, Daniele / Torzilli, Guido

The British journal of surgery

2022 Volume 109, Issue 5, Page(s) 401–404

MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant ; Colorectal Neoplasms/surgery ; Hepatectomy ; Humans ; Liver Neoplasms/surgery
Language	English
Publishing date	2022-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znac010
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Article ; Online: Biological Risk in Italian Prisons: From the COVID-19 Management to the Development of a Standardized Model for Emergency Response.

Franchi, Cristiano / Giacalone, Ezio / Di Giovanni, Daniele / Moramarco, Stefania / Carestia, Mariachiara

International journal of environmental research and public health

2021 Volume 18, Issue 19

Abstract: Within the confinements of critical infrastructures, the COVID-19 pandemic is posing a series of challenges to Health Management. In the spotlight of highly contagious and quick spreading diseases within such enclosed facilities, whether it be a ... ...

Abstract	Within the confinements of critical infrastructures, the COVID-19 pandemic is posing a series of challenges to Health Management. In the spotlight of highly contagious and quick spreading diseases within such enclosed facilities, whether it be a detention facility or otherwise, the health and safety of those living within its internment is paramount. This paper aims to highlight the specific challenges and the possible solutions to counteract this problem, starting from the lessons learnt from the Italian prison system case study. Following the general description of the available resources within the Italian prisons, the study aimed at specifically describing the first counteracting measures deployed by the Italian prison authorities during the first phase of the COVID-19 outbreak (February-July 2020). The aim was to propose an integrated plan capable of responding to a biological threat within the prisons. In particular, the study describes the actions and technical features that, in accordance with national and international legal frameworks and the relevant organisational bodies that run the Italian Prison Service, had been adopted in managing, right from the start, the COVID-19 pandemic until Summer 2020. Available information and data showed the ability of the prison administration to comply almost completely with WHO's technical and human rights recommendations and also, in successfully handling prison emergencies both in terms of the sick and the deceased in line with the epidemiological framework of the general population. In addition, the paper proposes a draft of guidelines that should involve the National Health Service and the Prison Service that are aimed at supporting the local prison facilities with drawing up their own biological incident contingency plans. An approved, legal, standardised plan could increase the awareness of prison managers. It could even increase their self-confidence, in particular, with regard to cases of dispute and their ability to respond to them. In fact, it is valuable and forward-thinking to be able to demonstrate that every endeavour has been taken and that 'certified' best practices have been put in place in accordance with the national standards.
MeSH term(s)	COVID-19 ; Emergencies ; Humans ; Italy/epidemiology ; Pandemics ; Prisons ; SARS-CoV-2 ; State Medicine
Language	English
Publishing date	2021-10-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph181910353
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Article: A Direct Arylation Approach for the Preparation of Benzothiadiazole-Based Fluorophores for Application in Luminescent Solar Concentrators

Papucci, Costanza / Ventura, Francesco / Franchi, Daniele / Dessi, Alessio / Pucci, Andrea / Reginato, Gianna / Mordini, Alessandro / Calamante, Massimo / Zani, Lorenzo

Synlett

2023 Volume 34, Issue 12, Page(s) 1462–1466

Abstract: A straightforward synthetic protocol featuring direct C–H arylations as key steps has been optimized to prepare two benzo-2,1,3-thiadiazole (BTD)-based organic fluorophores. Their light absorption and emission properties, as well as their affinity with ... ...

Abstract	A straightforward synthetic protocol featuring direct C–H arylations as key steps has been optimized to prepare two benzo-2,1,3-thiadiazole (BTD)-based organic fluorophores. Their light absorption and emission properties, as well as their affinity with poly(methyl methacrylate) as the chosen polymer matrix, were found to be suitable for application in luminescent solar concentrators. Solar-concentration devices were fabricated with both emitters, and their relevant optical and photovoltaic properties are presented.
Keywords	direct arylation ; fluorophores ; benzothiadiazoles ; luminescent solar concentrator ; photovoltaics
Language	English
Publishing date	2023-03-21
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2042012-2
ISSN	1437-2096 ; 0936-5214
ISSN (online)	1437-2096
ISSN	0936-5214
DOI	10.1055/a-2059-3372
Database	Thieme publisher's database

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Article ; Online: Biliary and duodenal complications after « en bloc» liver-small bowel transplantation in children. A single center cohort study.

