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  1. Article ; Online: MGMT Promoter Methylation and Chemotherapy Outcomes in Low-Grade and Anaplastic Gliomas-Reply.

    Kinslow, Connor J / Cheng, Simon K / Wang, Tony J C

    JAMA oncology

    2023  Volume 9, Issue 12, Page(s) 1735–1736

    MeSH term(s) Humans ; Glioma/drug therapy ; Glioma/genetics ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Methylation ; DNA Methylation ; DNA Repair Enzymes/genetics ; Prognosis ; DNA Modification Methylases/genetics ; Tumor Suppressor Proteins/genetics
    Chemical Substances DNA Repair Enzymes (EC 6.5.1.-) ; MGMT protein, human (EC 2.1.1.63) ; DNA Modification Methylases (EC 2.1.1.-) ; Tumor Suppressor Proteins
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2023.4754
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  2. Article ; Online: Where Do We (INDI)GO From Here?

    Kinslow, Connor J / Brown, Paul D / Iwamoto, Fabio M / Wu, Cheng-Chia / Yu, James B / Cheng, Simon K / Wang, Tony J C

    International journal of radiation oncology, biology, physics

    2024  Volume 118, Issue 2, Page(s) 330–333

    Language English
    Publishing date 2024-01-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2023.09.008
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    Zs.A 1218: Show issues Location:
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  3. Article ; Online: Correction to: Incidental findings on 3 T neuroimaging: cross-sectional observations from the population-based Rhineland Study.

    Lohner, Valerie / Lu, Ran / Enkirch, Simon J / Stöcker, Tony / Hattingen, Elke / Breteler, Monique M B

    Neuroradiology

    2022  Volume 64, Issue 3, Page(s) 633

    Language English
    Publishing date 2022-01-12
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 123305-1
    ISSN 1432-1920 ; 0028-3940
    ISSN (online) 1432-1920
    ISSN 0028-3940
    DOI 10.1007/s00234-021-02880-y
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    Zs.A 658: Show issues Location:
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  4. Article ; Online: Extent of resection for low-grade gliomas - Prognostic or therapeutic?

    Kinslow, Connor J / Garton, Andrew L A / Rae, Ali I / Kocakavuk, Emre / McKhann, Guy M / Cheng, Simon K / Sisti, Michael B / Bruce, Jeffrey N / Wang, Tony J C

    Clinical neurology and neurosurgery

    2024  Volume 236, Page(s) 108117

    MeSH term(s) Humans ; Prognosis ; Glioma/surgery ; Brain Neoplasms/surgery ; Mutation ; Isocitrate Dehydrogenase/genetics
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2024-01-09
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2024.108117
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  5. Article ; Online: Relative Effects of Radiation-Induced Changes in Bone Mass, Structure, and Tissue Material on Vertebral Strength in a Rat Model.

    Emerzian, Shannon R / Wu, Tongge / Vaidya, Rachana / Tang, Simon Y / Abergel, Rebecca J / Keaveny, Tony M

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2023  Volume 38, Issue 7, Page(s) 1032–1042

    Abstract: The observed increased risk of fracture after cancer radiation therapy is presumably due to a radiation-induced reduction in whole-bone strength. However, the mechanisms for impaired strength remain unclear, as the increased fracture risk is not fully ... ...

    Abstract The observed increased risk of fracture after cancer radiation therapy is presumably due to a radiation-induced reduction in whole-bone strength. However, the mechanisms for impaired strength remain unclear, as the increased fracture risk is not fully explained by changes in bone mass. To provide insight, a small animal model was used to determine how much of this whole-bone weakening effect for the spine is attributable to changes in bone mass, structure, and material properties of the bone tissue and their relative effects. Further, because women have a greater risk of fracture after radiation therapy than men, we investigated if sex had a significant influence on bone's response to irradiation. Fractionated in vivo irradiation (10 × 3 Gy) or sham irradiation (0 Gy) was administered daily to the lumbar spine in twenty-seven 17-week-old Sprague-Dawley rats (n = 6-7/sex/group). Twelve weeks after final treatment, animals were euthanized, and lumbar vertebrae (L
    MeSH term(s) Rats ; Female ; Animals ; Rats, Sprague-Dawley ; Bone Density/physiology ; Bone and Bones ; Lumbar Vertebrae ; X-Ray Microtomography ; Fractures, Bone
    Language English
    Publishing date 2023-06-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.4828
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    Zs.A 2142: Show issues Location:
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  6. Article: Safety of Tattoos, Permanent Make-Up, and Medical Implants in Population-Based 3T Magnetic Resonance Brain Imaging: The Rhineland Study.

