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Article ; Online: Obinutuzumab interference with immunoelectrophoresis in a case of follicular lymphoma.

Atas, Unal / Karakus, Volkan / Tekin, Imge Bortay / Aydin, Ozgur / Sevindik, Omur Gokmen / Undar, Levent

International journal of laboratory hematology

2024

Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Letter
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.14284
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Article ; Online: Evaluation of Histopathologic Alterations in First-trimester COVID-19-positive Pregnancies Ending in Abortion.

Adanaş Aydin, Gültekin / Nalbant, Melike / Ünal, Serhat / Tosun, Serkan

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

2023 Volume 42, Issue 6, Page(s) 582–588

Abstract: This study aims to evaluate histopathologic alterations and the presence of chronic histiocytic intervillositis in first-trimester coronavirus-2019 (COVID-19)-positive pregnancies ending in abortion, compared with those at a similar gestational week and ... ...

Abstract	This study aims to evaluate histopathologic alterations and the presence of chronic histiocytic intervillositis in first-trimester coronavirus-2019 (COVID-19)-positive pregnancies ending in abortion, compared with those at a similar gestational week and undergoing curettage before the pandemic. This retrospective case-control study consisted of 9 patients who were infected with COVID-19 and undergoing curettage for abortion between April 2020 and January 2021. The control group consisted of 34 patients with a similar gestational age who underwent curettage for abortion before August 2019. Demographic and clinical data were recorded. A histopathologic examination of the placental specimens was performed. The CD68 immunostaining was performed to detect intravillous and intervillous histiocytes. At the time of diagnosis of COVID 19, 7 patients (77.8%) of COVID-19-positive women had symptoms with the most common symptoms of fatigue (66.7%) and cough (55.6%). Histopathologic examination revealed that the rate of intravillous and intervillous calcification, intervillous fibrinoid deposition, hydropic villi and acute lymphocytic villitis, and fetal and maternal thrombi was significantly higher in the COVID-19-positive patients than the control group ( P =0.049, 0.002, 0.049, 0.014, 0.008, 0.001, and 0.014, respectively). There was a significant difference in the CD68 staining of the intravillous and intervillous histiocytes between the groups ( P =0.001). This study showed a significant increase in the intervillous fibrinoid deposition, thrombi formation in the maternal and fetal vascular structures, acute lymphocytic villitis, and an increase of CD68 + stained histiocytes in the intravillous and intervillous spaces in women infected with COVID-19 during the first trimester of pregnancy.
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	604859-6
ISSN	1538-7151 ; 0277-1691
ISSN (online)	1538-7151
ISSN	0277-1691
DOI	10.1097/PGP.0000000000000939
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Zs.A 1814: Show issues

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Article: Genetic Architecture of Depression: Where Do We Stand Now?

Unal-Aydin, Pinar / Aydin, Orkun / Arslan, Ayla

Advances in experimental medicine and biology

2021 Volume 1305, Page(s) 203–230

Abstract: The research of depression genetics has been occupied by historical candidate genes which were tested by candidate gene association studies. However, these studies were mostly not replicable. Thus, genetics of depression have remained elusive for a long ... ...

Abstract	The research of depression genetics has been occupied by historical candidate genes which were tested by candidate gene association studies. However, these studies were mostly not replicable. Thus, genetics of depression have remained elusive for a long time. As research moves from candidate gene association studies to GWAS, the hypothesis-free non-candidate gene association studies in genome-wide level, this trend will likely change. Despite the fact that the earlier GWAS of depression were not successful, the recent GWAS suggest robust findings for depression genetics. These altogether will catalyze a new wave of multidisciplinary research to pin down the neurobiology of depression.
MeSH term(s)	Depression/genetics ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-981-33-6044-0_12
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Article ; Online: Comparison of Maternal and Perinatal Outcomes Associated with Delta (B.1.617.2) and Other Variants of Severe Acute Respiratory Syndrome-Coronavirus 2.

Unal, Serhat / Kilic, Isa / Aydin, Gultekin Adanas / Ozsoy, Hilal Gulsum Turan

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2023 Volume 33, Issue 7, Page(s) 809–814

Abstract: Objective: To compare the frequency of adverse maternal and perinatal outcomes associated with delta (B.1.617.2) and other variants of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2).: Study design: An observational study. Place and ... ...