Hervieux, Erik / Capito, Carmen / Franchi-Abella, Stéphanie / Pariente, Danièle / Lozach, Cécile / Sauvat, Frédérique / Lacaille, Florence / Chardot, Christophe

Pediatric transplantation

2021 Volume 25, Issue 6, Page(s) e14014

Abstract: Background: The technique of « en bloc» liver and small bowel transplantation (L-BT) spares a biliary anastomosis, but does not protect against biliary complications. We analyze biliary and duodenal complications (BDC) in our pediatric series.: ... ...

Abstract	Background: The technique of « en bloc» liver and small bowel transplantation (L-BT) spares a biliary anastomosis, but does not protect against biliary complications. We analyze biliary and duodenal complications (BDC) in our pediatric series. Methods: Between 1994 and 2020, 54 L-BT were performed in 53 children. The procurement technique included in situ vascular dissection and pancreatic reduction to the head until 2009 (group A). Thereafter, the whole pancreas was recovered (group B). Results: Nine BDCs occurred in 8/53 (15%) patients (7 in group A and 1 in group B): leak of the donor's duodenal stump (2), stenosis of the extra-pancreatic bile duct (5), and intra-pancreatic bile duct stenosis (2). Median delay for diagnosis of stricture was 8 months (4-168). Interventional radiology was successful in one child only, the others required reoperations. Two patients died, of biliary cirrhosis or cholangitis, 15-month and 12-year post-L-BT. One was listed and liver re-transplanted 13 years post-L-BT. At last follow-up, two patients only had normal liver tests and ultrasound. Conclusion: BDC after L-BT can cause severe morbidities. Pancreatic reduction might increase this risk. Early surgical complications or chronic pancreatic rejection might be co-factors. Early diagnosis and treatment are key to the long-term prognosis.
MeSH term(s)	Adolescent ; Biliary Tract Diseases/epidemiology ; Child ; Child, Preschool ; Duodenal Diseases/epidemiology ; Female ; France/epidemiology ; Humans ; Infant ; Intestine, Small/transplantation ; Liver Transplantation ; Male ; Pancreas/surgery ; Postoperative Complications/epidemiology ; Retrospective Studies
Language	English
Publishing date	2021-06-13
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14014
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Article: Recent Advances in Organic Dyes for Application in Dye-Sensitized Solar Cells under Indoor Lighting Conditions.

D'Amico, Francesco / de Jong, Bas / Bartolini, Matteo / Franchi, Daniele / Dessì, Alessio / Zani, Lorenzo / Yzeiri, Xheila / Gatto, Emanuela / Santucci, Annalisa / Di Carlo, Aldo / Reginato, Gianna / Cinà, Lucio / Vesce, Luigi

Materials (Basel, Switzerland)

2023 Volume 16, Issue 23

Abstract: Among the emerging photovoltaic (PV) technologies, Dye-Sensitized Solar Cells (DSSCs) appear especially interesting in view of their potential for unconventional PV applications. In particular, DSSCs have been proven to provide excellent performances ... ...

Abstract	Among the emerging photovoltaic (PV) technologies, Dye-Sensitized Solar Cells (DSSCs) appear especially interesting in view of their potential for unconventional PV applications. In particular, DSSCs have been proven to provide excellent performances under indoor illumination, opening the way to their use in the field of low-power devices, such as wearable electronics and wireless sensor networks, including those relevant for application to the rapidly growing Internet of Things technology. Considering the low intensity of indoor light sources, efficient light capture constitutes a pivotal factor in optimizing cell efficiency. Consequently, the development of novel dyes exhibiting intense absorption within the visible range and light-harvesting properties well-matched with the emission spectra of the various light sources becomes indispensable. In this review, we will discuss the current state-of-the-art in the design, synthesis, and application of organic dyes as sensitizers for indoor DSSCs, focusing on the most recent results. We will start by examining the various classes of individual dyes reported to date for this application, organized by their structural features, highlighting their strengths and weaknesses. On the basis of this discussion, we will then draft some potential guidelines in an effort to help the design of this kind of sensitizer. Subsequently, we will describe some alternative approaches investigated to improve the light-harvesting properties of the cells, such as the co-sensitization strategy and the use of concerted companion dyes. Finally, the issue of measurement standardization will be introduced, and some considerations regarding the proper characterization methods of indoor PV systems and their differences compared to (simulated) outdoor conditions will be provided.
Language	English
Publishing date	2023-11-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16237338
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Article ; Online: Biological Risk in Italian Prisons