    Lohner, Valerie / Enkirch, Simon J / Hattingen, Elke / Stöcker, Tony / Breteler, Monique M B

    Frontiers in neurology

    2022  Volume 13, Page(s) 795573

    Abstract: Excluding persons from magnetic resonance imaging (MRI) research studies based on their medical history or because they have tattoos, can create bias and compromise the validity and generalizability of study results. In the population-based Rhineland ... ...

    Abstract Excluding persons from magnetic resonance imaging (MRI) research studies based on their medical history or because they have tattoos, can create bias and compromise the validity and generalizability of study results. In the population-based Rhineland Study, we limited exclusion criteria for MRI and allowed participants with passive medical implants, tattoos or permanent make-up to undergo MRI. Thereby, we could include 16.6% more people than would have been possible based on common recommendations. We observed no adverse events or artifacts. This supports that most passive medical implants, tattoos and permanent make-up are MRI suitable and can be scanned in research settings.
    Language English
    Publishing date 2022-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.795573
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  7. Article: Misclassification of Diffuse Gliomas-Letter.

    Kinslow, Connor J / Canoll, Peter / Cheng, Simon K / Wang, Tony J C

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2020  Volume 26, Issue 5, Page(s) 1198

    MeSH term(s) Glioma ; Humans ; Isocitrate Dehydrogenase
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2020-02-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-19-3257
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    Zs.A 4223: Show issues Location:
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  8. Article ; Online: Deciphering Tumor Cell Evolution in Cutaneous T-Cell Lymphomas: Distinct Differentiation Trajectories in Mycosis Fungoides and Sézary Syndrome.

    Jiang, Tony T / Cao, Simon / Kruglov, Oleg / Virmani, Aman / Geskin, Larisa J / Falo, Louis D / Akilov, Oleg E

    The Journal of investigative dermatology

    2023  Volume 144, Issue 5, Page(s) 1088–1098

    Abstract: Cutaneous T-cell lymphomas are a heterogeneous group of neoplasms originating in the skin, with mycosis fungoides (MF) and Sézary syndrome (SS) representing the most common variants. The cellular origin of cutaneous lymphomas has remained controversial ... ...

    Abstract Cutaneous T-cell lymphomas are a heterogeneous group of neoplasms originating in the skin, with mycosis fungoides (MF) and Sézary syndrome (SS) representing the most common variants. The cellular origin of cutaneous lymphomas has remained controversial owing to their immense phenotypic heterogeneity that obfuscates lineage reconstruction on the basis of classical surface biomarkers. To overcome this heterogeneity and reconstruct the differentiation trajectory of malignant cells in MF and SS, TCR sequencing was performed in parallel with targeted transcriptomics at the single-cell resolution among cutaneous samples in MF and SS. Unsupervised lineage reconstruction showed that Sézary cells exist as a population of CD4
    MeSH term(s) Humans ; Sezary Syndrome/pathology ; Sezary Syndrome/genetics ; Sezary Syndrome/immunology ; Mycosis Fungoides/pathology ; Mycosis Fungoides/genetics ; Mycosis Fungoides/immunology ; Skin Neoplasms/pathology ; Skin Neoplasms/genetics ; Skin Neoplasms/immunology ; Cell Differentiation ; Male ; Lymphoma, T-Cell, Cutaneous/pathology ; Lymphoma, T-Cell, Cutaneous/genetics ; Middle Aged ; Female ; Aged ; Cell Proliferation/genetics
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.10.018
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    Ui VI Zs.124: Show issues Location:
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  9. Article ; Online: Pyrene-Appended Boronic Acids on Graphene Foam Electrodes Provide Quantum Capacitance-Based Molecular Sensors for Lactate.