Abstract	Objective: To compare the frequency of adverse maternal and perinatal outcomes associated with delta (B.1.617.2) and other variants of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Study design: An observational study. Place and Duration of the Study: Bursa City Hospital, Bursa, Turkey, from March 2020 to February 2022. Methodology: The study included 423 pregnant women diagnosed with COVID-19 based on real-time reverse transcriptase-polymerase chain reaction (RT-PCR) testing. The patients were divided into the delta variant (n=135) and other variants (n=288) (alpha, beta, gamma) groups, and maternal and perinatal outcomes were compared between the groups. Data including symptoms, laboratory findings, radiological findings, hospital and intensive care unit (ICU) stay, delivery outcomes, and mortality rates were recorded. Results: The delta variant group demonstrated higher rates of moderate and severe pneumonia than the other variant group (p=0.005). According to the World Health Organization (WHO) classification, 49.6% and 18.5% of patients experienced moderate and severe disease, respectively in the delta variant group, compared to 38.5% and 10.1%, respectively in the other variant group (p=0.001). A total of 20.0% of the patients in the delta variant group and 8.3% of the patients in the other variant group required ICU stay. The length of ICU stay was significantly longer in the delta variant group (p=0.001). Conclusion: The rates of maternal morbidity and mortality increased in the pregnant population with low rates of vaccination in the period of the fourth wave which was associated with the delta variant. No significant difference was observed in perinatal morbidity between the delta and other variants. Key words: COVID-19, Delta variant, Maternal morbidity, Perinatal outcomes, Adverse pregnancy outcomes.
MeSH term(s)	Humans ; Female ; Pregnancy ; SARS-CoV-2 ; COVID-19/epidemiology ; Pregnancy Outcome ; Pregnancy Complications, Infectious/epidemiology
Language	English
Publishing date	2023-07-04
Publishing country	Pakistan
Document type	Observational Study ; Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2023.07.809
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Article ; Online: Anastomosis Groups and Pathogenicity of Rhizoctonia solani Kühn Isolates Obtained from Pistachio (Pistacia vera L.) Saplings in Siirt Province, Turkey

Mehmet Hadi AYDIN / Filiz ÜNAL

Türkiye Tarımsal Araştırmalar Dergisi, Vol 8, Iss 1, Pp 18-

2021 Volume 26

Abstract: Pathogenicity and anastomosis groups of seven Rhizoctonia-like isolates obtained from infected pistachio (Pistacia vera L.) seedlings were determined, in the central district of Siirt province at Southeast Anatolia Region in Turkey. Browning on the crown ...

Abstract	Pathogenicity and anastomosis groups of seven Rhizoctonia-like isolates obtained from infected pistachio (Pistacia vera L.) seedlings were determined, in the central district of Siirt province at Southeast Anatolia Region in Turkey. Browning on the crown root of the collected saplings and drying of plants were observed. In the pathogenicity test, the most virulent isolate was Rs2 with a disease severity of 93.75%. The anastomosis group of this isolate, which caused the saplings to dry completely was determined as Rhizoctonia solani AG-4. The moderately virulent Rs3 and Rs1 isolates were determined as the binucleate AG-F group. These two isolates caused yellowing of the seedling leaves and browning of the roots, however, the plants did not die and preserved their vitality to a certain extent. The R9 and R14 isolates identified as anastomosis group AG-F did not cause any symptoms on inoculated plants and on the negative control. The Rs7 and Rs10 isolates were identified as the anastomosis group AG-4 and were determined to be pathogenic in saplings. The results of this study are the first record for the virulence and anastomosis groups of Rhizoctonia species that cause root and crown root diseases in Siirt pistachio.
Keywords	pistachio ; rhizoctonia ; pathogenicity ; anastomosis group ; polymerase chain reaction ; Agriculture ; S ; Agriculture (General) ; S1-972
Subject code	580
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Siirt University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Development of Neuroimaging-Based Biomarkers in Psychiatry.

Aydin, Orkun / Unal Aydin, Pinar / Arslan, Ayla

Advances in experimental medicine and biology

2019 Volume 1192, Page(s) 159–195

Abstract: This chapter presents an overview of accumulating neuroimaging data with emphasis on translational potential. The subject will be described in the context of three disease states, i.e., schizophrenia, bipolar disorder, and major depressive disorder, and ... ...

Abstract	This chapter presents an overview of accumulating neuroimaging data with emphasis on translational potential. The subject will be described in the context of three disease states, i.e., schizophrenia, bipolar disorder, and major depressive disorder, and for three clinical goals, i.e., disease risk assessment, subtyping, and treatment decision.
MeSH term(s)	Biomarkers ; Bipolar Disorder/diagnostic imaging ; Brain/diagnostic imaging ; Clinical Decision-Making ; Depressive Disorder, Major/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Neuroimaging ; Psychiatry ; Risk Assessment ; Schizophrenia/diagnostic imaging
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-11-08
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-981-32-9721-0_9
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Article ; Online: The effect of emotion recognition and mindfulness on depression symptoms: A case-control study.