Cristiano Franchi / Ezio Giacalone / Daniele Di Giovanni / Stefania Moramarco / Mariachiara Carestia

International Journal of Environmental Research and Public Health, Vol 18, Iss 10353, p

From the COVID-19 Management to the Development of a Standardized Model for Emergency Response

2021 Volume 10353

Abstract	Within the confinements of critical infrastructures, the COVID-19 pandemic is posing a series of challenges to Health Management. In the spotlight of highly contagious and quick spreading diseases within such enclosed facilities, whether it be a detention facility or otherwise, the health and safety of those living within its internment is paramount. This paper aims to highlight the specific challenges and the possible solutions to counteract this problem, starting from the lessons learnt from the Italian prison system case study. Following the general description of the available resources within the Italian prisons, the study aimed at specifically describing the first counteracting measures deployed by the Italian prison authorities during the first phase of the COVID-19 outbreak (February–July 2020). The aim was to propose an integrated plan capable of responding to a biological threat within the prisons. In particular, the study describes the actions and technical features that, in accordance with national and international legal frameworks and the relevant organisational bodies that run the Italian Prison Service, had been adopted in managing, right from the start, the COVID-19 pandemic until Summer 2020. Available information and data showed the ability of the prison administration to comply almost completely with WHO’s technical and human rights recommendations and also, in successfully handling prison emergencies both in terms of the sick and the deceased in line with the epidemiological framework of the general population. In addition, the paper proposes a draft of guidelines that should involve the National Health Service and the Prison Service that are aimed at supporting the local prison facilities with drawing up their own biological incident contingency plans. An approved, legal, standardised plan could increase the awareness of prison managers. It could even increase their self-confidence, in particular, with regard to cases of dispute and their ability to respond to them. In fact, it is valuable ...
Keywords	biological risk ; communicable diseases ; indoor facilities ; prison system ; epidemics ; outbreaks ; Medicine ; R
Subject code	027
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Prokineticin 2 and Cytokine Content in the Synovial Fluid of Knee Osteoarthritis and Traumatic Meniscal Tear Patients: Preliminary Results.

Turati, Marco / Franchi, Silvia / Crippa, Marco / Rizzi, Laura / Rigamonti, Luca / Sacerdote, Paola / Gatti, Simone Daniel / Piatti, Massimiliano / Galimberti, Giulia / Munegato, Daniele / Amodeo, Giada / Omeljaniuk, Robert J / Zatti, Giovanni / Torsello, Antonio / Bigoni, Marco

Journal of clinical medicine

2023 Volume 12, Issue 13

Abstract: Knee osteoarthritis (OA) is a chronic degenerative inflammatory-based condition caused by a cascade of different intra-articular molecules including several cytokines. Among the cytokines, prokineticins (PKs) have recently been identified as important ... ...

Abstract	Knee osteoarthritis (OA) is a chronic degenerative inflammatory-based condition caused by a cascade of different intra-articular molecules including several cytokines. Among the cytokines, prokineticins (PKs) have recently been identified as important mediators of inflammation and pain. This observational study examined the potential involvement of PK2 in degenerative or traumatic knee disease. Fifteen patients presenting knee osteoarthritis (OA group) and 15 patients presenting a traumatic meniscal tear (TM group) were studied. Synovial fluid samples from affected knees were assessed for PK2, IL-10, and TNF-α using the ELISA method. At a long-term follow-up (minimum 5 years, mean = 6.1 years), patients in the TM group underwent clinical re-evaluation with PROMs (Tegner Activity Scale, IKDC, Lysholm, SKV); in addition, X-ray visualization was used to assess the presence of secondary OA. PK2 was detected in synovial fluids of both TM and OA patients and the levels were comparable between the two groups, while IL-10 levels were significantly greater in the OA group than those in TM patients. PK2 levels correlated with those of IL-10. PK2 levels were greater in blood effusions compared to clear samples, did not differ significantly between sexes, nor were they related to differences in weight, height, or injury (meniscal laterality, time since dosing). No correlation was found between PROMs and radiological classifications in patients in the TM group at final follow-up. These data are the first observations of PK2 in synovial fluid following traumatic meniscus injury. These findings suggest possible further prognostic indices and therapeutic targets to limit the development of secondary OA.
Language	English
Publishing date	2023-06-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12134330
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