    Wikeley, Simon M / Przybylowski, Jakub / Gardiner, Jordan E / James, Tony D / Fletcher, Philip J / Isaacs, Mark A / Lozano-Sanchez, Pablo / Caffio, Marco / Marken, Frank

    ACS sensors

    2024  Volume 9, Issue 3, Page(s) 1565–1574

    Abstract: Molecular recognition and sensing can be coupled to interfacial capacitance changes on graphene foam surfaces linked to double layer effects and coupled to enhanced quantum capacitance. 3D graphene foam film electrodes (Gii-Sens; thickness approximately ... ...

    Abstract Molecular recognition and sensing can be coupled to interfacial capacitance changes on graphene foam surfaces linked to double layer effects and coupled to enhanced quantum capacitance. 3D graphene foam film electrodes (Gii-Sens; thickness approximately 40 μm; roughness factor approximately 100) immersed in aqueous buffer media exhibit an order of magnitude jump in electrochemical capacitance upon adsorption of a charged molecular receptor based on pyrene-appended boronic acids (here, 4-borono-1-(pyren-2-ylmethyl)pyridin-1-ium bromide, or abbreviated T1). This pyrene-appended pyridinium boronic acid receptor is employed here as a molecular receptor for lactate. In the presence of lactate and at pH 4.0 (after pH optimization), the electrochemical capacitance (determined by impedance spectroscopy) doubles again. Lactic acid binding is expressed with a Hillian binding constant (
    MeSH term(s) Humans ; Lactic Acid/analysis ; Graphite/chemistry ; Boronic Acids/chemistry ; Sweat/chemistry ; Electrodes
    Chemical Substances Lactic Acid (33X04XA5AT) ; Graphite (7782-42-5) ; Boronic Acids
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.4c00027
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  10. Article ; Online: Anticoagulant Rodenticide Toxicity in Terrestrial Raptors: Tools to Estimate the Impact on Populations in North America and Globally.

    Elliott, John E / Silverthorn, Veronica / English, Simon G / Mineau, Pierre / Hindmarch, Sofi / Thomas, Philippe J / Lee, Sandi / Bowes, Victoria / Redford, Tony / Maisonneuve, France / Okoniewski, Joseph

    Environmental toxicology and chemistry

    2024  Volume 43, Issue 5, Page(s) 988–998

    Abstract: Anticoagulant rodenticides (ARs) have caused widespread contamination and poisoning of predators and scavengers. The diagnosis of toxicity proceeds from evidence of hemorrhage, and subsequent detection of residues in liver. Many factors confound the ... ...

    Abstract Anticoagulant rodenticides (ARs) have caused widespread contamination and poisoning of predators and scavengers. The diagnosis of toxicity proceeds from evidence of hemorrhage, and subsequent detection of residues in liver. Many factors confound the assessment of AR poisoning, particularly exposure dose, timing and frequency of exposure, and individual and taxon-specific variables. There is a need, therefore, for better AR toxicity criteria. To respond, we compiled a database of second-generation anticoagulant rodenticide (SGAR) residues in liver and postmortem evaluations of 951 terrestrial raptor carcasses from Canada and the United States, 1989 to 2021. We developed mixed-effects logistic regression models to produce specific probability curves of the toxicity of ∑SGARs at the taxonomic level of the family, and separately for three SGARs registered in North America, brodifacoum, bromadiolone, and difethialone. The ∑SGAR threshold concentrations for diagnosis of coagulopathy at 0.20 probability of risk were highest for strigid owls (15 ng g
    MeSH term(s) Rodenticides/toxicity ; Animals ; Anticoagulants/toxicity ; Anticoagulants/poisoning ; Raptors ; 4-Hydroxycoumarins/poisoning ; 4-Hydroxycoumarins/toxicity ; Canada ; Environmental Monitoring
    Chemical Substances Rodenticides ; Anticoagulants ; 4-Hydroxycoumarins ; bromfenacoum (A25P3CP5S7) ; bromadiolone (J2FR050NM5) ; difethialone (KOL4VXI5O0)
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 46234-2
    ISSN 1552-8618 ; 0730-7268
    ISSN (online) 1552-8618
    ISSN 0730-7268
    DOI 10.1002/etc.5829
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    Zs.A 2312: Show issues Location:
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