Aydın, Orkun / Tvrtkovic, Selma / Çakıroğlu, Elif / Ünal-Aydın, Pınar / Esen-Danacı, Ayşen

Scandinavian journal of psychology

2023

Abstract: Abnormalities in emotion recognition (ER) are frequently reported in depression, with lower recognition accuracy in patients with major depressive disorder (MDD) when compared to healthy individuals. Mindfulness was found to directly impact the severity ... ...

Abstract	Abnormalities in emotion recognition (ER) are frequently reported in depression, with lower recognition accuracy in patients with major depressive disorder (MDD) when compared to healthy individuals. Mindfulness was found to directly impact the severity of depressive symptoms, by recognizing negative cognitions and dysfunctional reactions. The aims of this study were to compare ER and mindfulness levels between MDD patients and healthy controls (HCs), as well as to examine whether ER and mindfulness are related to symptom severity in MDD patients. Sixty-eight patients with MDD and 93 HCs participated in the study. A sociodemographic form, reading the mind in the eyes test (RMET), five facet mindfulness questionnaire-short form (FFMQ-S) and the Montgomery-Asberg depression scale (MADRS) were administered. Group comparison in ER and mindfulness was performed using the multivariate analysis of covariance (MANCOVA). Bivariate correlations and hierarchical linear regression analyses were performed to assess the associations between depression severity, ER and mindfulness in the patient group. Higher level of mindfulness was found in HCs relative to MDD group, however, no ER difference was present between the groups. A positive association between depression severity and the non-reactivity facet of mindfulness was found. On the other hand, ER was not significantly associated with symptom severity among individuals with MDD. Non-reactivity, unlike other dimensions of mindfulness, seems to increase with the severity of depressive symptoms among MDD patients. A particular focus on this subdimension in mindfulness techniques may yield better outcomes in alleviation of depressive symptoms.
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	219197-0
ISSN	1467-9450 ; 0036-5564
ISSN (online)	1467-9450
ISSN	0036-5564
DOI	10.1111/sjop.12992
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Article ; Online: The role of metacognitions in cyberbullying and cybervictimization among adolescents diagnosed with major depressive disorder and anxiety disorders: A case-control study.

Ünal-Aydın, Pınar / Özkan, Yekta / Öztürk, Masum / Aydın, Orkun / Spada, Marcantonio M

Clinical psychology & psychotherapy

2023 Volume 30, Issue 3, Page(s) 659–670

Abstract: Cyberbullying is becoming increasingly widespread as individuals use technology more widely and frequently. Recent studies have shown a growing vulnerability for cyberbullying and cybervictimization, particularly in the adolescent population. We argue ... ...

Abstract	Cyberbullying is becoming increasingly widespread as individuals use technology more widely and frequently. Recent studies have shown a growing vulnerability for cyberbullying and cybervictimization, particularly in the adolescent population. We argue that dysfunctional metacognitions, which have been found to be prominent in various psychiatric disorders, may also play a role in predicting cyberbullying and cybervictimization over and above a variety of established factors including daily Internet use, social media use, depression and anxiety. For this purpose, we recruited 121 adolescents diagnosed with major depressive disorder (MDD) and 122 adolescents diagnosed with anxiety disorders (AD) from the child and adolescent psychiatric department of 'Çankırı State Hospital' along with age and gender matched healthy controls (n = 120). Participants completed the DSM-5 Depression and Anxiety Severity Scales, the Social Media Disorder Scale (SMDS), the Metacognitions Questionnaire for Children (MCQ-C) and the Revised Cyberbullying Inventory-II (RCBI-II). Cybervictimization scores were found to be higher in the MDD and AD groups when compared with healthy controls. Cyberbullying scores in the MDD group were higher than healthy controls. Additionally, the Superstition, Punishment and Responsibility subdimension of the MCQ-C was a significant predictor of cybervictimization in the AD group while controlling for daily Internet use, social media use and anxiety. However, metacognitions were not associated with cyberbullying in the MDD and AD groups, as well as with cybervictimization in the MDD group. We concluded that dysfunctional metacognitions may be a preventive therapeutic target in reducing the impact of cyberbullying in adolescents with AD.
MeSH term(s)	Child ; Humans ; Adolescent ; Cyberbullying/psychology ; Depressive Disorder, Major/diagnosis ; Case-Control Studies ; Metacognition ; Anxiety Disorders/diagnosis ; Bullying/psychology
Language	English
Publishing date	2023-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1169313-7
ISSN	1099-0879 ; 1063-3995
ISSN (online)	1099-0879
ISSN	1063-3995
DOI	10.1002/cpp.2826
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Article: Anastomosis Groups and Pathogenicity of Rhizoctonia solani Kühn Isolates Obtained from Pistachio (Pistacia vera L.) Saplings in Siirt Province, Turkey

Mehmet Hadi AYDIN / Filiz ÜNAL

Türkiye tarımsal araştırmalar dergisi. 2021 Feb., v. 8, no. 1

2021

Abstract	Pathogenicity and anastomosis groups of seven Rhizoctonia-like isolates obtained from infected pistachio (Pistacia vera L.) seedlings were determined, in the central district of Siirt province at Southeast Anatolia Region in Turkey. Browning on the crown root of the collected saplings and drying of plants were observed. In the pathogenicity test, the most virulent isolate was Rs2 with a disease severity of 93.75%. The anastomosis group of this isolate, which caused the saplings to dry completely was determined as Rhizoctonia solani AG-4. The moderately virulent Rs3 and Rs1 isolates were determined as the binucleate AG-F group. These two isolates caused yellowing of the seedling leaves and browning of the roots, however, the plants did not die and preserved their vitality to a certain extent. The R9 and R14 isolates identified as anastomosis group AG-F did not cause any symptoms on inoculated plants and on the negative control. The Rs7 and Rs10 isolates were identified as the anastomosis group AG-4 and were determined to be pathogenic in saplings. The results of this study are the first record for the virulence and anastomosis groups of Rhizoctonia species that cause root and crown root diseases in Siirt pistachio.
Keywords	Pistacia vera ; Rhizoctonia ; Thanatephorus cucumeris ; Turkey (country) ; disease severity ; pistachios ; seedlings ; virulence
Language	English
Dates of publication	2021-02
Size	p. 18-26.
Publishing place	Siirt University
Document type	Article
ISSN	2528-858X
DOI	10.19159/tutad.781041
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The problematic use of social networking sites associates with elevated symptoms in patients with major depressive disorder.

Aydin, Orkun / Çökmüş, Fikret Poyraz / Balikçi, Kuzeymen / Sücüllüoğlu-Dikici, Didem / Ünal-Aydin, Pınar

The International journal of social psychiatry

2020 Volume 66, Issue 5, Page(s) 496–503

Abstract: Background: Although excessive use of social networking site (SNS) is related to undesired effects on healthy individual's psychological well-being, there is a huge gap in studies performed with individuals who suffer from various mental disorders.: ... ...

Abstract	Background: Although excessive use of social networking site (SNS) is related to undesired effects on healthy individual's psychological well-being, there is a huge gap in studies performed with individuals who suffer from various mental disorders. Aim: The main goal of this study is to examine the association between problematic utilization of SNSs and depressive symptoms across patients diagnosed with major depressive disorder (MDD). Methods: 111 patients diagnosed with MDD (diagnoses confirmed via the Structured Clinical Interview for DSM-5-Clinician Version (SCID-5/CV)) and 108 healthy controls (HCs) were recruited for the study. Montgomery-Asberg Depression Rating Scale (MADRS) and Bergen Social Media Addiction Scale (BSMAS) were administered by both MDD and HC groups. Group comparisons were estimated with multivariate analysis of covariance (MANCOVA) analyses. To identify the relationship between SNS addiction and depressive symptoms, the Pearson correlations were performed, and finally, we computed the multiple linear regression analyses to determine whether SNS addiction predicts depressive symptoms. Results: The results revealed that MDD group is more addicted to SNS relative to HC. In addition, depressive symptoms were significantly predicted by 'relapse' subdimension and the overall score of SNS addiction in the MDD group. Conclusion: Our study illustrated the detrimental effects of excessive SNSs usage on depressive symptoms in MDD particularly for the individuals in 'relapse' state of SNS addiction. The mental health workers should consider the usage patterns of SNSs in patients diagnosed with MDD during their clinical observation and management.
MeSH term(s)	Adult ; Case-Control Studies ; Depressive Disorder, Major ; Female ; Humans ; Internet Addiction Disorder/psychology ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Social Media ; Social Networking ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2020-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	3062-4
ISSN	1741-2854 ; 0020-7640
ISSN (online)	1741-2854
ISSN	0020-7640
DOI	10.1177/0020764020919791
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